Female, Hypoalbuminemia, And Prolonged Prothrombin Time Associated With Quality Of Life In Chronic Hepatitis B
FEMALE, HYPOALBUMINEMIA, AND PROLONGED PROTHROMBIN TIME ASSOCIATED WITH QUALITY OF LIFE IN
CHRONIC HEPATITIS B
Gontar Alamsyah Siregar, Sahat Halim, Ricky Rivalino Sitepu, Muhammad Syakur Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine,
University of Sumatera Utara/ Adam Malik Hospital, Medan, Indonesia
Abstract Objectives. The purpose of this study was determine the health related quality of life (HRQOL) in chronic hepatitis B and also aimed to assess factors (baseline information of demographics and laboratory parameters) related with HRQOL in CHB patients. Methods. Quality of life was prospectively investigated in February – July 2013. Simple random sampling was done to get 60 CHB patients, with or without cirrhosis. Diagnosis of chronic HBV infection was based on the presence of hepatitis B surface antigen for more than six months, elevated serum alanine aminotransferase levels, with or without HBV DNA as detected. The chronic liver disease questionnaire (CLDQ) was applied to measure the HRQOL. Complete blood count, prothrombin time (PT) with international normalized ratio (INR), alanine and aspartate aminotransferase, alkaline phosphatase, γ-glutamyl transferase, total bilirubin, albumin, blood urea nitrogen, and serum creatinine were recorded. SPSS for Windows version 22.0 was used for statistical analysis with 95% confidence intervals, analyzed using independent sample t test and stepwise linear regression. Results. Abdomen symptoms, fatigue, systemic symptoms, activity, emotional function, worry, and summary scores of the quality of life were significantly decreased in cirrhosis as compared to patients without cirrhosis (p
CHRONIC HEPATITIS B
Gontar Alamsyah Siregar, Sahat Halim, Ricky Rivalino Sitepu, Muhammad Syakur Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine,
University of Sumatera Utara/ Adam Malik Hospital, Medan, Indonesia
Abstract Objectives. The purpose of this study was determine the health related quality of life (HRQOL) in chronic hepatitis B and also aimed to assess factors (baseline information of demographics and laboratory parameters) related with HRQOL in CHB patients. Methods. Quality of life was prospectively investigated in February – July 2013. Simple random sampling was done to get 60 CHB patients, with or without cirrhosis. Diagnosis of chronic HBV infection was based on the presence of hepatitis B surface antigen for more than six months, elevated serum alanine aminotransferase levels, with or without HBV DNA as detected. The chronic liver disease questionnaire (CLDQ) was applied to measure the HRQOL. Complete blood count, prothrombin time (PT) with international normalized ratio (INR), alanine and aspartate aminotransferase, alkaline phosphatase, γ-glutamyl transferase, total bilirubin, albumin, blood urea nitrogen, and serum creatinine were recorded. SPSS for Windows version 22.0 was used for statistical analysis with 95% confidence intervals, analyzed using independent sample t test and stepwise linear regression. Results. Abdomen symptoms, fatigue, systemic symptoms, activity, emotional function, worry, and summary scores of the quality of life were significantly decreased in cirrhosis as compared to patients without cirrhosis (p