1st Report of the Malaysian Registry of Renal Biopsy 2007
SECONDARY GLOMERULONEPHRITIS
39
3.1.4: Renal function at presentation
Forty percent of all patients have impaired renal function defined as e-GFR 60mlmin1.73 m
2
at the time of presentation. Seven percent had e-GFR of less than 15 mlmin.
3.1.4.1: Renal function at presentation by age group The frequency of impaired renal function increases after the age of 35. Between 36-39 of patients had
e-GFR of less than 60 mlmin1.73 m
2
below the age of 35 and the proportion rises to 43 in the age group of 35 to 45 and 53 in age group of 45-to 55. Table Figure 3.1.4.1
Table 3.1.4.1: Renal function by age group, 2005-2007
e-GFR mlmin1.73
m
2
15- 25 25-35
35-45 45-55
55-65 =65
Total n
n n
n n
n n
15 22 8 15 6 9 6 7 11 1 25 1
33.3 55 7
15 to
30 24 9 25 11 15 10 12 17 0 0 0 0 76 10
30 to
60 55 19 46 20 37 25 21 30 2 50 1 33.3
162 23 60
to 90
70 26 63 26 59 38 20 29 0 0 1 33.3 213 29
=90 103 38 86 37 31 21 9 13 1 25 0 0 230 31
Total 274 100 235 100 151 100
69 100
4 100
3 100
736 100
Figure 3.1.4.1: Renal function by age group, 2005-2007
Pe rc
e n
ta g
e
Age group 10
20 30
40 50
60 70
80 90
100 GFR: 15
GFR: 15-30 GFR: 30-60
GFR: 60-90 GFR: =90
15-25 25-35
35-45 45-55
55-65 =65
SECONDARY GLOMERULONEPHRITIS
1st Report of the Malaysian Registry of Renal Biopsy 2007
40
3.1.4.2: Renal function at presentation by gender There were no differences in the renal function at presentation between the two genders. Figure
3.1.4.2 Figure 3.1.4.2: Renal function by gender, 2005-2007
Pe rc
e n
ta g
e
Gender 10
20 30
40 50
60 70
80 90
100 GFR: 15
GFR: 15-30 GFR: 30-60
GFR: 60-90 GFR: =90
Male Female
3.1.4.3: Renal function at presentation by histopathology In the proliferative lupus nephritis class III, IV, V+III and V+IV, class IV or V+IV have worse renal function
than class III or class V+III Table and Figure 3.1.4.3. However, we could not ascertain whether the renal failure at the time of presentation were acute or chronic.
Table 3.1.4.3: Renal function at presentation by histopathology, 2005-2007
e-GFR mlmin1.73
m
2
I II
III and V+III
IV and IV+V
V and V+II
VI Total
n n
n n
n n
n
15 0 0 2 3 7 5 32 8 4 5 0 0 45 6
15 to
30 0 0 2 3 9 6 54
13 5 6 1 50 71
10 30
to 60
0 0 6 9 31 22 105 25 16 18 0 0 158 22 60
to 90
0 0 24 38 46 33 114 27 26 31 0 0 210 30 =90
3 100 30 47 47 34 112 27 34 40 1 50 227 32
Total 3
100 64
100 140 100 417 100 85
100 2
100 711 100
25 cases are missing on lupus subclass
1st Report of the Malaysian Registry of Renal Biopsy 2007
SECONDARY GLOMERULONEPHRITIS
41 Figure 3.1.4.3: Renal function at presentation by histopathology, 2005-2007
Pe rc
e n
ta g
e
Lupus histopathology 10
20 30
40 50
60 70
80 90
100 GFR: 15
GFR: 15-30 GFR: 30-60
GFR: 60-90 GFR: =90
I II
III and V+III IV and IV+V
V and V+II VI
3.1.5: Histopathological diagnosis