Renal function at presentation

1st Report of the Malaysian Registry of Renal Biopsy 2007 SECONDARY GLOMERULONEPHRITIS 39

3.1.4: Renal function at presentation

Forty percent of all patients have impaired renal function defined as e-GFR 60mlmin1.73 m 2 at the time of presentation. Seven percent had e-GFR of less than 15 mlmin. 3.1.4.1: Renal function at presentation by age group The frequency of impaired renal function increases after the age of 35. Between 36-39 of patients had e-GFR of less than 60 mlmin1.73 m 2 below the age of 35 and the proportion rises to 43 in the age group of 35 to 45 and 53 in age group of 45-to 55. Table Figure 3.1.4.1 Table 3.1.4.1: Renal function by age group, 2005-2007 e-GFR mlmin1.73 m 2 15- 25 25-35 35-45 45-55 55-65 =65 Total n n n n n n n 15 22 8 15 6 9 6 7 11 1 25 1 33.3 55 7 15 to 30 24 9 25 11 15 10 12 17 0 0 0 0 76 10 30 to 60 55 19 46 20 37 25 21 30 2 50 1 33.3 162 23 60 to 90 70 26 63 26 59 38 20 29 0 0 1 33.3 213 29 =90 103 38 86 37 31 21 9 13 1 25 0 0 230 31 Total 274 100 235 100 151 100 69 100 4 100 3 100 736 100 Figure 3.1.4.1: Renal function by age group, 2005-2007 Pe rc e n ta g e Age group 10 20 30 40 50 60 70 80 90 100 GFR: 15 GFR: 15-30 GFR: 30-60 GFR: 60-90 GFR: =90 15-25 25-35 35-45 45-55 55-65 =65 SECONDARY GLOMERULONEPHRITIS 1st Report of the Malaysian Registry of Renal Biopsy 2007 40 3.1.4.2: Renal function at presentation by gender There were no differences in the renal function at presentation between the two genders. Figure 3.1.4.2 Figure 3.1.4.2: Renal function by gender, 2005-2007 Pe rc e n ta g e Gender 10 20 30 40 50 60 70 80 90 100 GFR: 15 GFR: 15-30 GFR: 30-60 GFR: 60-90 GFR: =90 Male Female 3.1.4.3: Renal function at presentation by histopathology In the proliferative lupus nephritis class III, IV, V+III and V+IV, class IV or V+IV have worse renal function than class III or class V+III Table and Figure 3.1.4.3. However, we could not ascertain whether the renal failure at the time of presentation were acute or chronic. Table 3.1.4.3: Renal function at presentation by histopathology, 2005-2007 e-GFR mlmin1.73 m 2 I II III and V+III IV and IV+V V and V+II VI Total n n n n n n n 15 0 0 2 3 7 5 32 8 4 5 0 0 45 6 15 to 30 0 0 2 3 9 6 54 13 5 6 1 50 71 10 30 to 60 0 0 6 9 31 22 105 25 16 18 0 0 158 22 60 to 90 0 0 24 38 46 33 114 27 26 31 0 0 210 30 =90 3 100 30 47 47 34 112 27 34 40 1 50 227 32 Total 3 100 64 100 140 100 417 100 85 100 2 100 711 100 25 cases are missing on lupus subclass 1st Report of the Malaysian Registry of Renal Biopsy 2007 SECONDARY GLOMERULONEPHRITIS 41 Figure 3.1.4.3: Renal function at presentation by histopathology, 2005-2007 Pe rc e n ta g e Lupus histopathology 10 20 30 40 50 60 70 80 90 100 GFR: 15 GFR: 15-30 GFR: 30-60 GFR: 60-90 GFR: =90 I II III and V+III IV and IV+V V and V+II VI

3.1.5: Histopathological diagnosis