Dinda Welltsazia Rindhi 22010110120110 BAB8KTI
58
DAFTAR PUSTAKA
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Damage and mortality in a group of British patients with systemic lupus
erythematosus followed up for over 10 years. Rheumatology 2009;48:673–675.
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And Pulmonary Organ Scores Are Predictors Of Severe Outcome In Patients
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10. Zvezdanovic L, Dordevic V, Cosic V, et al. The significance of cytokines in
diagnosis of autoimmune diseases. Jugoslov Med Biohem 2006;25:363-372.
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16. Kanda N, Tsuchida T, Tamaki K. Estrogen enhancement of anti-double-stranded
DNA antibody and immunoglobulin G production in peripheral blood
mononuclear cells from patients with systemic lupus erythematosus. Arthritis
Rheum 1999;42:328–37.
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pathogenesis, clinical manifestations, and diagnosis. Eular 2012;20:476-505.
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Erythematosus. EAJM 2009;41:180-185.
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therapy and systemic lupus erythematosus. Clin Rev Allergy Immunol 2005
Dec;29(3):219-28.
20. Freire EAM, Souto LM, Chiconelli RM. Assesments Measures in Systemic Lupus
Erythematosus. Rev Bras Reumatol 2011;51(1):70-80.
21. Dafna Gladman, Ellen Ginzler, Charles Goldsmith, et al. The development and
initial
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collaborating
clinics/American college of rheumatology damage index for systemic lupus
erythematosus. Arthritis Rheum 1996;39:363-369.
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22. Rekha Lopez, Julie ED, Matthew DB, et al. Lupus disease activity and the risk of
subsequent organ damage and mortality in a large lupus cohort. Rheumatology
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23. Friska Jifanti, Alwi Mappiasse. Studi Retrospektif Lupus Eritematosus di
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24. C Gordon. Long-term complications of systemic lupus erythematosus.
Rheumatology 2002;41:1095–1100.
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Systemic Lupus
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61
Lampiran 1. Ethical clearance
62
63
Lampiran 3. Spreedsheet data
Data identitas pasien LES
Jenis
Kelamin
Usia
(tahun)
RT.01 RW.02 Karang Turi - Guntur - Demak
P
30
C407771
RT.04 RW.01 Krajan - Tanggungharjo - Grobogan
P
36
3
C279140
RT.03 RW.01 Bumirejo - Karangawen -Demak
P
25
4
C250542
RT.09 RW.07 Cilosari Dalam - Semarang Timur - Semarang
P
43
5
C440322
RT.12 RW.03 Kanguru Utara - Gayamsari - Semarang
P
20
6
C448422
RT.05 RW.10 Garuda - Taman - Pemalang
P
25
7
C419540
RT.02 RW.03 Jolosekti - Tulis - Batang
P
27
8
C422190
RT.14 RW.03 Hayam Wuruk - Mangun Harjo - Madiun
P
11
9
C424321
RT.03 RW.02 Bodeh - Tegowanu - Grobogan
P
20
10
C413041
RT.07 RW.01 Dopang - Pucak Wangi - Pati
P
27
11
C347571
RT.04 RW.02 Pusponjolo Dalem X- Semarang Barat - Semarang
P
22
12
C124761
RT.04 RW.03 Rowosari - Limpung - Batang
P
36
13
C412047
RT.02 RW.03 Kedunggong - Sukolilo - Pati
P
26
14
C429778
RT.03 RW.07 Bondo - Bangsiri - Jepara
P
30
15
C454278
RT.01 RW.08 Cijeruk - Sragi - Pekalongan
P
23
16
C339328
RT.06 RW.01 Gebugan - Bergas - Semarang
P
35
17
C177418
RT.03 RW.05 Tandang - Tembalang - Semarang
P
23
18
C190848
Tambak Rejo - Gayamsari - Semarang
P
25
19
C417628
RT.04 RW.01 Bacem - Banjarejo - Blora
P
30
20
C421411
RT.01 RW.01 Jagung Kidul - Kesesi - Pekalongan
P
22
21
C410471
RT.19 RW.04 Kaladawa -Talang - Tegal
P
29
22
C392700
P
57
23
C449648
P
31
24
C409805
RT.02 RW.02 Rawoh - Karang Rayung - Grobogan
RT.01 RW.08 Lamper Tengah Raya - Semarang Tengah Semarang
RT.04 RW.14 Perumdis - Sidomukti - Salatiga
P
26
25
C419749
RT.01 RW.03 Karang - Juwana - Pati
P
12
26
C451619
RT.02 RW.05 Krasak - Bonang - Demak
P
36
27
C418193
RT.02 RW.09 Ngluwuk - Cluwak - Pati
P
37
28
C364933
RT.05 RW.03 Karangasem -Wirosari - Grobogan
P
46
29
C235394
RT.11 RW.03 Kauman I - Mranggen - Demak
P
34
30
C434352
RT.05 RW.04 Pakujan - Paguyangan - Brebes
P
29
31
C319339
RT.08 RW.19 Ratu Ratih - Pedurungan - Semarang
P
22
32
C421524
RT.02 RW.02 Raji - Kota Demak - Demak
P
15
33
B145494
RT.03 RW.01 Gedong Songo Timur - Semarang Barat - Semarang
P
37
No.
No.CM
1
C444418
2
Alamat
64
34
C359545
RT.02 RW.04 Tlogomulyo - Pedurungan - Semarang
L
23
35
C143677
RT.02 RW.02 Kauman - Juwana - Pati
P
23
36
C414898
Semarang
P
39
37
C430801
RT.12 RW.03 Tandang - Candisari - Semarang
P
30
38
C405223
RT.03 RW.05 Jrebeng - Beringin - Salatiga
P
20
39
C381709
RT.03 RW.02 Tenggerdesa - Sale - Rembang
P
16
40
C302939
RT.06 RW.05 Simbang - Boja - Kendal
P
32
41
C239089
RT.02 RW.02 Pringapus - Pringapus - Semarang
P
14
42
C431986
RT.07 RW.02 Jambon - Todanan - Blora
P
20
43
C427934
RT.02 RW.01 Purwosari - Kudus Kota - Kudus
P
28
65
Data diagnostik pasien LES menurut kriteria ACR 1997
No.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
No. CM
Ruam
Malar
Ruam
Diskoid
Fotosensitifitas
C444418
C407771
C279140
C250542
C440322
C448422
C419540
C422190
C424321
C413041
C347571
C124761
C412047
C429778
C454278
C339328
C177418
C190848
C417628
C421411
C410471
C392700
C449648
C409805
C419749
C451619
C418193
C364933
C235394
C434352
C319339
C421524
B145494
C359545
C143677
C414898
C430801
C405223
C381709
C302939
Ulkus
Mulut
1
1
1
1
1
1
1
1
Pleuritis
1
1
Perikarditis
1
1
1
1
1
1
Serositis
Artritis
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
66
41
42
C239089
C431986
1
1
43
C427934
1
1
1
Gangguan Imunologi
No.
Anti-DNA +
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
1
Anti-Sm +
Antibodi Antifosfolipid +
1
ANA
+
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Jumlah
4
4
5
4
7
5
8
4
9
6
4
4
6
5
5
5
4
7
8
5
10
4
5
7
8
6
7
5
6
5
4
4
5
11
5
10
7
4
9
1
67
40
41
42
1
7
5
7
1
1
43
5
Data aktifitas penyakit pasien LES menurut MEX-SLEDAI di RSUP dr. Kariadi
Semarang
No.
No. CM
1
C444418
2
3
C407771
C279140
4
C250542
5
C440322
6
C448422
7
C419540
8
C422190
Gangguan
Neurologis
(8)
Gangguan
Ginjal (6)
Vaskulitis (4)
Hemolisis
(3)
Miositis
(3)
Artritis
(2)
2
6
2
6
2
9
C424321
10
C413041
8
3
11
C347571
12
C124761
3
13
C412047
3
14
C429778
3
15
C454278
16
C339328
17
C177418
18
C190848
3
19
C417628
3
20
C421411
21
C410471
22
C392700
23
C449648
24
C409805
25
C419749
26
C451619
27
C418193
2
68
28
C364933
29
C235394
30
C434352
31
C319339
32
C421524
33
B145494
3
34
C359545
3
2
35
C143677
36
C414898
3
2
37
C430801
38
C405223
3
2
39
C381709
40
C302939
41
C239089
42
C431986
43
C427934
6
8
4
3
No.
Gangguan
Muskulokutaneus (2)
1
2
2
Serositis (2)
2
3
2
4
2
Demam /
Fatigue (1)
1
1
5
6
1
7
2
8
2
1
9
Leukopenia
/
Limfopenia
(1)
Jumlah
Kategori
2
Sedang
5
Sedang
8
Berat
5
Sedang
6
Berat
1
Ringan
4
Sedang
3
Sedang
11
Berat
10
1
1
Ringan
11
1
1
Ringan
3
Sedang
4
Sedang
3
Sedang
12
13
1
14
15
2
3
Sedang
16
2
1
2
Sedang
17
2
2
Sedang
69
18
2
1
6
Berat
19
2
1
6
Berat
20
2
2
Sedang
21
2
2
Sedang
22
2
6
Berat
2
Sedang
23
1
1
2
24
2
1
3
Sedang
25
2
1
3
Sedang
26
2
1
3
Sedang
27
1
1
Ringan
28
1
1
Ringan
29
6
Berat
30
0
Ringan
31
0
Ringan
32
12
Berat
3
Sedang
8
Berat
0
Ringan
10
Berat
2
Sedang
1
6
Berat
1
3
Sedang
2
Sedang
33
34
2
1
35
36
2
37
2
2
1
38
39
2
40
2
41
1
42
2
43
1
Ringan
2
Sedang
3
Sedang
Data kerusakan organ pasien LES berdasarkan SLICC/ACR Damage Index di RSUP
dr. Kariadi Semarang
No.
No. CM
1
C444418
2
C407771
Okular
Atrofi
n.
Katarak
Opticus
Neuropsikiatri
Gangguan
Kognitif
Kejang
Trauma
Pembuluh
Darah Otak
Neuropati
Myelitis
Transversa
70
3
C279140
4
C250542
5
C440322
6
C448422
7
C419540
8
C422190
9
C424321
10
C413041
11
C347571
12
C124761
13
C412047
14
C429778
15
C454278
16
C339328
17
C177418
18
C190848
19
C417628
20
C421411
21
C410471
22
C392700
23
C449648
24
C409805
25
C419749
26
C451619
27
C418193
28
C364933
29
C235394
30
C434352
31
C319339
32
C421524
33
B145494
34
C359545
35
C143677
36
C414898
37
C430801
38
C405223
39
C381709
40
C302939
1
1
1
1
71
41
C239089
42
C431986
43
C427934
Ginjal
No.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
LFG >
50%
Proteninuria
Paru
Gagal Ginjal
Stadium
Terminal
Hipertensi
Pulmonal
Fibrosis
Pilmonal
Shrinking
Lung
Infark
Pulmonal
72
30
31
32
33
34
35
36
37
38
39
40
41
42
43
Gastrointestinal
No
.
Infark
Insufisiensi
Mesenterika
Periton
itis
Kronik
Striktur
Esofagus
Atrofi
/Kelema
han
Otot
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
1
Muskuloskeletal
Deformi Osteopo Nekro
tas /
rosis
sis
Artritis
dengan
Avas
Erosif
Fraktur
kular
Osteo
mielit
is
73
19
1
20
21
22
23
24
25
26
27
28
29
1
30
31
32
1
33
34
1
35
36
1
37
38
1
39
40
41
42
43
No.
Alopenia
Kulit
Jaringan
Parut
Luas
Ulkus
Premature
Gonadal
Failure
Kerusakan
Organ
Diabetes
Keganasan
Jumlah
Ya
1
0
Tidak
1
2
1
1
1
3
1
1
1
4
0
1
5
0
1
6
0
1
7
1
1
2
1
74
8
0
9
2
10
0
1
11
0
1
12
0
1
13
0
1
14
0
1
15
0
1
16
0
1
17
0
1
18
19
1
1
1
1
1
1
3
1
20
0
1
21
0
1
22
0
1
23
0
1
24
1
25
0
26
1
27
0
1
28
0
1
29
1
2
1
1
1
1
30
0
1
31
0
1
32
2
33
0
34
1
35
0
36
2
37
0
38
1
39
0
1
40
0
1
41
0
1
42
0
1
43
0
1
1
1
1
1
1
1
1
75
Lampiran 4. Output analisis program statistik
Explore
Usia
Descriptives
Usia
Kerusakan Organ
Ya
Tidak
Mean
95% Conf idence
Interv al f or Mean
5% Trimmed Mean
Median
Variance
St d. Dev iation
Minimum
Maximum
Range
Interquart ile Range
Skewness
Kurt osis
Mean
95% Conf idence
Interv al f or Mean
5% Trimmed Mean
Median
Variance
St d. Dev iation
Minimum
Maximum
Range
Interquart ile Range
Skewness
Kurt osis
Lower Bound
Upper Bound
Lower Bound
Upper Bound
St at ist ic
27,38
23,01
St d. Error
2,008
31,76
27,43
26,00
52,423
7,240
15
39
24
14
,087
-,862
27,87
24,12
,616
1,191
1,830
31,61
27,37
27,50
100,464
10,023
11
57
46
11
,794
1,355
,427
,833
76
Tests of Normality
a
Usia
Kerusakan Organ
Ya
Tidak
Kolmogorov -Smirnov
St at ist ic
df
Sig.
,137
13
,200*
,116
30
,200*
St at ist ic
,960
,956
*. This is a lower bound of the true signif icance.
a. Lillief ors Signif icance Correction
60
22
50
40
Usia
30
20
10
Ya
Tidak
Kerusakan Organ
Shapiro-Wilk
df
13
30
Sig.
,753
,238
77
T-Test
Group Statisti cs
Usia
Kerusakan Organ
Ya
Tidak
N
13
30
Mean
27,38
27,87
St d. Dev iation
7,240
10,023
St d. Error
Mean
2,008
1,830
Independent Samples Test
Lev ene's Test f or
Equality of Variances
t-t est f or Equality of
Means
Usia
Equal v ariances
Equal v ariances
assumed
not assumed
,676
,416
-,156
-,177
41
31,280
,877
,860
F
Sig.
t
df
Sig. (2-tailed)
Mean Dif f erence
St d. Error Dif f erence
95% Conf idence Interv al
of the Dif f erence
Lower
Upper
-,482
-,482
3,087
2,717
-6,715
5,751
-6,021
5,057
78
Crosstabs
Aktifi tas Penyaki t * Kerusakan Organ Crosstabulation
Aktif itas
Peny akit
Berat
Sedang
Ringan
Total
Kerusakan Organ
Ya
Tidak
9
2
3,3
7,7
Count
Expected Count
% wit hin
Kerusakan Organ
% of Total
Count
Expected Count
% wit hin
Kerusakan Organ
% of Total
Count
Expected Count
% wit hin
Kerusakan Organ
% of Total
Count
Expected Count
% wit hin
Kerusakan Organ
% of Total
Pearson Chi-Square
Likelihood Ratio
Linear-by -Linear
Association
N of Valid Cases
16,396
11
11,0
69,2%
6,7%
25,6%
20,9%
4
7,0
4,7%
19
16,0
25,6%
23
23,0
30,8%
63,3%
53,5%
9,3%
0
2,7
44,2%
9
6,3
53,5%
9
9,0
,0%
30,0%
20,9%
,0%
13
13,0
20,9%
30
30,0
20,9%
43
43,0
100,0%
100,0%
100,0%
30,2%
69,8%
100,0%
Chi-Square Tests
Value
19,576a
21,018
Total
2
2
Asy mp. Sig.
(2-sided)
,000
,000
1
,000
df
43
a. 2 cells (33,3%) hav e expected count less t han 5. The
minimum expected count is 2,72.
79
NPar Tests
Two-Sample Kolmogorov-Smirnov Test
Frequencies
Kerusakan Organ
Aktif itas Peny akit Ya
Tidak
Total
N
13
30
43
Test Statisticsa
Most Ext reme
Dif f erences
Absolute
Positiv e
Negativ e
Kolmogorov -Smirnov Z
Asy mp. Sig. (2-tailed)
a. Grouping Variable: Kerusakan Organ
Akt if itas
Peny akit
,626
,000
-,626
1,884
,002
80
Lampiran 5. Dokumentasi penelitian
81
Lampiran 6. Biodata mahasiswa
Identitas
Nama
: Dinda Welltsazia Rindhi
NIM
: 22010110120110
Tempat/tanggal lahir : Balikpapan,13 November 1992
Jenis kelamin
: Perempuan
Alamat
: Jalan Galang Sewu Raya no. 1A Tembalang
Nomor HP
: 085246061399
e-mail
: welltsazia@gmail.com
Riwayat Pendidikan Formal
1. SD
: SDIT Istiqamah Balikpapan
Lulus tahun: 2004
2. SMP
: SMPIT Istiqamah Balikpapan
Lulus tahun: 2007
3. SMA
: SMAN 1 Balikpapan
Lulus tahun: 2010
4. FK UNDIP : Masuk tahun : 2010
DAFTAR PUSTAKA
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Edisi kelima. Jakarta: Interna Publishing, 2009 ; 2565-2579.
2. Yoga I Kasjmir, Kusworini Handono, Linda Kurniaty. Diagnosis dan pengelolaan
LES rekomendasi perhimpunan reumatologi Indonesia. Available from:
3. Sharon A Chambers, Elizabeth Allen, Anisur Rahman and David Isenberg.
Damage and mortality in a group of British patients with systemic lupus
erythematosus followed up for over 10 years. Rheumatology 2009;48:673–675.
4. Stoll T, Seifert B, Isenberg DA. SLICC/ACR Damage Index Is Valid, And Renal
And Pulmonary Organ Scores Are Predictors Of Severe Outcome In Patients
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activity and damage in patients with systemic lupus erythematosus—a 5-yr
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7. Manson JJ, Isenberg DA. The Pathogenesis of systemic lupus erythematosus. J
Netherl Med 2003;61(11):343-346.
8. Silva C, Isenberg DA. Etiology and pathology of systemic lupus erythematosus.
Hospt Pharm 2001;7:1-7.
9. AJG Swaak, HG Van Den Brink. RJT Smeenk, et al. Systemic lupus
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59
10. Zvezdanovic L, Dordevic V, Cosic V, et al. The significance of cytokines in
diagnosis of autoimmune diseases. Jugoslov Med Biohem 2006;25:363-372.
11. Eisenberg H. SLE-Rituximab in lupus. Arthritis Res Ther. 2003; 5(4): 157–159.
12. Mok CC, Lau CS. Pathogenesis of systemic lupus erythematosus. J Clin Pathol
2003;56:481-490.
13. Sequeira JF, Keser G, Greenstein B, et al. Systemic lupus erythematosus: sex
hormones in male patients. Lupus 1993;2:315–17.
14. McMurry RW, May W (2003) Sex hormones and systemic lupus erythematosus.
Arthritis Rheum 2003;48:2100-10.
15. Kanda N, Tamaki K. Estrogen enhances immunoglobulin production by human
peripheral blood mononuclear cells. J Allergy Clin Immunol 1999;103:282–8.
16. Kanda N, Tsuchida T, Tamaki K. Estrogen enhancement of anti-double-stranded
DNA antibody and immunoglobulin G production in peripheral blood
mononuclear cells from patients with systemic lupus erythematosus. Arthritis
Rheum 1999;42:328–37.
17. Bertsias G, Cervera R, Boumpas DT. Systemic lupus erythematosus:
pathogenesis, clinical manifestations, and diagnosis. Eular 2012;20:476-505.
18. Sahin A. Mycophenolate Mofetil in the Treatment of Systemic Lupus
Erythematosus. EAJM 2009;41:180-185.
19. Zandmann-Goddard G, Levy Y, Shoenfeld Y. Intravenous immunoglobulin
therapy and systemic lupus erythematosus. Clin Rev Allergy Immunol 2005
Dec;29(3):219-28.
20. Freire EAM, Souto LM, Chiconelli RM. Assesments Measures in Systemic Lupus
Erythematosus. Rev Bras Reumatol 2011;51(1):70-80.
21. Dafna Gladman, Ellen Ginzler, Charles Goldsmith, et al. The development and
initial
validation
of
the
systemic
lupus
international
collaborating
clinics/American college of rheumatology damage index for systemic lupus
erythematosus. Arthritis Rheum 1996;39:363-369.
60
22. Rekha Lopez, Julie ED, Matthew DB, et al. Lupus disease activity and the risk of
subsequent organ damage and mortality in a large lupus cohort. Rheumatology
2012;51:491_498.
23. Friska Jifanti, Alwi Mappiasse. Studi Retrospektif Lupus Eritematosus di
Subdivisi Alergi Imunologi Bagian Ilmu Kesehatan Kulit dan Kelamin RSUP dr.
Wahidin Sudirohusodo Makassar Periode 2005-2010. PharmaMedika 2010;2:2.
24. C Gordon. Long-term complications of systemic lupus erythematosus.
Rheumatology 2002;41:1095–1100.
25. George Bertsias, Ricard Cervera, Dimitrios T Boumpas.
Systemic Lupus
Erythematosus: Pathogenesis and Clinical Features in EULAR Textbook on
Rheumatic Diseases page 484.
26. Zahra Sayed, et al. Evaluation of Damage Index and Its Association With Risk
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61
Lampiran 1. Ethical clearance
62
63
Lampiran 3. Spreedsheet data
Data identitas pasien LES
Jenis
Kelamin
Usia
(tahun)
RT.01 RW.02 Karang Turi - Guntur - Demak
P
30
C407771
RT.04 RW.01 Krajan - Tanggungharjo - Grobogan
P
36
3
C279140
RT.03 RW.01 Bumirejo - Karangawen -Demak
P
25
4
C250542
RT.09 RW.07 Cilosari Dalam - Semarang Timur - Semarang
P
43
5
C440322
RT.12 RW.03 Kanguru Utara - Gayamsari - Semarang
P
20
6
C448422
RT.05 RW.10 Garuda - Taman - Pemalang
P
25
7
C419540
RT.02 RW.03 Jolosekti - Tulis - Batang
P
27
8
C422190
RT.14 RW.03 Hayam Wuruk - Mangun Harjo - Madiun
P
11
9
C424321
RT.03 RW.02 Bodeh - Tegowanu - Grobogan
P
20
10
C413041
RT.07 RW.01 Dopang - Pucak Wangi - Pati
P
27
11
C347571
RT.04 RW.02 Pusponjolo Dalem X- Semarang Barat - Semarang
P
22
12
C124761
RT.04 RW.03 Rowosari - Limpung - Batang
P
36
13
C412047
RT.02 RW.03 Kedunggong - Sukolilo - Pati
P
26
14
C429778
RT.03 RW.07 Bondo - Bangsiri - Jepara
P
30
15
C454278
RT.01 RW.08 Cijeruk - Sragi - Pekalongan
P
23
16
C339328
RT.06 RW.01 Gebugan - Bergas - Semarang
P
35
17
C177418
RT.03 RW.05 Tandang - Tembalang - Semarang
P
23
18
C190848
Tambak Rejo - Gayamsari - Semarang
P
25
19
C417628
RT.04 RW.01 Bacem - Banjarejo - Blora
P
30
20
C421411
RT.01 RW.01 Jagung Kidul - Kesesi - Pekalongan
P
22
21
C410471
RT.19 RW.04 Kaladawa -Talang - Tegal
P
29
22
C392700
P
57
23
C449648
P
31
24
C409805
RT.02 RW.02 Rawoh - Karang Rayung - Grobogan
RT.01 RW.08 Lamper Tengah Raya - Semarang Tengah Semarang
RT.04 RW.14 Perumdis - Sidomukti - Salatiga
P
26
25
C419749
RT.01 RW.03 Karang - Juwana - Pati
P
12
26
C451619
RT.02 RW.05 Krasak - Bonang - Demak
P
36
27
C418193
RT.02 RW.09 Ngluwuk - Cluwak - Pati
P
37
28
C364933
RT.05 RW.03 Karangasem -Wirosari - Grobogan
P
46
29
C235394
RT.11 RW.03 Kauman I - Mranggen - Demak
P
34
30
C434352
RT.05 RW.04 Pakujan - Paguyangan - Brebes
P
29
31
C319339
RT.08 RW.19 Ratu Ratih - Pedurungan - Semarang
P
22
32
C421524
RT.02 RW.02 Raji - Kota Demak - Demak
P
15
33
B145494
RT.03 RW.01 Gedong Songo Timur - Semarang Barat - Semarang
P
37
No.
No.CM
1
C444418
2
Alamat
64
34
C359545
RT.02 RW.04 Tlogomulyo - Pedurungan - Semarang
L
23
35
C143677
RT.02 RW.02 Kauman - Juwana - Pati
P
23
36
C414898
Semarang
P
39
37
C430801
RT.12 RW.03 Tandang - Candisari - Semarang
P
30
38
C405223
RT.03 RW.05 Jrebeng - Beringin - Salatiga
P
20
39
C381709
RT.03 RW.02 Tenggerdesa - Sale - Rembang
P
16
40
C302939
RT.06 RW.05 Simbang - Boja - Kendal
P
32
41
C239089
RT.02 RW.02 Pringapus - Pringapus - Semarang
P
14
42
C431986
RT.07 RW.02 Jambon - Todanan - Blora
P
20
43
C427934
RT.02 RW.01 Purwosari - Kudus Kota - Kudus
P
28
65
Data diagnostik pasien LES menurut kriteria ACR 1997
No.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
No. CM
Ruam
Malar
Ruam
Diskoid
Fotosensitifitas
C444418
C407771
C279140
C250542
C440322
C448422
C419540
C422190
C424321
C413041
C347571
C124761
C412047
C429778
C454278
C339328
C177418
C190848
C417628
C421411
C410471
C392700
C449648
C409805
C419749
C451619
C418193
C364933
C235394
C434352
C319339
C421524
B145494
C359545
C143677
C414898
C430801
C405223
C381709
C302939
Ulkus
Mulut
1
1
1
1
1
1
1
1
Pleuritis
1
1
Perikarditis
1
1
1
1
1
1
Serositis
Artritis
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
66
41
42
C239089
C431986
1
1
43
C427934
1
1
1
Gangguan Imunologi
No.
Anti-DNA +
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
1
Anti-Sm +
Antibodi Antifosfolipid +
1
ANA
+
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Jumlah
4
4
5
4
7
5
8
4
9
6
4
4
6
5
5
5
4
7
8
5
10
4
5
7
8
6
7
5
6
5
4
4
5
11
5
10
7
4
9
1
67
40
41
42
1
7
5
7
1
1
43
5
Data aktifitas penyakit pasien LES menurut MEX-SLEDAI di RSUP dr. Kariadi
Semarang
No.
No. CM
1
C444418
2
3
C407771
C279140
4
C250542
5
C440322
6
C448422
7
C419540
8
C422190
Gangguan
Neurologis
(8)
Gangguan
Ginjal (6)
Vaskulitis (4)
Hemolisis
(3)
Miositis
(3)
Artritis
(2)
2
6
2
6
2
9
C424321
10
C413041
8
3
11
C347571
12
C124761
3
13
C412047
3
14
C429778
3
15
C454278
16
C339328
17
C177418
18
C190848
3
19
C417628
3
20
C421411
21
C410471
22
C392700
23
C449648
24
C409805
25
C419749
26
C451619
27
C418193
2
68
28
C364933
29
C235394
30
C434352
31
C319339
32
C421524
33
B145494
3
34
C359545
3
2
35
C143677
36
C414898
3
2
37
C430801
38
C405223
3
2
39
C381709
40
C302939
41
C239089
42
C431986
43
C427934
6
8
4
3
No.
Gangguan
Muskulokutaneus (2)
1
2
2
Serositis (2)
2
3
2
4
2
Demam /
Fatigue (1)
1
1
5
6
1
7
2
8
2
1
9
Leukopenia
/
Limfopenia
(1)
Jumlah
Kategori
2
Sedang
5
Sedang
8
Berat
5
Sedang
6
Berat
1
Ringan
4
Sedang
3
Sedang
11
Berat
10
1
1
Ringan
11
1
1
Ringan
3
Sedang
4
Sedang
3
Sedang
12
13
1
14
15
2
3
Sedang
16
2
1
2
Sedang
17
2
2
Sedang
69
18
2
1
6
Berat
19
2
1
6
Berat
20
2
2
Sedang
21
2
2
Sedang
22
2
6
Berat
2
Sedang
23
1
1
2
24
2
1
3
Sedang
25
2
1
3
Sedang
26
2
1
3
Sedang
27
1
1
Ringan
28
1
1
Ringan
29
6
Berat
30
0
Ringan
31
0
Ringan
32
12
Berat
3
Sedang
8
Berat
0
Ringan
10
Berat
2
Sedang
1
6
Berat
1
3
Sedang
2
Sedang
33
34
2
1
35
36
2
37
2
2
1
38
39
2
40
2
41
1
42
2
43
1
Ringan
2
Sedang
3
Sedang
Data kerusakan organ pasien LES berdasarkan SLICC/ACR Damage Index di RSUP
dr. Kariadi Semarang
No.
No. CM
1
C444418
2
C407771
Okular
Atrofi
n.
Katarak
Opticus
Neuropsikiatri
Gangguan
Kognitif
Kejang
Trauma
Pembuluh
Darah Otak
Neuropati
Myelitis
Transversa
70
3
C279140
4
C250542
5
C440322
6
C448422
7
C419540
8
C422190
9
C424321
10
C413041
11
C347571
12
C124761
13
C412047
14
C429778
15
C454278
16
C339328
17
C177418
18
C190848
19
C417628
20
C421411
21
C410471
22
C392700
23
C449648
24
C409805
25
C419749
26
C451619
27
C418193
28
C364933
29
C235394
30
C434352
31
C319339
32
C421524
33
B145494
34
C359545
35
C143677
36
C414898
37
C430801
38
C405223
39
C381709
40
C302939
1
1
1
1
71
41
C239089
42
C431986
43
C427934
Ginjal
No.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
LFG >
50%
Proteninuria
Paru
Gagal Ginjal
Stadium
Terminal
Hipertensi
Pulmonal
Fibrosis
Pilmonal
Shrinking
Lung
Infark
Pulmonal
72
30
31
32
33
34
35
36
37
38
39
40
41
42
43
Gastrointestinal
No
.
Infark
Insufisiensi
Mesenterika
Periton
itis
Kronik
Striktur
Esofagus
Atrofi
/Kelema
han
Otot
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
1
Muskuloskeletal
Deformi Osteopo Nekro
tas /
rosis
sis
Artritis
dengan
Avas
Erosif
Fraktur
kular
Osteo
mielit
is
73
19
1
20
21
22
23
24
25
26
27
28
29
1
30
31
32
1
33
34
1
35
36
1
37
38
1
39
40
41
42
43
No.
Alopenia
Kulit
Jaringan
Parut
Luas
Ulkus
Premature
Gonadal
Failure
Kerusakan
Organ
Diabetes
Keganasan
Jumlah
Ya
1
0
Tidak
1
2
1
1
1
3
1
1
1
4
0
1
5
0
1
6
0
1
7
1
1
2
1
74
8
0
9
2
10
0
1
11
0
1
12
0
1
13
0
1
14
0
1
15
0
1
16
0
1
17
0
1
18
19
1
1
1
1
1
1
3
1
20
0
1
21
0
1
22
0
1
23
0
1
24
1
25
0
26
1
27
0
1
28
0
1
29
1
2
1
1
1
1
30
0
1
31
0
1
32
2
33
0
34
1
35
0
36
2
37
0
38
1
39
0
1
40
0
1
41
0
1
42
0
1
43
0
1
1
1
1
1
1
1
1
75
Lampiran 4. Output analisis program statistik
Explore
Usia
Descriptives
Usia
Kerusakan Organ
Ya
Tidak
Mean
95% Conf idence
Interv al f or Mean
5% Trimmed Mean
Median
Variance
St d. Dev iation
Minimum
Maximum
Range
Interquart ile Range
Skewness
Kurt osis
Mean
95% Conf idence
Interv al f or Mean
5% Trimmed Mean
Median
Variance
St d. Dev iation
Minimum
Maximum
Range
Interquart ile Range
Skewness
Kurt osis
Lower Bound
Upper Bound
Lower Bound
Upper Bound
St at ist ic
27,38
23,01
St d. Error
2,008
31,76
27,43
26,00
52,423
7,240
15
39
24
14
,087
-,862
27,87
24,12
,616
1,191
1,830
31,61
27,37
27,50
100,464
10,023
11
57
46
11
,794
1,355
,427
,833
76
Tests of Normality
a
Usia
Kerusakan Organ
Ya
Tidak
Kolmogorov -Smirnov
St at ist ic
df
Sig.
,137
13
,200*
,116
30
,200*
St at ist ic
,960
,956
*. This is a lower bound of the true signif icance.
a. Lillief ors Signif icance Correction
60
22
50
40
Usia
30
20
10
Ya
Tidak
Kerusakan Organ
Shapiro-Wilk
df
13
30
Sig.
,753
,238
77
T-Test
Group Statisti cs
Usia
Kerusakan Organ
Ya
Tidak
N
13
30
Mean
27,38
27,87
St d. Dev iation
7,240
10,023
St d. Error
Mean
2,008
1,830
Independent Samples Test
Lev ene's Test f or
Equality of Variances
t-t est f or Equality of
Means
Usia
Equal v ariances
Equal v ariances
assumed
not assumed
,676
,416
-,156
-,177
41
31,280
,877
,860
F
Sig.
t
df
Sig. (2-tailed)
Mean Dif f erence
St d. Error Dif f erence
95% Conf idence Interv al
of the Dif f erence
Lower
Upper
-,482
-,482
3,087
2,717
-6,715
5,751
-6,021
5,057
78
Crosstabs
Aktifi tas Penyaki t * Kerusakan Organ Crosstabulation
Aktif itas
Peny akit
Berat
Sedang
Ringan
Total
Kerusakan Organ
Ya
Tidak
9
2
3,3
7,7
Count
Expected Count
% wit hin
Kerusakan Organ
% of Total
Count
Expected Count
% wit hin
Kerusakan Organ
% of Total
Count
Expected Count
% wit hin
Kerusakan Organ
% of Total
Count
Expected Count
% wit hin
Kerusakan Organ
% of Total
Pearson Chi-Square
Likelihood Ratio
Linear-by -Linear
Association
N of Valid Cases
16,396
11
11,0
69,2%
6,7%
25,6%
20,9%
4
7,0
4,7%
19
16,0
25,6%
23
23,0
30,8%
63,3%
53,5%
9,3%
0
2,7
44,2%
9
6,3
53,5%
9
9,0
,0%
30,0%
20,9%
,0%
13
13,0
20,9%
30
30,0
20,9%
43
43,0
100,0%
100,0%
100,0%
30,2%
69,8%
100,0%
Chi-Square Tests
Value
19,576a
21,018
Total
2
2
Asy mp. Sig.
(2-sided)
,000
,000
1
,000
df
43
a. 2 cells (33,3%) hav e expected count less t han 5. The
minimum expected count is 2,72.
79
NPar Tests
Two-Sample Kolmogorov-Smirnov Test
Frequencies
Kerusakan Organ
Aktif itas Peny akit Ya
Tidak
Total
N
13
30
43
Test Statisticsa
Most Ext reme
Dif f erences
Absolute
Positiv e
Negativ e
Kolmogorov -Smirnov Z
Asy mp. Sig. (2-tailed)
a. Grouping Variable: Kerusakan Organ
Akt if itas
Peny akit
,626
,000
-,626
1,884
,002
80
Lampiran 5. Dokumentasi penelitian
81
Lampiran 6. Biodata mahasiswa
Identitas
Nama
: Dinda Welltsazia Rindhi
NIM
: 22010110120110
Tempat/tanggal lahir : Balikpapan,13 November 1992
Jenis kelamin
: Perempuan
Alamat
: Jalan Galang Sewu Raya no. 1A Tembalang
Nomor HP
: 085246061399
: welltsazia@gmail.com
Riwayat Pendidikan Formal
1. SD
: SDIT Istiqamah Balikpapan
Lulus tahun: 2004
2. SMP
: SMPIT Istiqamah Balikpapan
Lulus tahun: 2007
3. SMA
: SMAN 1 Balikpapan
Lulus tahun: 2010
4. FK UNDIP : Masuk tahun : 2010