Pengaruh Hasil Fraksinasi Ekstrak Etanol
Jurnal Sains dan Teknologi Farmasi Vol. 19 Suplemen 1 (Desember 2017)
Pengaruh Hasil Fraksinasi Ekstrak Etanol Daun
Lado-lado (Litsea cubeba,Pers) Terhadap Kadar
Asam Urat Serum Darah Mencit Putih Jantan
Tinggi Asam Urat
Rizky Yulion
P1*,
Suhatri,
Helmi Ariin.
1
Fakutas Farmasi
Universitas Andalas,
Padang
Corresponding Author:
Rizky Yulion P
Fakutas Farmasi Universitas
Andalas
rizkyyulionputra30@gmail.
com
ABSTRACT: Uric acid is the end product of purine metabolism in humans and imbalance of uric acid levels in the
blood to triggered hyperuricemia then incidence and prevalence is quite high in Indonesia. This study was conducted
to determine whether hyperuricemic affects the decrease of uric acid level in white male mouse hyperurisemia by
using lado-lado (Litsea cubeba,Pers) leaf. Sample was extracted with 70% ethanol and subsequently fractionated
by using hexane, ethyl acetate and water residual solvents. potassium oxonate doses 250 mg/kgBW and long
bean juice (Vigna unguiculata,Walp) doses 0.5 mL/20 gramBB frequency 3 times daily as inducer. It taked for 5
days to hyperuricemia condition. At the time of treatment, only use long peanut juice for inducer. Doses 12,5 mg/
kgBW; 25 mg/kgBW and 50 mg/kgBW and variations of 7, 14 and 21 days on hyperuricemic condition. Serum uric
acid levels were measured by using a clinical photometer with an enzymatic principle. The resultant decrease in
uric acid levels was best obtained at the fraction of ethyl acetate of lado-lado leaves (0,05) maka dilakukan uji anova. Didapatkan efek
terbaik fraksi etil asetat (P
Pengaruh Hasil Fraksinasi Ekstrak Etanol Daun
Lado-lado (Litsea cubeba,Pers) Terhadap Kadar
Asam Urat Serum Darah Mencit Putih Jantan
Tinggi Asam Urat
Rizky Yulion
P1*,
Suhatri,
Helmi Ariin.
1
Fakutas Farmasi
Universitas Andalas,
Padang
Corresponding Author:
Rizky Yulion P
Fakutas Farmasi Universitas
Andalas
rizkyyulionputra30@gmail.
com
ABSTRACT: Uric acid is the end product of purine metabolism in humans and imbalance of uric acid levels in the
blood to triggered hyperuricemia then incidence and prevalence is quite high in Indonesia. This study was conducted
to determine whether hyperuricemic affects the decrease of uric acid level in white male mouse hyperurisemia by
using lado-lado (Litsea cubeba,Pers) leaf. Sample was extracted with 70% ethanol and subsequently fractionated
by using hexane, ethyl acetate and water residual solvents. potassium oxonate doses 250 mg/kgBW and long
bean juice (Vigna unguiculata,Walp) doses 0.5 mL/20 gramBB frequency 3 times daily as inducer. It taked for 5
days to hyperuricemia condition. At the time of treatment, only use long peanut juice for inducer. Doses 12,5 mg/
kgBW; 25 mg/kgBW and 50 mg/kgBW and variations of 7, 14 and 21 days on hyperuricemic condition. Serum uric
acid levels were measured by using a clinical photometer with an enzymatic principle. The resultant decrease in
uric acid levels was best obtained at the fraction of ethyl acetate of lado-lado leaves (0,05) maka dilakukan uji anova. Didapatkan efek
terbaik fraksi etil asetat (P