Korelasi Kadar Hepsidin dan Reticulocyte Hemoglobin Pada Penderita Gagal Ginjal Terminal Dengan Hemodialisis Reguler

KORELASI KADAR HEPSIDIN DAN RETICULOCYTE HEMOGLOBIN
PADA PENDERITA GAGAL GINJAL TERMINAL
DENGAN HEMODIALISIS REGULER
A Ginting1, RA Ganie1, S Nasution2
Departemen Patologi Klinik1, Departemen Ilmu Penyakit Dalam2
Fakultas Kedokteran Universitas Sumatera Utara-RSUP.H.Adam Malik,
Medan
ABSTRAK
Latar belakang: Anemia merupakan komplikasi yang kerap terjadi pada
pasien PGK, terlebih lagi pada yang menjalani hemodialisis reguler yang
dikenal dengan anemia renal. Reticulocyte Hemoglobin(Ret.He)
merepresentasikan nilai rata-rata distribusi kandungan hemoglobin di
dalam retikulosit dan dapat menggambarkan ketersediaan besi dalam
proses eritropoiesis di sumsum tulang. Hepsidin merupakan hormon yang
berperan dalam regulasi dan metabolisme besi.Korelasi kadar hepsidin
dan Ret.He belum diketahui secara jelas.
Tujuan: Mengetahui korelasi kadar Hepsidin dan Ret.He pada penderita
gagal ginjal terminal dengan hemodialisis reguler.
Metode : Penelitian ini merupakan analitik observasional dengan
pendekatan potong lintang yang dilakukan di RSUP H. Adam Malik
Medan, pada bulan Desember 2015 – Maret 2016. Sebanyak 31 sampel

penderita gagal ginjal terminal yang menjalani hemodialisis reguler lebih 3
bulan dengan frekuensi 2x/ minggu dan menandatangani informed
consent memenuhi kriteria inklusi. Semua subjek penelitian diperiksa
darah lengkap, Ret-He dan Hepsidin serum.
Hasil : Pada penelitian ini, didapati median kadar Ret.He sebesar 33,6 pg
(28,2 – 38,7 pg) dan median kadar Hepsidin 0,3 ng/ml (0,09-4 ng/ml).
Pada uji spearman’s rhodidapat korelasi positif yang tidak signifikan
antara kadar Hepsidin dan Ret.He(r= 0,135, p = 0,467).
Kesimpulan: Terdapat korelasi yang tidak signifikan antara kadar
Hepsidin dengan Ret.He pada penderita gagal ginjal terminal dengan
hemodialisis reguler.
Kata Kunci: Anemia renal , Hepsidin, Ret-He, PGK, hemodialisis

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THE CORRELATION OF HEPCIDIN AND RETICULOCYTE
HEMOGLOBIN IN END-STAGE RENAL DISEASE WITH REGULAR
HEMODIALYSIS
A Ginting1, RA Ganie1, S Nasution2

Department of Clinical Pathology1, Departemen of Interna Medicine 2
Medical School University of Sumatera Utara / H. Adam Malik Hospital,
Medan

ABSTRACT
Background: Anemia is a complication that often occurs in CKD patients,
especially in those who are undergoing reguler hemodialysis, known as
renal anemia. Reticulocyte Hemoglobin (RET-He) represents the average
value of the hemoglobin distributionin reticulocytes and can describe the
availability of iron in bone marrow erythropoiesis. Hepcidin is a hormone
that plays a role in iron regulation and metabolism.The correlation of
hepcidin and Ret.He levels is not clearly known.
Objective : To determine the correlation of hepcidin and reticulocyte
hemoglobin (RET-He) levels in end-stage renal disease (ESRD) patients
with regular hemodialysis
Method : This study is an analytical observation and cross sectional
design that were conducted at Adam Malik Hospital, in December 2015. A
total of 31 samples of patients with ESRD undergoing regular
hemodialysis over 3 months with a frequency of two times per week were
included. All study subjects’ full blood count, Ret-He and Hepcidin serum

were examined.
Result : in this study, median of Ret.He level is 33,6 pg ( 28,2-38,7 pg)
and median of hepcidin levels is 0,3 ng/ml (0.09- 4 ng/ml). In Spearman’s
rho test there is no significant correlation between Hepcidin with Ret.He
levels. (r = 0.135; p = 0467).
Conclusion: There is no significant correlation between Hepcidin with
Ret.He level in ESRD patients who are undergoing regular hemodialysis.
Keywords: Renal anemia , Hepcidin, Ret-he, CKD, hemodialysis

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