Formulasi dan Evaluasi Aktivitas Emulgel dari Kombinasi Avobenzone dan Oktilmetoksisinamat sebagai Tabir Surya
FORMULASI DAN EVALUASI EMULGEL DARI KOMBINASI
AVOBENZONE DAN OKTILMETOKSISINAMAT
SEBAGAI TABIR SURYA
ABSTRAK
Latar belakang: Dewasa ini, penggunaan tabir surya dalam bentuk krim, losion,
gel dan emulsi banyak digunakan untuk melindungi kulit dari sinar matahari.
Sediaan tabir surya diformulasikan menggunakan kombinasi Avobenzone dan
Oktilmetoksisinamat sebagai penyerap ultraviolet A dan ultraviolet B dalam
bentuk emulgel karena memilki system penghantaran obat yang baik
dibandingkan sediaan lain.
Tujuan: Penelitian ini bertujuan untuk memformulasikan Avobenzone dan
Oktilmetoksisinamat yang berfungsi sebagai tabir surya dalam sediaan emulgel.
Metode: Emulgel tabir surya dibuat menggunakan Hidroksipropilmetilselulosa
(HPMC), propilen glikol, metil paraben dan propil paraben sebagai basis gel dan
Avobenzone, Oktilmetoksisinamat, paraffin cair, dan variasi konsentrasi Tween
20 yaitu F1: 0,1%; F2: 0,5%; F3: 1%; F4: 1,5%; F5: 2%; F6: 2,5%; dan F7: 3%
sebagai basis emulsi. Pengujian sediaan meliputi pengamatan organoleptis,
pengamatan homogenitas, penentuan tipe emulsi, pH, viskositas, ukuran partikel
menggunakan mikroskop selama penyimpanan 8 minggu dimana pengukuran
dilakukan setiap 1 minggu dalam suhu kamar,iritasi terhadap kulit manusia, dan
penentuan nilai SPF sediaan.
Hasil: Hasil penelitian menunjukkan bahwa sediaan emulgel tabir surya berwarna
putih susu dan tidak berbau. Hasil pengamatan stabilitas emulgel tabir surya
formula 7 menggunakan Tween 20 dengan konsentrasi 3% menunjukkan emulgel
yang paling stabil karena tidak mengalami perubahan organoleptis, pembentukan
krim (creaming) pada emulgel terjadi setelah 8 minggu, memiliki viskositas
paling tinggi, memiliki ukuran rata-rata partikel paling kecil 20,89 µm, tidak
mengiritasi kulit, dan memiliki nilai SPF paling tinggi yaitu 13,26±0,03. Sediaan
emulgel tabir surya yang dibuat memiliki pH 4,83-6,16 dan memiliki tipe emulsi
minyak dalam air.
Kesimpulan: Dapat disimpulkan bahwa semakin tinggi konsentrasi Tween 20
maka semakin stabil sediaan emulgel dan nilai SPF sediaan tabir surya yang
dihasilkan termasuk dalam kategori maksimal yaitu SPF antara 8-15.
Kata kunci : Avobenzone, Oktilmetoksisinamat, Tween 20, Emulgel, SPF.
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FORMULATION AND EVALUATION OF EMULGEL
WITH COMBINATION OF AVOBENZONE AND
OCTYLMETHOXYCINNAMATE AS SUNSCREEN
ABSTRACT
Background: Nowadays, sunscreens in cream, lotion, gel and emulsion forms are
widely used to protect skin from sunshine. Sunscreen preparation is formulated
using Avobenzone and Octylmethoxycinnamate combinations as ultraviolet A and
ultraviolet B absorber in emulgel form since its drug delivery system which better
than another preparation.
Purpose: This research purpose was to formulated Avobenzone and
Octylmethoxycinnamate of which function as sunscreen in emulgel preparation.
Method: Emulgel sunscreen was made using Hydroxypropilmethylcelulose
(HPMC), propylene glycol, methyl paraben and propyl paraben as gel basic and
using Avobenzone, Octylmethoxycinnamate, dilute paraffin, and some variant of
Tween 20 concentrations as F1: 0.1%; F2: 0.5%; F3: 1%; F4: 1.5%; F5: 2%; F6:
2.5%; and F7: 3% as emulsion basic. Preparations was tested, included
organoleptic and homogeneity observations, emulsion types determination, pH,
viscosity, particle size by microscop for 8 weeks which the measuring was done
every 1 week at room temperature, human skin irritation, and SPF value
determination.
Results: Results of the research showed that emulgel sunscreen preparation has
milk white color and scentless. Result of stability observation, formula 7 emulgel
sunscreen using 3% concentration of Tween 20 showed be themost stable emulgel
since it did not under go organoleptic changes, creaming on emulgel occured after
8 weeks, highest viscosity, smallest mean of particle size is 20.89 µm, didn’t
cause skin irritation, and has highest SPF value as 13.26±0.03. Emulgel sunscreen
preparation which had been made has pH of 4.83-6.16 and had oil in water (o/w)
emulsion type.
Conclusion: It can be conclude that as higher as concentration of Tween 20 will
make emulgel preparation more stable and the SPF value of sunscreen obtain
include in maximal category SPF value between 8 to 15.
Keyword: Avobenzone, Octylmethoxycinnamate, Tween 20, Emulgel, SPF.
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AVOBENZONE DAN OKTILMETOKSISINAMAT
SEBAGAI TABIR SURYA
ABSTRAK
Latar belakang: Dewasa ini, penggunaan tabir surya dalam bentuk krim, losion,
gel dan emulsi banyak digunakan untuk melindungi kulit dari sinar matahari.
Sediaan tabir surya diformulasikan menggunakan kombinasi Avobenzone dan
Oktilmetoksisinamat sebagai penyerap ultraviolet A dan ultraviolet B dalam
bentuk emulgel karena memilki system penghantaran obat yang baik
dibandingkan sediaan lain.
Tujuan: Penelitian ini bertujuan untuk memformulasikan Avobenzone dan
Oktilmetoksisinamat yang berfungsi sebagai tabir surya dalam sediaan emulgel.
Metode: Emulgel tabir surya dibuat menggunakan Hidroksipropilmetilselulosa
(HPMC), propilen glikol, metil paraben dan propil paraben sebagai basis gel dan
Avobenzone, Oktilmetoksisinamat, paraffin cair, dan variasi konsentrasi Tween
20 yaitu F1: 0,1%; F2: 0,5%; F3: 1%; F4: 1,5%; F5: 2%; F6: 2,5%; dan F7: 3%
sebagai basis emulsi. Pengujian sediaan meliputi pengamatan organoleptis,
pengamatan homogenitas, penentuan tipe emulsi, pH, viskositas, ukuran partikel
menggunakan mikroskop selama penyimpanan 8 minggu dimana pengukuran
dilakukan setiap 1 minggu dalam suhu kamar,iritasi terhadap kulit manusia, dan
penentuan nilai SPF sediaan.
Hasil: Hasil penelitian menunjukkan bahwa sediaan emulgel tabir surya berwarna
putih susu dan tidak berbau. Hasil pengamatan stabilitas emulgel tabir surya
formula 7 menggunakan Tween 20 dengan konsentrasi 3% menunjukkan emulgel
yang paling stabil karena tidak mengalami perubahan organoleptis, pembentukan
krim (creaming) pada emulgel terjadi setelah 8 minggu, memiliki viskositas
paling tinggi, memiliki ukuran rata-rata partikel paling kecil 20,89 µm, tidak
mengiritasi kulit, dan memiliki nilai SPF paling tinggi yaitu 13,26±0,03. Sediaan
emulgel tabir surya yang dibuat memiliki pH 4,83-6,16 dan memiliki tipe emulsi
minyak dalam air.
Kesimpulan: Dapat disimpulkan bahwa semakin tinggi konsentrasi Tween 20
maka semakin stabil sediaan emulgel dan nilai SPF sediaan tabir surya yang
dihasilkan termasuk dalam kategori maksimal yaitu SPF antara 8-15.
Kata kunci : Avobenzone, Oktilmetoksisinamat, Tween 20, Emulgel, SPF.
iii
FORMULATION AND EVALUATION OF EMULGEL
WITH COMBINATION OF AVOBENZONE AND
OCTYLMETHOXYCINNAMATE AS SUNSCREEN
ABSTRACT
Background: Nowadays, sunscreens in cream, lotion, gel and emulsion forms are
widely used to protect skin from sunshine. Sunscreen preparation is formulated
using Avobenzone and Octylmethoxycinnamate combinations as ultraviolet A and
ultraviolet B absorber in emulgel form since its drug delivery system which better
than another preparation.
Purpose: This research purpose was to formulated Avobenzone and
Octylmethoxycinnamate of which function as sunscreen in emulgel preparation.
Method: Emulgel sunscreen was made using Hydroxypropilmethylcelulose
(HPMC), propylene glycol, methyl paraben and propyl paraben as gel basic and
using Avobenzone, Octylmethoxycinnamate, dilute paraffin, and some variant of
Tween 20 concentrations as F1: 0.1%; F2: 0.5%; F3: 1%; F4: 1.5%; F5: 2%; F6:
2.5%; and F7: 3% as emulsion basic. Preparations was tested, included
organoleptic and homogeneity observations, emulsion types determination, pH,
viscosity, particle size by microscop for 8 weeks which the measuring was done
every 1 week at room temperature, human skin irritation, and SPF value
determination.
Results: Results of the research showed that emulgel sunscreen preparation has
milk white color and scentless. Result of stability observation, formula 7 emulgel
sunscreen using 3% concentration of Tween 20 showed be themost stable emulgel
since it did not under go organoleptic changes, creaming on emulgel occured after
8 weeks, highest viscosity, smallest mean of particle size is 20.89 µm, didn’t
cause skin irritation, and has highest SPF value as 13.26±0.03. Emulgel sunscreen
preparation which had been made has pH of 4.83-6.16 and had oil in water (o/w)
emulsion type.
Conclusion: It can be conclude that as higher as concentration of Tween 20 will
make emulgel preparation more stable and the SPF value of sunscreen obtain
include in maximal category SPF value between 8 to 15.
Keyword: Avobenzone, Octylmethoxycinnamate, Tween 20, Emulgel, SPF.
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