Perbandingan HOMA-IR Pada pasien Hipertiroid Sebelum Dan Sesudah Pengobatan

  LAMPIRAN 1

LEMBAR PENJELASAN KEPADA CALON SUBJEK PENELITIAN

Ass Wr.Wb, Selamat pagi / siang Bapak / Ibu Yth, pada hari ini, saya, dr. Darma Liza

  

Efendi, peserta Pendidikan Pasca Sarjana Ilmu Penyakit Dalam / Magister Klinik FK USU

Medan, akan melakukan penelitian yang berjudul “ PERBANDINGAN HOMA-IR PADA

PASIEN HIPERTIROID SEBELUM DAN SESUDAH PENGOBATAN”. Penelitian ini

bertujuan untuk mengetahui perbaikan Resistensi Insulin pada penderita hipertiroid yang telah

menda[pat pengobatan 3 dan 6 bulan dibandingkan pasien baru. Sebagai informasi yang

dikatakan Penyakit hipertiroid adalah penyakit yang disebabkan suatu aktifitas yang berlebihan

dari kelenjar gondok, sedangkan fase remisi adalah penderita hipertiroid yang telah

mendapatkan obat anti tiroid dan sudah menunjukan fungsi tiroid yang normal baik secara

gambaran klinis maupun laboratoris. Dan Resistensi insulin adalah ketidaksanggupan insulin

memberi efik biologis yang normal pada kadar gula darah tertentu, dikatakan resistensi insulin

bila dibutuhkan kadar insulin yang lebih banyak untuk mencapai kadar gula darah yang normal

misalnya untuk menjaga kadar gula darah dalam batas normal pada orang sehat hanya

memerlukan 5 unit insulina sementara pada orang gemuk diperlukan 10-15 init Pada Bapak/Ibu yang bersedia mengikuti penelitian ini nantinya akan diminta mengisi

surat persetujuan ikut dalam penelitian, mengikuti wawancara untuk mencari adanya hal-hal

yang dapat mengganggu penelitian, dilakukan pengukuran tekanan darah (TD), berat badan

(BB), tinggi badan (TB), parameter kegemukan (IMT) ,pemeriksaan laboratorium berupa

pemeriksaan darah sebanyak 15 cc (1 sendok makan) yang akan diambil dari lengan oleh ahlinya

untuk menilai parameter darah rutin, kadar gula darah puasa dan 2 jam sesudah makan, Insulin

plasma ( parameter resistensi insulin ), hormon T3,T4, TSH.

  Segala biaya pemeriksaan laboratorium menjadi tanggung jawab peneliti. Bila masih

terdapat pertanyaan atau keluhan sewaktu penelitian ini berjalan, maka Bapak/Ibu dapat

menghubungi saya pada: Nama : dr.Darma Liza Efendi Alamat : Jl. T.Imam Bonjol No.196 Binjai 20721 Telepon : (061)- 77410257 dan 0811650799

  Peneliti, ( dr.Darma Liza Efendi )

  LAMPIRAN 2

SURAT PERSETUJUAN SETELAH PENJELASAN

( INFORMED CONSENT )

  Saya yang bertanda tangan di bawah ini : Nama : .........................................................................

  Alamat : ......................................................................... Umur : ......................................................................... Jenis Kelamin : Laki – laki / perempuan

Setelah mendapat penjelasan dari peneliti tentang kebaikan dan keburukan prosedur penelitian

ini dan saya telah memahaminya, menyatakan bersedia untuk ikut dalam penelitian tentang

Perbandingan HOMA-IR pada pasien hipertiroid sebelum dan sesudah pengobatan.

  

Demikianlah surat pernyataan bersedia ikut dalam penelitian ini saya buat untuk dapat

dipergunakan seperlunya.

  Medan, ............................2010

Saksi, Yang memberi pernyataan,

(................................................) (................................................)

  LAMPIRAN 3

   LEMBAR KERJA PROFIL PESERTA PENELITIAN I. IDENTITAS PRIBADI.

  Nama : Kode: X/ Y Tempat/Tanggal Lahir : Jenis Kelamin : Laki-laki/Perempuan. Pendidikan Terakhir : Pekerjaan : Status : Kawin/Belum Kawin. No Telp/Hp :................

  II. PEMERIKSAAN FISIK Sensorium :

  x

  Pernafasan : .......... /menit Tekanan Darah: ............. mmHg

  o

  Temperatur : ........... C

  x

  Nadi : ............. /menit

  III. PEMERIKSAAN LABORATORIUM Parameter Nilai Hb (gr/dl)

3 Leukosit (mm )

  Ureum (mg/dl) Creatinin (mg/dl) Eosinofil pH

  IV. SPIROMETRI FEV1 % prediksi:

  V. FOTO TORAKS Kesan:

  VI. EKG Kesimpulan: LAMPIRAN 4

  LAMPIRAN 4 MASTER TABEL HASIL PENELITIAN Fase sebelum pengobatan

  U M TGL U TB BB

  IMT NO. NAMA TGL LAHIR J.KEL PERIKSA R (cm) (Kg) (KG/M2)

  (th ) 1 16-08-2011 Helfi Sofiana

  34 28-05-1977 PR 146

  40

  18.8

  2 22-08-2011 Rospita P 54 17-07-1957 PR 157

  49

  19.9 3 09/10/2011 Bambang 33 10/11/1977 LK 171

  56

  19.2 4 13-09-2011 Aliza Malase 39 29-08-1972 LK 154

  41

  17.3 5 24-09-2011 Nurhayati 41 18-09-1970 PR 165

  44

  16.2 6 23-09-2011 Jumiarsih 38 12/05/1972 PR 152

  44

  19.0 7 28-09-2011 Nini 46 03/03/1965 PR 154

  39

  16.4 8 28-09-2011 Meriza 37 04/10/1974 PR 155

  45

  18.7 9 31-09-2011 Sukarsih 39 01/01/1971 PR 152

  45

  19.5 10 10/04/2011 Partini 48 23-07-1963 PR 147

  62

  28.7 11 10/12/2011 Parlindungan 49 27-05-2011 LK 180

  69

  21.3 12 10/12/2011 yenni 23 11/05/1987 PR 157

  47

  19.1 13 26-10-2011 Desi D 21 12/09/1989 PR 153

  48

  20.5 14 28-10-2011 Salamah 40 13-05-1971 PR 148

  42

  19.2 15 28-10-2011 Manaek I S 19 28-05-1992 LK 175

  60

  19.6 16 30-10-2011 Marianna 35 10/03/1976 PR 150

  51

  22.7 KGD HO HO T3/ng/m T4/ug/dl

  INSULIN T3/ng/ml TSH/uIU/ml N KGD 2JPP MA- MA- l (0.58- (4.87- PUASA(uIU/ (0.58-

  (0.35-4.94) (mg/ (mg/dl)

  IR(N<2.7 B(N>107 1.59) 11.72) ml) 1.59) dl) 7) )

  4,61 16,67 <0.0025

  83 98 2,8

  0.57 50.4 4,61 2,42 15,59 0,0027 86 138 6,7 1.422 104 2,42 3,51 19,02 <0.0025 86 116 6,6 1.4 103 3,51 2,24 17,49 0,0178 87 107 2,7

  0.58 40.5 2,24 4,83 23,27 0,0084 94 108 5,4

  1.25 14.51 4,83 3,77 22,08 0,0029 70 109 5,8 1 298 3,77 7,74 18,99 0,0028

  64 71 3,2 0.5 1152 7,74 3,48 18,14 <0.0025

  71 89 2,5 0.43 112.5 3,48 3,53 21,56 <0.0025 85 120

  6

  1.26 98 3,53 3,11 18,11 <0.0025 100 111 7,4

  1.82 72 3,11 2,48 15,98 0,007 90 116

  10 2.22 133 2,48 6,3 23,43 <0.0025 83 119 7,4 1.51 133.2 6,3

  1,82 12,49 0,0044 86 130 10,2 2.16 159.6 1,82 1,36 10,33 0,0117 89 124 7,5 1.65 103.8 1,36 1,05 2,22 2,1057

  88 71 5,8

  1.26 83.52 1,05 6,28 22,43 <0.0030 65 158 4,7 0.754 846 6,28

  Fase sesudah pengobatan

  INSUL KGD KGD B T3/ng/

  HOMA

  IMT( T4/ug/dl TSH/uIU/

  IN HOMA- N B(

  2JPP - ml N NAMA J.KEL KG/ (4.87- ml(0.35- PUAS B(N>10 Masa/bln

  O. Kg (0.58- (mg/dl (mg/dl

  IR(N< M2) 11.72) 4.94) 7)

  A(uIU/ ) 1.59) ) ) 2.77) ml)

  1 Helfi Sofiana PR 41 19.2 1,98 11,78 <0.0025

  88 95 7,6 1.651 109.44

  4

  2 Rospita P PR 59 23.9 2 16,32 <0.0025 90 155 4,7

  1.04

  62.67

  7

  3 Bambang LK 65 22.2 6,18 21.04 0.0013 95 106

  8.4

  1.97

  94.5

  3

  4 Aliza Malase LK 49 20.7 0,92 6,39 0,4091

  73 80 8,8 1.58 316.8

  6

  5 Nurhayati PR 53 19.5

  7.21 21.52 0.0044 80 114

  8.20 1.61 173.64

  6

  6 Jumiarsih PR 50 21.6

  1.27

  1.12 5.66 17.848 85 106

  9.8 2.05 160.36

  6 12 yenni PR 52 21.1 6,74 22,91 <0.0025 84 105 8,3 1.72 142.28

  6

  13 Desi D PR 52 22.2 2.49 16,22 0.007

  90

  99

  10.90 2.42 145.33

  5

  14 Salamah PR 46 21.0

  3.82

  6

  

13.41

89 101

  7.10 1.65 103.8

  5

  15 Manaek I S LK 61 19.9

  2.89 8.77 0.003 86 107

  14

  1.26

  83.52

  5

  16 Marianna PR 48 21.3 0,77 4,77 0,8322 74 120 4,2 0.754 846

  11 Parlindungan LK 73 22.5

  13 2.85 180

  0.97

  81

  5.55

  

4.16

65 106

  21.5 3.45 967.5

  6

  7 Nini PR 47 19.8

  2.48 5.13 0.0033 84 116

  6.80 1.41 116.57

  6

  8 Meriza PR 51 21.2

  1.62 7.31 <0.0025

  87

  98

  5.80 1.16 116

  6

  9 Sukarsih PR 53 22.9

  1.24 5.14 0.1447 88 101

  8.0 1.73 115.2

  6

  10 Partini PR 70 32.4

  1.03

  7.51

  

3.67

  89

  6 LAMPIRAN 5 Uji Statistik

  

One-Sample Kolmogorov-Smirnov Test

_{16 37.25 9.910 .147 .112 -.147 .586 .882 16 157.25 10.169 .260 .260 -.134 1.039 .230 16 48.88 8.655 .182 .182 -.127 .727 .666} 16 19.756 2.8902 .230 .230 -.170 .921 .365 _{16 3.6581 1.88984 .164 .164 -.105 .656 .783 16 17.3625 5.48858 .186 .134 -.186 .743 .638 16 .136338 .5251811 .527 .527 -.399 2.107 .000 16 82.9375 10.21417 .252 .129 -.252 1.010 .260} 16 111.5625 22.42014 .169 .103 -.169 .677 .748 _{16 5.9188 2.36508 .127 .127 -.105 .508 .959 15 1.2243 .58487 .131 .131 -.118 .509 .958 16 219.0019 315.82152 .387 .387 -.259 1.548 .017} 16 157.25 10.169 .260 .260 -.134 1.039 .230 _{16 54.38 8.899 .249 .249 -.111 .996 .275 16 21.963 3.0661 .255 .255 -.184 1.020 .250 16 2.5569 2.16172 .262 .262 -.204 1.049 .221} 16 10.6150 6.71570 .241 .241 -.156 .962 .313 _{16 2.531981 5.3394581 .375 .375 -.318 1.500 .022 16 83.81 7.687 .197 .148 -.197 .789 .562 16 106.00 16.501 .226 .226 -.127 .903 .388} 16 9.194 4.2080 .225 .225 -.118 .899 .394 _{15 1.8853 .75284 .182 .182 -.100 .704 .705 16 197.1981 213.78795 .345 .345 -.265 1.378 .045} ^{Um ur (tahun) Tinggi badan sebelum rem isi Berat badan sebelum rem isi Indeks mas a tubuh sebelum rem isi T3 sebelum rem isi T4 sebelum rem isi TSH sebelum rem isi KGDN sebelum rem isi KGD 2J PP sebelum rem isi Ins ulin Puasa sebelum rem isi HOMA-IR sebelum rem isi HOMA-B sebelum rem isi Tinggi badan sesudah rem isi Berat badan sesudah rem isi Indeks mas a tubuh sesudah rem isi T3 ses udah rem isi T4 ses udah rem isi TSH sesudah rem isi KGDN sesudah rem isi KGD 2J PP sesudah rem isi Ins ulin Puasa sesudah} _{rem isi HOMA-IR sesudah rem isi HOMA-B sesudah rem isi} ^{N Mean Std. Deviati on Normal Parameters a,b Absolute Positive Negative Most Extrem e Differences Kolmogorov-Sm irnov Z As ymp. Sig. (2-tailed)} _{Test di stribution is Norm al. a. Calculated from data. b.}

  49.63

  Berat badan sebelum pengobatan .018

  Test of Homogeneity of Variances

  N Mean Std. Deviation Std. Error Lower Bound Upper Bound 95% Confidence Interval for Mean Minimum Maximum

  73 Awal 3 bulan 6 bulan Total

  39

  55.16

  49.92

  48 52.54 9.018 1.302

  73

  41

  59.12

  16 54.38 8.899 2.225

  Oneway [DataSet1] D:\01 ABDUL JALIL AMRI ARMA 1958\05 DATA PPDS\SpPD darma 07072013\SpPD Dharma Liza\Data Dharma SpPD 09-06-13.sav

  73

  41

  59.12

  49.63

  16 54.38 8.899 2.225

  69

  39

  53.49

  44.26

  16 48.88 8.655 2.164

  

Descriptives

Berat badan sebelum pengobatan

  2 45 .983 Levene Statistic df1 df2 Sig. N Mean Std. Deviation Std. Error Lower Bound Upper Bound 95% Confidence Interval for Mean Minimum Maximum

  32.4 Awal 3 bulan 6 bulan Total

  Oneway [DataSet1] D:\01 ABDUL JALIL AMRI ARMA 1958\05 DATA PPDS\SpPD darma 07072013\SpPD Dharma Liza\Data Dharma SpPD 09-06-13.sav

  16.2

  32.4 48 21.227 3.1259 .4512 20.319 22.135

  19.2

  32.4 16 21.963 3.0661 .7665 20.329 23.596

  19.2

  28.7 16 21.963 3.0661 .7665 20.329 23.596

  16.2

  

Descriptives

Indeks mas a tubuh sebelum pengobatan 16 19.756 2.8902 .7226 18.216 21.296

  Mean Difference (I-J) Std. Error Sig. Lower Bound Upper Bound 95% Confidence Interval

  ANOV A

  (I) klp Awal 3 bulan 6 bulan

  3 bulan 6 bulan Awal 6 bulan Awal 3 bulan

  11.78 .000 3.118 1.000 -6.28 6.28 (J) klp

  11.78 .000 3.118 1.000 -6.28 6.28 5.500 3.118 .085 -.78

  Post Hoc Tests Multiple Comparisons Dependent Variable: Berat badan sebelum pengobatan LSD

  Sum of Squares df Mean S quare F Sig.

  47 Between Groups W ithin Groups Total

  3499.250 45 77.761 3821.917

  Berat badan sebelum pengobatan 322.667 2 161.333 2.075 .137

• 5.500 3.118 .085 -11.78 .78
• 5.500 3.118 .085 -11.78 .78 5.500 3.118 .085 -.78

  Test of Homogeneity of Variances

  Indeks mas a tubuh sebelum pengobatan Levene Statistic df1 df2 Sig.

  .000

  2 45 1.000

  ANOV A

  Indeks mas a tubuh sebelum pengobatan Sum of Squares df Mean S quare F Sig.

  Between Groups 51.920 2 25.960 2.868 .067 W ithin Groups

  407.334 45 9.052 Total 459.255

47 Post Hoc Tests

  Multiple Comparisons

  Dependent Variable: Indeks mas a tubuh s ebelum pengobatan LSD

  Mean 95% Confidence Interval

  Difference (I) klp (J) klp (I-J) Std. Error Sig. Lower Bound Upper Bound Awal 3 bulan

• 2.2062* 1.0637 .044 -4.349 -.064 6 bulan -2.2062* 1.0637 .044 -4.349 -.064 3 bulan Awal

  2.2062* 1.0637 .044 .064 4.349 6 bulan .0000 1.0637 1.000 -2.142 2.142 6 bulan Awal

  2.2062* 1.0637 .044 .064 4.349 3 bulan .0000 1.0637 1.000 -2.142 2.142

• . The mean difference is s ignificant at the .05 level.

  Oneway [DataSet1] D:\01 ABDUL JALIL AMRI ARMA 1958\05 DATA PPDS\SpPD darma 07072013\SpPD Dharma Liza\Data Dharma SpPD 09-06-13.sav

  Descriptives

  T3 sebelum pengobatan 95% Confidence Interval for

  Mean N Mean Std. Deviation Std. Error Lower Bound Upper Bound Minimum Maximum

  Awal 16 3.6581 1.88984 .47246 2.6511 4.6651

  1.05

  7.74 3 bulan 16 2.5569 2.16172 .54043 1.4050 3.7088 .77

  7.21 6 bulan 5 3.0560 1.34706 .60243 1.3834 4.7286

  1.77

  5.09 Total 37 3.1005 1.97653 .32494 2.4415 3.7595 .77

  7.74

• -1.10125 .69379 .122 -2.5112 .3087

• -.49912 1.00540 .623 -2.5423 1.5441

• -.60212 1.00540 .553 -2.6453 1.4411

  .49912 1.00540 .623 -1.5441 2.5423

  (J) klp 3 bulan 6 bulan Awal 6 bulan Awal 3 bulan (I) klp

  Descriptives

  N Mean Std. Deviation Std. Error Lower Bound Upper Bound 95% Confidence Interval for

  24.44 Awal 3 bulan 6 bulan Total

  2.22

  24.44 37 14.2278 6.77343 1.11355 11.9695 16.4862

  7.62

  22.91 5 15.7580 6.03148 2.69736 8.2689 23.2471

  3.82

  23.43 16 10.6150 6.71570 1.67892 7.0365 14.1935

  2.22

  T4 sebelum pengobatan 16 17.3625 5.48858 1.37214 14.4378 20.2872

  Oneway [DataSet1] D:\01 ABDUL JALIL AMRI ARMA 1958\05 DATA PPDS\SpPD darma 07072013\SpPD Dharma Liza\Data Dharma SpPD 09-06-13.sav

  Test of Homogeneity of Variances

  Di fference

(I-J) Std. Error Sig. Lower Bound Upper Bound

95% Confidence Interval

  Awal 3 bulan 6 bulan Mean

  

1.10125 .69379 .122 -.3087 2.5112

.60212 1.00540 .553 -1.4411 2.6453

  Post Hoc Tests Multiple Comparisons Dependent Vari able: T3 sebelum pengobatan LSD

  Squares df Mean S quare F Sig.

  36 Between Groups W ithin Groups Total Sum of

  2 4.857 1.261 .296 130.926 34 3.851 140.640

  ANOV A T3 sebelum pengobatan 9.713

  2 34 .699 Levene Statistic df1 df2 Sig.

  T3 sebelum pengobatan .363

  Mean Minimum Maximum Mean Minimum Maximum

  N Mean Std. Deviation Std. Error Lower Bound Upper Bound 95% Confidence Interval for

  

6.74750* 2.16412 .004 2.3495 11.1455

1.60450 3.13611 .612 -4.7688 7.9778

  Awal 3 bulan 6 bulan Total

  TSH sebelum pengobatan 16 .13634 .525181 .131295 -.14351 .41619 .003 2.106 16 2.53198 5.339458 1.334865 -.31322 5.37718 .001 17.848 5 .00460 .000894 .000400 .00349 .00571 .003 .005 37 1.15449 3.671745 .603631 -.06973 2.37871 .001 17.848

  Descriptives

  Oneway [DataSet1] D:\01 ABDUL JALIL AMRI ARMA 1958\05 DATA PPDS\SpPD darma 07072013\SpPD Dharma Liza\Data Dharma SpPD 09-06-13.sav

  Difference

(I-J) Std. Error Sig. Lower Bound Upper Bound

95% Confidence Interval The mean difference is s ignificant at the .05 level.

  Awal 3 bulan 6 bulan Mean

  Post Hoc Tests Multiple Comparisons Dependent Variable: T4 sebelum pengobatan LSD

  Test of Homogeneity of Variances

  Sum of Squares df Mean S quare F Sig.

  36 Between Groups W ithin Groups Total

  1273.891 34 37.467 1651.657

  T4 sebelum pengobatan 377.766 2 188.883 5.041 .012

  ANOV A

  2 34 .289 Levene Statistic df1 df2 Sig.

  T4 sebelum pengobatan 1.287

• 6.74750* 2.16412 .004 -11.1455 -2.3495
• 5.14300 3.13611 .110 -11.5163 1.2303
• 1.60450 3.13611 .612 -7.9778 4.7688

  5.14300 3.13611 .110 -1.2303 11.5163

  (J) klp 3 bulan 6 bulan Awal 6 bulan Awal 3 bulan (I) klp
• .

  Test of Homogeneity of Variances

  TSH sebelum pengobatan Levene Statistic df1 df2 Sig.

  8.250

  2 34 .001

  ANOV A

  TS H sebelum pengobat an Sum of Squares df Mean S quare F Sig.

  Between Groups 53.557 2 26.779 2.109 .137

  W ithin Groups 431.784 34 12.700

  Total 485.342

36 Post Hoc Tests

  Multiple Comparisons Dependent Variable: TSH sebelum pengobatan LSD

  Mean 95% Confidence Interval Difference (I) klp (J) klp (I-J) Std. Error Sig. Lower Bound Upper Bound

  Awal 3 bulan

• 2.395644 1.259938 .066 -4.95615 .16486 6 bulan .131738 1.825823 .943 -3.57878 3.84226 3 bulan Awal

  2.395644 1.259938 .066 -.16486 4.95615

  6 bulan

  2.527381 1.825823 .175 -1.18314 6.23790

  6 bulan Awal

  -.131738 1.825823 .943 -3.84226 3.57878

  3 bulan
• 2.527381 1.825823 .175 -6.23790 1.18314

  Oneway [DataSet1] D:\01 ABDUL JALIL AMRI ARMA 1958\05 DATA PPDS\SpPD darma 07072013\SpPD Dharma Liza\Data Dharma SpPD 09-06-13.sav

  

Descriptives

KGDN sebelum pengobatan 95% Confidence Interval for

  Mean N Mean Std. Deviation Std. Error Lower Bound Upper Bound Minimum Maximum Awal

  16 82.94 10.214 2.554

  77.49

  88.38 64 100 3 bulan 16 83.81 7.687 1.922

  79.72

  87.91

  65

  95 6 bulan 5 91.60 15.307 6.845 72.59 110.61 65 104 Total

  37 84.49 10.120 1.664

  81.11

  87.86 64 104

  Test of Homogeneity of Variances KGDN sebelum pengobatan Levene

  Statistic df1 df2 Sig.

  1.227

  2 34 .306 ANOV A

  KGDN sebelum pengobatan Sum of Squares df Mean S quare F Sig. Between Groups 298.668

  2 149.334 1.498 .238 W ithin Groups 3388.575 34 99.664 Total 3687.243

36 Post Hoc Tests

  Multiple Comparisons Dependent Variable: KGDN s ebelum pengobatan LSD

  Mean 95% Confidence Interval Difference (I) klp (J) klp (I-J) Std. Error Sig. Lower Bound Upper Bound

  Awal 3 bulan

• .875 3.530 .806 -8.05

  6.30 6 bulan

• 8.662 5.115 .099 -19.06

  1.73 3 bulan Awal .875 3.530 .806 -6.30 8.05 6 bulan

• 7.787 5.115 .137 -18.18

  2.61 6 bulan Awal 8.662 5.115 .099 -1.73

  19.06 3 bulan 7.787 5.115 .137 -2.61

  18.18 Oneway [DataSet1] D:\01 ABDUL JALIL AMRI ARMA 1958\05 DATA PPDS\SpPD darma 07072013\SpPD Dharma Liza\Data Dharma SpPD 09-06-13.sav

  Oneway [DataSet1] D:\01 ABDUL JALIL AMRI ARMA 1958\05 DATA PPDS\SpPD darma 07072013\SpPD Dharma Liza\Data Dharma SpPD 09-06-13.sav

  Post Hoc Tests Multiple Comparisons Dependent Variable: KGD 2J PP sebelum pengobatan LSD

  The mean difference is s ignificant at the .05 level.

  Mean Difference

(I-J) Std. Error Sig. Lower Bound Upper Bound

95% Confidence Interval

  (I) klp Awal 3 bulan 6 bulan

  3 bulan 6 bulan Awal 6 bulan Awal 3 bulan

  37.31 21.800* 10.369 .043 .73 42.87 (J) klp

  8.98

  4.84

  20.10

  5.563 7.156 .442 -8.98

  Sum of Squares df Mean S quare F Sig.

  

Descriptives

KGD 2J PP sebelum pengobatan 16 111.56 22.420 5.605

  36 Between Groups W ithin Groups Total

  13926. 738 34 409.610 15738. 432

  KGD 2J PP sebelum pengobatan 1811.695 2 905.847 2.211 .125

  ANOV A

  2 34 .355 Levene Statistic df1 df2 Sig.

  KGD 2J PP sebelum pengobatan 1.067

  Test of Homogeneity of Variances

  95% Confidence Interval for Mean Minimum Maximum

  71 160 Awal 3 bulan 6 bulan Total N Mean Std. Deviation Std. Error Lower Bound Upper Bound

  99.62 123.51 71 158 16 106.00 16.501 4.125 97.21 114.79 80 155 5 127.80 23.994 10.730 98.01 157.59 103 160 37 111.35 20.909 3.437 104.38 118.32

• 16.237 10.369 .127 -37.31
• 5.563 7.156 .442 -20.10

• -21.800* 10.369 .043 -42.87 -.73

  16.237 10.369 .127 -4.84
• .

  Descriptives

  Ins ulin Puasa s ebelum pengobatan 95% Confidence Interval for

  Mean N Mean Std. Deviation Std. Error Lower Bound Upper Bound Minimum Maximum

  Awal 16 5.9188 2.36508 .59127 4.6585 7.1790

  2.50

  10.20 3 bulan 16 9.1938 4.20800 1.05200 6.9515 11.4360

  4.20

  21.50 6 bulan 5 17.0360 19.71704 8.81773 -7.4459 41.5179

  3.91

  50.20 Total 37 8.8373 8.12912 1.33642 6.1269 11.5477

  2.50

  50.20 Test of Homogeneity of Variances

  Ins ulin Puasa s ebelum pengobatan Levene Statistic df1 df2 Sig.

  16.720

  2 34 .000 ANOV A

  Ins ulin Puasa s ebelum pengobatan Sum of Squares df Mean S quare F Sig. Between Groups 474.413 2 237.207 4.235 .023 W ithin Groups

  1904.560 34 56.016 Total 2378.974

36 Post Hoc Tests

  Multiple Comparisons Dependent Variable: Ins ulin Puas a sebelum pengobatan LSD

  Mean 95% Confidence Interval Difference (I) klp (J) klp (I-J) Std. Error Sig. Lower Bound Upper Bound

  Awal 3 bulan

• -3.27500 2.64614 .224 -8.6526 2.1026

  6 bulan

• -11.11725* 3.83462 .007 -18.9101 -3.3244

  3 bulan Awal

  3.27500 2.64614 .224 -2.1026 8.6526

  6 bulan -7.84225* 3.83462 .049 -15.6351 -.0494 6 bulan Awal

  11.11725* 3.83462 .007 3.3244 18.9101

  3 bulan

  7.84225* 3.83462 .049 .0494 15.6351

  *.

  The mean difference is s ignificant at the .05 level.

  Oneway [DataSet1] D:\01 ABDUL JALIL AMRI ARMA 1958\05 DATA PPDS\SpPD darma 07072013\SpPD Dharma Liza\Data Dharma SpPD 09-06-13.sav

  Descriptives

  HOMA-IR s ebelum pengobatan 95% Confidence Interval for

  Mean N Mean Std. Deviation Std. Error Lower Bound Upper Bound Minimum Maximum

  Awal 16 1.2366 .56719 .14180 .9344 1.5389 .43 2.22 3 bulan

  16 1.8707 .72967 .18242 1.4819 2.2595 .76

  3.45 6 bulan 5 3.6960 4.53514 2.02818 -1.9351 9.3271 .98

  11.64 Total 37 1.8432 1.81158 .29782 1.2392 2.4472 .43

  11.64 Test of Homogeneity of Variances

  HOMA-IR s ebelum pengobatan Levene Statistic df1 df2 Sig.

  14.498

  2 34 .000 ANOV A

  HOMA -IR s ebelum pengobatan Sum of Squares df Mean S quare F Sig. Between Groups 23.063

  2 11.532 4.124 .025 W ithin Groups 95.082 34 2.797 Total 118.145

36 Post Hoc Tests

  Multiple Comparisons Dependent Variable: HOMA-IR sebelum pengobatan LSD

  Mean 95% Confidence Interval Difference (I) klp (J) klp (I-J) Std. Error Sig. Lower Bound Upper Bound

  Awal 3 bulan

• .63406 .59124 .291 -1.8356 .5675 6 bulan -2.45938* .85679 .007 -4.2006 -.7182 3 bulan Awal .63406 .59124 .291 -.5675 1.8356 6 bulan
• 1.82531* .85679 .040 -3.5665 -.0841 6 bulan Awal 2.45938* .85679 .007 .7182 4.2006 3 bulan 1.82531* .85679 .040 .0841 3.5665 *. The mean difference is s ignificant at the .05 level.

  Oneway [DataSet1] D:\01 ABDUL JALIL AMRI ARMA 1958\05 DATA PPDS\SpPD darma 07072013\SpPD Dharma Liza\Data Dharma SpPD 09-06-13.sav

  

Descriptives

HOMA-B sebelum pengobatan 95% Confidence Interval for

  Mean N Mean Std. Deviation Std. Error Lower Bound Upper Bound Minimum Maximum Awal 16 219.0019 315.82152 78.95538 50.7125 387.2913 14.51 1152.00 3 bulan

  16 197.1981 213.78795 53.44699 83.2786 311.1177 62.67 967.50 6 bulan 5 164.6740 159.54171 71.34922 -33.4232 362.7712 34.33 363.60 Total

  37 202.2316 252.51513 41.51323 118.0389 286.4244 14.51 1152.00 Test of Homogeneity of Variances

  HOMA-B sebelum pengobatan Levene Statistic df1 df2 Sig.

  .884

  2 34 .423 ANOV A

  HOMA -B s ebelum pengobatan Sum of Squares df Mean S quare F Sig. Between Groups 11958. 114 2 5979.057 .089 .915 W ithin Groups 2283542

  34 67163. 001 Total 2295500

36 Post Hoc Tests

  Multiple Comparisons Dependent Variable: HOMA-B sebelum pengobatan LSD

  Mean 95% Confidence Interval Difference (I) klp (J) klp (I-J) Std. Error Sig. Lower Bound Upper Bound

  Awal 3 bulan 21.80375 91.62628 .813 -164.4033 208.0108 6 bulan

54.32787 132.77909 .685 -215.5117 324.1675

3 bulan Awal -21.80375 91.62628 .813 -208.0108 164.4033

  6 bulan

32.52413 132.77909 .808 -237.3155 302.3637

6 bulan Awal

• -54.32787 132.77909 .685 -324.1675 215.5117

  3 bulan

• -32.52413 132.77909 .808 -302.3637 237.3155

  T-Test [DataSet1] E:\ABDUL JALIL A A\15DATAPPDS\SpPD Dharma Liza\Data Dharma Liza 08-05-12.sav

  Paired Samples Statistics

  Pair

  4 T4 sebelum remisi T4 ses udah remisi

  Pair

  5 TSH sebelum remis i TSH sesudah remis i

  Pair

  6 KGDN sebelum remisi KGDN sesudah remisi

  Pair

  7 KGD 2J PP sebelum remisi KGD 2J PP sesudah remisi

  8 Ins ulin Puasa s ebelum remisi Ins ulin Puasa s esudah remisi

  3 T3 sebelum remisi T3 ses udah remisi

  Pair

  9 HOMA-IR sebelum remis i HOMA-IR sesudah remis i

  Pair

  10 HOMA-B sebelum remisi HOMA-B sesudah remisi

  Pair

  11 Mean N Std. Deviation Std. Error

  Mean The correlation and t cannot be computed because the s tandard error of the difference is 0.

  Pair

  Pair

  157.25

  2.531981 16 5.3394581 1.3348645 82.9375 16 10.21417 2.55354

  a

  16 10.169 2.542 157.25

  a

  16 10.169 2.542

  48.88 16 8.655 2.164

  54.38 16 8.899 2.225 19.756 16 2.8902 .7226 21.963 16 3.0661 .7665 3.6581 16 1.88984 .47246 2.5569 16 2.16172 .54043

  17.3625 16 5.48858 1.37214 10.6150 16 6.71570 1.67892 .136338 16 .5251811 .1312953

  83.81 16 7.687 1.922 111.5625 16 22.42014 5.60503

  2 Indeks mas a tubuh sebelum remisi Indeks mas a tubuh sesudah remisi

  106.00 16 16.501 4.125 5.9188 16 2.36508 .59127

  9.194 16 4.2080 1.0520 1.2710 14 .57715 .15425 1.9457 14 .74261 .19847

  219.0019 16 315.82152 78.95538 197.1981 16 213.78795 53.44699

  Tinggi badan sebelum remisi Tinggi badan sesudah remisi

  Pair

  1 Berat badan sebelum remisi Berat badan ses udah remisi

  Pair

  a.

  Paired Samples Correlations N Correlation Sig.

  Pair Berat badan sebelum 2 remisi & Berat badan 16 .918 .000 sesudah remis i

  Pair Indeks mas a tubuh 3 sebelum remis i & 16 .877 .000 Indeks mas a tubuh sesudah remis i Pair T3 sebelum remisi & T3

  16 .299 .260 4 sesudah remis i Pair T4 sebelum remisi & T4 16 .199 .461 5 sesudah remis i Pair TSH sebelum remis i &

  16 -.124 .648

  6 TSH sesudah remis i Pair KGDN sebelum remisi & 16 .496 .051

  7 KGDN ses udah remisi Pair KGD 2J PP sebelum 8 remisi & KGD 2J PP 16 .348 .187 sesudah remis i Pair Ins ulin Puasa s ebelum

  9 remisi & Insulin Puasa 16 .238 .374 sesudah remis i Pair HOMA-IR s ebelum 10 remisi & HOMA-IR

  14 .422 .133 sesudah remis i Pair HOMA-B sebelum remis i 11 & HOMA-B sesudah

  16 .014 .959 remisi

• 5.500 3.559 .890 -7.396 -3.604 -6.181 15 .000
• 2.2062 1.4870 .3718 -2.9986 -1.4139 -5.935 15 .000 1.10125 2.40844 .60211 -.18212 2.38462 1.829
• 2.39564 5.4294967 1.3573742 -5.28882 .4975308 -1.765 15 .098
• .87500 9.25113 2.31278 -5.80458 4.05458 -.378 15 .710 5.56250 22.74780 5.68695 -6.55895 17.68395 .978
• 3.27500 4.30821 1.07705 -5.57068 -.97932 -3.041 15 .008
• .67471 .72320 .19328 -1.09228 -.25715 -3.491 13 .004 21.80375 378.87020 94.71755 -180.082 223.68943 .230

  9 HOMA-IR s ebelum remisi - HOMA-IR sesudah remis i Pair

  

Paired Samples Test

  15 .087 6.74750 7.78369 1.94592 2.59986 10.89514 3.468 15 .003

  15 .344

  Interval of the Difference Paired Differences t df Sig. (2-tailed)

  Pair

  2 Indeks mas a tubuh sebelum remis i - Indeks masa tubuh ses udah remisi

  Pair

  3 T3 sebelum remisi - T3 sesudah remis i Pair

  4 T4 sebelum remisi - T4 sesudah remis i Pair

  5 TSH sebelum remis i - TSH sesudah remis i Pair

  6 KGDN sebelum remisi - KGDN sesudah remisi Pair

  7 KGD 2J PP sebelum remisi - KGD 2J PP sesudah remis i Pair

  8 Ins ulin Puasa s ebelum remisi - Ins ulin Puas a sesudah remis i Pair

10 HOMA-B sebelum remis i

  11 Mean Std. Deviation

Std. Error

Mean Lower Upper 95% Confidence

• HOMA-B s esudah remisi Pair

  8.17

  HOMA-B sesudah remisi < HOMA-B sebelum remis i d. HOMA-B sesudah remisi > HOMA-B sebelum remis i e. HOMA-B sesudah remisi = HOMA-B sebelum remis i f.

  N Mean Rank Sum of Ranks TSH sesudah remis i < TSH s ebelum remis i a. TSH sesudah remis i > TSH s ebelum remis i b. TSH sesudah remis i = TSH s ebelum remis i c.

  TSH sesudah remis i - TSH sebelum remis i HOMA-B sesudah remisi - HOMA-B sebelum remisi

  16 Negative Ranks Positive Ranks Ties Total Negative Ranks Positive Ranks Ties Total

  f

  87.00

  8.70

  e

  10

  49.00

  d

  15 .821 Berat badan sebelum remisi - Berat badan sesudah remis i

  6

  16

  c

  8.46 110.00

  b

  13

  26.00

  a

  3

  NPar Tests [DataSet1] E:\ABDUL JALIL A A\15DATAPPDS\SpPD Dharma Liza\Data Dharma Liza 08-05-12.sav Wilcoxon Signed Ranks Test Ranks

  8.67

  b Te st S tati stics

  HOMA -B sesudah TS H s esudah remisi - remisi - TS H HOMA -B sebelum sebelum remisi remisi

  a a

  Z

• 2. 175 -.982 As ymp. S ig. (2-tailed)

  .030 .326 a. Based on negative ranks.

  b.

  W ilcox on Signed Rank s Test

  Frequencies [DataSet1] E:\ABDUL JALIL A A\15DATAPPDS\SpPD Dharma Liza\Data Dharma Liza 08-05-12.sav

  Statistics

  Jenis k elamin N Valid

  16 Missing

  Jenis kelamin

  Cumulative Frequency Percent Valid Percent Percent

  Valid Perempuan

  12

  75.0

  75.0

  75.0 Laki-laki

  4

  25.0 25.0 100.0 Total 16 100.0 100.0

  Correlations [DataSet1] F:\SpPD Dharma Liza\Data Dharma Liza 08-05-12.sav Correlations

  Co T3 sebelum Insulin Puasa T4 sebelum rre remisi sebelum remisi remisi lati

• T3 sebelum remisi Pearson Correlation

  1 -,398 ,705 on s

  Sig. (2-tailed) ,127 ,002 [Da

  N

  16

  16

  16 taS et1

  Insulin Puasa sebelum Pearson Correlation -,398 1 -,209 ] remisi Sig. (2-tailed) ,127 ,436

  F:\ SpP N

  16

  16

  16 D

• T4 sebelum remisi Pearson Correlation ,705 -,209

  1 Dha rma

  Sig. (2-tailed) ,002 ,436 Liz

  N

  16

  16 16 a\D ata **. Correlation is significant at the 0.01 level (2-tailed). Dha rma Liza 08-05-12.sav Correlations

  T3 sesudah T4 sesudah Insulin Puasa remisi remisi sesudah remisi

• T3 sesudah remisi Pearson Correlation

  1 ,881 -,112 Sig. (2-tailed) ,000 ,678 N

  16

  16

  16

• T4 sesudah remisi Pearson Correlation ,881

  1 -,137 Sig. (2-tailed) ,000 ,613 N

  16

  16

  16 Insulin Puasa sesudah Pearson Correlation -,112 -,137

  1 remisi Sig. (2-tailed) ,678 ,613 N

  16

  16

  16 **. Correlation is significant at the 0.01 level (2-tailed).

  Nonparametric Correlations [DataSet1] F:\SpPD Dharma Liza\Data Dharma Liza 08-05-12.sav

  Correlations Insulin Puasa TSH sesudah sesudah remisi remisi

  

Spearman's rho Insulin Puasa sesudah Correlation Coefficient 1,000 ,236

remisi Sig. (2-tailed) . ,379 N

  16

  16 TSH sesudah remisi Correlation Coefficient ,236 1,000 Sig. (2-tailed) ,379 .

  N

  16

  16 Correlations [DataSet1] F:\SpPD Dharma Liza\Data Dharma Liza 08-05-12.sav

  

Correlations

Indeks masa Berat badan tubuh sebelum Insulin Puasa HOMA-IR sebelum remisi remisi sebelum remisi sebelum remisi

  Berat badan sebelum remisi Pearson Correlation 1 ,641 ,590 ,629 Sig. (2-tailed) ,007 ,016 ,009 N

  16

  16

  16

  16

• Indeks masa tubuh sebelum Pearson Correlation ,641

  1 ,415 ,456 remisi Sig. (2-tailed) ,007 ,110 ,076 N

  16

  16

  16

  16

  Insulin Puasa sebelum Pearson Correlation ,590 ,415 1 ,979 remisi Sig. (2-tailed) ,016 ,110 ,000 N

  16

  16

  16

  16

  HOMA-IR sebelum remisi Pearson Correlation ,629 ,456 ,979

  1 Sig. (2-tailed) ,009 ,076 ,000 N

  16

  16

  16

  16 **. Correlation is significant at the 0.01 level (2-tailed).

• . Correlation is significant at the 0.05 level (2-tailed).

  Nonparametric Correlations [DataSet1] F:\SpPD Dharma Liza\Data Dharma Liza 08-05-12.sav

  Correlations Insulin Puasa HOMA-B sebelum remisi sebelum remisi

  Spearman's rho Insulin Puasa sebelum Correlation Coefficient 1,000 ,184 remisi Sig. (2-tailed) . ,495 N

  16

  16 HOMA-B sebelum remisi Correlation Coefficient ,184 1,000 Sig. (2-tailed) ,495 .

  N

  16

  16 Correlations

  [DataSet1] F:\SpPD Dharma Liza\Data Dharma Liza 08-05-12.sav

Correlations

  Indeks masa Berat badan tubuh sesudah Insulin Puasa HOMA-IR sesudah remisi remisi sesudah remisi sesudah remisi

• Berat badan sesudah remisi Pearson Correlation

  1 ,612 ,218 ,368 Sig. (2-tailed) ,012 ,417 ,161 N

  16

  16

  16

  16

• Indeks masa tubuh sesudah Pearson Correlation ,612

  1 ,193 ,304 remisi Sig. (2-tailed) ,012 ,475 ,252 N

  16

  16

  16

  16

• Insulin Puasa sesudah Pearson Correlation ,218 ,193

  1 ,953 remisi Sig. (2-tailed) ,417 ,475 ,000 N

  16

  16

  16

  16

• HOMA-IR sesudah remisi Pearson Correlation ,368 ,304 ,953

  1 Sig. (2-tailed) ,161 ,252 ,000 N

  16

  16

  16

  16 *. Correlation is significant at the 0.05 level (2-tailed).

• . Correlation is significant at the 0.01 level (2-tailed).

  LAMPIRAN 6

DAFTAR RIWAYAT HIDUP

I. Identitas

  Nama : dr. Darma Liza Efendi Tempat/Tgl.Lahir : Binjai / 07 Agustus 1978 Suku/ Bangsa : Minang / Indonesia Agama : Islam Alamat : Jl. T.Imam Bonjol No.196 Binjai 20721 Pekerjaan : PNS

  NIP : 19780807 200701 1 003 Pangkat/ Gol. : Penata Muda Tk.I (III/b) Istri : dr.Deasy hendriati Anak :

  1. Clarissa Nadhira Rizki

  2. Muhammad Davino Athallah

  3. Sherin Aqilla Cataleya Alamat Pekerjaan : Dinas kesehatan Kota Medan Jl. Rotan komplek Petisah Medan Telp (061) 4520331 Telepon selular : 0811650799

  II. Pendidikan SD Negeri No.020254, Tamat Tahun 1990 SMP Negeri 1 Binjai, Tamat Tahun 1993 SMU Negeri 1 Binjai, Tamat Tahun 1996 Fakultas Kedokteran Universitas Sumatera Utara, Tamat Tahun 2002

  PPDS Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Sumatera Utara (2008 - sekarang) di Medan

  III. Riwayat Pekerjaan

  1. Dokter RS PTPN II Bangkatan Binjai

  2. Dokter RS Kesrem TNI-AD Binjai

  3. Dokter PTT PEMKO Medan

  4. Dokter RSUD Aceh Singkil Kab. Aceh Singkil

  IV. KARYA ILMIAH

  1. Efendi DL, Keliat EN, Abidin A. Laporan kasus TB extra paru pada kehamilan yang didiagnosa dengan PCR TB, PERPARI, Palembang 2010

  2. Efendi DL, Lubis AR, Lubis HR. Profil lipid pada pasien penyakit ginjal kronis yang menjalani Hemodialisis di RSUP.H.Adam malik Medan, PERNEFRI, Semarang 2010

  V. PARTISIPASI DALAM KEGIATAN ILMIAH

  1. Peserta Pertemuan ilmiah tahunan (PIT) IX 2008 “How to choose an Appropriate OAD” Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Sumatera Utara, 15 April 2008

  2. Peserta Advanced Cardiac Life Support Course (ACLS), Indonesian Heart Association, Dharma deli Hotel Medan, 21-23 Nopember 2008

  3. Peserta Pertemuan ilmiah “medical Up date IDI Sumut 2009 29-31 Oktober 2009

4. Peserta Scientific Weekend “Early Insulin Inisiation, How, When and What

  Insulin according to Daily Practice Need” , Grand Swiss Belhotel Medan,

  21 November 2009

  5. Peserta Roadshow Ilmiah PD PAPDI “Penggunaan Testosteron pada Aging

Male ”, Hotel Grand Aston City Hall Medan, 6 Maret 2010.

  6. Peserta Simposium the 11th Annual Scientific Meeting Internal Medicine Departemen Ilmu Penyakit Dalam, Grand Aston Medan 1-3 April 2010

  7. Peserta Workshop Ultrasonography the 11th annual scientific Meeting Internal Medicine, Grand Aston Medan. 3 April 2010

  8. Pembicara Makalah Bebas Oral/Poster pada Symposium the 11th National Congress of PERPARI, Chest and Critical Care in internal medicine Temu ilmiah Penyakit dalam FK UNSRI 2010, Hotel Novotel, Palembang, 4-5 Juni 2010

  

9. Peserta seminar sehari “ CARB Smart Nutrition for Diabetic Complication”

Medan, 12 Juni 2010

  

10. Peserta “Continuing Medical Education Activity an Update on Diabetes

mellitus July 2010.

  

11. Peserta Simposium Rheumatology Update 2010, Hotel Grand Aston City

Hall Medan, 30-31 Juli 2010

  

12. Pembicara Makalah Bebas Oral/Poster pada Annual Meeting of Indonesian

of Nephrology (InaSN) 2010 A Comprehensive Approch to Kidney Disease and Hypertension,PERNEFRI, Hotel Patrajasa, Semarang, 22-24 Oktober 2010

  

13. Peserta Roadshow “Medical Skill Update (MEDSKUP) Cardio-Metabolic”,

Grand Aston City Hall Medan, 2 April 2011 th

14. Peserta Simposium The 6 New Trend in Cardiovascular Management , JW.

  Marriott Hotel Medan, 23-25 Juni 2011

  

15. Peserta Seminar Sehari Lymphoma Update : Deteksi Dini dan

Penatalaksanaan, RSUP. H. Adam Malik Medan, 16 Juli 2011

  

16. Peserta Coure Cum Workshop on Hypertension for clinical Practice, Hotel

JW Marriot Medan, 10 September 2011

  17. Peserta Simposium PERNEFRI 2011 di Hotel JW Marriot, 15 Oktober 2011