Sintesis dan Karakterisasi Film Galaktomanan Ikat Silang Glutaraldehida Melalui Reaksi Kondensasi dari Galaktomanan Kolang-Kaling (Arenga pinnata)

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SINTESIS DAN KARAKTERISASI FILM GALAKTOMANAN IKAT
SILANGGLUTARALDEHIDA MELALUI REAKSI KONDENSASI
GALAKTOMANAN KOLANG-KALING
(Arenga pinnata)

ABSTRAK

Galaktomanan kolang-kaling ikat silang glutaraldehida (GIG) telah dapat diperoleh
dari reaksi galaktomanan kolang-kaling(GKK) dengan glutaraldehida pada pH 2.
Dalam penelitian ini terlebih dahulu dilakukan ekstraksi galaktomanan dari kolangkaling menggunakan air suling diperolehkadarnya 4,427%. Analisis gugus fungsi
galaktomanan ikat silang glutaraldehida dengan spektrofotometer FT-IR
menghasilkan pita serapan pada daerah bilangan gelombang 1150-1085 cm-1yang
menunjukkan adanya gugus fungsi C-O-C asimetrik, serta terjadinya perubahan
absorbansi gugus hidroksil yang semakin kecil jika jumlah Glutaraldehida semakin
besar.Hasil analisis SEM (Scanning Electron Microscpic) galaktomanan ikat silang
glutaraldehida menunjukkan telah terjadi perubahan morfologi permukaan. Pada
galaktomanan kolang-kaling bentuk permukaan halus, sedangkan bentuk
permukaan galaktomanan ikat silang glutaraldehida kasar dan bergelombang. Hasil
pengukuran ketebalan menghasilkan tebal film 0,20-0,82 mm. Hasil pengukuran

derajat swelling galaktomanan ikat silang glutaraldehida yang diperoleh, yaitu
semakin banyak glutaraldehida, maka indeks swelling semakin kecil, dari nilai
indeks swelling ini kemungkinan Galaktomanan kolang-kaling ikat silang
glutaraldehida dapat diaplikasikan sebagai matriks pembawa obat.
Kata kunci : Galaktomanan, Glutaraldehida, ikat silang, GKK ikat
silang Glutaraldehida.

Universitas Sumatera Utara

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SYNTHESIS AND CHARACTERISTIC FILM OF GLUTARALDEHYDE
CROSSLINKED GALACTOMANAN THROUGH
CONDENSATION GALACTOMANAN OF
SUGAR PALM FRUIT
(Arenga pinnata)

ABSTRACT

Galactomannan of sugar palm fruitcrosslinked glutaraldehyde (GIG) can be

obtained from Galactomannan of sugar palm fruit(GKK) reaction with
glutaraldehyde at pH 2.First in this research galactomannan from sugar palm fruit
Extraction of used distilled water that resulted 4,427%. The analysis of functional
groups glutaraldehyde absorption band in wave number 1150-1085 cm-1 which
shows the group of C-O-Casymmetric, as well as changes in absorbance of
hydroxyl groups are getting smaller if the greater number of glutaraldehyde. The
result of SEM (Scanning electron Microscopic) glutaraldehyde crosslinked
galactomanan appeared there has been a change that morphology of surface. At
galactomannan of sugar palm fruit has a smooth surface shape, while the surface
shape glutaraldehyde crosslinked galactomanan was rough and have pore. The
measurement of thickness appeared that thick of film have obtained was 0.20-0.82
mm. The measurementdegree of swelling glutaraldehyde crosslinked
galactomananthat is more glutaraldehyde, then the smaller the swelling index,
swelling of the value of properties likely Galactomannan of sugar palm fruit
crosslinked glutaraldehyde can be applied to drug carrier matrix.
Keywords :

Galactomanan, Glutaraldehyde, crosslinked, Glutaraldehyde
crosslinked galactomanan.

Universitas Sumatera Utara