Pengaruh Ekstrak Metanol Daun Suren (Toona sureni Bl Merr) Terhadap Fungsi Hati dan Nilai Darah (Rattus norvegicus L.) Jantan yang Dipapari Karbon Tetraklorida (CCl4)
PENGARUH EKSTRAK METANOL DAUN SUREN
(Toona sureni BL Merr). TERHADAP FUNGSI HATI DAN NILAI DARAH
TIKUS (Rattus norvegicus L.) JANTAN YANG DIPAPARI KARBON
TETRAKLORIDA (CCl4)
ABSTRAK
Pengaruh ekstrak metanol daun suren (Toona sureni BL Merr) terhadap fungsi
hati jumlah eritrosit dan kadar hemoglobin tikus (Rattus norvegicus) jantan yang
dipapari oleh karbon tetraklorida (CCl4) telah dilakukan dari April sampai dengan
November 2015. Penelitian menggunakan rancangan acak lengkap dan dibagi ke
dalam 8 perlakuan: yaitu 2 kontrol positif, 2 kontrol pelarut, kontrol normal, 3
perlakuan yaitu pemberian ekstrak suren dengan konsentrasi berbeda (100, 150
dan 200 mg/kg/BB). Tikus perlakuan dipapari CCl4 selama 10 hari kemudian
diberi ekstrak suren selama 14 hari dan darah diambil dari jantung. Hasilnya
menunjukkan pemberian ekstrak daun suren menurunkan kadar SGPT dan
meningkatkan jumlah eritrosit secara signifikan pada dosis 100 mg/ kg/BB.
Kata Kunci : Eritrosit, Fungsi hati, Hemoglobin, Toona sureni Bl Merr, SGPT.
Universitas Sumatera Utara
THE EFFECT OF METHANOL EXTRACT OF SUREN LEAVES
EXTRACT (Toona sureni Bl Merr.) ON THE FUNCTION OF LIVER AND
RED BLOOD INDICES IN MALE RAT (Rattus norvegicus L.) INDUCED
BY CARBON TETRACLORIDE (CCl4)
ABSTRACT
The effect of methanol extract of suren leaves (Toona sureni BL Merr) on the
function of liver, erythrocyte count and haemoglobin level in male rat (Rattus
norvegicus) induced by carbon tetracloride (CCl4) had been studied from April to
November 2015. This research performed with completely randomized design and
treatment was divided into 8 groups: 2 groups of positive control, 2 groups of
solvent control, normal control, and 3 groups of extract concentration (100, 150
and 200 mg/kg/bw). The rats were exposed to CCl4 for 10 days and followed by
suren extract for 14 days and the blood sample collected from the heart by cardiac
puncture method. The result showed methanol extract of suren leaves decreased
SGPT level and increased erythrocytes count significantly at 100 mg/kg/bw.
Keywords: Erythrocytes, Haemoglobin, Liver function, Toona sureni Bl Merr,
SGPT.
Universitas Sumatera Utara
(Toona sureni BL Merr). TERHADAP FUNGSI HATI DAN NILAI DARAH
TIKUS (Rattus norvegicus L.) JANTAN YANG DIPAPARI KARBON
TETRAKLORIDA (CCl4)
ABSTRAK
Pengaruh ekstrak metanol daun suren (Toona sureni BL Merr) terhadap fungsi
hati jumlah eritrosit dan kadar hemoglobin tikus (Rattus norvegicus) jantan yang
dipapari oleh karbon tetraklorida (CCl4) telah dilakukan dari April sampai dengan
November 2015. Penelitian menggunakan rancangan acak lengkap dan dibagi ke
dalam 8 perlakuan: yaitu 2 kontrol positif, 2 kontrol pelarut, kontrol normal, 3
perlakuan yaitu pemberian ekstrak suren dengan konsentrasi berbeda (100, 150
dan 200 mg/kg/BB). Tikus perlakuan dipapari CCl4 selama 10 hari kemudian
diberi ekstrak suren selama 14 hari dan darah diambil dari jantung. Hasilnya
menunjukkan pemberian ekstrak daun suren menurunkan kadar SGPT dan
meningkatkan jumlah eritrosit secara signifikan pada dosis 100 mg/ kg/BB.
Kata Kunci : Eritrosit, Fungsi hati, Hemoglobin, Toona sureni Bl Merr, SGPT.
Universitas Sumatera Utara
THE EFFECT OF METHANOL EXTRACT OF SUREN LEAVES
EXTRACT (Toona sureni Bl Merr.) ON THE FUNCTION OF LIVER AND
RED BLOOD INDICES IN MALE RAT (Rattus norvegicus L.) INDUCED
BY CARBON TETRACLORIDE (CCl4)
ABSTRACT
The effect of methanol extract of suren leaves (Toona sureni BL Merr) on the
function of liver, erythrocyte count and haemoglobin level in male rat (Rattus
norvegicus) induced by carbon tetracloride (CCl4) had been studied from April to
November 2015. This research performed with completely randomized design and
treatment was divided into 8 groups: 2 groups of positive control, 2 groups of
solvent control, normal control, and 3 groups of extract concentration (100, 150
and 200 mg/kg/bw). The rats were exposed to CCl4 for 10 days and followed by
suren extract for 14 days and the blood sample collected from the heart by cardiac
puncture method. The result showed methanol extract of suren leaves decreased
SGPT level and increased erythrocytes count significantly at 100 mg/kg/bw.
Keywords: Erythrocytes, Haemoglobin, Liver function, Toona sureni Bl Merr,
SGPT.
Universitas Sumatera Utara