Hubungan besar varises esofagus secara endoskopi dengan Forns index pada penderita sirosis hati

  Lampiran 1 : Surat Persetujuan Komite Etik

  Lampiran 2

  Selamat pagi/ siang Bapak/ Ibu, pada hari ini saya, dr. Rizqi Arini Siregar, peserta Pendidikan Pasca Sarjana Ilmu Penyakit Dalam/ Magister Klinik FK-USU Medan akan melakukan penelitian yang berjudul ”Hubungan Besar Varises Esofagus Secara Endoskopi dengan Forns Index pada Penderita Sirosis Hati”.

  Kepada Bapak/ Ibu yang bersedia mengikuti penelitian ini nantinya akan diminta mengisi surat persetujuan ikut dalam penelitian, mengikuti wawancara untuk mencari adanya hal-hal yang dapat mengganggu penelitian, dan dilakukan pemeriksaan laboratorium berupa pemeriksaan darah sebanyak 15 cc (1 sendok makan) yang akan diambil dari lengan oleh ahli untuk menilai sebuah skor yang disebut Forns index melalui parameter trombosit, γGT, dan kolesterol. Kemudian hasil skor tersebut akan saya bandingkan dengan hasi pemeriksaan endoskopi.

  Manfaat penelitian ini adalah dapat memberikan informasi tentang adanya varises esofagus pada penderita sirosis hati serta meringankan biaya pemeriksaan untuk pemantauan varises esofagus dan pemeriksaan menjadi lebih sederhana, murah dan tidak membutuhkan waktu yang lama. Pada penelitian ini tidak menimbulkan efek samping apapun, hanya risiko yang dapat terjadi dari penelitian ini adalah terjadinya lebam setelah pengambilan darah.

  Setelah hasil akhir diperoleh, nantinya akan terlihat apakah terdapat hubungan antara besar varises esofagus secara endoskopi dengan Forns index. Bila masih terdapat pertanyaan atau keluhan sewaktu penelitian ini berjalan, maka Bapak/Ibu dapat menghubungi saya pada: Nama : dr. Rizqi Arini Siregar Alamat : Jl. Tridharma No. 148 Kampus USU Medan Telepon : 081370433555

  Lampiran 3

SURAT PERSETUJUAN SETELAH PENJELASAN

(INFORMED CONSENT )

  Saya yang bertanda tangan dibawah ini : Nama :...........................................................................................

  Alamat :........................................................................................... Umur :........................ Tahun Jenis Kelamin : Laki-laki/ Perempuan* No Telp/ HP :

  Setelah mendapat penjelasan dari peneliti tentang kebaikan dan keburukan prosedur penelitian ini, menyatakan BERSEDIA ikut serta dalam penelitian tentang ”Hubungan Besar Varises Esofagus Secara Endoskopi dengan Forns Index pada Penderita Sirosis Hati”. Apabila sewaktu-waktu saya mengundurkan diri dari penelitian ini, kepada saya tidak dituntut apapun.

  Demikianlah surat persetujuan bersedia ikut dalam penelitian ini saya buat, untuk dapat digunakan seperlunya.

  Medan, ...........................2014

  Lampiran 4 DATA PESERTA Tanggal: MR : No. Peserta :

  I. IDENTITAS PRIBADI

  Nama : Tempat/ Tanggal lahir : Jenis kelamin : Laki-laki / Perempuan Pendidikan terakhir : Pekerjaan : Status : Kawin / Belum Kawin. No Telp................

  Faktor risiko : No. Telp/Hp :

  II. PEMERIKSAAN FISIK

  III. PEMERIKSAAN LABORATORIUM Parameter Nilai

  Trombosit (sel/mm

  3

  )

  Lampiran 5 DAFTAR RIWAYAT HIDUP

  Nama : dr. Rizqi Arini Siregar Tempat/Tgl Lahir : Medan/ 30 Agustus 1987 Suku/Bangsa : Mandailing / Indonesia Agama : Islam Alamat : Jl. Tridharma No. 148 Kampus USU Medan

  SD Harapan 1 Medan Tamat Tahun 1999 SLTP Harapan 1 Medan Tamat Tahun 2002 SMA Negeri 1 Medan Tamat Tahun 2005 FK Universitas Sumatera Utara Tamat Tahun 2010

  Dokter jaga Klinik Polimas Tasbi Medan 2010 Pegawai Negeri Sipil di RS Pendidikan USU 2012-sekarang

  IDI Medan PAPDI Sumatera Utara effects of phlebotomy in patients with chronic hepatitis C.

  European Journal of Gastroenterology & Hepatology 2011, 23:1178-1184.

  3. Ziegler PD, Glotzer TV, Daoud EG, Singer DE, Ezekowitz MD, Hoyt RH, et al. Detection of previously undiagnosed atrialfibrillation in patients with stroke risk factors and usefulness of continuous monitoring in primary stroke prevention. Am J Carrdiol 2012;110:1309-1314.

  4. Ito H, Mifune M, Abe M, Oshikiri K, Antoku S, Takeuchi Y, et al.

  Hypertension resistant to antihypertensive agents commonly occurs with the progression of diabetic nephropathy in Japanese patients with type 2 diabetes mellitus: a prospective observational study. BMC Nephrology 2012, 13:48.

  5. Yoo HH, Martin LC, Kochi AC, Telini LSR, Barretti P, caramori JT, et al. Could albumin level explain the higher mortality in hemodyalisis patients with pulmonary hypertension? BMC

  Nephrology 2012, 13:80.

  6. Gonzalez JG, Mireles LG, Rodriguez RR, Almaguer DG, Lavalle FJ, Tamez HE, et al. Hyperglicemia related to high-dose glucocorticoid use in noncritically ill patients. Diabetology &

  Metabolic Syndrome 2013, 5:18.

  7. Polverino E, Cilloniz C, Dambrava P, Gabarrus A, Ferrer M, Agusti C, et al. Systemic corticosteroids for community-acquired pneumonia: Reasons for use and lack of benefit on outcome.

  9. Monteagudo M, Blanco TR, Liagostera M, Valero C, Bayona X, Ferrer M, et al. Factors associated with changes in quality of life of COPD patients: A prospective study in primary care. Respiratory Medicine (2013) 107, 1589-1597.

  10. Lind M, Boman K, Johansson L, Nilsson TK, Jarvholm LS, Jansson JH. D-dimer predicts major bleeding, cardiovascular events and all-cause mortality during warfarin treatment. Clinical

  Biochemistry 47 (2014) 570-573.

  11. Alam A, Huang M, Yi QL, Lin Y, Hannach B. Perioperative transfusion-related acute lung injury: The Canadian Blood Services Experience. Transfusion and Apheresis Science xxx (2014) xxx-xxx.

  Diare Kronik pada Penderita HIV/AIDS 2. Penyakit Arteri Perifer 3. Penyakit Batu Ginjal 4. Sindroma Steven Johnson 5. Reaksi Transfusi

  Peserta Kursus “Advanced Trauma Life Support”. IKABI. Medan, 17-19 Desember 2010.

  5. Peserta Kursus “Medical Update IDI SUMUT 2011”. Minor Surgery dan Assessment of Fracture. IDI SUMUT. Medan, 19 Juni 2011.

  6. Peserta Simposium “Clinical Rheumatology in Daily Practice”.

  Rheumatology Update 2011. Medan, 9-1 Juli 2011.

  7. Peserta Simposium “Patophysiology and Recent Management of Chronic

  Constipation and Acute Diarrhea ”. The Indonesian Society of Gastroenterology. Medan, 13 November 2011.

  8. Peserta Kursus “Ultrasonografi”. Gastroentero-hepatologi Update 2012.

  Medan, 4 Oktober 2012.

  9. Peserta Kursus “Hepatitis B dan C”. Gastroentero-hepatologi Update 2012.

  Medan, 4 Oktober 2012.

  10. Peserta Workshop “Terapi Insulin”. Dies Natalis 60 FK-USU. Medan, 11 September 2012.

  11. Peserta Simposium “Kongres Nasional XV Perhimpunan Dokter Spesialis

Penyakit Dalam Indonesia (KOPAPDI XV) ”, Medan, 12-15 Desember 2012.

  12. Peserta Workshop “Managing Diabetes Mellitus: From A to Z”. Jeanne Latu Conference, 2 Maret 2013.

  13. Peserta Simposium “Diagnosis & Tatalaksana Terpadu Hemofilia” Indonesian Hemophilia Society. Medan, 15 Maret 2014.

  14. Peserta Kursus “Diagnosis & Tatalaksana Terpadu Hemofilia” Indonesian Hemophilia Society. Medan, 15 Maret 2014.

  15. Peserta Pelatihan Program Pengembangan Pendidikan Keprofesian

  Berkelanjutan Ultrasonografi Tahap Satu bagi Spesialis dan PPDS Penyakit Dalam. Departemen Penyakit Dalam FK USU dan PUSKI. Medan, 7-10 Mei

  Lampiran 6 DATA HASIL PENELITIAN ₉ Al Kol. Forns N L/ Plt.(10 Bil. bu Etio.S ø Grup o. Nama Umur P MR /L) Total AST min CP H

VE ø Tot. index ΔPT INR Asites ɣ GT ALT

  Ma Yeddin

  1 Ben

  62 L 523553

  84

  3.72

  98

  3.5

  2.2 1.2 (-) B (-) F2 besar 106 103 157 9.69103

  2 Mazidah

  62 P 524508 157

  2.31

  79

  1.9

  4 1.4 (-) C Hep.B F2 besar

  10 36 160 5.84699

  3 Mhd. Nur

  37 L 518074 104

  2.05

  99

  2.9

  2.9 1.3 (-) B Hep.B F2 besar

  55 38 167 6.58019

  4 Rohmah

  53 P 529692

  57

  3.03

  41

  1

  8.9 1.8 berat C Hep.B F3 besar

  6

  15 60 9.47657

  5 Suwarni

  60 P 516285 162 1.57 118

  2

  3.8 1.4 berat B (-) F2 besar

  42

  40 95 7.66595 W.

  6 Simanullang

  48 L 530162 103

  0.98

  90

  2.7

  7 1.7 sedang B Hep.B F2 besar

  66 45 114 8.39724

  7 Zulkariadi

  41 L 527796

  83

  2.14

  56

  1.7

  5.2 1.5 berat C Hep.B F2 besar 100 27 107 8.9492 Morlan

  8 Sinaga

  59 L 435662

  39

  0.79

  38

  2.1

  6.1 1.7 berat C Hep.B F3 besar 254 66 151 12.6879 Rismawati

  9 A.

  35 P 553513 114

  1.1

  71

  2.6

  1.7 1.3 sedang B (-) F1 kecil

  10 18 194 4.39067 Pangihutan

  10 Marpaung

  54 L 591287 107

  4.2

  77

  2.7

  1.6 1.6 min B Hep.B F3 besar 118

  57 92 9.44809 Al Ismet

  11 Perkasa

  46 L 525959 116 3.45 134

  2.5

  1.1 1.1 min C Hep.B F2 besar 37 110 163 6.73954

  12 Asijah

  70 P 604776 208

  0.56

  31

  3.2

  1.7 2 sedang C (-) F3 besar 164 21 118 8.1597

  13 Asli Manalu

  53 L 604819 298

  0.81

  18

  4.1

  1.9 1.2 min A Hep.B F3 besar 200 63 208 4.96439

  14 Wilson

  60 L 593013 445

  0.37

  23

  2.1

  7.2 1.9 berat B (-) F1 kecil 251 16 368 2.0764 Erisa br

  15 Siahaan

  58 P 620072

  33

  0.62

  18

  2

  2.9 1.2 sedang B Hep.C F3 besar

  18 15 150 11.0984

  16 Syafiah

  53 P 590663 190

  0.98

  41

  2

  6.9 1.5 sedang C Hep.B F2 besar

  59

  31 97 6.97413

  17 Wagini

  88 P 618409 210 14.97 567

  2.4

  4 1.3 (-) B (-) F1 kecil 530 130 296 7.34725 Bosmen

  18 Simanjuntak

  53 L 591558

  73

  5.79

  93

  1.2

  1.5 1.6 (-) B Hep.B F1 kecil

  36

  39 93 9.6393

  19 Hotmaida

  42 P 619717

  72

  8.97

  38

  2.1

  4.2 1.3 sedang C (-) F3 besar 202 37 173 9.10302 Darmen

  20 Syahputra

  41 L 570666 114

  1.04

  41

  3.2

  1.2 1.3 sedang C (-) F3 besar 124 22 104 8.16556 Naunjur

  21 Siahaan

  57 P 612356

  32

  0.71

  34

  3.2

  2.1 1.1 (-) B Hep.B F3 besar 105 33 108 13.0998 Jimmy

  22 Panjaitan

  36 L 548819

  66

  2.66

  47

  1.9

  1.7 1.7 sedang C (-) F2 besar

  62 27 192 7.65254 Redia

  23 Sianturi

  62 P 621249 162 4.78 175

  1.6

  5.8 1.3 sedang C Hep.B F2 besar 343 76 120 9.06978 Hasoloan

  24 Siagian

  74 L 624605 136

  3.17

  91

  2.7

  2.7 15 (-) A C F1 kecil

  13 71 127 7.5769 Irhas

  25 Hutagalung

  44 L 606767

  77

  1.12

  34

  4.1

  4.6 1.4 sedang C Hep.B F3 besar

  14 27 102 7.96343

  26 M.Syahni

  41 L 602903

  44

  1.25

  22

  2.2

  4.5 1.4 min B (-) F3 besar

  80

  16 62 11.392 Iskandar N.

  56 L 562188 336

  25

  4.2 1.4 sedang (-) F1

  33

  14

  27 Lubis

  0.92

  5.3 B kecil 204 3.42829 Tetap

  52 L 606204 363 111

  2.9

  1.1 Hep.B F1 203

  38

  28 8.8 1.9 sedang C kecil 395 1.6742 Resta

  63 P 605787

  31

  20

  2 2.4 (-) F3

  11

  16

  29 Ginting

  0.3 2 (-) A besar 70 12.3162 Mula Tua

  30 Sinaga

  81 L 15785 115

  2.75

  25

  1.6

  3.8 1 sedang C (-) F1 kecil

  31 20 107 9.37412 Dra. Elida

  49 P 136302

  73

  44

  3.2 1.8 (-) F2 132

  52

  31 Nasution

  1.2 1.2 sedang C besar 156 9.49998 Rahayu

  47 L 136431 447

  26

  2

  1.1 Hep.B F1 311

  53

  32 Wijati

  1.3 1 sedang B kecil 221 3.44113 Saharuddin

  60 L 156651 91 176

  2.8

  2.4 Hep.B F2 199 161

  33 2.02 1.9 sedang B besar 199 9.23066 Mulia

  59 L 136481 183

  97

  3

  1.5 Hep.B F3 280

  72

  34 Siregar

  1.79 2.6 berat C besar 196 7.29369 Armen

  53 L 548865

  87

  36

  1.5 1.4 (-) F2 139

  29

  35 Sembiring

  1.49 3.8 berat B besar 113 9.86507 Karno

  62 L 137040 132

  94

  2.4

  1.2 Hep.B F2 34 197

  36 1.63 2.3 sedang C besar 102 8.15781 Atika P

  20 P 554549

  58

  23

  2

  1.6 Hep.B F3

  20

  31

  37 Nasution

  0.99 7.4 sedang C besar 175 5.37362 Arifin

  52 L 597758 93 343

  2.9

  1.5 Hep.B F3

  11

  21

  38 Nasution

  7.63 0.1 sedang C besar 107 7.69315 M. Syahyan

  41 L 602903

  54

  29

  2.2 1.1 (-) F3

  8

  37

  39 0.68 0.8 (-) A besar 62 8.95249 Jumain

  50 L 614860 103

  44

  2.1

  0.9 Hep.B F1 121 233

  40 0.26 3.3 (-) A kecil 137 8.69016 Jolli Serman

  34 L 606232 135

  91

  4.4

  1 Hep.B F2

  86

  55

  41 1.26 1.7 (-) B besar 178 5.66532 Daud S.

  53 L 618951 139

  40

  1.7 1.6 (-) F2

  18

  21

  42 3.58 9 sedang C besar 110 6.84354 Uparis

  60 L 459933

  78

  62

  2.7

  1.3 F3

  66

  45

  43 Simamora

  3.7 1.3 berat C (-) besar 163 9.35536 Apul

  48 L 619935 103 131

  2.5

  2.4 Hep.B F1

  79

  74

  44 Sidabutar

  2.72 21 sedang C kecil 162 7.86566 Januar

  48 L 560001

  82

  86

  2.7

  1.7 Hep.B F2

  89

  55

  45 Siahaan

  2.99 11 min C besar 137 9.02264 Nisma

  46 Siregar

  55 P 647935 154

  0.25

  31

  2.8

  0.5 1 sedang B (-) F1 kecil

  26 13 102 7.0503 Nurmansyah

  47

  38 L 693933 204 1.37 284

  3.4

  2.5 1 min A Hep.B F1 kecil 190 105 115 6.2594 Koko

  0.9

  48 Saputra

  48 L 632455 111

  6.04

  94

  2.9 0.5 (-) B Hep.B F1 kecil

  46 49 125 7.72708 Mestianaa

  49 Sinurat

  41 P 639024

  73

  0.9

  76

  2

  4.2 1 min C Hep.B F2 besar

  60 49 176 7.98621 Nuzul Indra

  50

  33 L 642094 240 3.46 241

  3.1

  2.5 1 sedang B Hep.B F2 besar 463 46 222 4.45908 Poniah

  51

  62 P 639024

  89

  3.54

  44

  2.9

  10 2 min B Hep.B F1 kecil

  16

  22 92 8.94325 Lampiran 7

  

ANALISA STATISTIKA

Frequency Table Jenis Kelamin

  Frequency Percent Valid Percent Cumulative Percent Valid L 34 66,7 66,7 66,7

  P 17 33,3 33,3 100,0 Total 51 100,0 100,0

  EtioSH

  Valid Frequency Percent Percent Cumulative Percent

  Valid (-) 19 37,3 37,3 37,3 Hep.B 30 58,8 58,8 96,1 Hep.C 2 3,9 3,9 100,0 Total 51 100,0 100,0

  Child Pugh

  Frequency Percent Valid Percent Cumulative Percent

  Valid A 6 11,8 11,8 11,8 B 21 41,2 41,2 52,9 C 24 47,1 47,1 100,0 Total 51 100,0 100,0

  Asites

  Frequency Percent Valid Percent Cumulative Percent

  Valid (-) 12 23,5 23,5 23,5 berat 8 15,7 15,7 39,2 min 8 15,7 15,7 54,9 sedang 23 45,1 45,1 100,0

  Total 51 100,0 100,0

  Diameter Varises Esofagus

  Frequency Percent Valid Percent Cumulative Percent

  Valid F1 15 29,4 29,4 29,4 F2 19 37,3 37,3 66,7 F3 17 33,3 33,3 100,0 Total 51 100,0 100,0

  Ukuran Varises Esofagus

  Frequency Percent Valid Percent Cumulative Percent

  Valid besar 36 70,6 70,6 70,6 kecil 15 29,4 29,4 100,0

  Total 51 100,0 100,0

  Descriptives

  Statistic Std. Error umur Mean 52,04 1,726

  95% Confidence Interval for Mean

  Lower Bound

  48,57 Upper Bound

  55,51 5% Trimmed Mean 51,69 Median 53,00 Variance 151,958 Std. Deviation 12,327 Minimum

  20 Maximum

  88 Range

  68 Interquartile Range

  18 Skewness ,297 ,333 Kurtosis 1,130 ,656

  PLT (ribu/ul) Mean 134,51 13,501 95% Confidence Interval for Mean

  Lower Bound

  107,39 Upper Bound

  161,63 5% Trimmed Mean 123,90 Median 104,00 Variance 9296,575 Std. Deviation 96,419 Minimum

  31 Maximum 447 Range 416 Interquartile Range

  89 Skewness 1,829 ,333 Kurtosis 3,303 ,656

  AST (unit/L) Mean 87,20 13,412 95% Confidence Interval for Mean

  Lower Bound

  60,26 Upper Bound

  114,13 5% Trimmed Mean 72,63 Median 56,00 Variance 9173,441 Std. Deviation 95,778 Minimum

  18 Maximum 567 Range 549 Interquartile Range

  63 Skewness 3,213 ,333 Kurtosis 12,818 ,656

  ALT (unit/L) Mean 52,69 6,397 95% Confidence Interval for Mean

  Lower Bound

  39,84 Upper Bound

  65,53 5% Trimmed Mean 46,47 Median 38,00 Variance 2086,940 Std. Deviation 45,683 Minimum

  13 Maximum 233 Range 220 Interquartile Range

  41 Skewness 2,266 ,333 Kurtosis 5,685 ,656

  GGT (UI/L) Mean 111,31 16,383 95% Confidence Interval for Mean

  Lower Bound

  78,41 Upper Bound

  144,22 5% Trimmed Mean 97,51 Median 66,00 Variance 13688,860 Std. Deviation 116,999 Minimum

  6 Maximum 530 Range 524 Interquartile Range 138 Skewness 1,760 ,333 Kurtosis 3,293 ,656 Bilirubin Total (mg/dl)

  Mean 2,6414 ,38100 95% Confidence Interval for Mean

  Lower Bound

  1,8761 Upper Bound

  3,4066 5% Trimmed Mean 2,2931 Median 1,6300 Variance 7,403 Std. Deviation 2,72087 Minimum ,25 Maximum 14,97 Range 14,72 Interquartile Range 2,48 Skewness 2,506 ,333 Kurtosis 8,051 ,656

  Albumin (g/L) Mean 2,540 ,1053 95% Confidence Interval for Mean

  Lower Bound

  2,328 Upper Bound

  2,751 5% Trimmed Mean 2,520 Median 2,500 Variance ,566 Std. Deviation ,7522 Minimum 1,0 Maximum 4,4 Range 3,4 Interquartile Range ,9 Skewness ,479 ,333 Kurtosis ,158 ,656

  PT (detik) Mean 3,8833 ,49169 95% Confidence Interval for Mean

  Lower Bound

  2,8957 Upper Bound

  4,8709 5% Trimmed Mean 3,4962 Median 2,7000 Variance 12,330 Std. Deviation 3,51136 Minimum ,10 Maximum 20,60 Range 20,50 Interquartile Range 3,50 Skewness 2,518 ,333 Kurtosis 9,336 ,656

  INR Mean 1,7027 ,26645 95% Confidence Interval for Mean

  Lower Bound

  1,1676 Upper Bound

  2,2379 5% Trimmed Mean 1,4373 Median 1,3600 Variance 3,621 Std. Deviation 1,90283 Minimum ,90 Maximum 14,80 Range 13,90 Interquartile Range ,46 Skewness 6,778 ,333 Kurtosis 47,433 ,656

  Tests of Normality

  Kolmogorov-Smirnov Shapiro-Wilk

  a Statistic df Sig. Statistic df Sig.

  umur ,111 51 ,157 ,972 51 ,271 PLT (ribu/ul) ,204 51 ,000 ,802 51 ,000 AST (unit/L) ,255 51 ,000 ,642 51 ,000 ALT (unit/L) ,207 51 ,000 ,745 51 ,000 GGT (UI/L) ,184 51 ,000 ,806 51 ,000 Bilirubin Total (mg/dl)

  ,190 51 ,000 ,737 51 ,000 Albumin (g/L) ,113 51 ,121 ,967 51 ,161 PT (detik) ,170 51 ,001 ,772 51 ,000 INR ,370 51 ,000 ,257 51 ,000

  a. Lilliefors Significance Correction

  Descriptives

  Statistic Std. Error KolTot Mean 149,0980 9,45911

  95% Confidence Interval for Mean

  Lower Bound

  130,0989 Upper Bound

  168,0972 5% Trimmed Mean 142,0937 Median 137,0000 Variance 4563,210 Std. Deviation 67,55154 Minimum 60,00 Maximum 395,00 Range 335,00 Interquartile Range 72,00 Skewness 1,742 ,333 Kurtosis 4,197 ,656

  Tests of Normality a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig. KolTot ,121 51 ,062 ,850 51 ,000

  a. Lilliefors Significance Correction

  Child Pugh * Ukuran Varises Esofagus Crosstab

  Ukuran Varises Esofagus besar Kecil Total

  Child Pugh A Count

  3

  3

  6 Expected Count 4,2 1,8 6,0 % within Child Pugh 50,0% 50,0% 100,0%

  % within Ukuran 8,3% 20,0% 11,8%

  Varises Esofagus B Count

  12

  9

  21 Expected Count 14,8 6,2 21,0 % within Child Pugh 57,1% 42,9% 100,0% % within Ukuran

  33,3% 60,0% 41,2% Varises Esofagus

  C Count

  21

  3

  24 Expected Count 16,9 7,1 24,0 % within Child Pugh 87,5% 12,5% 100,0% % within Ukuran

  58,3% 20,0% 47,1% Varises Esofagus

  Total Count

  36

  15

  51 Expected Count 36,0 15,0 51,0 % within Child Pugh 70,6% 29,4% 100,0% % within Ukuran

  100,0% 100,0% 100,0% Varises Esofagus

  Chi-Square Tests

  Value df Asymp. Sig. (2-sided) Pearson Chi- Square

  6,360

  a

  2 ,042 Likelihood Ratio 6,706 2 ,035 N of Valid Cases

  51 a. 2 cells (33,3%) have expected count less than 5. The minimum expected count is 1,76.

  Risk Estimate

  Value Odds Ratio for Child Pugh (A / B)

  a

  a. Risk Estimate statistics cannot be computed. They are only computed for a 2*2 table without empty cells.

  Case Processing Summary

  Ukuran Varises Esofagus

  Cases Valid Missing Total

  N Percent N Percent N Percent Umur (tahun)

  Besar 36 100,0% 0 0,0% 36 100,0% Kecil 15 100,0% 0 0,0% 15 100,0%

  Descriptives

  Grup Statistic Std. Error umur besar Mean 50,19 1,809

  95% Confidence Interval for Mean

  Lower Bound

  46,52 Upper Bound

  53,87 5% Trimmed Mean 50,62 Median 53,00 Variance 117,818 Std. Deviation 10,854 Minimum

  20 Maximum

  70 Range

  50 Interquartile Range

  19 Skewness -,596 ,393 Kurtosis ,158 ,768 kecil Mean 56,47 3,816 95% Confidence Interval for Mean

  Lower Bound

  48,28 Upper Bound

  64,65 5% Trimmed Mean 55,91 Median 53,00 Variance 218,410 Std. Deviation 14,779 Minimum

  35 Maximum

  88 Range

  53 Interquartile Range

  14 Skewness ,844 ,580 Kurtosis ,368 1,121

  Tests of Normality

  Grup Kolmogorov-Smirnov Shapiro-Wilk

  a Statistic Df Sig. Statistic Df Sig.

  umur besar ,130 36 ,132 ,954 36 ,138 kecil ,179 15 ,200 ,924

• 15 ,223 *. This is a lower bound of the true significance.

  a. Lilliefors Significance Correction

  Case Processing Summary

  Ukuran Varises Esofagus

  Cases Valid Missing Total N Percent N Percent N Percent

  Trombosit (ribu/ul)

  Besar 36 100,0% 0 0,0% 36 100,0% Kecil 15 100,0% 0 0,0% 15 100,0%

  Billirubin Total (mg/dl)

  Besar 36 100,0% 0 0,0% 36 100,0% Kecil 15 100,0% 0 0,0%

  15 100,0% AST (unit/L)

  Besar 36 100,0% 0 0,0% 36 100,0% Kecil 15 100,0% 0 0,0% 15 100,0%

  Albumin (UI/L)

  Besar 36 100,0% 0 0,0% 36 100,0% Kecil 15 100,0% 0 0,0% 15 100,0%

  PT (detik) Besar 36 100,0% 0 0,0% 36 100,0% Kecil 15 100,0% 0 0,0% 15 100,0%

  INR Besar 36 100,0% 0 0,0% 36 100,0% Kecil 15 100,0% 0 0,0% 15 100,0%

  Gamma GT (UI/L)

  Besar 36 100,0% 0 0,0% 36 100,0% Kecil 15 100,0% 0 0,0% 15 100,0%

  ALT (unit/L)

  Besar 36 100,0% 0 0,0% 36 100,0% Kecil 15 100,0% 0 0,0% 15 100,0%

  Kolesterol Total (mg/dl)

  Besar 36 100,0% 0 0,0% 36 100,0% Kecil 15 100,0% 0 0,0%

  15 100,0% Forns Index Besar 36 100,0% 0 0,0% 36 100,0%

  Kecil 15 100,0% 0 0,0% 15 100,0%

  Descriptives

  Ukuran Varises Esofagus Statistic Std.

  Error Trombosit (ribu/ul) Besar Mean

  107,1389 10,192

  37 95% Confidence Interval for Mean

  Lower Bound 86,4473 Upper Bound 127,8305

  5% Trimmed Mean 102,1728 Median 89,0000 Variance 3739,837 Std. Deviation 61,15421 Minimum 31,00 Maximum 298,00 Range 267,00 Interquartile Range 70,50 Skewness 1,232 ,393 Kurtosis 1,604 ,768

  Kecil Mean 200,2000

  33,963

  31

  95% Confidence Interval Lower Bound 127,3559 for Mean Upper Bound 273,0441

  5% Trimmed Mean 193,5556 Median 136,0000 Variance 17302,600 Std. Deviation 131,53935 Minimum 73,00 Maximum 447,00 Range 374,00 Interquartile Range 233,00 Skewness 1,047 ,580 Kurtosis -,418 1,121

  Billirubin Total Besar Mean 2,2600 ,31764 (mg/dl)

  95% Confidence Interval Lower Bound 1,6152 for Mean Upper Bound 2,9048

  5% Trimmed Mean 2,0228 Median 1,6000 Variance 3,632

  Std. Deviation 1,90581 Minimum ,30 Maximum 8,97 Range 8,67 Interquartile Range 2,37 Skewness 1,948 ,393 Kurtosis 4,440 ,768

  Kecil Mean 3,5567

  1,0356

  3 95% Confidence Interval for Mean

  Lower Bound 1,3355 Upper Bound 5,7779

  5% Trimmed Mean 3,1063 Median 2,7200 Variance 16,088 Std. Deviation 4,01097 Minimum ,25 Maximum 14,97 Range 14,72 Interquartile Range 4,87

  Skewness 1,912 ,580 Kurtosis 3,985 1,121

  AST (unit/L) Besar Mean 77,4167

  11,302

  15 95% Confidence Interval for Mean

  Lower Bound 54,4721 Upper Bound 100,3613

  5% Trimmed Mean 68,4815 Median 51,5000 Variance 4598,593 Std. Deviation 67,81293 Minimum 18,00 Maximum 343,00 Range 325,00 Interquartile Range 61,75 Skewness 2,279 ,393 Kurtosis 6,314 ,768

  Kecil Mean 110,6667

  36,904

  98 95% Confidence Interval Lower Bound 31,5134 for Mean Upper Bound 189,8200 5% Trimmed Mean 90,1852 Median 71,0000 Variance 20429,667 Std. Deviation 142,93238 Minimum 23,00 Maximum 567,00 Range 544,00 Interquartile Range 85,00 Skewness 2,724 ,580 Kurtosis 7,965 1,121

  Albumin (UI/L) Besar Mean 2,5342 ,12888 95% Confidence Interval for Mean

  Lower Bound 2,2725 Upper Bound 2,7958

  5% Trimmed Mean 2,5108 Median 2,4500 Variance ,598 Std. Deviation ,77328 Minimum 1,00

  Maximum 4,40 Range 3,40 Interquartile Range 1,08 Skewness ,545 ,393 Kurtosis ,076 ,768

  Kecil Mean 2,5533 ,18718 95% Confidence Interval for Mean

  Lower Bound 2,1519 Upper Bound 2,9548

  5% Trimmed Mean 2,5370 Median 2,6000 Variance ,526 Std. Deviation ,72493 Minimum 1,20 Maximum 4,20 Range 3,00 Interquartile Range ,80 Skewness ,327 ,580 Kurtosis 1,114 1,121

  PT (detik) Besar Mean 3,6556 ,43209

  95% Confidence Interval Lower Bound 2,7784 for Mean Upper Bound 4,5327

  5% Trimmed Mean 3,4895 Median 2,7500 Variance 6,721 Std. Deviation 2,59253 Minimum ,10 Maximum 10,60 Range 10,50 Interquartile Range 3,35 Skewness 1,038 ,393 Kurtosis ,386 ,768

  Kecil Mean 1,3361

  4,4300

  1 95% Confidence Interval Lower Bound 1,5643 for Mean

  Upper Bound 7,2957 5% Trimmed Mean 3,7500 Median 2,7000 Variance 26,778 Std. Deviation 5,17473 Minimum ,50 Maximum 20,60 Range 20,10 Interquartile Range 3,85 Skewness 2,488 ,580 Kurtosis 6,990 1,121

  INR Besar Mean 1,4703 ,05381 95% Confidence Interval for Mean

  Lower Bound 1,3610 Upper Bound 1,5795

  5% Trimmed Mean 1,4425 Median 1,3800 Variance ,104 Std. Deviation ,32288 Minimum 1,00 Maximum 2,41 Range 1,41 Interquartile Range ,44 Skewness 1,302 ,393

  Kurtosis 1,986 ,768 Kecil Mean 2,2607 ,90178

  95% Confidence Interval Lower Bound ,3265 for Mean Upper Bound 4,1948

  5% Trimmed Mean 1,6396 Median 1,2800 Variance 12,198 Std. Deviation 3,49258 Minimum ,90 Maximum 14,80 Range 13,90 Interquartile Range ,63 Skewness 3,785 ,580 Kurtosis 14,503 1,121

  Gamma GT (UI/L) Besar Mean 17,223

  105,0278

  67 95% Confidence Interval Lower Bound 70,0619 for Mean

  Upper Bound 139,9937 5% Trimmed Mean 93,5556 Median 73,0000 Variance 10679,571 Std. Deviation 103,34201 Minimum 6,00 Maximum 463,00 Range 457,00 Interquartile Range 113,75 Skewness 1,708 ,393 Kurtosis 3,286 ,768

  Kecil Mean 126,4000

  38,161

  41 95% Confidence Interval for Mean

  Lower Bound 44,5519 Upper Bound 208,2481

  5% Trimmed Mean 110,4444 Median 46,0000 Variance 21844,400 Std. Deviation 147,79851 Minimum 10,00 Maximum 530,00

  Range 520,00 Interquartile Range 177,00 Skewness 1,691 ,580 Kurtosis 2,877 1,121

  ALT (unit/L) Besar Mean 49,7778

  6,5452

  2 95% Confidence Interval for Mean

  Lower Bound 36,4903 Upper Bound 63,0653

  5% Trimmed Mean 44,4198 Median 37,5000 Variance 1542,235 Std. Deviation 39,27130 Minimum 15,00 Maximum 197,00 Range 182,00 Interquartile Range 29,50 Skewness 2,321 ,393 Kurtosis 6,057 ,768 Kecil Mean 15,327

  59,6667

  12 95% Confidence Interval Lower Bound 26,7933 for Mean

  Upper Bound 92,5401 5% Trimmed Mean 52,6296 Median 39,0000 Variance 3523,810 Std. Deviation 59,36168 Minimum 13,00 Maximum 233,00 Range 220,00 Interquartile Range 56,00 Skewness 2,035 ,580 Kurtosis 4,656 1,121

  Kolesterol Total Besar Mean 7,3498

  135,1667 (mg/dl)

  2 95% Confidence Interval Lower Bound 120,2457 for Mean

  Upper Bound 150,0876 5% Trimmed Mean 134,8148 Median 128,5000 Variance 1944,714 Std. Deviation 44,09891 Minimum 60,00 Maximum 222,00 Range 162,00 Interquartile Range 69,00 Skewness ,068 ,393 Kurtosis -,933 ,768

  Kecil Mean 182,5333

  25,480

  13 95% Confidence Interval for Mean

  Lower Bound 127,8839 Upper Bound 237,1828

  5% Trimmed Mean 175,7593 Median 137,0000 Variance 9738,552 Std. Deviation 98,68410 Minimum 92,00 Maximum 395,00

  Range 303,00 Interquartile Range 114,00 Skewness 1,228 ,580 Kurtosis ,450 1,121

  Forns Index Besar Mean 8,4678 ,34164 95% Confidence Interval for Mean

  Lower Bound 7,7742 Upper Bound 9,1614

  5% Trimmed Mean 8,4308 Median 8,2814 Variance 4,202 Std. Deviation 2,04986 Minimum 4,46 Maximum 13,10 Range 8,64 Interquartile Range 2,42 Skewness ,296 ,393 Kurtosis ,134 ,768

  Kecil Mean 6,3656 ,69116

  95% Confidence Interval for Mean Lower Bound 4,8832 Upper Bound 7,8480

  5% Trimmed Mean 6,4444 Median 7,3472 Variance 7,166 Std. Deviation 2,67686 Minimum 1,67 Maximum 9,64 Range 7,97 Interquartile Range 5,25 Skewness -,598 ,580 Kurtosis -1,056 1,121

  Tests of Normality

  Ukuran Varises Esofag us

  Kolmogorov-Smirnov Shapiro-Wilk

  a

  Statisti c Df Sig. Statistic df Sig. Trombosit (ribu/ul) Besar ,147 36 ,048 ,905 36 ,005 Kecil ,237 15 ,023 ,806 15 ,004

  Billirubin Total (mg/dl)

  Besar ,164 36 ,015 ,797 36 ,000 Kecil ,235 15 ,025 ,784 15 ,002

  AST (unit/L) Besar ,208 36 ,000 ,756 36 ,000 Kecil ,310 15 ,000 ,626 15 ,000

  Albumin (UI/L) Besar ,139 36 ,074 ,957 36 ,177 Kecil ,183 15 ,189 ,967 15 ,811

  PT (detik) Besar ,170 36 ,010 ,899 36 ,003 Kecil ,266 15 ,005 ,707 15 ,000

  INR Besar ,142 36 ,065 ,895 36 ,003 Kecil ,419 15 ,000 ,383 15 ,000

  Gamma GT (UI/L) Besar ,169 36 ,011 ,829 36 ,000 Kecil ,240 15 ,020 ,783 15 ,002

  ALT (unit/L) Besar ,205 36 ,001 ,745 36 ,000 Kecil ,216 15 ,058 ,767 15 ,001

  Kolesterol Total (mg/dl)

  Besar ,135 36 ,098 ,959 36 ,195 Kecil ,211 15 ,071 ,830 15 ,009

• Forns Index Besar ,113

  36 ,200 ,972 36 ,479 Kecil ,201 15 ,105 ,899 15 ,093 *. This is a lower bound of the true significance.

  a. Lilliefors Significance Correction

  T-Test Group Statistics

  Ukuran Varises Std. Error Esofagus N Mean Std. Deviation Mean

  Albumin besar 36 2,5342 ,77328 ,12888 (UI/L) kecil 15 2,5533 ,72493 ,18718

  Independent Samples Test

  Levene's Test for Equality of Variances t-test for Equality of Means

• ,0191
• ,4883
• ,082 49 ,935

  27,91

  4

  23

  Total besar Kecil KatFI >=7,92 Count

  Ukuran Varises Esofagus

  KatFI * Ukuran Varises Esofagus Crosstabulation

  4 ,44641

  6

  7 ,2272

  2 ,933

  Equal variances not assumed

  9 ,45006

  9

  7 ,2334

  9 ,466

  Equal variances assumed ,53

  Albu min (UI/L)

  95% Confidence Interval of the Difference Lower Upper

  Std. Error Differ ence

  (2- tailed) Mean Differ ence

  F Sig. T df Sig.

• ,0191
• ,4847
• ,084

  27 Expected Count 19,1 7,9 27,0

  % within Ukuran 63,9% 26,7% 52,9%

  Varises Esofagus <7,92 Count

  13

  11

  24 Expected Count 16,9 7,1 24,0 % within Ukuran

  36,1% 73,3% 47,1% Varises Esofagus

  Total Count

  36

  15

  51 Expected Count 36,0 15,0 51,0 % within Ukuran

  100,0% 100,0% 100,0% Varises Esofagus

  ROC Curve Case Processing Summary

  Ukuran Varises Esofagus Valid N (listwise)

  a

  Positive

  36 Negative

  15 Larger values of the test result variable(s) indicate stronger evidence for a positive actual state.

  a. The positive actual state is Besar.

  Area Under the Curve

  Test Result Variable(s): Forns Index Asymptotic 95% Confidence Interval

  Asymptotic

  a b

  Area Std. Error Sig. Lower Bound Upper Bound

  ,717 ,079 ,016 ,561 ,872

  a. Under the nonparametric assumption

  b. Null hypothesis: true area = 0.5

  Coordinates of the Curve

  Test Result Variable(s): Forns Index Positive if Greater Than or Equal To

  a

  Sensitivity 1 - Specificity ,6742 1,000 1,000 1,8753 1,000 ,933 2,7523 1,000 ,867 3,4347 1,000 ,800 3,9159 1,000 ,733 4,4249 1,000 ,667 4,7117 ,972 ,667 5,1690 ,944 ,667 5,5195 ,917 ,667 5,7562 ,889 ,667 6,0532 ,861 ,667

  6,4198 ,861 ,600 6,6599 ,833 ,600 6,7915 ,806 ,600 6,9088 ,778 ,600 7,0122 ,750 ,600 7,1720 ,750 ,533 7,3205 ,722 ,533 7,4621 ,722 ,467 7,6147 ,722 ,400 7,6592 ,694 ,400 7,6795 ,667 ,400 7,7101 ,639 ,400 7,7964 ,639 ,333 7,9145 ,639 ,267 7,9748 ,611 ,267 8,0720 ,583 ,267 8,1588 ,556 ,267 8,1626 ,528 ,267 8,2814 ,500 ,267

  8,5437 ,472 ,267 8,8167 ,472 ,200 8,9462 ,472 ,133 8,9508 ,444 ,133 8,9876 ,417 ,133 9,0462 ,389 ,133 9,0864 ,361 ,133 9,1668 ,333 ,133 9,2930 ,306 ,133 9,3647 ,278 ,133 9,4111 ,278 ,067 9,4623 ,250 ,067 9,4883 ,222 ,067 9,5696 ,194 ,067 9,6652 ,194 ,000 9,7781 ,167 ,000 10,4817 ,139 ,000 11,2452 ,111 ,000 11,8541 ,083 ,000

  12,5020 ,056 ,000 12,8938 ,028 ,000 14,0998 ,000 ,000

  a. The smallest cutoff value is the minimum observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values.