Pengaruh Matriks Hidroksi Propil Metil Selulosa Terhadap Profil Pelepasan In Vitro Salbutamol Dalam Bentuk Tablet Lepas Lambat - Widya Mandala Catholic University Surabaya Repository
LAMPIRAN A
Hasil Uji Mutu Fisik Granul
Mutu fisik Batch Di uji Formula Tablet Salbutamol Persyaratan yang diuji FA FB FC FDI 1 4,67 4,75 4,39 4,3
II 2 4,65 4,73 4,37 4,28 Kadar air
III 3 4,69 4,77 4,41 4,32 3-5 (Voigt, 1995) (persen)
X 4,67 475 4,39 4,3
SD 0,02 0,02 0,02 0,02
1 9,69 9,55 9,39 9,11
I 2 9,65 9,53 9,33 9,12 3 9,67 9,52 9,37 9,15 1 9,64 9,55 9,38 9,17 Waktu
II 2 9,66 9,58 9,35 9,18 alir (detik) 3 9,63 9,57 9,34 9,11 Tidak lebih dari 1 9,69 9,54 9,38 9,15 10 detik
III 2 9,68 9,55 9,36 9,14 (Banker & 3 9,67 9,59 9,37 9,13 Anderson, X 9,66 9,55 9,36 9,14 1986)
SD 0,02 0,02 0,01 0,02
1 35,62 36,1 36,6 35,33
I 2 34,69 35,24 36,98 35,95 3 35,3 36,18 35,8 35,12 1 34,38 35,19 35,9 36,91 Sudut diam
II 2 34,76 36,12 36,87 37,1 25-40 (derajat) 3 35,76 35,87 36,2 35,76 (Banker & 1 35,9 35,9 36,98 36,99 Anderson,
III 2 34,1 36,58 35,17 35,13 1986) 3 34,96 36,97 35,67 36,96
X 35,05 36,01 36,15 36,13
SD 0,63 0,56 0,73 0,85
1 13,48 13,78 14,01 13,94
I 2 13,25 13,51 14,62 13,35 3 13,48 13,51 14,01 13,35 1 13,91 13,78 14,62 13,94 Indeks
II 2 13,48 13,32 13,5 14,05 11-15 = baik Kompresibilitas 3 13,69 13,32 13,5 14,05 (persen) 1 13,25 13,78 14,79 13,9
III 2 13,48 13,51 13,89 13,35 (Siregar, 1992) 3 13,69 13,78 13,89 13,35
X 13,52 13,58 14,09 13,69
SD 0,21 0,19 0,47 0,33
LAMPIRAN B Hasil Uji Kekerasan Tablet Salbutamol
Batch I
Batch II
Formula A Formula B Formula C Formula D
14,1 13,9
X±SD 13,63±0,38 13,39±0,51 13,91±0,15 13,99±0,17
1 13,5 13,5 13,7 14,1 2 13,6 13,6 13,8 13,7 3 13,1 13,1 14,0 14,1 4 14,1 14,1 14,1 14,2 5 14,0 14,0 14,1 13,8 6 13,9 13,9 13,9 13,8 7 13,2 13,2 13,8 14,0 8 13,9 12,9 14,1 13,9 9 13,1 13,1 13,7 14,1 10 13,9 12,5 13,9 14,2
No
Kekerasan Tablet
SalbutamolX±SD 13,67±0,20 13,76±0,32 14,01±0,15 13,99±0,11
13,9 14,0
10 13,7 13,7
14,0 14,1
9 13,8 13,3
14,3 13,9
8 13,9 14,1
7 13,4 13,9
No
Kekerasan Tablet
Salbutamol13,9 13,8
6 13,6 14,2
13,8 13,9
5 13,9 13,7
14,2 14,0
4 13,8 13,4
13,9 14,2
3 13,3 13,8
14,1 14,1
2 13,7 14,1
13,9 14,0
1 13,6 13,4
Formula A Formula B Formula C Formula D
Batch III
No Kekerasan Tablet Salbutamol Formula A Formula B Formula C Formula D
1 13,7 13,2 13,5 13,9 2 13,5 13,8 13,7 13,8 3 13,4 14,1 13,9 14,1 4 13,7 13,7 14,0 14,2 5 13,1 13,8 14,1 14,1 6 13,9 13,2 14,1 13,9 7 13,7 13,2 13,9 13,9 8 13,0 13,6 13,8 14,1 9 13,3 14,1 14,1 14,2 10 13,8 14,0 14,0 14,0
X±SD 13,51±0,30 13,67±0,36 13,91±0,19 14,02±0,13
LAMPIRAN C
Hasil Uji Kerapuhan Tablet Salbutamol
Batch I Formula Replikasi Berat awal (gram)
Berat
akhir
(gram)
Kerapuhan(%) X±SD
A 1 5,989 5,978 0,184 2 5,997 5,986 0,183 0,183±0,000215 3 5,983 5,972 0,184
B 1 5,813 5,802 0,189 2 5,815 5,804 0,189 0,189±0,000228 3 5,802 5,791 0,190
C 1 5,997 5,986 0,183 2 5,951 5,940 0,185 0,183±0,001231 3 6,031 6,020 0,182
D 1 6,023 6,012 0,183 2 5,997 5,986 0,183 0,184±0,001341 3 5,938 5,927 0,185
Batch II Formula Replikasi Berat awal (gram)
Berat
akhir
(gram)
Kerapuhan(%) X±SD
A 1 5,989 5,978 0,184 2 5,997 5,986 0,183 0,183±0,000215 3 5,983 5,972 0,184
B 1 5,813 5,802 0,189 2 5,815 5,804 0,189 0,189±0,000228 3 5,802 5,791 0,190
C 1 5,997 5,986 0,183 2 5,951 5,940 0,185 0.183±0,001231 3 6,031 6,020 0,182
D 1 6,023 6,012 0,183 2 5,997 5,986 0,183 0,184±0,001341 3 5,938 5,927 0,185
Batch III Formula Replikasi Berat awal (gram)
Berat
akhir
(gram)
Kerapuhan(%) X±SD
A 1 5,989 5,978 0,184 2 5,997 5,986 0,183 0,183±0,000215 3 5,983 5,972 0,184
B 1 5,813 5,802 0,189 2 5,815 5,804 0,189 0,189±0,000228 3 5,802 5,791 0,190
C 1 5,997 5,986 0,183 2 5,951 5,940 0,185 0.183±0,001231 3 6,031 6,020 0,182
D 1 6,023 6,012 0,183 2 5,997 5,986 0,183 0,184±0,001341
LAMPIRAN D
Hasil Penetapan Kadar Tablet Lepas Lambat Salbutamol
Batch I
Formula Replikasi absorbansi Csampel Cteoritis %kadar X±SD
1 0,045 6,3056 6,2587 100,75 99,75 A 2 0,044 6,1667 6,2442 98,76 ± 3 0,044 6,2222 6,2379 99,75 0,99
1 0,043 6,0278 6,1506 98,00 98,57 B 2 0,044 6,1667 6,2379 98,86 ± 3 0,045 6,3611 6,4355 98,84 0,48
1 0,044 6,1667 6,2587 98,53 98,76 C 2 0,044 6,1667 6,2483 98,69 ± 3 0,045 6,3611 6,4210 99,07 0,27
1 0,044 6,1667 6,1526 100,23 99,82 D 2 0,046 6,4444 6,4022 100,66 ± 3 0,043 6,0833 6,1714 98,57 1,1
Batch II
Formula Replikasi absorbansi Csampel Cteoritis %kadar X±SD
1 0,045 6,3056 6,2566 100,78 100,50 A 2 0,045 6,3056 6,2421 101,02 ± 3 0,044 6,2222 6,2400 99,72 0,69
1 0,043 6,0278 6,1006 98,81 98,87 B 2 0,044 6,1667 6,2421 98,79 ± 3 0,043 6,0833 6,1443 99,01 0,12
1 0,045 6,3056 6,2670 100,61 99,60 C 2 0,043 6,0278 6,0778 99,18 ± 3 0,044 6,2222 6,2837 99,02 0,87
1 0,045 6,3056 6,2483 100,92 100,60 D 2 0,045 6,3056 6,2774 100,45 ± 3 0,044 6,2222 6,1942 100,45 0,26
Batch III
Formula Replikasi absorbansi Csampel Cteoritis %kadar X±SD
1 0,044 6,1667 6,2171 99,19 100,39 A 2 0,045 6,3056 6,2421 101,02 ± 3 0,046 6,5000 6,4376 100,97 1,04
1 0,045 6,3056 6,2629 100,68 100,25 B 2 0,043 6,0278 6,0798 99,14 ± 3 0,046 6,5000 6,4397 100,94 0,96
1 0,043 6,0278 6,0986 98,84 99,6 C 2 0,045 6,3056 6,2504 100,88 ± 3 0,044 6,2222 6,2795 99,09 1,11
1 0,044 6,1667 6,2587 98,53 99,5 D 2 0,043 6,0278 6,0798 99,14 ± 3 0,045 6,3611 6,3086 100,83 1,19
LAMPIRAN E Contoh Perhitungan Contoh perhitungan sudut diam:
Formula A: W persegi panjang = 4,28 gram W lingkaran = 0,88 gram Luas persegi panjang = 21,5 x 28
2
= 602 cm
,
88
2 ×
Luas lingkaran = 602 = 123,78 cm
4 ,
28
A
2
r =
123 ,
78
= = 39,42
3 ,
14
r = 6,28 cm
t 4 ,
5
tg α = = = 0,72
r 6 ,
28
α = 35,62°
Contoh perhitungan indeks kompresibilitas:
Formula A : Berat gelas = 125,89 g (W )
1 Berat gelas + granul = 165,69 g (W )
2 V = 100 ml
1 V = 86 ml
2 − ( W − W ) ( 165 ,
69 125 ,
89 )2
V 100
1 − ( 165 ,
69 125 , 89 ) ( W − W )
2
1
Bj mampat = = = 0,46V
87
2 Bj . nyata
% kompresibilitas = = 13,48%
1 − x 100 % Bj . mampat
Contoh perhitungan akurasi & presisi:
- Dapar Bahan +Dapar fosfat Konsent Matriks fosfat pH
% aktif pH 6,8 Pipet rasi (mg) 6,8
(mg) ad (ppm) ad 100 9,6 290,4 100 0,65 10 6,24
Absorbansi = 0,044 ( y = 0,0072x – 0,0004 Konsentrasi sebenarnya = 6,1667 ppm Konsentrasi teoritis = 6,2338 ppm % perolehan kembali = (konsentrasi sebenarnya / konsentrasi teoritis) x
100% = (6,1667 / 6,2338) x 100%
= 98,92 %
SD
Untuk menghitung % KV =
x 100 %
X 0,93
=
x 100 % 99,72
= 0,9331 %
75
Contoh perhitungan % obat terlepas:
Wt ×
% obat terlepas = 100 %
PK × dosis 100
Formula A replikasi 1 pada t = 30 menit
2,4072 × =
% obat terlepas =
100 % 25,02 % 100,22 ×
9 ,
6 100
Contoh perhitungan AUC pada disolusi:
Rumus: Wt + W t x t – t
n n-1 n n-1
Wt = 2,4072
n-1
Wt = 3,1779
n
t = 90 menit
n
t = 60 menit
n-1
2 , 4072 3 , 1779
- AUC = −
x (
90 60 )
2 =83,7765 Luas ) = 360 x penetapan kadar x dosis = 360 x 100,22% x 9,6 mg = 3463,6032 % ED Formula A batch 1= (* AUC / luas )) x 100% = (2268.7611/3463,6032) x 100% = 65,50 %
Perhitungan persamaan orde satu:
Rumus: ln (
X -C ) = ln C - k . t t
Dari persamaan regresi ln (
X -C ) versus t (waktu), maka didapatkan suatu t persamaan regresi dan nilai r, slope serta intersept. Nilai k adalah –slope. diss X adalah rata-rata penetapan kadar.
LAMPIRAN F Persamaan Formula A
Persamaan Orde Nol
10
(Formula A) 200 400 r = 0.980345 r tabel = 0,404
Persamaan Higuchi
20 Formula A
10 Linear (Formula A)
5
10
15
20 r = 0,9926 r tabel = 0,404
Persamaan orde satu
4 Formula A
2 Linear (Formula A) 200 400
- 2 r = -0,9793 r tabel = 0,404
LAMPIRAN G Persamaan Formula B
Persamaan orde nol r = 0,9859 r tabel = 0,404
Persamaan Higuchi r = 0,9988 r tabel = 0,404
Persamaan orde satu r = -0,9909 r tabel = 0,404
5
10 100 200 300 400 Formula B Linear (Formula B)
5
10
5
10
15
20 Formula B Linear (Formula
B)
2
4 100 200 300 400 Formula B Linear (Formula B)
- 2
LAMPIRAN H Persamaan Formula C
10
C)
4 100 200 300 400 Formula C Linear (Formula
2
C)
20 Formula C Linear (Formula
15
5
Persamaan Orde Nol r = 0,9826 r tabel = 0,404
10
5
10 100 200 300 400 Formula C Linear (Formula C)
5
Persamaan Orde Satu r = 0,9890 r tabel = 0,404
Persamaan Higuchi r = 0,9960 r tabel = 0,404
- 2
LAMPIRAN I Persamaan Formula D
Persamaan Orde Nol
10 Formula D
5 Linear (Formula
D) 100 200 300 400 r = 0,9769 r tabel = 0,404
Persamaan Higuchi
8
6 Formula D
4
2 Linear (Formula D)
5
10
15
20 r = 0,9888 r tabel = 0,404
Persamaan Orde Satu
2 Formula D
1 Linear (Formula
D) 100 200 300 400
- 1 r = 0,9547 r tabel = 0,404
LAMPIRAN J
Sertifikat Hidroksi Propil Metil Selulosa
LAMPIRAN K
Sertifikat Analisis Polivinil Pirolidon K-30
LAMPIRAN L
Sertifikat Analisis Talkum
LAMPIRAN M M
Sertifikat Analisis Magn gnesium Stearat
LAMPIRAN N
Sertifikat Analisis Laktosa
LAMPIRAN O
Sertifikat Analisis Natrium Hidroksida
LAMPIRAN P
Sertifikat Analisa Kalium Dihidrogen Fosfat
LAMPIRAN
Tabel Uji r
N Q ji rLAMPIRAN Tabel Uji HSD N R D (0,05)
LAMPIRAN S Hasil Uji Statistik Kadar Air Antar Formula
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1
3
14.01 4.67 0.0004 Column 2
3
14.25 4.75 0.0004 Column 3
3
13.17 4.39 0.0004 Column 4
3
12.9 4.3 0.0004 ANOVA
Source of
Variation SS df MS F P-value F crit
Between Groups 0.421425 3 0.140475 3.1875 0.1191 4.0661 Within Groups 0.0032 8 0.0004 Total 0.424625
11
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . - # $ , , " ! "
LAMPIRAN T Hasil Uji Statistik Waktu AlirAntar Formula
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1
3
29.01 9.67 0.0004 Column 2
3 28.6 9.5333 0.000233 Column 3
3 28.09 9.3633 0.000933 Column 4
3 27.38 9.1266 0.000433 ANOVA
Source of P- Variation SS df MS F value F crit
Between Groups 0.493667 3 0.1645 3.91111 0.0683 4.0661 Within Groups 0.004 8 0.0005 Total 0.497667
11
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . - # $ , , " ! "
LAMPIRAN U
Hasil Uji Indeks Kompresibilitas Antar Formula
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 3 105.61 35.203 0.223233 Column 2 3 107.52 35.84 0.2716 Column 3 3 109.38 36.46 0.3628 Column 4 3 106.4 35.466 0.186233 ANOVA
Source of P-
Variation SS df MS F value F crit
Between Groups 2.673292 3 0.8910 3.414602 0.0732 4.0661 Within Groups 2.087733 8 0.2609 Total 4.761025
11
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . - # $ , , " ! "
LAMPIRAN V Hasil Uji Statistik Sudut Diam Antar Formula
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1
3 40.21 13.40333 0.017633 Column 2
3
40.8 13.6 0.0243 Column 3
3 42.64 14.21333 0.124033 Column 4
3 40.64 13.54667 0.116033 ANOVA
P-
Source of Variation SS df MS F value F crit
Between Groups 1.154092 3 0.384697 3.456698 0.0695 4.0661 Within Groups 0.564 8 0.0705 Total 1.718092
11
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . - # $ , , " ! "
LAMPIRAN W
Hasil Uji Statistik Kekerasan Tablet Formula A Antar Batch
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 10 136.7 13.67 0.040111 Column 2 10 136.3 13.63 0.149 Column 3 10 135.1 13.51 0.092111 ANOVA
Source of P- Variation SS df MS F value F crit
Between Groups 0.138667 2 0.069333 0.739629 0.4867 3.3541 Within Groups 2.531 27 0.093741 Total 2.669667
29
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . # $ - , , " ! "
LAMPIRAN X
Hasil Uji Statistik Kekerasan Tablet Formula B Antar Batch
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 10 137.6 13.76 0.102667 Column 2 10 133.9 13.39 0.269889 Column 3 10 136.7 13.67 0.131222 ANOVA
Source of P- Variation SS df MS F value F crit
Between Groups 0.744667 2 0.372333 2.217247 0.1283 3.3541 Within Groups 4.534 27 0.167926 Total 5.278667
29
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . # $ - , , " ! "
LAMPIRAN Y Hasil Uji Statistik Kekerasan Tablet Formula C Antar Batch
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 10 140.1 14.01 0.025444 Column 2 10 139.1 13.91 0.025444 Column 3 10 139.1 13.91 0.038778 ANOVA
Source of P- Variation SS df MS F value F crit
Between Groups 0.0666667 2 0.033333 1.115242 0.3424 3.3541 Within Groups 0.807 27 0.029889 Total 0.8736667
29
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . # $ - , , " ! "
LAMPIRAN Z
Hasil Uji Statistik Kekerasan Tablet Formula D Antar Batch
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 10 139.9 13.99 0.014333 Column 2 10 139.9 13.99 0.032111 Column 3 10 140.2 14.02 0.019556 ANOVA
Source of P- Variation SS df MS F value F crit
Between Groups 0.006 2 0.003 0.136364 0.8731 3.3541 Within Groups 0.594 27 0.022 Total
0.6
29
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . # $ - , , " ! "
LAMPIRAN AA Hasil Uji Statistik Kekerasan Tablet Antar Formula Batch 1
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 10 136.7 13.67 0.040111 Column 2 10 137.6 13.76 0.102667 Column 3 10 140.1 14.01 0.025444 Column 4 10 139.9 13.99 0.014333 ANOVA
Source of P-
Variation SS df MS F value F crit
Between Groups 0.85475 3 0.284917 2.242848 0.0715 2.8662 Within Groups 1.643 36 0.045639 Total 2.49775
39
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . # $ , , - " ! "
LAMPIRAN AB Hasil Uji Statistik Kekerasan Tablet Antar Formula Batch 2
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 10 136.3 13.63 0.149 Column 2 10 133.9 13.39 0.269889 Column 3 10 139.1 13.91 0.025444 Column 4 10 139.9 13.99 0.032111 ANOVA
Source of Variation SS df MS F P-value F crit
Between Groups 2.256 3 0.752 2.313433 0.07149 2.8662 Within Groups 4.288 36 0.119111 Total 6.544
39
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . # $ , , - " ! "
LAMPIRAN AC Hasil Uji Statistik Kekerasan Tablet Antar Formula Batch 3
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 10 135.1 13.51 0.092111 Column 2 10 136.7 13.67 0.131222 Column 3 10 139.1 13.91 0.038778 Column 4 10 140.2 14.02 0.019556 ANOVA
Source of P-
Variation SS df MS F value F crit
Between Groups 1.59475 3 0.531583 2.549112 0.0704 2.8662 Within Groups 2.535 36 0.070417 Total 4.12975
39
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . # $ , , - " ! "
Hasil Uji Statistik Kerapuhan Tablet Formula A Antar Batch
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 3 0.567987 0.189328
5.21E-08 Column 2 3 0.567987 0.189328
5.21E-08 Column 3 3 0.567987 0.189328
5.21E-08 ANOVA
Source of P- Variation SS df MS F value F crit
Between -8.47E- Groups
2 22 -5.6E-16 1 5.1432 3.1259E- 5.2099E-
Within Groups
07
6
08 3.1259E-
Total
07
8
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . # $ - , , " ! "
LAMPIRAN AE
Hasil Uji Statistik Kerapuhan Tablet Formula B Antar BatchAnova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 3 0.5679 0.189328
5.21E-08 Column 2 3 0.5679 0.189328
5.21E-08 Column 3 3 0.5679 0.189328
5.21E-08 ANOVA
Source of P-
Variation SS df MS F value F crit
Between -8.47E- Groups
2 22 -5.6E-16 1 5.1432 Within 3.1259E- 5.2099E- Groups
07
6
08 3.1259E-
Total
07
8
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . - # $ , , " ! "
Hasil Uji Statistik Kerapuhan Tablet Formula C Antar Batch
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 3 0.550659 0.183553
1.52E-06 Column 2 3 0.550659 0.183553
1.52E-06 Column 3 3 0.550659 0.183553
1.52E-06 ANOVA
Source of P-
Variation SS df MS F value F crit
Between -1.7E- Groups
21 2 -8.5E-22 -5.6E-16 1 5.1432 Within
9.09E- Groups
06
6
1.52E-06
9.09E- Total
06
8
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . - # $ , , " ! "
Hasil Uji Statistik Kerapuhan Tablet Formula D Antar Batch
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 3 0.5513 0.183769
1.8E-06 Column 2 3 0.5513 0.183769
1.8E-06 Column 3 3 0.5513 0.183769
1.8E-06 ANOVA
Source of P-
Variation SS df MS F value F crit
Between
4.71E- Groups
1.69E-21
2
8.47E-22
16 1 5.1432 Within Groups
1.08E-05
6
1.8E-06 Total
1.08E-05
8
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . # $ , , - " ! "
LAMPIRAN AH Hasil Uji Statistik Kerapuhan Tablet Antar Formula Batch 1
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 3 0.550949 0.18365
4.64E-08 Column 2 3 0.567987 0.189329
5.21E-08 Column 3 3 0.550659 0.183553
1.52E-06 Column 4 3 0.551306 0.183769
1.8E-06 ANOVA
Source of P-
Variation SS df MS F value F crit
Between
7.25E- Groups
05
3
2.42E-05 2.321472 0.070 4.0661 Within
6.82E- Groups
06
8
8.53E-07
7.93E- Total
05
11
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . - # $ , , " ! "
LAMPIRAN AI Hasil Uji Statistik Kerapuhan Tablet Antar Formula Batch 2
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 3 0.550949 0.18365
4.64E-08 Column 2 3 0.567987 0.189329
5.21E-08 Column 3 3 0.550659 0.183553
1.52E-06 Column 4 3 0.551306 0.183769
1.8E-06 ANOVA
Source of
Variation SS df MS F P-value F crit
Between
7.25E- Groups
05
3
2.42E-05 2.321472 0.070 4.0661 Within
6.82E- Groups
06
8
8.53E-07
7.93E- Total
05
11
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . - # $ , , " ! "
LAMPIRAN AJ Hasil Uji Statistik Kerapuhan Tablet Antar Formula Batch 3
Anova: Single Factor SUMMARY
Groups Count Sum Average Variance
Column 1 3 0.550949 0.18365
4.64E-08 Column 2 3 0.567987 0.189329
5.21E-08 Column 3 3 0.550659 0.183553
1.52E-06 Column 4 3 0.551306 0.183769
1.8E-06 ANOVA
Source of P-
Variation SS df MS F value F crit
Between Groups
7.25E-05
3
2.42E-05 2.321472 0.070 4.0661 Within Groups
6.82E-06
8
8.53E-07 Total
7.93E-05
11
! " ! # $ % & ' $ ( ) *+ , ,
# # $ . - # $ , , " ! "