1615 - 1623_Haemmerich_54.ppt 2713KB Jun 23 2011 01:06:44 PM

HIFU mediated drug delivery:
Vascular shutdown facilitates drug
depot effect
Gasselhuber A.1, Appanaboyina S. 1,
Dreher M.R.2, Wood B.J.2, Haemmerich D.1
Dept. Pediatrics, Medical Univ. of South Carolina
2
Center for Interventional Oncology, National Cancer Institute
1

Disclosures


none

2

Low-Temperature Sensitive
Liposomes (LTSL)

Drug release (Doxorubicin)

at hyperthermic temperatures

Doxorubicin Release from LTSL
(from Gasselhuber et al.,
Int J Hyperthermia 2010)

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HIFU-mediated targeted
drug delivery

From Staruch et al., Int J Hyperthermia 2011
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Study Goal


Computer Simulation of HIFU+LTSL drug delivery
•
•



Heat transfer model
Drug Delivery Model

Two heating scenarios:
 7 min hyperthermia (42 ºC)
 7 min hyperthermia + brief ablation pulse
(to shut down blood flow)

Computer Model:
HIFU + LTSL
Tissue
Temperature

LTSL Release

Perfusion
Heat-Transfer Model

Intravascular
Space

Tissue
Pharmacokinetic Model

6

Mathematical Drug
Delivery Model

Drug delivery from LTSL in tumor
(see also Gasselhuber et al., Int J Hyperthermia 2010)
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Hyperthermia vs.
HT+Ablation
Hyperthermia

HT+Ablation

Temperature

Perfusion

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Hyperthermia

HT+Ablation

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Drug Concentrations: HT
+ Ablation

HIFU

HIFU+Ablation

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Summary


Elimination of blood flow by brief high-temperature
heating pulse considerably increases tissue drug
uptake
 Depot Effect
 Other blood flow reducing methods
(embolization) would have similar effect

Questions?

ABLATION. MUSC.EDU
Funding: NIH R01CA118990,
R21 CA135519

Charleston, SC

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