Hubungan Kadar Adrenocorticotropine Hormone dan Enzim 11 β-Hydroxylasedengan Profil Lipid Serum pada Obesitas, Overweight dan Normal

  Lampiran 1. Lembar Ethical Clearance

  Lampiran 2. Lembar Penjelasan Mengenai Penelitian

PENJELASAN MENGENAI PENELITIAN LEMBAR PENJELASAN KEPADA CALON SUBJEK PENELITIAN

  Selamat pagi Saudara, Nama saya dr. Jenny Novina Sitepu dan akan melakukan penelitian dengan judul Hubungan Profil Lipid dengan Kadar Adrenocorticotropine Hormone (ACTH) dan Enzim 11-

  β Hydroxylase pada Obesitas, Overweight, dan Normal. Penelitian ini bertujuan untuk mengetahui gambaran profil lipid, kadar ACTH dan enzim 11- β Hydroxylase pada obesitas, overweight, dan normal, serta bagaimana hubungan variabel-variabel tersebut.

  Dengan diketahuinya gambaran profil lipid, kadar ACTH dan enzim 11- β Hydroxylase pada obesitas, overweight, dan normal, serta bagaimana hubungan variabel-variabel tersebut maka didapatkan informasi ilmiah mengenai gambaran profil lipid, kadar ACTH dan enzim 11-

  β Hydroxylase pada obesitas, overweight, dan tubuh normal, serta bagaimana hubungan variabel-variabel tersebut. Selain itu, hasil penelitian ini juga dapat bahan masukan untuk penyuluhan kesehatan mengenai dampak obesitas dan overweight terhadap kesehatan, bahan masukan untuk penelitian kesehatan lebih lanjut dalam menurunkan risiko penyakit kardiovaskuler pada orang dengan obesitas dan overweight serta masyarakat menjadi lebih berhati-hati terhadap dampak negatif obesitas dan overweight terhadap kesehatan.

  Jika Saudara bersedia mengikuti penelitian ini maka akan dilakukan pemeriksaan terhadap Saudara dengan cara melakukan wawancara, pengukuran tinggi badan, berat badan, lingkar pinggang serta pengambilan sampel darah vena untuk diperiksa di laboratorium. Proses pengambilan darah mungkin akan menimbulkan rasa tidak nyaman (sedikit sakit), namun hal tersebut tidak masalah. Setelah darah saudara diambil, petugas akan memberikan kapas alkohol untuk ditempelkan di tempat bekas penyuntikan. Idealnya darah akan segera berhenti. Namun, apabila tempat penyuntikan masih berdarah setelah 5 menit, anda dapat menghubungi dan menanyakan kepada saya. Apabila terjadi sedikit pembengkakan pada lokasi penyuntikan, Saudara tidak perlu kuatir. Saudara dapat mengompres bagian yang bengkak dengan air dingin atau apabila bengkak menetap, Saudara dapat menghubungi dan menanyakan kepada saya. Saya sangat mengharapkan keikutsertaan Saudara dalam penelitian ini, karena selain bermanfaat untuk diri sendiri, juga bermanfaat untuk orang lain.

  Selama penelitian ini, Saudara tidak dibebankan biaya apapun. Semua data/keterangan dari Saudara bersifat rahasia, tidak diketahui orang lain. Apabila Saudara ingin mengetahui hasil pemeriksaan yang dilakukan, Saudara dapat menghubungi saya dan saya akan memberikan catatan hasil pemeriksaan darah Saudara. Apabila keberatan, Saudara bebas untuk menolak mengikuti penelitian ini, tanpa khawatir akan mengurangi pelayanan yang kami berikan.

  Jika sudah mengerti dan bersedia mengikuti penelitian ini maka Saudara dapat mengisi lembar persetujuan (Informed Consent).

  Pemeriksaan yang akan dilakukan diatas pada lazimnya tidak akan menimbulkan hal yang berbahaya bagi Saudara sekalian. Namun, bila terjadi hal-hal yang tidak diinginkan yang disebabkan oleh perlakuan penelitian ini, maka Saudara dapat menghubungi saya.

  Nama : dr. Jenny Novina Sitepu Telp. : 085271594446 Demikian penjelasan ini saya sampaikan, kiranya hasil dari penelitian ini bermanfaat bagi kita semua.

  Medan, Juli 2014 Peneliti, (dr. Jenny Novina Sitepu) Lampiran 3. Lembar Persetujuan setelah Penjelasan

LEMBAR PERSETUJUAN SETELAH PENJELASAN (INFORMED CONSENT)

  Saya yang bertanda tangan dibawah ini: Nama : Umur : Jenis kelamin : Alamat : No.Telp./ HP :

Setelah mempelajari dan mendapatkan penjelasan yang sejelas-jelasnya

mengenai penelitian yang berjudul , dan setelah mengetahui dan menyadari sepenuhnya risiko yang mungkin terjadi, dengan ini saya menyatakan bahwa saya bersedia dengan sukarela menjadi subjek penelitian tersebut dan patuh akan ketentuan-ketentuan yang dibuat peneliti. Jika sewaktu-waktu ingin berhenti, saya berhak untuk tidak melanjutkan mengikuti penelitian ini tanpa ada sanksi apapun.

  Yang menyatakan, Peneliti ( ) (dr. Jenny Novina Sitepu)

  Saksi ( ) Lampiran 4. Surat Keterangan Melakukan Penelitian

  Lampiran 5. Daftar Obat yang Mempengaruhi Sekresi ACTH, Fungsi Adrenal (11 β- Hydroxylase), dan Profil Lipid

  1. Obat yang mempengaruhi ACTH:

  a. Menghambat ACTH:  Sintetik Glucocorticoid: Dexamethasone, Hydrocortisone,

Prednison, Prednisolone, Methylprednisolone,

Triamcinolone, Betamethasone, Fludrocortisone b. Meningkatkan ACTH:  Sintetis ACTH: Cosytropin, Cortrosyn, Synacthen

   Metyrapone (Metopirone)

  2. Obat yang mempengaruhi11

β-Hydroxylase

a. Hambat11 β-Hydroxylase: Aminoglutethimide (Cytadren),

  Ketokonazole, Metyrapone (Metopirone), Mitotane

  3. Obat yang meurunkan lipid darah:

  a. Statin: Atorvastatin, Fluvastatin, Lovastatin, Pravastatin, Rosuvastatin, Simvastatin b. Bile acid binding resins: Cholestyramine, Colestipol

  c. Penghambat absorbsi kolesterol: Ezetimibe

  d. Fibrate: Bezafibrate, Fenofibrate, Gemfibrozil

  e. Niacin Lampiran 6.

  Output SPSS

Deskriptif IMT, Lingkar Pinggang, ACTH, 11 β-Hydroxylase, dan Profil Lipid pada Obesitas Descriptive Statistics

  25

  25

  25

  25 40 214 80.52 37.275 Valid N (listwise)

  69 43.52 10.108 Trigliserida (mg/dl)

  29

  25

  25 71 171 103.12 26.908 Kolesterol HDL (mg/dl)

  25 17.0 199.4 70.160 46.8283 Kolesterol Total (mg/dl) 25 120 244 162.68 32.024 Kolesterol LDL (mg/dl)

  11 Beta-Hydroxylase (pg/ml)

  18.0 96.3 42.556 19.3599

  25

  80.0 93.0 85.928 4.5881 Adrenocorticotropine Hormone (ng/L)

  23.0 24.9 24.292 .6714 LingkarPinggang (cm)

  26.4 38.2 31.236 3.6000 LingkarPinggang (cm)

  N Minimum Maximum Mean Std. Deviation Indeks Massa Tubuh (Kg/m2)

  N Minimum Maximum Mean Std. Deviation Indeks Massa Tubuh (Kg/m2)

  β-Hydroxylase, dan Profil Lipid pada Overweight Descriptive Statistics

  25 38 170 91.24 40.122 Valid N (listwise)

  52 38.72 7.481 Trigliserida (mg/dl)

  22

  25

  25 73 182 125.92 27.354 Kolesterol HDL (mg/dl)

  25 6.9 149.3 52.764 44.2706 Kolesterol Total (mg/dl) 25 140 242 182.88 26.321 Kolesterol LDL (mg/dl)

  11 Beta-Hydroxylase (pg/ml)

  25 16.1 124.0 44.792 30.1530

  25 94.0 117.0 104.240 7.5196 Adrenocorticotropine Hormone (ng/L)

  25

Deskriptif IMT, Lingkar Pinggang, ACTH, 11 β-Hydroxylase, dan Profil Lipid Kelompok Normal Descriptive Statistics

  N Minimum Maximum Mean Std. Deviation Indeks Massa Tubuh (kg/m2)

  75

  75 38 214 79.99 36.132 Valid N (listwise)

  69 42.51 9.114 Trigliserida (mg/dl)

  22

  75

  75 66 182 109.13 28.644 Kolesterol HDL (mg/dl)

  75 3.5 199.4 55.449 41.4845 Kolesterol Total (mg/dl) 75 120 244 167.60 29.360 Kolesterol LDL (mg/dl)

  11 Beta-Hydroxylase (pg/ml)

  75 14.3 124.0 39.503 22.1232

  75 65.0 117.0 87.971 13.7345 Adrenocorticotropine Hormone (ng/L)

  18.6 38.2 25.200 5.1165 Waist Circumference (cm)

  75

  N Minimum Maximum Mean Std. Deviation Indeks Massa Tubuh (Kg/m2)

  25

  25 40 155 68.20 27.374 Valid N (listwise)

  62 45.28 8.600 Trigliserida (mg/dl)

  26

  25

  25 66 175 98.36 24.607 Kolesterol HDL (mg/dl)

  25 3.5 108.4 43.424 27.7481 Kolesterol Total (mg/dl) 25 125 213 157.24 23.651 Kolesterol LDL (mg/dl)

  11 Beta-Hydroxylase (pg/ml)

  14.3 55.5 31.160 10.6646

  25

  65.0 80.0 73.744 3.6241 Adrenocorticotropine Hormone (ng/L)

  25

  18.6 22.0 20.072 1.0502 Waist Circumference (cm)

  β-Hydroxylase, dan Profil Lipid Seluruh Sampel Descriptive Statistics

Uji Normalitas ACTH

  a. Sebelum transformasi data

Tests of Normality

a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig. Adrenocorticotropine

  .199 75 .000 .760 75 .000 Hormone (ng/L)

  a. Lilliefors Significance Correction

  b. Setelah transformasi data Tests of Normality a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig. tran_ACTH .095 75 .089 .956 75 .010

  a. Lilliefors Significance Correction

Uji Normalitas 11 β-Hydroxylase

  a. Sebelum transformasi data

Tests of Normality

a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig.

  11 Beta-Hydroxylase (pg/ml) .174 75 .000 .869 75 .000

  a. Lilliefors Significance Correction

  b. Setelah transformasi data Tests of Normality a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig.

• tran_hydroxylase .058

  75 .200 .982 75 .352

  a. Lilliefors Significance Correction *. This is a lower bound of the true significance.

Uji Normalitas Kolesterol Total

  a. Sebelum transformasi data Tests of Normality a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig. Kolesterol Total (mg/dl) .133 75 .002 .939 75 .001

  a. Lilliefors Significance Correction

  b. Setelah transformasi data Tests of Normality a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig. tran_kolesterol .113 75 .018 .965 75 .034

  a. Lilliefors Significance Correction

Uji Normalitas Kolesterol HDL Tests of Normality

  a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig.

• Kolesterol HDL (mg/dl) .075

  75 .200 .988 75 .712

  a. Lilliefors Significance Correction *. This is a lower bound of the true significance.

Uji Normalitas Kolesterol LDL

  a. Sebelum transformasi data Tests of Normality a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig. Kolesterol LDL (mg/dl) .118 75 .011 .937 75 .001

  a. Lilliefors Significance Correction

  b. Setelah transformasi data Tests of Normality a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig.

• tran_LDL .080

  75 .200 .974 75 .126

  a. Lilliefors Significance Correction *. This is a lower bound of the true significance.

Uji Normalitas Trigliserida

  a. Sebelum transformasi data Tests of Normality a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig. Trigliserida (mg/dl) .131 75 .003 .880 75 .000

  a. Lilliefors Significance Correction

  b. Setelah transformasi data Tests of Normality a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig.

• tran_trigliserida .073

  75 .200 .969 75 .059

  a. Lilliefors Significance Correction

  Tests of Normality a

  Kolmogorov-Smirnov Shapiro-Wilk Statistic df Sig. Statistic df Sig.

• tran_trigliserida .073

  75 .200 .969 75 .059 *. This is a lower bound of the true significance.

Hasil Uji T Tidak Berpasangan ACTH Obesitas dibanding Normal Group Statistics

  KategoriSa mpel N Mean Std. Deviation Std. Error Mean tran_ACTH Obesitas 25 1.5808 .23818 .04764

  Normal 25 1.4692 .15008 .03002

  Independent Samples Test

  Levene's Test for

  Equality of Variances t-test for Equality of Means

  95% Confidence Interval of the Sig.

  Difference (2- Mean Std. Error

  F Sig. t df tailed) Difference Difference Lower Upper tran_ACTH Equal variances 3.131 .083 1.983 48 .053 .11163 .05630 -.00157 .22484 assumed Equal variances

  1.983 40.463 .054 .11163 .05630 -.00212 .22539 not assumed

ACTH Overweight dibanding Normal Group Statistics

  KategoriSam pel N Mean Std. Deviation Std. Error Mean tran_ACTH Overweight 25 1.5928 .17613 .03523

  Normal 25 1.4692 .15008 .03002

  Independent Samples Test

  Levene's Test for

  Equality of Variances t-test for Equality of Means

  95% Confidence Interval of the Sig.

  Difference (2- Mean Std. Error

  F Sig. t df tailed) Difference Difference Lower Upper tran_ACTH Equal variances .371 .545 2.671 48 .010 .12363 .04628 .03058 .21668 assumed Equal variances

  2.671 46.821 .010 .12363 .04628 .03052 .21674 not assumed

  11 β-Hydroxylase Obesitas dibanding Normal Group Statistics

  KategoriSa mpel N Mean Std. Deviation Std. Error Mean tran_hydroxylase Obesitas 25 1.5727 .37867 .07573

  Normal 25 1.5369 .33603 .06721

  Independent Samples Test

  Levene's Test for

  Equality of Variances t-test for Equality of Means

  F Sig. t df Sig.

  (2- tailed) Mean

  Difference Std. Error

  Difference 95%

  Confidence Interval of the

  Difference Lower Upper tran_hydroxylase Equal variances assumed

  .617 .436 .354 48 .725 .03579 .10125 -.16779 .23938 Equal variances not assumed

  .354 47.331 .725 .03579 .10125 -.16786 .23945

  11 β-Hydroxylase Overweight dibanding Normal Group Statistics

  KategoriSam pel N Mean Std. Deviation Std. Error Mean tran_h ydroxyl ase

  Overweight 25 1.7613 .28021 .05604 Normal 25 1.5369 .33603 .06721

  

Independent Samples Test Levene's Test for Equality of Variances t-test for Equality of Means

  95% Confidence Interval of the

  Difference Sig. (2- Mean Std. Error

  F Sig. t df tailed) Difference Difference Lower Upper tran Equal

  2.56 _hy variances .153 .697 48 .014 .22437 .08751 .04843 .40032

  4 drox assumed ylas

  Equal

  2.56

  46.49 e variances not .014 .22437 .08751 .04828 .40046

  4

  9 assumed

Kolesterol Total Obesitas dibanding Normal Ranks

  KategoriSa mpel N Mean Rank Sum of Ranks Kolesterol Total (mg/dl) Obesitas

  25 32.20 805.00 Normal

  25 18.80 470.00 Total

  50

  a Test Statistics

  Kolesterol Total (mg/dl)

  Mann-Whitney U 145.000 Wilcoxon W 470.000 Z -3.251 Asymp. Sig. (2-tailed) .001

  a. Grouping Variable: KategoriSampel

Kolesterol Total Overweight dibanding Normal Ranks

  KategoriSam pel N Mean Rank Sum of Ranks Kolesterol Total (mg/dl) Overweight

  25 25.34 633.50 Normal

  25 25.66 641.50 Total

  50

  a Test Statistics

  Kolesterol Total (mg/dl)

  Mann-Whitney U 308.500 Wilcoxon W 633.500 Z -.078 Asymp. Sig. (2-tailed) .938

  a. Grouping Variable: KategoriSampel

Kolesterol HDL Obesitas dibanding Normal Group Statistics

  KategoriS ampel N Mean Std. Deviation Std. Error Mean Koleseterol HDL (mg/dl) Obesitas

  25 38.72 7.481 1.496 Normal

  25 45.28 8.600 1.720

  Independent Samples Test Levene's Test for Equality of Variances t-test for Equality of Means

  95% Confidence Interval of the Sig.

  Difference (2- Mean Std. Error

  F Sig. t df tailed) Difference Difference Lower Upper Koleseterol Equal HDL (mg/dl) variances assumed .157 .694 -2.878

  48 .006 -6.560 2.280 -11.144 -1.976 Equal variances not assumed

• 2.878 47.096 .006 -6.560 2.280 -11.146 -1.974

Kolesterol HDL Overweight dibanding Normal Group Statistics

  KategoriSam pel N Mean Std. Deviation Std. Error Mean Koleseterol HDL (mg/dl) Overweight

  25 43.52 10.108 2.022 Normal

  25 45.28 8.600 1.720

  Independent Samples Test Levene's Test for Equality of Variances t-test for Equality of Means

  95% Confidence

  Interval of the Sig.

  Difference (2- Mean Std. Error

  F Sig. t df tailed) Difference Difference Lower Upper Koleseterol Equal

• HDL variances 1.610 .211

  48 .510 -1.760 2.654 -7.097 3.577 .663

  (mg/dl) assumed Equal

• variances

  46.799 .511 -1.760 2.654 -7.100 3.580 not .663 assumed

Kolesterol LDL Obesitas dibanding Normal Group Statistics

  KategoriSa mpel N Mean Std. Deviation Std. Error Mean tran_LDL Obesitas 25 2.0898 .09827 .01965

  Normal 25 1.9813 .09930 .01986

  Independent Samples Test

  Levene's Test for

  Equality of Variances t-test for Equality of Means

  95% Confidence Interval of the Sig.

  Difference (2- Mean Std. Error

  F Sig. t df tailed) Difference Difference Lower Upper tran_LDL Equal variances .025 .876 3.881 48 .000 .10844 .02794 .05226 .16462 assumed

  Independent Samples Test

  Levene's Test for

  Equality of Variances t-test for Equality of Means

  95% Confidence Interval of the Sig.

  Difference (2- Mean Std. Error

  F Sig. t df tailed) Difference Difference Lower Upper tran_LDL Equal variances .025 .876 3.881 48 .000 .10844 .02794 .05226 .16462 assumed Equal variances

  3.881 47.995 .000 .10844 .02794 .05226 .16462 not assumed

Kolesterol LDL Overweight dibanding Normal Group Statistics

  KategoriSam pel N Mean Std. Deviation Std. Error Mean tran_LDL Overweight 25 2.0008 .10343 .02069

  Normal 25 1.9813 .09930 .01986

  Independent Samples Test

  Levene's Test for

  Equality of Variances t-test for Equality of Means

  95% Confidence Interval of the Sig.

  Difference (2- Mean Std. Error

  F Sig. t df tailed) Difference Difference Lower Upper tran_LDL Equal variances assumed

  .417 .521 .679 48 .500 .01949 .02868 -.03817 .07714 Equal variances not assumed

  .679 47.921 .500 .01949 .02868 -.03818 .07715

Trigliserida Obesitas dibanding Normal Group Statistics

  KategoriSa mpel N Mean Std. Deviation Std. Error Mean tran_trigliserida Obesitas 25 1.9183 .19772 .03954

  Normal 25 1.8078 .14535 .02907

  Independent Samples Test

  Levene's Test for

  Equality of Variances t-test for Equality of Means

  F Sig. t df Sig.

  (2- tailed) Mean

  Difference Std. Error

  Difference 95%

  Confidence Interval of the

  Difference Lower Upper tran_trigliserida Equal variances assumed

  5.099 .029 2.252 48 .029 .11055 .04908 .01187 .20923 Equal variances not assumed

  2.252 44.076 .029 .11055 .04908 .01164 .20945

Trigliserida overweight dibanding normal Group Statistics

• .03007
• .03015

  .15359

  75

  75

  75

  1.000 .135 .092 Sig. (1-tailed) . .124 .216 N

  Correlation Coefficient

  Kolesterol Total (mg/dl)

  (pg/ml) Spearman's rho

  11 Beta- Hydroxylase

  Hormone (ng/L)

  (mg/dl) Adrenocorticotropine

  Kolesterol Total

  1.352 46.345 .183 .06172 .04565

  KategoriSam pel N Mean Std. Deviation Std. Error Mean tran_trigliserida Overweight 25 1.8695 .17598 .03520

  .15350 Equal variances not assumed

  .831 .367 1.352 48 .183 .06172 .04565

  Difference Lower Upper tran_trigliserida Equal variances assumed

  Confidence Interval of the

  Difference 95%

  Difference Std. Error

  (2- tailed) Mean

  F Sig. t df Sig.

  Equality of Variances t-test for Equality of Means

  Levene's Test for

  Independent Samples Test

  Normal 25 1.8078 .14535 .02907

Uji Korelasi ACTH dan11 β-Hydroxylase dengan Kolesterol Total pada Seluruh Sampel Correlations

  Adrenocorticotropine Correlation .135 1.000 -.052

  Hormone (ng/L) Coefficient Sig. (1-tailed) .124 . .329 N

  75

  75

  75

  11 Beta- Correlation .092 -.052 1.000

  Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .216 .329 .

  N

  75

  75

  75 Uji Korelasi ACTH dan 11

  β-Hydroxylase dengan Kolesterol Total pada Obesitas Correlations

  11 Beta- Kolesterol Adrenocorticotropine Hydroxylase Total

  Hormone (ng/L) (pg/ml) (mg/dl) Spearman's Adrenocorticotropine Correlation

  1.000 -.061 .248 rho Hormone (ng/L) Coefficient Sig. (1-tailed) . .387 .116 N

  25

  25

  25

  11 Beta- Correlation

• .061 1.000 .097 Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .387 . .323 N

  25

  25

  25 Kolesterol Total Correlation .248 .097 1.000

  (mg/dl) Coefficient Sig. (1-tailed) .116 .323 .

  N

  25

  25

  25

Uji Korelasi ACTH dan 11 β-Hydroxylase dengan Kolesterol Total pada

  Overweight Correlations

  11 Beta- Kolesterol Adrenocorticotropine Hydroxylase Total

  Hormone (ng/L) (pg/ml) (mg/dl) Spearman's Adrenocorticotropine Correlation

  1.000 -.137 .145 rho Hormone (ng/L) Coefficient Sig. (1-tailed) . .257 .244 N

  25

  25

  25

  11 Beta- Correlation

• .137 1.000 .270 Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .257 . .096 N

  25

  25

  25 Kolesterol Total Correlation .145 .270 1.000

  (mg/dl) Coefficient Sig. (1-tailed) .244 .096 .

  N

  25

  25

  25 Uji Korelasi ACTH dan 11

  β-Hydroxylase dengan Kolesterol Total pada Normal Correlations

  11 Beta- Kolesterol Adrenocorticotropine Hydroxylase Total

  Hormone (ng/L) (pg/ml) (mg/dl) Spearman's Adrenocorticotropine Correlation

  1.000 -.110 .098 rho Hormone (ng/L) Coefficient Sig. (1-tailed) . .300 .320 N

  25

  25

  25

  11 Beta- Correlation

• .110 1.000 .184 Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .300 . .189 N

  25

  25

  25 Kolesterol Total Correlation .098 .184 1.000

  (mg/dl) Coefficient Sig. (1-tailed) .320 .189 .

  N

  25

  25

  25 Uji Korelasi ACTH dan 11 β-Hydroxylase dengan Kolesterol HDL pada

Seluruh Sampel Correlations

  Koleseterol

  11 Beta- HDL Adrenocorticotropine Hydroxylase

  (mg/dl) Hormone (ng/L) (pg/ml) Spearman's Koleseterol HDL Correlation

  1.000 -.190 .018 rho (mg/dl) Coefficient Sig. (1-tailed) . .051 .440 N

  75

  75

  75 Adrenocorticotropine Correlation

• .190 1.000 -.052 Hormone (ng/L) Coefficient Sig. (1-tailed) .051 . .329 N

  75

  75

  75

  11 Beta- Correlation .018 -.052 1.000

  Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .440 .329 .

  N

  75

  75

  75

Uji Korelasi ACTH dan 11 β-Hydroxylase dengan Kolesterol HDL pada Obesitas Correlations

  11 Beta- Kolesterol Adrenocorticotropine Hydroxylase HDL

  Hormone (ng/L) (pg/ml) (mg/dl) Spearman's Adrenocorticotropine Correlation

  1.000 -.061 -.078 rho Hormone (ng/L) Coefficient Sig. (1-tailed) . .387 .355 N

  25

  25

  25

  11 Beta- Correlation

• .061 1.000 -.131 Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .387 . .267 N

  25

  25

  25 Kolesterol HDL Correlation

• .078 -.131 1.000 (mg/dl) Coefficient Sig. (1-tailed) .355 .267 . N

  25

  25

  25 Uji Korelasi ACTH dan 11

  β-Hydroxylase dengan Kolesterol HDL pada Overweight

  Correlations

  11 Beta- Kolesterol Adrenocorticotropine Hydroxylase HDL

  Hormone (ng/L) (pg/ml) (mg/dl) Spearman's Adrenocorticotropine Correlation

  1.000 -.137 -.145 rho Hormone (ng/L) Coefficient Sig. (1-tailed) . .257 .245 N

  25

  25

  25

  11 Beta- Correlation

• .137 1.000 .307 Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .257 . .068 N

  25

  25

  25 Kolesterol HDL Correlation

• .145 .307 1.000 (mg/dl) Coefficient Sig. (1-tailed) .245 .068 . N

  25

  25

  25 Uji Korelasi ACTH dan 11

  β-Hydroxylase dengan Kolesterol HDL pada Normal Correlations

  11 Beta- Kolesterol Adrenocorticotropine Hydroxylase HDL

  Hormone (ng/L) (pg/ml) (mg/dl) Spearman's Adrenocorticotropine Correlation

  1.000 -.110 -.275 rho Hormone (ng/L) Coefficient Sig. (1-tailed) . .300 .091 N

  25

  25

  25

  11 Beta- Correlation

• .110 1.000 .039 Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .300 . .427 N

  25

  25

  25 Kolesterol HDL Correlation

• .275 .039 1.000 (mg/dl) Coefficient Sig. (1-tailed) .091 .427 . N

  25

  25

  25

Uji Korelasi ACTH dan 11 β-Hydroxylase dengan Kolesterol LDL pada Seluruh Sampel Correlations

• .049
• 1.000 -.052

  (pg/ml) Kolesterol

  .049 -.052 1.000 Sig. (1-tailed) .337 .329 . N

  75

  75

  75

  Adrenocorticotropine Hormone (ng/L)

  11 Beta- Hydroxylase

  LDL (mg/dl)

  11 Beta- Hydroxylase (pg/ml)

  Spearman's rho Adrenocorticotropine Hormone (ng/L)

  Correlation Coefficient

  1.000 -.061 .161 Sig. (1-tailed) . .387 .221 N

  25

  25

  25

  Correlation Coefficient

  75

  Sig. (1-tailed) . .039 .337 N

  75

  Hormone (ng/L)

  11 Beta- Hydroxylase

  (pg/ml) Spearman's rho

  Kolesterol LDL (mg/dl)

  Correlation Coefficient

  1.000 .204

  75

  Kolesterol LDL

  75

  75 Adrenocorticotropine Hormone (ng/L)

  Correlation Coefficient

  .204

  Sig. (1-tailed) .039 . .329 N

  75

  (mg/dl) Adrenocorticotropine

• . Correlation is significant at the 0.05 level (1- tailed).

Uji Korelasi ACTH dan 11 β-Hydroxylase dengan Kolesterol LDL pada Obesitas Correlations

  11 Beta- Correlation

• .061 1.000 .085 Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .387 . .343 N

  25

  25

  25 Kolesterol LDL Correlation .161 .085 1.000

  (mg/dl) Coefficient Sig. (1-tailed) .221 .343 .

  N

  25

  25

  25 Uji Korelasi ACTH dan 11

  β-Hydroxylase dengan Kolesterol LDL pada Overweight

  Correlations

  11 Beta- Kolesterol Adrenocorticotropine Hydroxylase LDL

  Hormone (ng/L) (pg/ml) (mg/dl) Spearman's Adrenocorticotropine Correlation

  1.000 -.137 .271 rho Hormone (ng/L) Coefficient Sig. (1-tailed) . .257 .095 N

  25

  25

  25

  11 Beta- Correlation

• .137 1.000 .256 Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .257 . .109 N

  25

  25

  25 Kolesterol LDL Correlation .271 .256 1.000

  (mg/dl) Coefficient Sig. (1-tailed) .095 .109 .

  N

  25

  25

  25

Uji Korelasi ACTH dan 11 β-Hydroxylase dengan Kolesterol LDL pada Normal Correlations

  11 Beta- Kolesterol Adrenocorticotropine Hydroxylase LDL

  Hormone (ng/L) (pg/ml) (mg/dl) Spearman's Adrenocorticotropine Correlation

  1.000 -.110 .152 rho Hormone (ng/L) Coefficient Sig. (1-

  . .300 .235 tailed) N

  25

  25

  25

  11 Beta-Hydroxylase Correlation

• .110 1.000 .139 (pg/ml) Coefficient Sig. (1-

  .300 . .253 tailed) N

  25

  25

  25 Kolesterol LDL (mg/dl) Correlation .152 .139 1.000

  Coefficient Sig. (1- .235 .253 . tailed) N

  25

  25

  25 Uji Korelasi ACTH dan 11 β-Hydroxylase dengan Trigliserida pada Seluruh

Sampel Correlations

  11 Beta- Trigliserida Adrenocorticotropine Hydroxylase

  (mg/dl) Hormone (ng/L) (pg/ml) Spearman's Trigliserida (mg/dl) Correlation

  1.000 .061 .174 rho Coefficient Sig. (1-tailed) . .300 .068 N

  75

  75

  75 Adrenocorticotropine Correlation .061 1.000 -.052

  Hormone (ng/L) Coefficient Sig. (1-tailed) .300 . .329

  N

  75

  75

  75

  11 Beta- Correlation .174 -.052 1.000

  Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .068 .329 .

  N

  75

  75

  75 Uji Korelasi ACTH dan 11

  β-Hydroxylase denganTrigliserida pada Obesitas Correlations

  11 Beta- Adrenocorticotropine Hydroxylase Trigliserida

  Hormone (ng/L) (pg/ml) (mg/dl) Spearman's Adrenocorticotropine Correlation

  1.000 -.061 -.156 rho Hormone (ng/L) Coefficient Sig. (1-tailed) . .387 .229 N

  25

  25

  25

  11 Beta- Correlation

• .061 1.000 .172 Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .387 . .205 N

  25

  25

  25 Trigliserida (mg/dl) Correlation

• .156 .172 1.000 Coefficient Sig. (1-tailed) .229 .205 . N

  25

  25

  25

Uji Korelasi ACTH dan 11 β-Hydroxylase denganTrigliserida pada

  Overweight Correlations

  11 Beta- Adrenocorticotropine Hydroxylase Trigliserida

  Hormone (ng/L) (pg/ml) (mg/dl) Spearman's Adrenocorticotropine Correlation

  1.000 -.137 .143 rho Hormone (ng/L) Coefficient Sig. (1-tailed) . .257 .247 N

  25

  25

  25

  11 Beta- Correlation

• .137 1.000 .101 Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .257 . .315 N

  25

  25

  25 Trigliserida (mg/dl) Correlation .143 .101 1.000

  Coefficient Sig. (1-tailed) .247 .315 . N

  25

  25

  25 Uji Korelasi ACTH dan 11

  β-Hydroxylase denganTrigliserida pada Normal Correlations

  11 Beta- Adrenocorticotropine Hydroxylase Trigliserida

  Hormone (ng/L) (pg/ml) (mg/dl) Spearman's Adrenocorticotropine Correlation

  1.000 -.110 .129 rho Hormone (ng/L) Coefficient Sig. (1-tailed) . .300 .269 N

  25

  25

  25

  11 Beta- Correlation

• .110 1.000 .153 Hydroxylase (pg/ml) Coefficient Sig. (1-tailed) .300 . .233 N

  25

  25

  25 Trigliserida (mg/dl) Correlation .129 .153 1.000

  Coefficient Sig. (1-tailed) .269 .233 . N

  25

  25

  25 Uji Regresi Linear ACTH dan

  11 β-Hydroxylase dengan Kolesterol Total

c

  Model Summary

  Adjusted R Std. Error of the Model R R Square Square Estimate Durbin-Watson

  a

  1 .317 .101 .076 28.226

  b

  2 .303 .092 .080 28.168 1.566

  a. Predictors: (Constant), 11 Beta-Hydroxylase (pg/ml), Adrenocorticotropine Hormone(ng/L)

  b. Predictors: (Constant), 11 Beta-Hydroxylase (pg/ml)

  c. Dependent Variable: Kolesterol Total (mg/dl)

  

c

ANOVA Model Sum of Squares df Mean Square F Sig. a

  1 Regression 6425.343 2 3212.672 4.032 .022 Residual 57364.657 72 796.731 Total 63790.000

  74

  b

  2 Regression 5868.925 1 5868.925 7.397 .008 Residual 57921.075 73 793.439 Total 63790.000

  74

  a. Predictors: (Constant), 11 Beta-Hydroxylase (pg/ml), Adrenocorticotropine Hormone (ng/L)

  b. Predictors: (Constant), 11 Beta-Hydroxylase (pg/ml)

  c. Dependent Variable: Kolesterol Total (mg/dl)

  

Coefficients

a

  75 Std. Predicted Value -1.252 3.470 .000 1.000

  75

  75 Centered Leverage Value .000 .163 .013 .027

  75 Cook's Distance .000 .338 .019 .050

  75 Mahal. Distance .002 12.041 .987 2.001

  75 Stud. Deleted Residual -1.990 3.191 .007 1.024

  75 Deleted Residual -55.945 85.901 .232 29.019

  75 Stud. Residual -1.951 3.007 .004 1.011

  75 Std. Residual -1.916 2.966 .000 .993

  75 Residual -53.967 83.534 .000 27.977

  75 Adjusted Predicted Value 156.10 189.84 167.37 8.290

  3.256 11.819 4.342 1.530

  75 Standard Error of Predicted Value

  Minimum Maximum Mean Std. Deviation N Predicted Value 156.45 198.50 167.60 8.906

  Model Unstandardized

  Residuals Statistics

a

  a. Dependent Variable: Kolesterol Total (mg/dl)

  .215 .079 .303 2.720 .008 .303 .303 .303 1.000 1.000

  11 Beta- Hydroxylase (pg/ml)

  .215 .079 .304 2.719 .008 .303 .305 .304 1.000 1.000 2 (Constant) 155.697 5.453 28.552 .000

  11 Beta- Hydroxylase (pg/ml)

  .124 .148 .093 .836 .406 .092 .098 .093 1.000 1.000

  Adrenocorticotropine Hormone (ng/L)

  Zero- order Partial Part Tolerance VIF 1 (Constant) 150.780 8.029 18.779 .000

  Statistics B Std. Error Beta

  Correlations Collinearity

  Coefficients t Sig.

  Coefficients Standardized

  a. Dependent Variable: Kolesterol Total (mg/dl)