Hubungan Kadar Low-Density Lipoprotein Cholesterol dengan Kejadian dan Keparahan Stroke Akut
ABSTRAK
Latar Belakang : Peranan kolesterol serum sebagai penyebab stroke masih belum pasti.
Penelitian mengenai hubungan kadar low-density lipoprotein cholesterol (LDL-C) dengan
stroke akut masih sangat sedikit, dengan hasil yang tidak konsisten. Penelitian ini bertujuan
untuk mengetahui hubungan kadar LDL-C dengan kejadian dan korelasinya dengan
keparahan stroke akut.
Metode : Penelitian ini merupakan penelitian potong lintang terhadap 51 orang pasien
stroke akut yang dirawat di RSUP H. Adam Malik Medan. Subyek dikategorikan berdasarkan
tipe strokenya, yaitu: stroke iskemik dan hemoragik. Semua pasien menjalani penilaian skor
NIHSS saat masuk, skor SKG, penilaian volume lesi, pemeriksaan kadar lipid darah dan
penilaian keluaran dilakukan setelah 30 hari onset stroke.
Hasil : Subyek terdiri dari 26 (51%) laki-laki dan 25 (49%) perempuan dengan rerata umur
59.4+10.3 tahun. Dijumpai korelasi positif sangat lemah antara kadar LDL-C dengan
kejadian stroke iskemik dan hemoragik akut (r=0.178, p=0.472). Dijumpai korelasi negatif
antara kadar LDL-C dengan skor NIHSS (r=-0.279, p=0.048), juga dengan skor mRS dalam
30 hari (r=-0.343, p=0.014). Subyek dengan kadar LDL-C 130 mg/dl (p=0.037).
Kesimpulan : Dijumpai korelasi positif sangat lemah yang tidak signifikan antara kadar LDLC dengan kejadian stroke iskemik dan hemoragik akut. Dijumpai pula korelasi negatif lemah
yang signifikan antara kadar LDL-C dengan keparahan dan keluaran stroke akut dalam 30
hari.
Kata Kunci : low-density lipoprotein cholesterol- stroke akut- kejadian stroke-keparahan
stroke.
Universitas Sumatera Utara
ABSTRACT
Introduction : The role of serum cholesterol as the stroke etiology is still uncertain.
Studies that focused on the association between low-density lipoprotein cholesterol (LDLC) and acute stroke was still rare, with inconsistent results. The aim of this study is to
evaluate the correlation between LDL-C level and the acute stroke occurance and
severity.
Methods : We conducted a cross-sectional study of 51-acute stroke patients in Adam
Malik General Hospital, Medan. Subjects was categorized according to their stroke type:
ischemic and hemorrhagic stroke. All subjects underwent evaluation of NIHSS score on
admission, Glasgow Coma Scale score, lesion volume and measurement of blood lipid
level. The outcome was assessed in 30-days after stroke onset.
Results : Subjects consists of 26 (51%) male and 25 (49%) female, with mean age of
59.4+10.3 years. There was a positive correlation between LDL-C level and the
occurance of acute ischemic and hemorrhagic stroke (r=0.178,p=0.472). There were
negative correlations between LDL-C level and NIHSS score on admission (r=-0.279,
p=0.048), and mRS score in 30 days (r=-0.343, p=0.014). There was an increase in odds
ratio for mortality in 30 days (OR=6.0;95%CI,0.941-42.8) in subjects with LDL-C level
130 mg/dl (p=0.037).
Conclusions : There was an insignificant very weak positive correlation between LDL-C
level and the occurance of acute ischemic and hemorrhagic stroke. There were also a
significant weak negative correlation between LDL-C level and stroke severity and
outcome in 30-days.
Keywords : acute stroke- low-density lipoprotein cholesterol- stroke occurance- stroke
severity.
Universitas Sumatera Utara
Latar Belakang : Peranan kolesterol serum sebagai penyebab stroke masih belum pasti.
Penelitian mengenai hubungan kadar low-density lipoprotein cholesterol (LDL-C) dengan
stroke akut masih sangat sedikit, dengan hasil yang tidak konsisten. Penelitian ini bertujuan
untuk mengetahui hubungan kadar LDL-C dengan kejadian dan korelasinya dengan
keparahan stroke akut.
Metode : Penelitian ini merupakan penelitian potong lintang terhadap 51 orang pasien
stroke akut yang dirawat di RSUP H. Adam Malik Medan. Subyek dikategorikan berdasarkan
tipe strokenya, yaitu: stroke iskemik dan hemoragik. Semua pasien menjalani penilaian skor
NIHSS saat masuk, skor SKG, penilaian volume lesi, pemeriksaan kadar lipid darah dan
penilaian keluaran dilakukan setelah 30 hari onset stroke.
Hasil : Subyek terdiri dari 26 (51%) laki-laki dan 25 (49%) perempuan dengan rerata umur
59.4+10.3 tahun. Dijumpai korelasi positif sangat lemah antara kadar LDL-C dengan
kejadian stroke iskemik dan hemoragik akut (r=0.178, p=0.472). Dijumpai korelasi negatif
antara kadar LDL-C dengan skor NIHSS (r=-0.279, p=0.048), juga dengan skor mRS dalam
30 hari (r=-0.343, p=0.014). Subyek dengan kadar LDL-C 130 mg/dl (p=0.037).
Kesimpulan : Dijumpai korelasi positif sangat lemah yang tidak signifikan antara kadar LDLC dengan kejadian stroke iskemik dan hemoragik akut. Dijumpai pula korelasi negatif lemah
yang signifikan antara kadar LDL-C dengan keparahan dan keluaran stroke akut dalam 30
hari.
Kata Kunci : low-density lipoprotein cholesterol- stroke akut- kejadian stroke-keparahan
stroke.
Universitas Sumatera Utara
ABSTRACT
Introduction : The role of serum cholesterol as the stroke etiology is still uncertain.
Studies that focused on the association between low-density lipoprotein cholesterol (LDLC) and acute stroke was still rare, with inconsistent results. The aim of this study is to
evaluate the correlation between LDL-C level and the acute stroke occurance and
severity.
Methods : We conducted a cross-sectional study of 51-acute stroke patients in Adam
Malik General Hospital, Medan. Subjects was categorized according to their stroke type:
ischemic and hemorrhagic stroke. All subjects underwent evaluation of NIHSS score on
admission, Glasgow Coma Scale score, lesion volume and measurement of blood lipid
level. The outcome was assessed in 30-days after stroke onset.
Results : Subjects consists of 26 (51%) male and 25 (49%) female, with mean age of
59.4+10.3 years. There was a positive correlation between LDL-C level and the
occurance of acute ischemic and hemorrhagic stroke (r=0.178,p=0.472). There were
negative correlations between LDL-C level and NIHSS score on admission (r=-0.279,
p=0.048), and mRS score in 30 days (r=-0.343, p=0.014). There was an increase in odds
ratio for mortality in 30 days (OR=6.0;95%CI,0.941-42.8) in subjects with LDL-C level
130 mg/dl (p=0.037).
Conclusions : There was an insignificant very weak positive correlation between LDL-C
level and the occurance of acute ischemic and hemorrhagic stroke. There were also a
significant weak negative correlation between LDL-C level and stroke severity and
outcome in 30-days.
Keywords : acute stroke- low-density lipoprotein cholesterol- stroke occurance- stroke
severity.
Universitas Sumatera Utara