Mengenal Metil P-Hidroksibenzoat.
Pikiran Rakyat
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E T I L p a r a h id r o k s ib e n z o a t (CBH803) d ik e n a l ju g a d e n g a n n a m a m e til p a r a b e n , n ip a g in , a ta u E 2 1 8 . S e n y a w a in i m e r u p a k a n
p e n g e m b a n g a n d a r i a s a m o r g a n ik d a n a lk o h o l ( m e t i l e s te r d a r i
a s a m p a r a h id r o k s ib e n z o a t) y a n g b a n y a k d ih a s ilk a n s e c a r a a la m i o le h b e b e r a p a je n is b u a h - b u a h a n te r u ta m a b l u e b e r r y .
M e tilp a r a b e n m e m ilik i s if a t a n tija m u r . J ik a d ig u n a k a n s e b a g a i p e n g a w e t,
s e n y a w a in i a k a n b e r f u n g s i p a d a m e d ia d r o s o p h ila s e h in g g a m e n g h a m b a t
la ju p e r tu m b u h a n d r o s o p h ila p a d a ta h a p la r v a d a n k e p o m p o n g . K a r e n a h a l
te r s e b u t m a k a m e til p a r a b e n c u k u p lu a s p e n g g u n a a n n y a s e b a g a i p e n g a w e t
d a la m b e r b a g a i b id a n g , d i a n ta r a n y a s e b a g a i b e r ik u t :
1.
B id a n g m a k a n a n
M e tilp a r a b e n d a p a t d ite m u k a n s e b a g a i p e n g a w e t a n tija m u r p a d a p r o d u k - p r o d u k k e c a p , s a o s , s e r e a 1 ,p r o d u k - p r o d u k r o ti, s u s u b e k u , m in y a k d a n
le m a k , s e la i, s ir u p , c o k la t k a k a o , m in u m a n k a le n g , d a n b u m b u - b u m b u
ke-
m a s a n . M e tilp a r a b e n s e la in d a p a t m e n c e g a h p e m b u s u k a n s u a tu p r o d u k
m a k a n a n o le h ja m u r , ju g a d a p a t m e m p e r ta h a n k a n
r a s a s u a tu p r o d u k
d ib a n d in g k a n d e n g a n p e n g a w e t la in , m e tilp a r a b e n le b ih m u d a h la r u t
d a la m 'a ir s e h in g g a d in ila i a m a n s a a t te r lib a t k o n ta k d e n g a n c a ir a n .
D i d a la m tu b u h p u n s e n y a w a in ijik a m a s ih d a la m a m b a n g b a ta s te r te n tu , r e la tif a m a n k a r e n a m u d a h d is e r a p , b a ik m e la lu i s a lu r a n p e n c e r n a a n
m a u p u n k u lit, m u d a h d im e ta b o lis m e tu b u h s e h in g g a b is a le b ih c e p a t .
d ik e lu a r k a n tu b u h ta n p a te I ja d i a k u m u la s i. B P P O M m e n e ta p k a n s e s u a i
C o d e x A lim e n ta r iu s C o m m is io n ( C A C )b a h w a ju in la h a s u p a n m e til p a r a b e n
d a la m tu b u h p e r h a r i ( a c c e p t a b l e d a i l y i n t a k e ) a d a la h 1 0 m g /k g b e r a t
b a d a n . J ik a b e r a t b a d a n s e s e o r a n g 5 0 k g , b e r a r ti k o n s u m s i a m a n m e tilp a r a b e n m a k s im u m a d a la h 5 0 0 m g /h a r i. J ik a b e r a t k e c a p d a la m b u m b u
m i in s ta n 4 g r d a n k a n d u n g a n m e tilp a r a b e n n y a 1 m g , m a k a 5 0 0 m g m e ti1 p a r a b e n itu s e ta r a d e n g a n 2 k g k e c a p . J u m la h k e c a p s e b a n y a k in i tid a k
m u n g k in d ik o n s u m s i s e s e o r a n g d a la m s a tu h a r i. S e b e n a r n y a m e tilp a r a b e n ,
pada m akanan
d a p a t d ih ila n g k a n
d e n g a n te lm o lo g i te m p e r a tu r
tin g g i,
te ta p i b ia y a n y a c u k u p tin g g i.
W a la u p u n d in ila i a m a n b a g i tu b u h , te ta p s a ja k o n s e n tr a s i m e tilp a r a b e n
te ta p p e r lu d ia w a s p a d a i. S u a tu s tu d i y a n g d ip u b lik a s ik a n d a la m J o u r n a l o f
T o x i c o l o g y M e i 2008 m e la p o r k a n b a h w a e s te r p a r a b e n tid a k s e la lu
A p p lie d
d a p a t d ip e c a h d a n d ik e lu a r k a n tu b u h . S e n y a w a in i b is a b e r tin d a k s e b a g a i
e s tr o g e n y a n g m e n u m p u k d i o r g a n r e p r o d u k s i s e h in g g a m e n y e b a b k a n
m a s a la h k e s e h a ta n k r o n is s e p e r ti k a n k e r p a y u d a r a d a n in f e r tilita s p r ia .
2.
B id a n g k o s m e tik
M e tilp a r a b e n s u d a h c u k u p la m a d ig u n a k a n s e b a g a i a n tija m u r d a la m
p r o d u k - p r o d u k k o s m e tik , s e p e r ti p e le m b a b w a ja h , a n tip e n u a a n , p e w a r n a
r a m b u t, p r o d u k p e m u tih k u lit, g e l c u k u r , p e m b e r s ih w a ja h , d a n p r o d u k
s a m p o . D a la m p e n g g u n a a n n y a
u n tu k k o s m e tik , m e tilp a r a b e n ja r a n g
m e n im b u lk a n
ir ita s i m e s k ip u n m e m ic u a le r g i p a d a s e b a g ia n o r a n g .
S e n y a w a in i te r g o lo n g n o n t o x i c s e k a lip u n te r s e r a p k u lit. N a m u n , te ta p s a ja p e n g g u n a a n n y a p e r lu d iw a s p a d a i s e b a b b e b e r a p a p e n e litia n m e la p o r k a n
b a h w a m e tilp a r a b e n d a p a t b e r e a k s i d e n g a n u ltr a v io le t B ( U V B ) y a n g d a p a t
m e n g a k ib a tk a n k e r u s a k a n D N A
3 . B id a n g f a r m a s i
D a la m in d u s tr l f a r m a s i, m e til p a r a b e n d ig u n a k a n u n tu k m e lin d u n g i o b a t
d a r i b a k te r i, s e p e r ti p a d a a n tib io tik tr o p ik a l, k o r tik o s tir o id , d a n o b a t te te s
m a ta . ( Y . Z a k ia h A .) * * *
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Jum a t
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E T I L p a r a h id r o k s ib e n z o a t (CBH803) d ik e n a l ju g a d e n g a n n a m a m e til p a r a b e n , n ip a g in , a ta u E 2 1 8 . S e n y a w a in i m e r u p a k a n
p e n g e m b a n g a n d a r i a s a m o r g a n ik d a n a lk o h o l ( m e t i l e s te r d a r i
a s a m p a r a h id r o k s ib e n z o a t) y a n g b a n y a k d ih a s ilk a n s e c a r a a la m i o le h b e b e r a p a je n is b u a h - b u a h a n te r u ta m a b l u e b e r r y .
M e tilp a r a b e n m e m ilik i s if a t a n tija m u r . J ik a d ig u n a k a n s e b a g a i p e n g a w e t,
s e n y a w a in i a k a n b e r f u n g s i p a d a m e d ia d r o s o p h ila s e h in g g a m e n g h a m b a t
la ju p e r tu m b u h a n d r o s o p h ila p a d a ta h a p la r v a d a n k e p o m p o n g . K a r e n a h a l
te r s e b u t m a k a m e til p a r a b e n c u k u p lu a s p e n g g u n a a n n y a s e b a g a i p e n g a w e t
d a la m b e r b a g a i b id a n g , d i a n ta r a n y a s e b a g a i b e r ik u t :
1.
B id a n g m a k a n a n
M e tilp a r a b e n d a p a t d ite m u k a n s e b a g a i p e n g a w e t a n tija m u r p a d a p r o d u k - p r o d u k k e c a p , s a o s , s e r e a 1 ,p r o d u k - p r o d u k r o ti, s u s u b e k u , m in y a k d a n
le m a k , s e la i, s ir u p , c o k la t k a k a o , m in u m a n k a le n g , d a n b u m b u - b u m b u
ke-
m a s a n . M e tilp a r a b e n s e la in d a p a t m e n c e g a h p e m b u s u k a n s u a tu p r o d u k
m a k a n a n o le h ja m u r , ju g a d a p a t m e m p e r ta h a n k a n
r a s a s u a tu p r o d u k
d ib a n d in g k a n d e n g a n p e n g a w e t la in , m e tilp a r a b e n le b ih m u d a h la r u t
d a la m 'a ir s e h in g g a d in ila i a m a n s a a t te r lib a t k o n ta k d e n g a n c a ir a n .
D i d a la m tu b u h p u n s e n y a w a in ijik a m a s ih d a la m a m b a n g b a ta s te r te n tu , r e la tif a m a n k a r e n a m u d a h d is e r a p , b a ik m e la lu i s a lu r a n p e n c e r n a a n
m a u p u n k u lit, m u d a h d im e ta b o lis m e tu b u h s e h in g g a b is a le b ih c e p a t .
d ik e lu a r k a n tu b u h ta n p a te I ja d i a k u m u la s i. B P P O M m e n e ta p k a n s e s u a i
C o d e x A lim e n ta r iu s C o m m is io n ( C A C )b a h w a ju in la h a s u p a n m e til p a r a b e n
d a la m tu b u h p e r h a r i ( a c c e p t a b l e d a i l y i n t a k e ) a d a la h 1 0 m g /k g b e r a t
b a d a n . J ik a b e r a t b a d a n s e s e o r a n g 5 0 k g , b e r a r ti k o n s u m s i a m a n m e tilp a r a b e n m a k s im u m a d a la h 5 0 0 m g /h a r i. J ik a b e r a t k e c a p d a la m b u m b u
m i in s ta n 4 g r d a n k a n d u n g a n m e tilp a r a b e n n y a 1 m g , m a k a 5 0 0 m g m e ti1 p a r a b e n itu s e ta r a d e n g a n 2 k g k e c a p . J u m la h k e c a p s e b a n y a k in i tid a k
m u n g k in d ik o n s u m s i s e s e o r a n g d a la m s a tu h a r i. S e b e n a r n y a m e tilp a r a b e n ,
pada m akanan
d a p a t d ih ila n g k a n
d e n g a n te lm o lo g i te m p e r a tu r
tin g g i,
te ta p i b ia y a n y a c u k u p tin g g i.
W a la u p u n d in ila i a m a n b a g i tu b u h , te ta p s a ja k o n s e n tr a s i m e tilp a r a b e n
te ta p p e r lu d ia w a s p a d a i. S u a tu s tu d i y a n g d ip u b lik a s ik a n d a la m J o u r n a l o f
T o x i c o l o g y M e i 2008 m e la p o r k a n b a h w a e s te r p a r a b e n tid a k s e la lu
A p p lie d
d a p a t d ip e c a h d a n d ik e lu a r k a n tu b u h . S e n y a w a in i b is a b e r tin d a k s e b a g a i
e s tr o g e n y a n g m e n u m p u k d i o r g a n r e p r o d u k s i s e h in g g a m e n y e b a b k a n
m a s a la h k e s e h a ta n k r o n is s e p e r ti k a n k e r p a y u d a r a d a n in f e r tilita s p r ia .
2.
B id a n g k o s m e tik
M e tilp a r a b e n s u d a h c u k u p la m a d ig u n a k a n s e b a g a i a n tija m u r d a la m
p r o d u k - p r o d u k k o s m e tik , s e p e r ti p e le m b a b w a ja h , a n tip e n u a a n , p e w a r n a
r a m b u t, p r o d u k p e m u tih k u lit, g e l c u k u r , p e m b e r s ih w a ja h , d a n p r o d u k
s a m p o . D a la m p e n g g u n a a n n y a
u n tu k k o s m e tik , m e tilp a r a b e n ja r a n g
m e n im b u lk a n
ir ita s i m e s k ip u n m e m ic u a le r g i p a d a s e b a g ia n o r a n g .
S e n y a w a in i te r g o lo n g n o n t o x i c s e k a lip u n te r s e r a p k u lit. N a m u n , te ta p s a ja p e n g g u n a a n n y a p e r lu d iw a s p a d a i s e b a b b e b e r a p a p e n e litia n m e la p o r k a n
b a h w a m e tilp a r a b e n d a p a t b e r e a k s i d e n g a n u ltr a v io le t B ( U V B ) y a n g d a p a t
m e n g a k ib a tk a n k e r u s a k a n D N A
3 . B id a n g f a r m a s i
D a la m in d u s tr l f a r m a s i, m e til p a r a b e n d ig u n a k a n u n tu k m e lin d u n g i o b a t
d a r i b a k te r i, s e p e r ti p a d a a n tib io tik tr o p ik a l, k o r tik o s tir o id , d a n o b a t te te s
m a ta . ( Y . Z a k ia h A .) * * *
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