Gambaran Kadar Gamma Glutamyl Transferase Serum Pada Diabetes Mellitus Tipe 2.

ABSTRAK

Irene Evelyn 2011

Pembimbing I : Adrian Suhendra, dr. Sp.PK.,M.Kes
Pembimbing II : Heddy Herdiman, dr.,M.Kes

Latar Belakang Diabetes Mellitus (DM) merupakan salah satu penyakit
metabolik dengan sifat kronis yang jumlah penderitanya terus meningkat dari
tahun ke tahun. DM adalah keadaan dimana terjadi peningkatan kadar glukosa
dalam darah. Hiperglikemia akan meingkatkan Reactive Oxygen Species (ROS)
yang toksik melebihi pertahanan antioksidan endogen sehingga akan
menimbulkan pembentukan stres oksidatif. Stres oksidatif yang berlebihan akan
menyebabkan kerusakan jaringan dan sel, dalam hal ini hepar sehingga akan
meningkatkan enzim Gamma glutamyltransferase (GGT) dalam darah.
Tujuan Penelitian Untuk mengetahui gambaran kadar GGT serum pada
diabetes mellitus tipe 2.
Metode Penelitian Menggunakan desain penelitian observational dengan
rancangan penelitian cross sectional. Subjek atau bahan pemeriksaan diambil
secara consecutive sampling pada penderita diabetes mellitus tipe 2. Subjek
penelitian berjumlah 62 orang terdiri dari penderita diabetes mellitus tipe 2 baik

pria maupun wanita yang datang ke Poliklinik Penyakit Dalam Rumah Sakit
Efarina Etaham, Purwakarta. Lakukan pengambilan darah vena dan pemeriksaan
kadar GGT serum. Pemeriksaan GGT menggunakan metode fotometer yang
dilakukan secara otomatis dengan menggunakan alat ABX Pentra 400. Data yang
terkumpul dianalisis dengan metode deskriptif.
Hasil Dari 62 orang subjek penelitian terdapat peningkatan kadar GGT serum
sebanyak 58 orang (93,55%) yang terdiri dari 27 orang dari 29 orang laki-laki
(93,10%) dan 31 orang dari 33 orang perempuan (93,94%), sedangkan subjek
penelitian yang tidak mengalami peningkatan kadar GGT serum sebanyak 4 orang
(6,45%).
Kesimpulan Terdapat peningkatan kadar GGT serum pada diabetes melitus
tipe 2.
Kata kunci : gamma glutamyltransferase, diabetes mellitus tipe 2, hiperglikemia,
stres oksidatif

iv

ABSTRACT
Irene Evelyn 2011

Tutor I : Adrian Suhendra, dr., Sp.PK., M.Kes
Tutor II : Heddy Herdiman, dr.,M.Kes

Background Diabetes Mellitus (DM) is a chronic metabolic disease with the
nature of the number of sufferers continues to increase from year to year. DM is a
situation where there is an increase in blood glucose levels. Hyperglycemia will
boost the Reactive Oxygen Species (ROS) are toxic endogenous antioxidant
defenses, so exceeded would lead to the formation of oxidative stress. Excessive
oxidative stress will cause damage to tissues and cells, in this case so that it will
increase the hepatic enzyme gamma glutamyltransferase (GGT) in the blood.
Research Objectives To know the description of GGT serum levels in type 2
diabetes melitus.
Method Using the observational study design with cross sectional study
design. Subject or examination material taken consecutive sampling in patients
with type 2 diabetes mellitus. There are 62 people as research subjects consisting
of patients (both men and women) were type 2 DM admitted to Internal Medicine
Departement of Efarina Etaham Purwakarta Hospital. Then do the venous blood
sampling and examination of serum GGT levels. Examination of GGT using
photometer method which is done automatically by using a tool ABX Pentra 400.
The collected data were analyzed with descriptive methods.

Result There are 58 people from 62 people (93,55%) consisting of 27 from 29
men (93.10%) and 31from 33 women (93.94%) who got increasing level of serum
GGT whereas there are 4 people (6,45%) who did not get increasing level of
serum GGT.
Conclusion There is an increase in serum GGT levels in type 2 diabetes
mellitus
Key Words : gamma glutamyltransferase, type 2 diabetes mellitus, hyperglicemia,
stress oksidative

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