Introduction Directory UMM :Data Elmu:jurnal:A:Atherosclerosis:Vol154.Issue1.Jan2001:
Atherosclerosis 154 2001 229 – 236
Remnant-like particle RLP cholesterol is an independent cardiovascular disease risk factor in women: results from the
Framingham Heart Study
Judith R. McNamara
a,b,c,
, Paulesh K. Shah
b
, Katsuyuki Nakajima
d
, L. Adrienne Cupples
e
, Peter W.F. Wilson
f
, Jose M. Ordovas
c
, Ernst J. Schaefer
b,c
a
Lipid Research Laboratory, New England Medical Center,
750
Washington Street, Box
216
, Boston, MA
02111
, USA
b
Lipid Research Laboratory, Di6ision of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Boston, MA, USA
c
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts Uni6ersity, Boston, MA, USA
d
Otsuka America Pharmaceutical Incorporated, Rock6ille, MD, USA
e
Department of Epidemiology and Biostatistics, Boston Uni6ersity School of Public Health, Boston, MA, USA
f
National Heart, Lung, and Blood Institute
’
s Framingham Heart Study, National Institutes of Health, Framingham, MA, USA Received 9 December 1999; received in revised form 16 March 2000; accepted 23 March 2000
Abstract
Remnants of triglyceride-rich lipoproteins TRL of both intestinal and liver origin are considered to be atherogenic, but separation of remnant lipoproteins from other TRL is difficult. An assay has been developed that allows immunoseparation of
remnant-like particles RLP and measurement of cholesterol RLP-C and triglyceride RLP-TG. We measured RLP-C and RLP-TG in fast plasma samples obtained from 1567 women participating in cycle 4 of the Framingham heart study FHS. When
values from 83 women with cardiovascular disease CVD were compared with the values from 1484 women without disease, concentrations in women with CVD were found to be significantly higher for both RLP-C 0.215 9 0.102 vs. 0.186 9 0.162 mmoll;
+
15.6; P B 0.0001 and RLP-TG 0.319 9 0.352 vs. 0.251 9 0.716 mmoll; + 27.0; P B 0.0002. Logistic regression analysis revealed that RLP-C was significantly associated with prevalent CVD in women P B 0.002 after adjustment with other major
risk factors. In conclusion, we have documented that RLP-C is an independent risk factor for CVD in women, and provides significantly more information than do triglycerides. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
Keywords
:
Lipoproteins; Very low density lipoproteins; Chylomicrons; Triglycerides; Apolipoprotein B; Cardiovascular disease www.elsevier.comlocateatherosclerosis