Linearitas dan Sensitivitas Metode Parameter Data Kandungan Obat Sediaan Data Presisi Kandungan Piroksikam dalam Matriks Hidrokoloid a. Intraday

57 Gambar 1. Kurva Kalibrasi Piroksikam

6. Linearitas dan Sensitivitas Metode Parameter

Nilai λ Panjang Gelombang Max. 354 Rentang Linearitas 0.2 – 2.0 µgmL Slope 0.0009 Intercept 0.0482 Correlation Coefficient R 2 0.9998 LOD µgmL 0.0897 LOQ µgmL 0.2719

7. Data Kandungan Obat Sediaan

Hydrocolloid Matrix Piroksikam Persamaan kurva kalibrasi: y = 0.0482x + 0.0009 X = kadar ; Y = AUC Tabel Kandungan Obat Piroksikam dalam Sediaan Formula Abs Kadar Terukur µgmL Q Obat µg Q Obat mg �̅ Q Obat SD CV Q Obat Teoritis mg Recovery PVP 1 1 0.683 14.151 707.573 0.708 0.612 0.064 10.458 0.682 89.726 2 0.567 11.745 587.241 0.587 3 0.590 12.222 611.100 0.611 4 0.601 12.450 622.510 0.623 5 0.513 10.624 531.224 0.531 PVP 2 1 0.528 10.936 546.784 0.547 0.642 0.125 19.485 0.675 95.174 2 0.635 13.156 657.780 0.658 3 0.558 11.558 577.905 0.578 4 0.824 17.077 853.838 0.854 y = 0.0482x + 0.0009 R² = 0.9998 0.0000 0.2000 0.4000 0.6000 0.8000 1.0000 1.2000 5 10 15 20 25 A b so rb a n si Kosentrasi µgml Kurva Kalibrasi Piroksikam 58 5 0.556 11.517 575.830 0.576 PVP 3 1 0.645 13.363 668.154 0.668 0.559 0.073 13.074 0.672 83.219 2 0.481 9.961 498.029 0.498 3 0.484 10.023 501.141 0.501 4 0.512 10.604 530.187 0.530 5 0.578 11.973 598.651 0.599

8. Data Presisi Kandungan Piroksikam dalam Matriks Hidrokoloid a. Intraday

Hari ke- Konsentrasi µgml Abs �̅ Abs C terukur µgml �̅ C ukur µgml Recovery �̅ Rec SD CV No adisi 1 5.312 0.263 0.265 5.438 5.472 102.367 103.018 0.813 0.789 2 5.312 0.267 5.521 103.930 3 5.312 0.264 5.459 102.758 Adisi 1 1 7.312 0.326 0.328 6.745 6.779 71.641 73.370 1.585 2.160 2 7.312 0.329 6.807 74.753 3 7.312 0.328 6.786 73.715 Adisi 2 1 9.312 0.430 0.433 8.902 8.972 89.762 91.491 2.559 2.796 2 9.312 0.431 8.923 90.281 3 9.312 0.439 9.089 94.430 Adisi 3 1 11.312 0.510 0.511 10.562 10.576 87.504 87.735 0.200 0.228 2 11.312 0.511 10.583 87.850 3 11.312 0.511 10.583 87.850

b. Interday

Hari ke- Konsentrasi µgml Abs �̅ Abs C terukur µgml �̅ C ukur µgml Recovery �̅ Rec SD CV No adisi 1 5.343 0.225 0.249 4.649 5.154 87.018 95.738 7.654 7.995 2 5.468 0.268 5.541 101.344 3 5.333 0.255 5.272 98.852 Adisi 1 1 7.343 0.350 0.348 7.243 7.208 94.987 91.341 4.257 4.661 2 7.468 0.348 7.201 86.662 3 7.333 0.347 7.180 92.375 Adisi 2 1 9.343 0.409 0.429 8.467 8.882 78.095 87.510 10.028 11.459 2 9.468 0.431 8.923 86.381 3 9.333 0.447 9.255 98.055 Adisi 3 1 11.343 0.560 0.538 11.600 11.150 104.276 96.146 7.193 7.481 2 11.468 0.535 11.081 93.549 3 11.333 0.520 10.770 90.612 59 Lampiran 8. Data Uji Pelepasan In Vitro Sediaan Hydrocolloid Matrix Piroksikam 1. Data Uji Pelepasan In Vitro

a. Replikasi 1 Formula PVP 1

Waktu menit Abs Kadar sebenarnya µgmL Q obat 3 mL µg Q obat 15 mL µg Q kum µg release AUC DE 15 0.018 0.355 1.064 5.322 5.322 0.870 34.564 19.214 30 0.071 1.454 4.363 21.815 22.880 3.739 98.048 45 0.167 3.446 10.338 51.691 57.118 9.334 182.815 60 0.246 5.085 15.255 76.276 92.041 15.041 542.030 90 0.316 6.537 19.612 98.060 129.081 21.094 655.723 120 0.283 5.853 17.558 87.790 138.423 22.621 1342.632 180 0.217 4.483 13.450 67.251 135.442 22.134 1363.442 240 0.197 4.068 12.205 61.027 142.668 23.314 1364.114 300 0.135 2.782 8.346 41.732 135.579 22.156 1333.661 360 0.111 2.284 6.853 34.263 136.456 22.299 AUC 6917.029 Luas Area 100 36000 Formula PVP 2 Waktu menit Abs Kadar sebenarnya µgmL Q obat 3 mL µg Q obat 15 mL µg Q kum µg release AUC DE 15 0.067 1.371 4.114 20.571 20.571 3.202 106.603 59.022 30 0.215 4.442 13.326 66.629 70.743 11.012 236.321 45 0.368 7.616 22.849 114.243 131.683 20.498 369.744 60 0.466 9.649 28.948 144.741 185.029 28.802 1045.718 90 0.623 12.907 38.720 193.600 262.836 40.913 1397.726 120 0.733 15.189 45.566 227.832 335.788 52.269 3562.537 180 0.880 18.239 54.716 273.579 427.102 66.483 4383.975 240 0.976 20.230 60.691 303.454 511.693 79.650 4967.951 300 0.911 18.882 56.645 283.226 552.156 85.948 5177.277 360 0.743 15.396 46.189 230.944 556.519 86.628 AUC 21247.853 Luas Area 100 36000 Formula PVP 3 60 Waktu menit Abs Kadar sebenarnya µgmL Q obat 3 mL µg Q obat 15 mL µg Q kum µg release AUC DE 15 0.029 0.583 1.749 8.745 8.745 1.564 85.902 45.257 30 0.173 3.571 10.712 53.558 55.307 9.890 205.284 45 0.275 5.687 17.060 85.301 97.761 17.481 328.506 60 0.379 7.844 23.533 117.666 147.187 26.319 967.897 90 0.517 10.707 32.122 160.612 213.666 38.207 1254.909 120 0.544 11.268 33.803 169.015 254.191 45.454 2965.311 180 0.578 11.973 35.919 179.595 298.575 53.390 3324.309 240 0.535 11.081 33.243 166.214 321.112 57.420 3484.977 300 0.452 9.359 28.077 140.384 328.525 58.746 3675.361 360 0.452 9.359 28.077 140.384 356.602 63.766 AUC 16292.456 Luas Area 100 36000

b. Replikasi 2 Formula PVP 1

Waktu menit Abs Kadar sebenarnya µgmL Q obat 3 mL µg Q obat 15 mL µg Q kum µg release AUC DE 15 0.098 2.015 6.044 30.218 30.218 4.938 111.993 45.622 30 0.178 3.674 11.023 55.114 61.158 9.994 196.607 45 0.265 5.479 16.438 82.189 99.255 16.220 314.939 60 0.400 8.280 24.840 124.201 157.705 25.772 905.753 90 0.494 10.230 30.691 153.454 211.799 34.612 1147.146 120 0.538 11.143 33.429 167.147 256.183 41.865 2843.599 180 0.648 13.425 40.276 201.380 323.844 52.922 3377.344 240 0.651 13.488 40.463 202.313 365.054 59.656 3686.204 300 0.591 12.243 36.728 183.641 386.844 63.217 3840.359 360 0.504 10.438 31.313 156.566 396.498 64.795 AUC 16432.944 Luas Area 100 36000 Formula PVP 2 Waktu menit Abs Kadar sebenarnya µgmL Q obat 3 mL µg Q obat 15 mL µg Q kum µg release AUC DE 15 0.074 1.517 4.550 22.749 22.749 3.541 102.752 67.799 30 0.196 4.048 12.143 60.716 65.266 10.159 205.439 45 0.303 6.268 18.803 94.015 110.707 17.233 427.221 60 0.707 14.649 43.948 219.741 255.237 39.730 1249.465 61 90 0.645 13.363 40.089 200.446 279.890 43.568 1515.439 120 0.803 16.641 49.923 249.616 369.149 57.462 4004.908 180 0.616 21.268 63.803 319.015 488.471 76.035 5043.171 240 0.692 23.882 71.645 358.226 591.485 92.070 5757.068 300 0.650 22.429 67.288 336.442 641.346 99.832 6102.129 360 0.943 19.546 58.637 293.185 665.378 103.572 AUC 24407.592 Luas Area 100 36000 Formula PVP 3 Waktu menit Abs Kadar sebenarnya µgmL Q obat 3 mL µg Q obat 15 mL µg Q kum µg release AUC DE 15 0.200 4.131 12.392 61.961 61.961 11.080 263.781 75.096 30 0.394 8.156 24.467 122.334 134.726 24.091 465.551 45 0.565 11.703 35.110 175.550 212.409 37.982 568.406 60 0.449 9.297 27.890 139.450 211.419 37.805 1638.849 90 0.964 19.981 59.944 299.720 399.579 71.451 2339.384 120 0.604 20.853 62.558 312.790 472.593 84.508 5173.993 180 0.867 17.969 53.907 269.533 491.894 87.959 5368.050 240 0.748 15.500 46.500 232.500 508.768 90.976 5529.386 300 0.641 13.280 39.840 199.201 521.969 93.337 5687.049 360 0.565 11.703 35.110 175.550 538.158 96.232 AUC 27034.450 Luas Area 100 36000

c. Replikasi 3

Formula PVP 1 Waktu menit Abs Kadar sebenarnya µgmL Q obat 3 mL µg Q obat 15 mL µg Q kum µg release AUC DE 15 0.124 2.554 7.662 38.309 38.309 6.260 181.488 36.244 30 0.329 6.807 20.421 102.106 109.768 17.938 325.375 45 0.411 8.508 25.525 127.624 155.707 25.445 417.923 60 0.424 8.778 26.334 131.670 185.278 30.278 978.222 90 0.431 8.923 26.770 133.849 213.790 34.937 1071.015 120 0.375 7.761 23.284 116.421 223.133 36.464 2259.263 180 0.347 7.180 21.541 107.707 237.703 38.845 2572.089 240 0.436 9.027 27.081 135.405 286.942 46.891 2601.443 300 0.210 4.338 13.015 65.073 243.691 39.823 2640.867 360 0.333 6.890 20.670 103.351 294.983 48.205 AUC 13047.683 62 Luas Area 100 36000 Formula PVP 2 Waktu menit Abs Kadar sebenarnya µgmL Q obat 3 mL µg Q obat 15 mL µg Q kum µg release AUC DE 15 0.076 1.558 4.674 23.371 23.371 3.638 126.876 34.780 30 0.260 5.376 16.127 80.633 85.307 13.279 249.982 45 0.348 7.201 21.604 108.019 128.820 20.052 344.530 60 0.399 8.259 24.778 123.890 166.295 25.885 881.646 90 0.464 9.608 28.824 144.118 211.301 32.891 1055.484 120 0.466 9.649 28.948 144.741 240.747 37.475 2396.736 180 0.475 9.836 29.508 147.541 272.496 42.417 2344.187 240 0.242 5.002 15.006 75.031 229.494 35.723 2296.288 300 0.299 6.185 18.554 92.770 262.239 40.820 2825.040 360 0.498 10.313 30.940 154.699 342.722 53.348 AUC 12520.769 Luas Area 100 36000 Formula PVP 3 Waktu menit Abs Kadar sebenarnya µgmL Q obat 3 mL µg Q obat 15 mL µg Q kum µg release AUC DE 15 0.173 3.571 10.712 53.558 53.558 9.577 247.755 71.150 30 0.388 8.031 24.093 120.467 131.178 23.457 477.655 45 0.612 12.678 38.035 190.176 224.981 40.230 711.645 60 0.749 15.521 46.562 232.811 305.651 54.656 1859.717 90 0.863 17.886 53.658 268.288 387.691 69.326 2211.170 120 0.848 17.575 52.724 263.620 436.680 78.086 4819.402 180 0.759 15.728 47.185 235.923 461.707 82.561 5008.117 240 0.640 13.259 39.778 198.890 471.859 84.376 5147.416 300 0.563 11.662 34.985 174.927 487.674 87.204 5131.122 360 0.390 8.073 24.218 121.089 468.822 83.833 AUC 25613.998 Luas Area 100 36000

d. Rata-rata Data Uji Pelepasan Obat

Waktu menit Formula PVP 1 Formula PVP 2 Formula PVP 3 15 4.023 3.460 7.407 30 10.557 11.483 19.146 63 45 17.000 19.261 31.898 60 23.697 31.472 39.593 90 30.214 39.124 59.661 120 33.650 49.068 69.349 180 37.967 61.645 74.637 240 43.287 69.148 77.591 300 41.732 75.533 79.762 360 45.100 81.183 81.277 DE360 33.693 53.867 63.834

e. Grafik rata-rata release vs waktu pelepasan obat piroksikam

10 20 30 40 50 60 70 80 90 50 100 150 200 250 300 350 400 Re lea se Waktu Menit Grafik Waktu vs Release Obat Piroksikam Formula 1 Formula 2 Formula 3 64 Lampiran 9. Data Uji Stabilitas Sediaan Hydrocolloid Matrix Piroksikam 1. Data Uji Stabilitas Sediaan

a. Stabilitas Minggu I Suhu 37

o C i. Uji Organoleptis Formula Warna Kejernihan Kehalusan Kelengketan PVP 1 Kuning Terdispersi Halus Kering PVP 2 Kuning Terdispersi Halus Kering PVP 3 Kuning Terdispersi Agak kasar ada gelembung Kering ii. Uji Keseragaman Bobot PVP 1 PVP 2 PVP 3 1 0.0140 0.0164 0.0048 2 0.0137 0.0155 0.0093 3 0.0100 0.0152 0.0072 4 0.0101 0.0187 0.0134 5 0.0111 0.0200 0.0157 6 0.0144 0.0114 0.0169 7 0.0110 0.0179 0.0163 8 0.0081 0.0161 0.0197 9 0.0113 0.0177 0.0192 10 0.0136 0.0173 0.0099 �̅ 0.01173 0.01662 0.01324 SD 0.00199 0.00223 0.00490 CV 16.97 13.43 37.04 iii. Uji Ketebalan PVP 1 PVP 2 PVP 3 1 0.10 0.15 0.15 2 0.10 0.15 0.15 3 0.10 0.15 0.15 4 0.10 0.15 0.15 5 0.10 0.15 0.15 �̅ 0.10 0.15 0.15 iv. Uji pH Sediaan pH PVP 1 7 PVP 2 6.9 PVP 3 6.9 65

v. Uji Moisture Content dan Moisture Absorption

Bobot awal Bobot akhir Bobot akhir MC �̅ MC SD CV MA �̅ MA SD CV P1 1 0.0140 0.0138 0.0141 1.449 4.228 2.839 67.147 2.174 2.673 2.243 83.946 2 0.0137 0.0133 0.0134 3.008 0.752 3 0.0100 0.0092 0.0095 8.696 3.261 4 0.0101 0.0096 0.0102 5.208 6.250 5 0.0111 0.0108 0.0109 2.778 0.926 P2 1 0.0164 0.0149 0.0155 10.067 6.721 2.918 43.423 4.027 2.736 0.917 33.531 2 0.0155 0.0147 0.0150 5.442 2.041 3 0.0152 0.0139 0.0142 9.353 2.158 4 0.0187 0.0177 0.0183 5.650 3.390 5 0.0200 0.0194 0.0198 3.093 2.062 P3 1 0.0048 0.0045 0.0050 6.667 4.051 3.241 79.990 11.111 5.208 3.589 68.926 2 0.0093 0.0086 0.0091 8.140 5.814 3 0.0072 0.0071 0.0074 1.408 4.225 4 0.0134 0.0133 0.0136 0.752 2.256 5 0.0157 0.0152 0.0156 3.289 2.632 vi. Uji Ketahanan Pelipatan Frekuensi PVP 1 105 PVP 2 111 PVP 3 45 vii. Uji Kandungan Obat dalam Sediaan Formula Abs Kadar Terukur µgmL Q Obat µg Q Obat mg �̅ Q Obat SD CV Q Obat Teoritis mg Recovery P1 1 0.513 10.624 531.224 0.531 0.513 0.057 11.202 0.682 75.215 2 0.456 9.442 472.095 0.472 3 0.420 8.695 434.751 0.435 4 0.545 11.288 564.419 0.564 5 0.543 11.247 562.344 0.562 P2 1 0.593 12.284 614.212 0.614 0.560 0.073 12.978 0.675 83.034 2 0.549 11.371 568.568 0.569 3 0.559 11.579 578.942 0.579 4 0.585 12.118 605.913 0.606 5 0.420 8.695 434.751 0.435 P3 1 0.633 13.114 655.705 0.656 0.648 0.050 7.745 0.672 96.464 2 0.639 13.239 661.929 0.662 66 3 0.542 11.226 561.307 0.561 4 0.665 13.778 688.900 0.689 5 0.650 13.467 673.340 0.673

b. Stabilitas Minggu I Suhu 45

o C i. Uji Organoleptis Formula Warna Kejernihan Kehalusan Kelengketan PVP 1 Kuning Terdispersi Halus Kering PVP 2 Kuning Terdispersi Halus Kering PVP 3 Kuning Terdispersi Agak kasar ada gelembung Kering ii. Uji Keseragaman Bobot PVP 1 PVP 2 PVP 3 1 0.0128 0.0086 0.0088 2 0.0129 0.0105 0.0133 3 0.0126 0.0112 0.0092 4 0.0154 0.0094 0.0098 5 0.0162 0.0090 0.0112 6 0.0145 0.0100 0.0121 7 0.0163 0.0103 0.0053 8 0.0132 0.0109 0.0062 9 0.0113 0.0093 0.0112 10 0.0135 0.0106 0.0083 �̅ 0.01387 0.00998 0.00954 SD 0.00158 0.00082 0.00240 CV 11.39 8.24 25.16 iii. Uji Ketebalan PVP 1 PVP 2 PVP 3 1 0.20 0.15 0.20 2 0.20 0.15 0.20 3 0.20 0.15 0.25 4 0.20 0.15 0.25 5 0.20 0.15 0.20 �̅ 0.20 0.15 0.22 67 iv. Uji pH Sediaan pH PVP 1 6.9 PVP 2 7 PVP 3 7

v. Uji Moisture Content dan Moisture Absorption

Bobot awal Bobot akhir Bobot akhir MC �̅ MC SD CV MA �̅ MA SD CV P1 1 0.0128 0.0127 0.0127 0.787 2.167 2.377 109.70 0.000 1.388 1.597 115.073 2 0.0129 0.0128 0.0130 0.781 1.562 3 0.0126 0.0123 0.0128 2.439 4.065 4 0.0154 0.0145 0.0146 6.207 0.690 5 0.0162 0.0161 0.0162 0.621 0.621 P2 1 0.0086 0.0082 0.0083 4.878 6.685 5.879 87.95 1.220 2.262 2.574 113.765 2 0.0112 0.0101 0.0102 10.891 0.990 3 0.0094 0.0082 0.0083 14.634 1.220 4 0.0100 0.0098 0.0099 2.041 1.020 5 0.0103 0.0102 0.0109 0.980 6.863 P3 1 0.0088 0.0083 0.0083 6.024 2.507 2.313 92.24 0.000 2.433 2.288 94.044 2 0.0092 0.0089 0.0090 3.371 1.124 3 0.0053 0.0052 0.0055 1.923 5.769 4 0.0062 0.0062 0.0063 0.000 1.613 5 0.0083 0.0082 0.0085 1.220 3.659 vi. Uji Ketahanan Pelipatan Frekuensi PVP 1 41 PVP 2 45 PVP 3 30 vii. Uji Kandungan Obat dalam Sediaan Formula Abs Kadar Terukur µgmL Q Obat µg Q Obat mg �̅ Q Obat SD CV Q Obat Teoritis mg Recovery P1 1 0.586 12.139 606.950 0.607 0.608 0.054 8.920 0.682 89.148 2 0.658 13.633 681.639 0.682 3 0.597 12.367 618.361 0.618 4 0.511 10.583 529.149 0.529 5 0.583 12.077 603.838 0.604 P2 1 0.454 9.400 470.021 0.470 0.478 0.075 15.657 0.675 70.770 68 2 0.447 9.255 462.759 0.463 3 0.579 11.994 599.689 0.600 4 0.381 7.886 394.295 0.394 5 0.446 9.234 461.722 0.462 P3 1 0.529 10.956 547.822 0.548 0.504 0.054 10.624 0.672 74.945 2 0.400 8.280 414.004 0.414 3 0.496 10.272 513.589 0.514 4 0.522 10.811 540.560 0.541 5 0.485 10.044 502.178 0.502

c. Stabilitas Minggu II Suhu 37

o C i. Uji Organoleptis Formula Warna Kejernihan Kehalusan Kelengketan PVP 1 Kuning Terdispersi Halus Kering PVP 2 Kuning Terdispersi Halus Kering PVP 3 Kuning Terdispersi Agak kasar ada gelembung Kering ii. Uji Keseragaman Bobot PVP 1 PVP 2 PVP 3 1 0.0116 0.0171 0.0087 2 0.0112 0.0123 0.0123 3 0.0115 0.0128 0.0083 4 0.0142 0.0119 0.0090 5 0.0124 0.0116 0.0092 6 0.0127 0.0119 0.0150 7 0.0127 0.0122 0.0137 8 0.0084 0.0111 0.0076 9 0.0141 0.0124 0.0117 10 0.0133 0.0117 0.0082 �̅ 0.01221 0.0125 0.01037 SD 0.00160 0.00160 0.00246 CV 13.12 12.78 23.76 iii. Uji Ketebalan PVP 1 PVP 2 PVP 3 1 0.20 0.25 0.25 2 0.20 0.25 0.25 3 0.20 0.25 0.25 4 0.20 0.25 0.25 5 0.20 0.25 0.25 69 �̅ 0.20 0.25 0.25 iv. Uji pH Sediaan pH PVP 1 7.4 PVP 2 7.4 PVP 3 7.4

v. Uji Moisture Content dan Moisture Absorption

Bobot awal Bobot akhir Bobot akhir MC �̅ MC SD CV MA �̅ MA SD CV P1 1 0.0116 0.0114 0.0122 1.754 1.211 0.526 43.449 7.018 6.735 2.819 41.861 2 0.0112 0.0110 0.0112 1.818 1.818 3 0.0115 0.0114 0.0124 0.877 8.772 4 0.0124 0.0123 0.0133 0.813 8.130 5 0.0127 0.0126 0.0136 0.794 7.937 P2 1 0.0171 0.0170 0.0178 0.588 5.459 3.329 60.990 4.706 3.763 1.969 52.313 2 0.0123 0.0115 0.0120 6.957 4.348 3 0.0128 0.0123 0.0125 4.065 1.626 4 0.0119 0.0112 0.0119 6.250 6.250 5 0.0116 0.0106 0.0108 9.434 1.887 P3 1 0.0087 0.0086 0.0092 1.163 0.851 0.944 110.976 6.977 8.579 4.493 52.375 2 0.0123 0.0122 0.0138 0.820 13.115 3 0.0083 0.0083 0.0087 0.000 4.819 4 0.0090 0.0088 0.0100 2.273 13.636 5 0.0092 0.0092 0.0096 0.000 4.348 vi. Uji Ketahanan Pelipatan Frekuensi PVP 1 36 PVP 2 35 PVP 3 25 vii. Uji Kandungan Obat dalam Sediaan Formula Abs Kadar Terukur µgmL Q Obat µg Q Obat mg �̅ Q Obat SD CV Q Obat Teoritis mg Recovery P1 1 0.441 9.131 456.535 0.457 0.596 0.080 13.346 0.682 87.444 2 0.622 12.886 644.295 0.644 3 0.585 12.118 605.913 0.606 4 0.617 12.782 639.108 0.639 70 5 0.614 12.720 635.996 0.636 P2 1 0.794 16.454 822.718 0.823 0.747 0.132 17.704 0.675 110.635 2 0.504 10.438 521.888 0.522 3 0.815 16.890 844.502 0.845 4 0.781 16.185 809.232 0.809 5 0.710 14.712 735.581 0.736 P3 1 0.594 12.305 615.249 0.615 0.509 0.114 22.388 0.672 75.748 2 0.585 12.118 605.913 0.606 3 0.406 8.405 420.228 0.420 4 0.525 10.873 543.672 0.544 5 0.348 7.201 360.062 0.360

d. Stabilitas Minggu II Suhu 45

o C i. Uji Organoleptis Formula Warna Kejernihan Kehalusan Kelengketan PVP 1 Kuning Terdispersi Halus Kering PVP 2 Kuning Terdispersi Halus Kering PVP 3 Kuning Terdispersi Agak kasar ada gelembung Kering ii. Uji Keseragaman Bobot PVP 1 PVP 2 PVP 3 1 0.0113 0.0083 0.0104 2 0.0112 0.0088 0.0136 3 0.0082 0.0093 0.0049 4 0.0077 0.0092 0.0080 5 0.0100 0.0117 0.0190 6 0.0098 0.0080 0.0096 7 0.0121 0.0115 0.0060 8 0.0139 0.0118 0.0073 9 0.0105 0.0114 0.0121 10 0.0101 0.0112 0.0139 �̅ 0.01048 0.01012 0.01048 SD 0.00171 0.00145 0.00406 CV 16.33 14.35 38.75 iii. Uji Ketebalan PVP 1 PVP 2 PVP 3 1 0.15 0.15 0.15 2 0.15 0.15 0.15 3 0.15 0.15 0.15 71 4 0.15 0.15 0.15 5 0.15 0.15 0.15 �̅ 0.15 0.15 0.15 iv. Uji pH Sediaan pH PVP 1 7.1 PVP 2 7.1 PVP 3 7.3

v. Uji Moisture Content dan Moisture Absorption

Bobot awal Bobot akhir Bobot akhir MC �̅ MC SD CV MA �̅ MA SD CV P1 1 0.0113 0.0112 0.0122 0.893 6.315 5.832 92.347 8.929 11.917 2.972 24.943 2 0.0112 0.0111 0.0122 0.901 9.910 3 0.0082 0.0076 0.0084 7.895 10.526 4 0.0077 0.0072 0.0083 6.944 15.278 5 0.0100 0.0087 0.0100 14.943 14.943 P2 1 0.0083 0.0082 0.0089 1.220 5.005 4.363 87.180 8.537 7.213 2.951 40.909 2 0.0088 0.0080 0.0084 10.000 5.000 3 0.0093 0.0092 0.0095 1.087 3.261 4 0.0092 0.0089 0.0097 3.371 8.989 5 0.0117 0.0107 0.0118 9.346 10.280 P3 1 0.0104 0.0103 0.0111 0.971 0.701 0.478 68.175 7.767 10.023 5.156 51.442 2 0.0136 0.0135 0.0146 0.741 8.148 3 0.0049 0.0049 0.0055 0.000 12.245 4 0.0080 0.0079 0.0093 1.266 17.722 5 0.0190 0.0189 0.0197 0.529 4.233 vi. Uji Ketahanan Pelipatan Frekuensi PVP 1 45 PVP 2 40 PVP 3 30 vii. Uji Kandungan Obat dalam Sediaan Formula Abs Kadar Terukur µgmL Q Obat µg Q Obat mg �̅ Q Obat SD CV Q Obat Teoritis mg Recovery P1 1 0.474 9.815 490.768 0.491 0.554 0.036 6.440 0.682 81.178 2 0.556 11.517 575.830 0.576 72 3 0.555 11.496 574.793 0.575 4 0.543 11.247 562.344 0.562 5 0.545 11.288 564.419 0.564 P2 1 0.521 10.790 539.523 0.540 0.540 0.024 4.397 0.675 80.022 2 0.518 10.728 536.411 0.536 3 0.501 10.376 518.776 0.519 4 0.560 11.600 579.979 0.580 5 0.508 10.521 526.037 0.526 P3 1 0.504 10.438 521.888 0.522 0.492 0.159 32.308 0.672 73.185 2 0.295 6.102 305.083 0.305 3 0.339 7.015 350.726 0.351 4 0.597 12.367 618.361 0.618 5 0.640 13.259 662.967 0.663

e. Stabilitas Minggu III Suhu 37

o C i. Uji Organoleptis Formula Warna Kejernihan Kehalusan Kelengketan PVP 1 Kuning Terdispersi Halus Kering PVP 2 Kuning Terdispersi Halus Kering PVP 3 Kuning Terdispersi Agak kasar ada gelembung Kering ii. Uji Keseragaman Bobot PVP 1 PVP 2 PVP 3 1 0.0128 0.0181 0.0125 2 0.0104 0.0176 0.0126 3 0.0124 0.0216 0.0078 4 0.0106 0.0209 0.0060 5 0.0105 0.0157 0.0082 6 0.0110 0.0138 0.0050 7 0.0110 0.0136 0.0111 8 0.0116 0.0154 0.0110 9 0.0120 0.0143 0.0068 10 0.0120 0.0121 0.0084 �̅ 0.01143 0.01631 0.00894 SD 0.000805 0.0030088 0.0025664 CV 7.04 18.45 28.71 iii. Uji Ketebalan PVP 1 PVP 2 PVP 3 1 0.15 0.15 0.15 73 2 0.15 0.15 0.15 3 0.15 0.15 0.15 4 0.15 0.15 0.15 5 0.15 0.15 0.15 �̅ 0.15 0.15 0.15 iv. Uji pH Sediaan pH PVP 1 7.2 PVP 2 7.2 PVP 3 7.2

v. Uji Moisture Content dan Moisture Absorption

Bobot awal Bobot akhir Bobot akhir MC �̅ MC SD CV MA �̅ MA SD CV P1 1 0.0128 0.0125 0.0131 2.400 1.429 1.220 85.41 4.800 6.139 2.593 42.233 2 0.0104 0.0101 0.0111 2.970 9.901 3 0.0124 0.0123 0.0131 0.813 6.504 4 0.0106 0.0106 0.0113 0.000 6.604 5 0.0105 0.0104 0.0107 0.962 2.885 P2 1 0.0181 0.0176 0.0185 2.841 1.909 2.004 104.98 5.114 3.596 1.309 36.392 2 0.0176 0.0175 0.0183 0.571 4.571 3 0.0216 0.0215 0.0223 0.465 3.721 4 0.0209 0.0199 0.0203 5.025 2.010 5 0.0157 0.0156 0.0160 0.641 2.564 P3 1 0.0125 0.0119 0.0126 5.042 4.692 3.633 77.43 5.882 4.753 3.070 64.593 2 0.0126 0.0122 0.0127 3.279 4.098 3 0.0078 0.0076 0.0078 2.632 2.632 4 0.0060 0.0059 0.0060 1.695 1.695 5 0.0082 0.0074 0.0081 10.811 9.459 vi. Uji Ketahanan Pelipatan Frekuensi PVP 1 25 PVP 2 35 PVP 3 20 vii. Uji Kandungan Obat dalam Sediaan Formula Abs Kadar Terukur µgmL Q Obat µg Q Obat mg �̅ Q Obat SD CV Q Obat Teoritis mg Recovery 74 P1 1 0.543 11.247 562.344 0.562 0.565 0.019 3.384 0.682 82.851 2 0.516 10.687 534.336 0.534 3 0.561 11.620 581.017 0.581 4 0.547 11.330 566.494 0.566 5 0.561 11.620 581.017 0.581 P2 1 0.586 12.139 606.950 0.607 0.599 0.028 4.699 0.675 88.781 2 0.535 11.081 554.046 0.554 3 0.596 12.346 617.324 0.617 4 0.604 12.512 625.622 0.626 5 0.572 11.849 592.427 0.592 P3 1 0.468 9.691 484.544 0.485 0.435 0.086 19.643 0.672 64.788 2 0.433 8.965 448.237 0.448 3 0.493 10.210 510.477 0.510 4 0.428 8.861 443.050 0.443 5 0.281 5.811 290.560 0.291

f. Stabilitas Minggu III Suhu 45

o C i. Uji Organoleptis Formula Warna Kejernihan Kehalusan Kelengketan PVP 1 Kuning Terdispersi Halus Kering PVP 2 Kuning Terdispersi Halus Kering PVP 3 Kuning Terdispersi Agak kasar ada gelembung Kering ii. Uji Keseragaman Bobot PVP 1 PVP 2 PVP 3 1 0.0097 0.0084 0.0078 2 0.0118 0.0112 0.0073 3 0.0116 0.0131 0.0072 4 0.0072 0.0125 0.0055 5 0.0112 0.0127 0.0141 6 0.0106 0.0088 0.0138 7 0.0107 0.0127 0.0157 8 0.0069 0.0075 0.0083 9 0.0113 0.0098 0.0123 10 0.0065 0.0065 0.0135 �̅ 0.00975 0.01032 0.01055 SD 0.0019734 0.0023108 0.0034837 CV 20.24 22.39 33.02 75 iii. Uji Ketebalan PVP 1 PVP 2 PVP 3 1 0.15 0.15 0.2 2 0.15 0.15 0.2 3 0.15 0.15 0.2 4 0.15 0.15 0.2 5 0.15 0.15 0.2 �̅ 0.15 0.15 0.2 iv. Uji pH Sediaan pH PVP 1 7.1 PVP 2 7.3 PVP 3 7.2

v. Uji Moisture Content dan Moisture Absorption

Bobot awal Bobot akhir Bobot akhir MC �̅ MC SD CV MA �̅ MA SD CV P1 1 0.0097 0.0096 0.0103 1.042 1.015 0.652 64.26 7.292 4.888 3.086 63.126 2 0.0118 0.0116 0.0122 1.724 5.172 3 0.0116 0.0116 0.0118 0.000 1.724 4 0.0072 0.0071 0.0077 1.408 8.451 5 0.0112 0.0111 0.0113 0.901 1.802 P2 1 0.0084 0.0083 0.0084 1.205 1.374 1.021 74.35 1.205 4.540 5.131 113.013 2 0.0112 0.0111 0.0126 0.901 13.514 3 0.0131 0.0128 0.0130 2.344 1.562 4 0.0125 0.0125 0.0130 0.000 4.000 5 0.0127 0.0124 0.0127 2.419 2.419 P3 1 0.0078 0.0077 0.0078 1.299 1.636 1.074 65.66 1.299 5.616 4.900 87.258 2 0.0073 0.0073 0.0083 0.000 13.699 3 0.0072 0.0070 0.0072 2.857 2.857 4 0.0055 0.0054 0.0056 1.852 3.704 5 0.0141 0.0138 0.0147 2.174 6.522 vi. Uji Ketahanan Pelipatan Frekuensi PVP 1 42 PVP 2 67 PVP 3 45 76 vii. Uji Kandungan Obat dalam Sediaan Formula Abs Kadar Terukur µgmL Q Obat µg Q Obat mg �̅ Q Obat SD CV Q Obat Teoritis mg Recovery P1 1 0.591 12.243 612.137 0.612 0.599 0.092 15.372 0.682 87.840 2 0.654 13.550 677.490 0.677 3 0.572 11.849 592.427 0.592 4 0.432 8.944 447.199 0.447 5 0.643 13.322 666.079 0.666 P2 1 0.515 10.666 533.299 0.533 0.498 0.065 13.132 0.675 73.721 2 0.480 9.940 496.992 0.497 3 0.420 8.695 434.751 0.435 4 0.567 11.745 587.241 0.587 5 0.421 8.716 435.788 0.436 P3 1 0.651 13.488 674.378 0.674 0.610 0.079 12.932 0.672 90.721 2 0.656 13.591 679.564 0.680 3 0.596 12.346 617.324 0.617 4 0.469 9.712 485.581 0.486 5 0.571 11.828 591.390 0.591

g. Stabilitas Minggu IV Suhu 37

o C i. Uji Organoleptis Formula Warna Kejernihan Kehalusan Kelengketan PVP 1 Kuning Terdispersi Halus Kering PVP 2 Kuning Terdispersi Halus Kering PVP 3 Kuning Terdispersi Agak kasar ada gelembung Kering ii. Uji Keseragaman Bobot PVP 1 PVP 2 PVP 3 1 0.0048 0.0141 0.0054 2 0.0095 0.0123 0.0058 3 0.0110 0.0112 0.0152 4 0.0114 0.0188 0.0143 5 0.0103 0.0143 0.0092 6 0.0112 0.0129 0.0144 7 0.0123 0.0204 0.0166 8 0.0113 0.0147 0.0091 9 0.0110 0.0161 0.0068 10 0.0111 0.0172 0.0057 �̅ 0.01039 0.0152 0.01025 SD 0.001986 0.0027709 0.0042048 77 CV 19.12 18.23 41.02 iii. Uji Ketebalan PVP 1 PVP 2 PVP 3 1 0.20 0.20 0.10 2 0.20 0.20 0.10 3 0.20 0.20 0.10 4 0.20 0.20 0.10 5 0.20 0.20 0.10 �̅ 0.20 0.20 0.10 iv. Uji pH Sediaan pH PVP 1 7.1 PVP 2 7 PVP 3 7

v. Uji Moisture Content dan Moisture Absorption

Bobot awal Bobot akhir Bobot akhir MC �̅ MC SD CV MA �̅ MA SD CV P1 1 0.0048 0.0047 0.0048 2.128 1.211 0.870 71.808 2.128 8.836 3.937 44.560 2 0.0095 0.0094 0.0103 1.064 9.574 3 0.0110 0.0110 0.0120 0.000 9.091 4 0.0114 0.0113 0.0126 0.885 11.504 5 0.0103 0.0101 0.0113 1.980 11.881 P2 1 0.0141 0.0139 0.0143 1.439 3.326 2.082 62.579 2.878 1.955 0.859 43.953 2 0.0123 0.0119 0.0120 3.361 0.840 3 0.0112 0.0110 0.0112 1.818 1.818 4 0.0188 0.0182 0.0187 3.297 2.747 5 0.0143 0.0134 0.0136 6.716 1.493 P3 1 0.0054 0.0047 0.0048 14.894 8.695 9.055 104.140 2.128 1.400 1.774 126.739 2 0.0058 0.0048 0.0050 20.833 4.167 3 0.0152 0.0142 0.0142 7.042 0.000 4 0.0143 0.0142 0.0143 0.704 0.704 5 0.0092 0.0092 0.0092 0.000 0.000 vi. Uji Ketahanan Pelipatan Frekuensi PVP 1 25 PVP 2 25 78 PVP 3 15 vii. Uji Kandungan Obat dalam Sediaan Formula Abs Kadar Terukur µgmL Q Obat µg Q Obat mg �̅ Q Obat SD CV Q Obat Teoritis mg Recovery P1 1 0.570 11.807 590.353 0.590 0.571 0.056 9.888 0.682 83.763 2 0.484 10.023 501.141 0.501 3 0.560 11.600 579.979 0.580 4 0.517 10.707 535.373 0.535 5 0.627 12.990 649.481 0.649 P2 1 0.677 14.027 701.349 0.701 0.655 0.088 13.393 0.675 97.080 2 0.556 11.517 575.830 0.576 3 0.545 11.288 564.419 0.564 4 0.747 15.479 773.963 0.774 5 0.638 13.218 660.892 0.661 P3 1 0.509 10.541 527.075 0.527 0.533 0.034 6.394 0.672 79.298 2 0.551 11.413 570.643 0.571 3 0.493 10.210 510.477 0.510 4 0.545 11.288 564.419 0.564 5 0.475 9.836 491.805 0.492

h. Stabilitas Minggu IV Suhu 45

o C i. Uji Organoleptis Formula Warna Kejernihan Kehalusan Kelengketan PVP 1 Kuning Terdispersi Halus Kering PVP 2 Kuning Terdispersi Halus Kering PVP 3 Kuning Terdispersi Agak kasar ada gelembung Kering ii. Uji Keseragaman Bobot PVP 1 PVP 2 PVP 3 1 0.0130 0.0108 0.0099 2 0.0076 0.0127 0.0120 3 0.0113 0.0109 0.0157 4 0.0121 0.0118 0.0172 5 0.0107 0.0136 0.0151 6 0.0087 0.0145 0.0087 7 0.0055 0.0168 0.0160 8 0.0144 0.0172 0.0158 9 0.0111 0.0107 0.0081 10 0.0134 0.0126 0.0068 79 �̅ 0.01078 0.01316 0.01253 SD 0.0026332 0.0022509 0.0036813 CV 24.43 17.10 29.38 iii. Uji Ketebalan PVP 1 PVP 2 PVP 3 1 0.15 0.15 0.20 2 0.15 0.15 0.20 3 0.15 0.15 0.20 4 0.15 0.15 0.20 5 0.15 0.15 0.20 �̅ 0.15 0.15 0.20 iv. Uji pH Sediaan pH PVP 1 7.2 PVP 2 7.2 PVP 3 7

v. Uji Moisture Content dan Moisture Absorption

Bobot awal Bobot akhir Bobot akhir MC �̅ MC SD CV MA �̅ MA SD CV P1 1 0.0130 0.0128 0.0133 1.562 1.010 1.084 107.339 3.906 3.572 1.934 54.155 2 0.0076 0.0076 0.0078 0.000 2.632 3 0.0113 0.0113 0.0116 0.000 2.655 4 0.0121 0.0118 0.0126 2.542 6.780 5 0.0107 0.0106 0.0108 0.943 1.887 P2 1 0.0108 0.0107 0.0109 0.935 0.983 1.013 103.055 1.869 4.850 3.037 62.624 2 0.0127 0.0127 0.0138 0.000 8.661 3 0.0109 0.0109 0.0112 0.000 2.752 4 0.0118 0.0116 0.012 1.724 3.448 5 0.0136 0.0133 0.0143 2.256 7.519 P3 1 0.0099 0.0099 0.0106 0.000 0.746 0.787 105.378 7.071 3.806 2.614 68.675 2 0.0120 0.0120 0.0126 0.000 5.000 3 0.0157 0.0155 0.0155 1.290 0.000 4 0.0172 0.0169 0.0174 1.775 2.959 5 0.0151 0.0150 0.0156 0.667 4.000 80 vi. Uji Ketahanan Pelipatan Frekuensi PVP 1 25 PVP 2 40 PVP 3 15 vii. Uji Kandungan Obat dalam Sediaan Formula Abs Kadar Terukur µgmL Q Obat µg Q Obat mg �̅ Q Obat SD CV Q Obat Teoritis mg Recovery P1 1 0.515 10.666 533.299 0.533 0.477 0.085 17.781 0.682 70.013 2 0.566 11.724 586.203 0.586 3 0.463 9.587 479.357 0.479 4 0.386 7.990 399.481 0.399 5 0.376 7.782 389.108 0.389 P2 1 0.648 13.425 671.266 0.671 0.651 0.045 6.883 0.675 96.496 2 0.552 11.434 571.680 0.572 3 0.641 13.280 664.004 0.664 4 0.655 13.571 678.527 0.679 5 0.648 13.425 671.266 0.671 P3 1 0.541 11.205 560.270 0.560 0.531 0.034 6.365 0.672 79.082 2 0.508 10.521 526.037 0.526 3 0.551 11.413 570.643 0.571 4 0.493 10.210 510.477 0.510 5 0.473 9.795 489.730 0.490 81 Lampiran 10. Data Uji Iritasi Hydrocolloid Matrix Piroksikam 1. Data Uji Iritasi Kulit Kontrol Positif Etil Asetat + Hypafix Kelinci 24 jam 48 jam 72 jam Eritema Udem Eritema Udem Eritema Udem 1 2 2 2 2 3 3 3 3 2 2 2 Total 7 7 7 Indeks Iritasi Primer : 7.0 Kesimpulan : Iritan kuat Kontrol Negatif Kasa + Hypafix Kelinci 24 jam 48 jam 72 jam Eritema Udem Eritema Udem Eritema Udem 1 2 3 Total Indeks Iritasi Primer : 0.0 Kesimpulan : Sangat ringan Basis 1 Kelinci 24 jam 48 jam 72 jam Eritema Udem Eritema Udem Eritema Udem 1 2 3 Total Indeks Iritasi Primer : 0.0 Kesimpulan : Sangat ringan Basis 2 Kelinci 24 jam 48 jam 72 jam Eritema Udem Eritema Udem Eritema Udem 1 2 3 Total Indeks Iritasi Primer : 0.0 Kesimpulan : Sangat ringan 82 Basis 3 Kelinci 24 jam 48 jam 72 jam Eritema Udem Eritema Udem Eritema Udem 1 2 3 Total Indeks Iritasi Primer : 0.0 Kesimpulan : Sangat ringan 83 Lampiran 11. Data Persen Wound Closure

a. Tikus Diabetes

Hari ke- Basis 2 Formula PVP 2 Kontrol Tikus 1 Tikus 2 Tikus 3 Tikus 1 Tikus 2 Tikus 3 Tikus 1 Tikus 2 Tikus 3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 1 3.846 2.706 5.796 3.888 5.666 12.364 3.785 2.575 3.586 2 8.379 13.745 16.847 9.268 16.362 14.984 13.898 12.297 10.812 3 10.323 21.281 21.281 13.706 20.675 15.292 24.212 14.793 19.627 4 25.296 26.618 37.600 17.242 25.588 21.281 31.435 21.180 29.044 5 38.693 34.047 46.957 20.022 36.586 34.054 46.859 37.156 30.262 6 40.916 49.247 51.476 32.698 44.326 40.534 64.085 42.100 51.060 7 53.142 62.179 69.909 55.020 63.621 50.289 67.313 61.545 57.923 8 66.087 73.462 76.383 65.283 79.199 61.540 75.591 76.538 76.936 9 80.301 84.261 80.363 77.747 83.203 69.063 79.260 82.425 89.027 10 86.914 87.469 83.863 86.428 86.173 75.086 88.116 86.539 89.115 11 92.553 91.924 85.674 90.046 92.010 83.553 92.528 91.516 90.730 12 94.340 93.014 87.865 92.681 93.890 87.174 92.600 93.665 92.956 13 96.684 96.098 90.537 95.335 94.691 90.727 95.525 94.784 93.956 14 97.674 97.247 92.166 97.270 96.839 94.404 96.217 96.040 94.890 15 98.489 98.650 95.011 98.154 98.641 96.231 97.299 97.412 96.063 16 100.000 100.000 97.693 100.000 100.000 98.652 100.000 98.995 98.689 17 100.000 100.000 100.000 100.000

b. Tikus Non Diabetes

Hari ke- Basis 2 Formula PVP 2 Kontrol Tikus 1 Tikus 2 Tikus 3 Tikus 1 Tikus 2 Tikus 3 Tikus 1 Tikus 2 Tikus 3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 1 1.814 10.145 15.292 4.386 5.052 10.766 5.099 4.354 5.978 2 6.893 12.381 15.818 6.822 8.220 17.148 12.473 6.899 14.121 3 11.960 26.935 32.081 12.237 9.841 27.559 23.917 10.523 15.985 4 18.049 28.666 44.403 19.630 9.942 27.692 52.737 23.443 19.726 5 34.158 33.919 50.506 43.035 11.308 28.322 55.444 24.538 22.859 6 35.592 34.378 59.116 62.361 26.457 39.105 58.818 29.102 38.363 7 58.578 43.212 67.484 70.751 44.558 49.703 60.021 53.534 49.039 8 66.034 49.505 78.485 75.210 51.635 59.971 72.801 69.879 69.330 9 76.939 64.716 87.915 89.509 77.418 78.362 84.820 77.684 79.691 10 83.602 83.525 89.303 92.218 87.334 88.567 93.008 86.165 85.430 11 91.538 92.279 92.070 95.661 92.102 92.623 95.610 90.224 88.235 12 92.208 95.368 94.038 96.074 93.411 94.374 96.591 93.438 90.906 13 97.475 97.133 96.533 97.896 94.986 97.295 97.765 96.166 94.380 14 98.536 97.479 97.981 98.795 97.320 98.393 100.000 97.680 97.204 84 15 100.000 100.000 100.000 100.000 100.000 100.000 100.000 100.000

c. Data Perhitungan Hari Penutupan Luka

Diabetes Tikus Kontrol Basis Formula 1 16 16 16 2 17 16 16 3 17 17 17 �̅ 16.667 16.333 16.333 SD 0.577 0.577 0.577 CV 3.464 3.535 3.535 Non Diabetes Tikus Kontrol Basis Formula 1 14 15 15 2 15 15 15 3 15 15 15 �̅ 14.667 15.000 15.000 SD 0.577 0.000 0.000 CV 3.936 0.000 0.000 85 Lampiran 12. Hasil Statistik Penelitian 1. Hasil Uji Statistik Keseragaman Bobot a. Basis Uji Normalitas Uji Homogenitas Uji ANAVA P-value di bawah 0.05  ada perbedaan yang signifikan 86 b. Formula Uji Normalitas Uji Homogenitas PLAGIAT MERUPAKAN TINDAKAN TIDAK TERPUJI 87 Uji Kruskal Walis P-value di bawah 0.05  ada perbedaan yang signifikan

2. Hasil Uji Statistik Moisture Content