Efek Kombinasi Ekstrak Aktif Daun Poguntano (Picria Fel-Terrae Lour.) Dengan Doxorubicin Terhadap Sel Kanker Payudara Secara In Vitro
DAFTAR PUSTAKA
Anonim. (2007). Picria fel-terrae Merr. Tanggal akses 05 April 2009.
http://www.globinmed.com/IMRContent/detail.aspx?id=BOT00054
Anonim. (2008). ATCC Cell Biology. Tanggal akses 15 Maret 2009.
http://www.atcc.org/common/catalog/numSearch/numResults.cfm?atccNu
m=HTB-22
Anonim . (2009). Picria fel-terrae Lour. Tanggal akses 01 April 2009.
http://www.proseanet.org/prohati2/browser.php?doosid=459
Adina, A.B. (2009). Efek Ekstrak Etanolik Kulit Jeruk Nipis [(Citrus aurantifolia
Cristm) Swingle] pada Sensitivitas Sel Kanker Payudara MCF-7 terhadap
Doxorubicin. Skripsi. Fakultas Farmasi UGM. Yogyakarta.
Allen, J.D., Arnold, V.L., Jeany, M.L., Martin, V.D.V., Olaf, V.T., Glen, R., Jan,
H.M.S., Gerrit, J.K., dan Alfred, H.S. (2002). Potent and Specific
Inhibition of the Breast Cancer Resistance Protein Multidrug Transporter
In Vitro and In Mouse Intestine by a Novel Analogue of Fumitremorgin C.
Molecular Cancer Therapeutics. 1: 415-425.
Bouker, K.B., Skaar, T.C., Riggins, R.B., Harburger, D.S., Fernandez, D.R.,
Zwart, A., Wang, A., dan Clarke, R. (2005). Interferon Regulatory Factor1 (IRF-1) Exhibits Tumor Suppressor Activities in Breast Cancer
Associated with Caspase Activation and Induction of Apoptosis.
Carcinogenesis. 26(9): 1527-1535.
Choi, Y., Poe, B., Eder, dan Angie. (2005). ABC Transporters as Multidrug
Resistance Mechanism and The Development of Chemosensitizers for
Their Reversal. Cancer Cell International. 5: 30.
Crawford, K.W., dan Bowen, W.D. (2002). Sigma-2 Receptor Agonists Activate a
Novel Apoptotic Pathway and Potentiate Antineoplastic Drugs in Breast
Tumor Cell Lines. Cancer Res. 62: 313–322.
Deng,
L., Lin-Lee, Y.C., Claret, F.X., dan Kuo, M.T. (2001). 2Acetylaminofluorene Up-regulates Rat mdr1b Expression Through
Generating Reactive Oxygen Species That Activate NF-κB Pathway. The
Journal of Biological Chemistry. 276(1): 413-420.
Desantis, C., Siegel, R., Bandi, P., dan Jemal, A. (2011). Breast Cancer Statistics.
CA Cancer J Clin 2011. 61(6): 409–418.
87
Universitas Sumatera Utara
Diandana, R. (2009). Mengenal Seluk Beluk Kanker. Cetakan Ketiga. Yogyakarta:
Katahati. Halaman 15, 22, 29-30.
Ditjen POM. (1979). Farmakope Indonesia. Edisi III. Jakarta: Direktorat Jenderal
Pengawas Obat dan Makanan. Halaman 7, 649, 659, 744, 748, 781-782.
Ditjen POM. (1986). Sediaan Galenik. Jakarta: Departemen Kesehatan RI.
Halaman 1,7, 10, 19, 21.
Ditjen POM. (1995). Materia Medika Indonesia. Jilid VI. Jakarta: Departemen
Kesehatan RI. Halaman 300-304, 306.
Ditjen POM. (2000). Parameter Standar Umum Ekstrak Tumbuhan Obat. Cetakan
Pertama. Jakarta: Depkes RI. Halaman 17, 31-32.
Dolinsky, C. (2002). Breast Cancer: The Basic. Abramson Cancer Center of The
University of Pennsylvania. www.oncolink.org. Tanggal akses 12 Januari
2012.
Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C., dan Parkin. (2010).
Estimates of Worldwide Burden of Cancer in 2008: Globocan 2008. Int J
Cancer. 127: 2893–2917.
Foster, J.S., Henley, D.C., Ahamed, S., dan Wimalasena, J. (2001). Estrogen and
Cell Cycle Regulation in Breast Cancer. Trend in Endocrinology and
Metabolism. 12(7): 320-327.
Gibbs, J.B. (2000). Mechanism-Based Target Identification and Drug Discovery
in Cancer Research. Science. 287: 1969-1973.
Hahn, W.C., dan Weinberg, R.A. (2002). Modelling The Molecular Circuitry of
Cancer. Nature Revies Cancer. 2: 331-341.
Harborne, J. B. (1987). Metode Fitokimia Penuntun Cara Modern Menganalisis
Tumbuhan. Penerjemah Kosasih Padmawinata dan Iwang Soediro. Edisi 2.
Bandung: Penerbit ITB. Halaman 48-49, 147-149.
Huang Y., Bruyne T.D., Apers S., Ma, Y., Claeys, M., Pieters, L., dan Vlietinck
A., (1999). Flavonoid Glucuronides from Picria fel-terrae. Elsevier
Science. 52(8): 1701–1703
Imai, Y., Ishikawa, E., Asada, S., dan Sugimoto, Y. (2005). Estrogen-Mediated
Post Transcriptional Down-regulation of Breast Cancer Resistance
Protein/ABCG2. Cancer Res. 65(2): 596-604.
88
Universitas Sumatera Utara
Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E., dan Forman, D. (2011).
Global Cancer Statistics. CA Cancer J Clin. 61(2): 69–90.
Juliano, R.L., dan Ling, V.A. (1976). A Surface Glycoprotein Modulating Drug
Permeability in Chinese Hamster Ovary Cell Mutants. Biochim Biophys
Acta. 455(1): 152-162.
Kitagawa, S. (2006). Inhibitory Effect of Polyphenols on P-GlycoproteinMediated Transport. Journal Biol Pharm Bull. 29(1): 1-6.
Kumar, V., Abas, A.K., dan Foustro, N. (2005). Pathology Basic of Dissease.
New York: Elsevier Inc. Halaman 270-336.
Kupcsik, L., dan Martin, J.S. (2011). Mammalian Cell Viability: Methods and
Protocols. New York: Humana Press. Halaman 13-18.
Lay, B.W. (1996). Analisis Mikroba di Laboratorium. Jakarta: Raja Grafindo
Persada. Halaman 57-58, 109.
Long, X., Fan, M., dan Bigsby, R.M., (2008). Apigenin Inhibits Antiestrogen
Resistant Breast Cancer Cell Growth Through Estrogen Receptor-AlphaDependent and Estrogen Receptor-Alpha-Independent Mechanisms. Mol
Cancer Ther. 7: 2096-2108.
Matheny, C. J. M., Lamb, M. W., Brouwer, K. L. R., dan Pollack, G. M. (2001).
Pharmacokinetic and Pharmacodynamic Implications of P-glycoprotein
Modulation. Pharmacotherapy. 21(7): 778-796.
Mechetner, E., Kyshtoobayeva, A., Zonis, S., Kim, H., Stroup, R., Garcia, R.,
Parker, R.J., dan Fruehauf, J.P. (1998). Levels of Multidrug Resistance
(MDR1) P-Glycoprotein Expression by Human Breast Cancer Correlate
with In Vitro Resistance to Taxol and Doxorubicin. Clinical Cancer
Research. 4: 389-398.
Notarbartolo, M., Poma, P., Perri, D., Dusonchet, L., Cervello, M., dan
Alessandro, N. (2005). Antitumor Effects of Curcumin, Alone or in
Combination with Cisplatin or Doxorubicin, on Human Hepatic Cancer
Cells. Analysis of Their Possible Relationship to Changes in NF-ĸB
Activation Levels and in IAP Gene Expression. Canc Lett. 224(1): 53-65.
Nurse, P. (2000). A Long Twentieth Century of the Cell Cycle and Beyond. Cell.
100:71–78.
Pecorino, L. (2005). Molecular Biology of Cancer Mechanism Target, and
Therapeutics. London: Oxford University Press. Halaman 20-85.
Perry, L.M., (1980). Medicinal Plants of East and Southeast Asia. London: The
MIT Press. Halaman 384.
89
Universitas Sumatera Utara
Reynolds, C.P., dan Maurer, B.J. (2005). Evaluating Response to Antineoplastic
Drug Combinations in Tissue Culture Models. Methods Mol Med. 110:
173-183.
Rios, J.L., Andujar, I., Escandell, J.M., Giner, R.M., Recio, M.C., (2012).
Cucurbitacins as inducers of cell death and a rich source of potential
anticancer compounds. PubMed. 18(12):1663-76.
Rock, E., dan DeMichele, A. (2003). Nutritional Approaches to Late Toxicities of
Adjuvant Chemotherapy in Breast Cancer Survivors. American Society for
Nutritional Sciences J Nutr. 133: 3785-3793.
Ruddon, R.W. (2007). Cancer Biology. New York: Oxford University Press.
Halaman 117-196.
Satria, D. (2012). Uji Sitotoksik Ekstrak Etanol dan Fraksi Kuda Laut
(Hippocampus trimacularies Leach.) terhadap Sel MCF-7. Skripsi. Medan:
Fakultas Farmasi USU.
Seo, H.S., Choi, H.S., Kim, S.R., Choi, Y.K., Woo, S.M., Shin, I., Woo, J.K.,
Park, S.Y., Shin, Y.C., dan Ko, S.K. (2012). Apigenin Induces Apoptosis
Via Extrinsic Pathway, Inducing p53 and Inhibiting STAT3 and NFκB
Signaling in HER2-Overexpressing Breast Cancer Cells. Molecular and
Cellular Biochemistry. 366(2): 319-334.
Sharma, G., Tyagi, A.K., Singh, R.P., Chan, D.C.F., dan Agarwal, R. (2004).
Synergistic Anti-Cancer Effect of Grape Seed Extract and Conventional
Cytotoxic Agent Doxorubicin Against Human Breast Carcinoma Cells.
Breast Cancer Research and Treatment. 85: 1-12.
Singal, P.K., dan Iliskovic, N. (1998). Doxorubicin-Induced Cardiomyopathy. N
Engl J Med. 339: 900-905.
Sudiana, I.K. (2011). Patobiologi Molekuler Kanker. Jakarta: Penerbit Salemba
Empat. Halaman 1, 45-52.
Torosian, M.H. (2002). Breast Cancer: A Guide to Detection and Multidiciplinary
Theraphy. New Jersey: Humana Press. Halaman 5-9.
Tsao, A.S., Kim, E.S., dan Hong, W.K. (2004). Chemoprevention of Cancer. CA
Cancer J Clin. 54: 150-180.
Tyagi, A.K., Agarwal, C., Chan, D.C.F., dan Agarwal, R. (2004). Synergistic
Anti-Cancer Effects of Silibinin with Conventional Cytotoxic Agents
90
Universitas Sumatera Utara
Doxorubicin, Cisplatin and Carboplatin Against Human Breast Carcinoma
MCF-7 and MDA-MB468 Cells. Oncology Reports. 11: 493-499.
Ujiki, M.B., Ding, X.Z., Salabat, M.R., Bentrem, D.J., Golkar, L., Milam, B.,
Talamonti, M.S., Bell, R.H., Iwamura, T., dan Adrian, T.E. (2006).
Apigenin Inhibits Pancreatic Cancer Cell Proliferation Through G2/M Cell
Cycle Arrest. Molecular Cancer. 5: 76.
Valeria. P. (2005). Changes in P-glycoprotein Activity are Mediated by The
Growth of a Tumour Cell Line as Multicellular Spheroids. Cancer Cell
International. 5: 20.
Wattanapitayakul,
S.K.,
Chularojmontri,
L.,
Herunsalee,
A.,
Charuchongkolwongse, S., Niumsakul, S., dan Bauer, J.A. (2005).
Screening of Antioxidants from Medicinal Plants for Cardioprotective
Effect Against Doxorubicin Toxicity. Basic & Clinical Pharmacology &
Toxicology. 96: 80.
Wong, H.L., Bendayan, R., Rauth, A.M., Xue, H.Y., Babakhanian, K., dan Wu,
X.Y. (2006). A Mechanistic Study of Enhanced Doxorubicin Uptake and
Retention in Multidrug Resistant Breast Cancer Cells Using A PolymerLipid Hybrid Nanoparticle System. The Journal of Pharmacology and
Experimental Therapeutics. 317(3): 1372-1381.
World Health Organization. (1998). Quality Control Methods For Medicinal
Plant Materials. Geneva: WHO. Halaman 26-27.
Zampieri, L., Bianchi, P., Ruff, P., dan Arbuthnot, P. (2002). Differential
Modulation by Estradiol of P-glycoprotein Drug Resistance Protein
Expression in Cultured MCF-7 and T47D Breast Cancer Cells. Anticancer
Res. 22(4): 2253-2259.
Zhou, J., Liu, M., Aneja, R., Chandra, R., Lage, H., dan Joshi, H.C. (2006).
Reversal of P-glycoprotein Mediated Multidrug Resistance in Cancer Cells
by The c-Jun-NH2-Terminal Kinase. Cancer Res. 66(1): 445-452.
Zhong, S.Q., Zhang, B.N., dan Huang, F.X. (1979). An Anti-Tumor Herb Cucao.
China: Chin Tradit Herb Drugs Lett 3. Halaman 45–46.
91
Universitas Sumatera Utara
Anonim. (2007). Picria fel-terrae Merr. Tanggal akses 05 April 2009.
http://www.globinmed.com/IMRContent/detail.aspx?id=BOT00054
Anonim. (2008). ATCC Cell Biology. Tanggal akses 15 Maret 2009.
http://www.atcc.org/common/catalog/numSearch/numResults.cfm?atccNu
m=HTB-22
Anonim . (2009). Picria fel-terrae Lour. Tanggal akses 01 April 2009.
http://www.proseanet.org/prohati2/browser.php?doosid=459
Adina, A.B. (2009). Efek Ekstrak Etanolik Kulit Jeruk Nipis [(Citrus aurantifolia
Cristm) Swingle] pada Sensitivitas Sel Kanker Payudara MCF-7 terhadap
Doxorubicin. Skripsi. Fakultas Farmasi UGM. Yogyakarta.
Allen, J.D., Arnold, V.L., Jeany, M.L., Martin, V.D.V., Olaf, V.T., Glen, R., Jan,
H.M.S., Gerrit, J.K., dan Alfred, H.S. (2002). Potent and Specific
Inhibition of the Breast Cancer Resistance Protein Multidrug Transporter
In Vitro and In Mouse Intestine by a Novel Analogue of Fumitremorgin C.
Molecular Cancer Therapeutics. 1: 415-425.
Bouker, K.B., Skaar, T.C., Riggins, R.B., Harburger, D.S., Fernandez, D.R.,
Zwart, A., Wang, A., dan Clarke, R. (2005). Interferon Regulatory Factor1 (IRF-1) Exhibits Tumor Suppressor Activities in Breast Cancer
Associated with Caspase Activation and Induction of Apoptosis.
Carcinogenesis. 26(9): 1527-1535.
Choi, Y., Poe, B., Eder, dan Angie. (2005). ABC Transporters as Multidrug
Resistance Mechanism and The Development of Chemosensitizers for
Their Reversal. Cancer Cell International. 5: 30.
Crawford, K.W., dan Bowen, W.D. (2002). Sigma-2 Receptor Agonists Activate a
Novel Apoptotic Pathway and Potentiate Antineoplastic Drugs in Breast
Tumor Cell Lines. Cancer Res. 62: 313–322.
Deng,
L., Lin-Lee, Y.C., Claret, F.X., dan Kuo, M.T. (2001). 2Acetylaminofluorene Up-regulates Rat mdr1b Expression Through
Generating Reactive Oxygen Species That Activate NF-κB Pathway. The
Journal of Biological Chemistry. 276(1): 413-420.
Desantis, C., Siegel, R., Bandi, P., dan Jemal, A. (2011). Breast Cancer Statistics.
CA Cancer J Clin 2011. 61(6): 409–418.
87
Universitas Sumatera Utara
Diandana, R. (2009). Mengenal Seluk Beluk Kanker. Cetakan Ketiga. Yogyakarta:
Katahati. Halaman 15, 22, 29-30.
Ditjen POM. (1979). Farmakope Indonesia. Edisi III. Jakarta: Direktorat Jenderal
Pengawas Obat dan Makanan. Halaman 7, 649, 659, 744, 748, 781-782.
Ditjen POM. (1986). Sediaan Galenik. Jakarta: Departemen Kesehatan RI.
Halaman 1,7, 10, 19, 21.
Ditjen POM. (1995). Materia Medika Indonesia. Jilid VI. Jakarta: Departemen
Kesehatan RI. Halaman 300-304, 306.
Ditjen POM. (2000). Parameter Standar Umum Ekstrak Tumbuhan Obat. Cetakan
Pertama. Jakarta: Depkes RI. Halaman 17, 31-32.
Dolinsky, C. (2002). Breast Cancer: The Basic. Abramson Cancer Center of The
University of Pennsylvania. www.oncolink.org. Tanggal akses 12 Januari
2012.
Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C., dan Parkin. (2010).
Estimates of Worldwide Burden of Cancer in 2008: Globocan 2008. Int J
Cancer. 127: 2893–2917.
Foster, J.S., Henley, D.C., Ahamed, S., dan Wimalasena, J. (2001). Estrogen and
Cell Cycle Regulation in Breast Cancer. Trend in Endocrinology and
Metabolism. 12(7): 320-327.
Gibbs, J.B. (2000). Mechanism-Based Target Identification and Drug Discovery
in Cancer Research. Science. 287: 1969-1973.
Hahn, W.C., dan Weinberg, R.A. (2002). Modelling The Molecular Circuitry of
Cancer. Nature Revies Cancer. 2: 331-341.
Harborne, J. B. (1987). Metode Fitokimia Penuntun Cara Modern Menganalisis
Tumbuhan. Penerjemah Kosasih Padmawinata dan Iwang Soediro. Edisi 2.
Bandung: Penerbit ITB. Halaman 48-49, 147-149.
Huang Y., Bruyne T.D., Apers S., Ma, Y., Claeys, M., Pieters, L., dan Vlietinck
A., (1999). Flavonoid Glucuronides from Picria fel-terrae. Elsevier
Science. 52(8): 1701–1703
Imai, Y., Ishikawa, E., Asada, S., dan Sugimoto, Y. (2005). Estrogen-Mediated
Post Transcriptional Down-regulation of Breast Cancer Resistance
Protein/ABCG2. Cancer Res. 65(2): 596-604.
88
Universitas Sumatera Utara
Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E., dan Forman, D. (2011).
Global Cancer Statistics. CA Cancer J Clin. 61(2): 69–90.
Juliano, R.L., dan Ling, V.A. (1976). A Surface Glycoprotein Modulating Drug
Permeability in Chinese Hamster Ovary Cell Mutants. Biochim Biophys
Acta. 455(1): 152-162.
Kitagawa, S. (2006). Inhibitory Effect of Polyphenols on P-GlycoproteinMediated Transport. Journal Biol Pharm Bull. 29(1): 1-6.
Kumar, V., Abas, A.K., dan Foustro, N. (2005). Pathology Basic of Dissease.
New York: Elsevier Inc. Halaman 270-336.
Kupcsik, L., dan Martin, J.S. (2011). Mammalian Cell Viability: Methods and
Protocols. New York: Humana Press. Halaman 13-18.
Lay, B.W. (1996). Analisis Mikroba di Laboratorium. Jakarta: Raja Grafindo
Persada. Halaman 57-58, 109.
Long, X., Fan, M., dan Bigsby, R.M., (2008). Apigenin Inhibits Antiestrogen
Resistant Breast Cancer Cell Growth Through Estrogen Receptor-AlphaDependent and Estrogen Receptor-Alpha-Independent Mechanisms. Mol
Cancer Ther. 7: 2096-2108.
Matheny, C. J. M., Lamb, M. W., Brouwer, K. L. R., dan Pollack, G. M. (2001).
Pharmacokinetic and Pharmacodynamic Implications of P-glycoprotein
Modulation. Pharmacotherapy. 21(7): 778-796.
Mechetner, E., Kyshtoobayeva, A., Zonis, S., Kim, H., Stroup, R., Garcia, R.,
Parker, R.J., dan Fruehauf, J.P. (1998). Levels of Multidrug Resistance
(MDR1) P-Glycoprotein Expression by Human Breast Cancer Correlate
with In Vitro Resistance to Taxol and Doxorubicin. Clinical Cancer
Research. 4: 389-398.
Notarbartolo, M., Poma, P., Perri, D., Dusonchet, L., Cervello, M., dan
Alessandro, N. (2005). Antitumor Effects of Curcumin, Alone or in
Combination with Cisplatin or Doxorubicin, on Human Hepatic Cancer
Cells. Analysis of Their Possible Relationship to Changes in NF-ĸB
Activation Levels and in IAP Gene Expression. Canc Lett. 224(1): 53-65.
Nurse, P. (2000). A Long Twentieth Century of the Cell Cycle and Beyond. Cell.
100:71–78.
Pecorino, L. (2005). Molecular Biology of Cancer Mechanism Target, and
Therapeutics. London: Oxford University Press. Halaman 20-85.
Perry, L.M., (1980). Medicinal Plants of East and Southeast Asia. London: The
MIT Press. Halaman 384.
89
Universitas Sumatera Utara
Reynolds, C.P., dan Maurer, B.J. (2005). Evaluating Response to Antineoplastic
Drug Combinations in Tissue Culture Models. Methods Mol Med. 110:
173-183.
Rios, J.L., Andujar, I., Escandell, J.M., Giner, R.M., Recio, M.C., (2012).
Cucurbitacins as inducers of cell death and a rich source of potential
anticancer compounds. PubMed. 18(12):1663-76.
Rock, E., dan DeMichele, A. (2003). Nutritional Approaches to Late Toxicities of
Adjuvant Chemotherapy in Breast Cancer Survivors. American Society for
Nutritional Sciences J Nutr. 133: 3785-3793.
Ruddon, R.W. (2007). Cancer Biology. New York: Oxford University Press.
Halaman 117-196.
Satria, D. (2012). Uji Sitotoksik Ekstrak Etanol dan Fraksi Kuda Laut
(Hippocampus trimacularies Leach.) terhadap Sel MCF-7. Skripsi. Medan:
Fakultas Farmasi USU.
Seo, H.S., Choi, H.S., Kim, S.R., Choi, Y.K., Woo, S.M., Shin, I., Woo, J.K.,
Park, S.Y., Shin, Y.C., dan Ko, S.K. (2012). Apigenin Induces Apoptosis
Via Extrinsic Pathway, Inducing p53 and Inhibiting STAT3 and NFκB
Signaling in HER2-Overexpressing Breast Cancer Cells. Molecular and
Cellular Biochemistry. 366(2): 319-334.
Sharma, G., Tyagi, A.K., Singh, R.P., Chan, D.C.F., dan Agarwal, R. (2004).
Synergistic Anti-Cancer Effect of Grape Seed Extract and Conventional
Cytotoxic Agent Doxorubicin Against Human Breast Carcinoma Cells.
Breast Cancer Research and Treatment. 85: 1-12.
Singal, P.K., dan Iliskovic, N. (1998). Doxorubicin-Induced Cardiomyopathy. N
Engl J Med. 339: 900-905.
Sudiana, I.K. (2011). Patobiologi Molekuler Kanker. Jakarta: Penerbit Salemba
Empat. Halaman 1, 45-52.
Torosian, M.H. (2002). Breast Cancer: A Guide to Detection and Multidiciplinary
Theraphy. New Jersey: Humana Press. Halaman 5-9.
Tsao, A.S., Kim, E.S., dan Hong, W.K. (2004). Chemoprevention of Cancer. CA
Cancer J Clin. 54: 150-180.
Tyagi, A.K., Agarwal, C., Chan, D.C.F., dan Agarwal, R. (2004). Synergistic
Anti-Cancer Effects of Silibinin with Conventional Cytotoxic Agents
90
Universitas Sumatera Utara
Doxorubicin, Cisplatin and Carboplatin Against Human Breast Carcinoma
MCF-7 and MDA-MB468 Cells. Oncology Reports. 11: 493-499.
Ujiki, M.B., Ding, X.Z., Salabat, M.R., Bentrem, D.J., Golkar, L., Milam, B.,
Talamonti, M.S., Bell, R.H., Iwamura, T., dan Adrian, T.E. (2006).
Apigenin Inhibits Pancreatic Cancer Cell Proliferation Through G2/M Cell
Cycle Arrest. Molecular Cancer. 5: 76.
Valeria. P. (2005). Changes in P-glycoprotein Activity are Mediated by The
Growth of a Tumour Cell Line as Multicellular Spheroids. Cancer Cell
International. 5: 20.
Wattanapitayakul,
S.K.,
Chularojmontri,
L.,
Herunsalee,
A.,
Charuchongkolwongse, S., Niumsakul, S., dan Bauer, J.A. (2005).
Screening of Antioxidants from Medicinal Plants for Cardioprotective
Effect Against Doxorubicin Toxicity. Basic & Clinical Pharmacology &
Toxicology. 96: 80.
Wong, H.L., Bendayan, R., Rauth, A.M., Xue, H.Y., Babakhanian, K., dan Wu,
X.Y. (2006). A Mechanistic Study of Enhanced Doxorubicin Uptake and
Retention in Multidrug Resistant Breast Cancer Cells Using A PolymerLipid Hybrid Nanoparticle System. The Journal of Pharmacology and
Experimental Therapeutics. 317(3): 1372-1381.
World Health Organization. (1998). Quality Control Methods For Medicinal
Plant Materials. Geneva: WHO. Halaman 26-27.
Zampieri, L., Bianchi, P., Ruff, P., dan Arbuthnot, P. (2002). Differential
Modulation by Estradiol of P-glycoprotein Drug Resistance Protein
Expression in Cultured MCF-7 and T47D Breast Cancer Cells. Anticancer
Res. 22(4): 2253-2259.
Zhou, J., Liu, M., Aneja, R., Chandra, R., Lage, H., dan Joshi, H.C. (2006).
Reversal of P-glycoprotein Mediated Multidrug Resistance in Cancer Cells
by The c-Jun-NH2-Terminal Kinase. Cancer Res. 66(1): 445-452.
Zhong, S.Q., Zhang, B.N., dan Huang, F.X. (1979). An Anti-Tumor Herb Cucao.
China: Chin Tradit Herb Drugs Lett 3. Halaman 45–46.
91
Universitas Sumatera Utara