Perbedaan Faal Hemostasis Pada Pasien Penyakit Jantung Koroner Dengan Dan Tanpa Diabetes Mellitus Tipe 2 Dengan Menggunakan Tromboelastografi (Teg)

61

LAMPIRAN 1

Universitas Sumatera Utara

62

LAMPIRAN 2
LEMBAR PENJELASAN KEPADA CALON SUBJEK PENELITIAN
Selamat pagi/siang Bapak/Ibu, pada hari ini saya, dr.Brama Ihsan Sazli,
peserta Pendidikan Pasca Sarjana Ilmu Penyakit Dalam / Magister Klinik FK
USU Medan akan melakukan penelitian yang berjudul ” Perbandingan faal
hemostasis pada pasien penyakit jantung koroner dengan dan tanpa DM tipe 2
dengan menggunakan tromboelastografi ”. Dimana faal hemostasis ini merupakan
tingkat proses pembekuan darah bapak.
Anda bebas memilih keikutsertaan dalam penelitian ini tanpa paksaan dari
pihak manapun. Bila Anda sudah memutuskan untuk ikut, Anda juga bebas untuk
mengundurkan diri/ berubah pikiran setiap saat tanpa dikenakan denda atau pun
sanksi apapun.
Apabila Anda bersedia berpartisipasi dalam penelitian ini, Anda diminta

menandatangani lembar persetujuan untuk peneliti. Prosedur selanjutnya adalah:
1. Anda akan diwawancarai oleh peneliti untuk menanyakan identitas subjek,
riwayat penyakit, riwayat obat-obatan, dan riwayat kesehatan lain yang
berhubungan dengan penelitian ini.
2. Anda akan diminta untuk dilakukan pengambilan darah sebanyak 1 kali.
Pengambilan darah dilakukan sehari setelah dilakukan prosedur.
3. Pengambilan darah akan dilakukan oleh perawat yang berkompeten dan
telah terbiasa melakukan tindakan tersebut.
4. Sampel darah akan dibawa untuk dilakukan pemeriksaan.
Sebagai subjek penelitian, Anda berkewajiban mengikuti aturan atau
petunjuk penelitian seperti yang tertulis di atas. Bila ada yang belum jelas, Anda
dapat bertanya kepada peneliti.
Pada dasarnya, pengambilan darah hanya akan menyebabkan risiko
minimal. Risiko yang mungkin terjadi adalah lebam/kulit kebiruan atau sedikit
perdarahan pada daerah tempat pengambilan darah. Anda dapat menekan daerah
suntikan jika darah masih mengalir dan mengompres daerah suntikan jika terjadi
lebam/kulit kebiruan.
Segala biaya pemeriksaan laboratorium dan penyediaan obat menjadi
tanggung jawab peneliti. Bila masih terdapat pertanyaan atau keluhan sewaktu
penelitian ini berjalan, maka Bapak/Ibu dapat menghubungi saya pada:

Nama
: dr.Brama Ihsan Sazli
Alamat
: Jl. Gaperta no 188 Medan
Telepon
: 085296630320
Peneliti,

(dr.Brama Ihsan Sazli)

Universitas Sumatera Utara

63

LAMPIRAN 3
SURAT PERSETUJUAN SETELAH PENJELASAN
(INFORMED CONCERN )

Saya yang bertanda tangan dibawah ini :
Nama

:...........................................................................................
Alamat
:...........................................................................................
Umur
:........................ Tahun
Jenis Kelamin : Laki-laki/ Perempuan.
No Telp/HP :
Setelah mendapat penjelasan dari peneliti tentang kebaikan dan keburukan
prosedur penelitian ini , menyatakan secara sadar dan tanpa paksaan bersedia ikut
serta dalam penelitian” Perbandingan faal hemostasis pada pasien Diabetes
Mellitus tipe 2 dan Penyakit Jantung Koroner dengan menggunakan
tromboelastografi”.
Demikianlah surat persetujuan bersedia ikut dalam penelitian ini saya buat, untuk
dapat digunakan seperlunya.
…........................2015
Saksi

(…..........................................)

Medan,


Yang Memberi Pernyataan

(…..........................................)

Universitas Sumatera Utara

64

LAMPIRAN 4
KERTAS KERJA PROFIL PESERTA PENELITIAN
I.IDENTITAS PRIBADI
Nama
Tempat/Tanggal Lahir
Jenis Kelamin
Pendidikan Terakhir
Pekerjaan
Status
Telp/Hp:….............


:

Kode : X / Y

:
: Laki-laki/Perempuan.
:
:
:
Kawin/Belum

Kawin.

No

II.ANAMNESIS PENYAKIT DAN PENGOBATAN
Anamnesis Penyakit dan Terapi
1. Diabetes Mellitus / dalam terapi Diabetes mellitus
2. Hipertensi, kardiovaskular dan stroke
3. Penyakit kronis

4. Penyakit gangguan fungsi ginjal
5. Penyakit gangguan fungsi hati
6. Hamil/Menyusui/Terapi Hormonal
7. Perokok.

Ya

Tidak

III.PEMERIKSAAN FISIK
Tekanan Darah
: ….... mmHg.
Pemeriksaan Parameter Antrometri.
Parameter Antropometri
Berat Badan (kg)
Tinggi Badan (m2)
Indeks Massa Tubuh (kg/m2 )

Pre- Test


Post-Test

IV.PEMERIKSAAN LABORATORIUM
Rutin:
Hemostasis Konvensional:
V. Hasil Tromboelastografi:

Universitas Sumatera Utara

65

LAMPIRAN 5
Data Penelitian

Universitas Sumatera Utara

66

Keterangan:
Jenis Kelamin: 1: laki-laki

2: Wanita
Obese, Merokok, Dislipidemia, HT, Diabetes, riwayat keluarga, riwayat ACS,
Aspirin, Clopidogrel, Statin:
1: ya
2: tidak

Universitas Sumatera Utara

67

LAMPIRAN 6
Output Analisis

Tests of Normality
Kolmogorov-Smirnova
diabetes
usia

Statistic


1

df

.109

2

Shapiro-Wilk
Sig.

15

.120

26

Statistic

df


Sig.

.200

*

.972

15

.888

.200

*

.963

26


.461

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.

Group Statistics
diabetes
usia

N

Mean

Std. Deviation

Std. Error Mean

1

15

56.80

9.428

2.434

2

26

56.46

6.243

1.224

Independent Samples Test
Levene's Test for Equality of
Variances
F
usia

t-test for Equality of Means

Sig.

Equal variances assumed

t

3.006

.091

Equal variances not assumed

df
.138

39

.124

21.219

Independent Samples Test
t-test for Equality of Means

Sig. (2-tailed)
usia

Mean Difference

Std. Error
Difference

Equal variances assumed

.891

.338

2.446

Equal variances not assumed

.902

.338

2.725

Independent Samples Test
t-test for Equality of Means
95% Confidence Interval of the
Difference
Lower
usia

Upper

Equal variances assumed

-4.608

5.285

Equal variances not assumed

-5.325

6.002

Crosstabs
sex * diabetes Crosstabulation
diabetes
1

2

Total

Universitas Sumatera Utara

68

sex

1

Count
Expected Count

2

12

24

36

13.2

22.8

36.0

3

2

5

1.8

3.2

5.0

Count
Expected Count

Total

Count
Expected Count

15

26

41

15.0

26.0

41.0

Chi-Square Tests
Value
Pearson Chi-Square
Continuity Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear Association
N of Valid Cases

Asymp. Sig. (2sided)

df

1.346a
.442
1.291

1
1
1

.246
.506
.256

1.313
41

1

.252

Exact Sig. (2sided)

Exact Sig. (1sided)

.336

.249

a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is 1,83.
b. Computed only for a 2x2 table

Explore
Tests of Normality
Kolmogorov-Smirnova
diabetes
TDS

Statistic

df

Shapiro-Wilk
Sig.

1

.179

15

2

.191

26

Statistic

df

Sig.

*

.946

15

.460

.015

.933

26

.093

.200

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
T-Test
Group Statistics
diabetes
TDS

N

Mean

Std. Deviation

Std. Error Mean

1

15

127.00

18.689

4.826

2

26

131.81

19.291

3.783

Independent Samples Test
Levene's Test for Equality of
Variances
F
TDS

Equal variances assumed

t-test for Equality of Means

Sig.
.003

t
.959

Equal variances not assumed

df
-.777

39

-.784

30.127

Independent Samples Test
t-test for Equality of Means

Universitas Sumatera Utara

69

Sig. (2-tailed)
TDS

Std. Error
Difference

Mean Difference

Equal variances assumed

.442

-4.808

6.186

Equal variances not assumed

.439

-4.808

6.132

Independent Samples Test
t-test for Equality of Means
95% Confidence Interval of the
Difference
Lower
TDS

Upper

Equal variances assumed

-17.319

7.704

Equal variances not assumed

-17.328

7.713

Explore
diabetes
Tests of Normality
Kolmogorov-Smirnova
diabetes
HR

Statistic

1

df

.217

2

Shapiro-Wilk
Sig.

.113

Statistic

df

Sig.

15

.055

.843

15

.014

26

*

.963

26

.458

.200

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
Mann-Whitney Test
Ranks
iabetes
HR

N

Mean Rank

Sum of Ranks

1

15

21.93

329.00

2

26

20.46

532.00

Total

41
Test Statisticsb
HR

Mann-Whitney U
Wilcoxon W
Z
Asymp. Sig. (2-tailed)
Exact Sig. [2*(1-tailed Sig.)]

181.000
532.000
-.380
.704
.718a

a. Not corrected for ties.
b. Grouping Variable: diabetes
Explore
Tests of Normality
Kolmogorov-Smirnova
diabetes
BMI

1

Statistic
.138

df

Shapiro-Wilk
Sig.

15

.200

Statistic
*

.918

df

Sig.
15

.178

Universitas Sumatera Utara

70

2

.123

.200*

26

.943

26

.160

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
T-Test
Group Statistics
diabetes
BMI

N

Mean

Std. Deviation

Std. Error Mean

1

15

25.4367

3.79212

.97912

2

26

25.5288

3.29004

.64523

Independent Samples Test
Levene's Test for Equality of
Variances
F
BMI

t-test for Equality of Means

Sig.

Equal variances assumed

t

.287

.595

Equal variances not assumed

df
-.082

39

-.079

26.049

Independent Samples Test
t-test for Equality of Means

Sig. (2-tailed)
BMI

Std. Error
Difference

Mean Difference

Equal variances assumed

.935

-.09218

1.12789

Equal variances not assumed

.938

-.09218

1.17260

Independent Samples Test
t-test for Equality of Means
95% Confidence Interval of the
Difference
Lower
BMI

Upper

Equal variances assumed

-2.37355

2.18919

Equal variances not assumed

-2.50228

2.31792

merokok * diabetes Crosstabulation
diabetes
1
Merokok

1

Count

Total

Total

12

24

36

13.2

22.8

36.0

3

2

5

Expected Count

1.8

3.2

5.0

Count

15

26

41

15.0

26.0

41.0

Expected Count
2

2

Count

Expected Count

Chi-Square Tests

Universitas Sumatera Utara

71

Value
Pearson Chi-Square
Continuity Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear Association
N of Valid Cases

Asymp. Sig. (2sided)

df

Exact Sig. (2sided)

1.346a
.442
1.291

1
1
1

.246
.506
.256

1.313
41

1

.252

Exact Sig. (1sided)

.336

.249

a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is 1,83.
b. Computed only for a 2x2 table

hipertensi * diabetes Crosstabulation
diabetes
1
hipertensi

1

Count

Total

Total
19

29

10.6

18.4

29.0

5

7

12

Expected Count

4.4

7.6

12.0

Count

15

26

41

15.0

26.0

41.0

Expected Count
2

2
10

Count

Expected Count

Chi-Square Tests
Value
.189a
.006
.187

Pearson Chi-Square
Continuity Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear Association
N of Valid Cases

Asymp. Sig. (2sided)

df
1
1
1

Exact Sig. (2sided)

Exact Sig. (1sided)

.664
.938
.665
.730

.184
41

1

.668

a. 1 cells (25,0%) have expected count less than 5. The minimum expected count is 4,39.
b. Computed only for a 2x2 table
NPar Tests
Two-Sample Kolmogorov-Smirnov Test
Frequencies
diabetes
Merokok

N

1

15

2

26

Total

41

Test Statisticsa
merokok
Most Extreme Differences

Absolute

.123

Positive

.123

Universitas Sumatera Utara

.464

72

Negative
Kolmogorov-Smirnov Z

.000
.380

Asymp. Sig. (2-tailed)

.999

a. Grouping Variable: diabetes
NPar Tests
Two-Sample Kolmogorov-Smirnov Test

Frequencies
diabetes
Hipertensi

N

1

15

2

26

Total

41

Test Statisticsa
hipertensi
Most Extreme Differences

Absolute

.064

Positive

.064

Negative
Kolmogorov-Smirnov Z

.000
.198

Asymp. Sig. (2-tailed)

1.000

a. Grouping Variable: diabetes

riwACS * diabetes Crosstabulation
diabetes
1
riwACS

1

2
Total

2

Total

Count

11

9

20

Expected Count

7.3

12.7

20.0

4

17

21

Expected Count

7.7

13.3

21.0

Count

15

26

41

15.0

26.0

41.0

Count

Expected Count

Chi-Square Tests
Value
Pearson Chi-Square
Continuity Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear Association
N of Valid Cases

5.707a
4.263
5.874

Asymp. Sig. (2sided)

df
1
1
1

Exact Sig. (2sided)

Exact Sig. (1sided)

.017
.039
.015
.025

5.568
41

1

.018

a. 0 cells (,0%) have expected count less than 5. The minimum expected count is 7,32.
b. Computed only for a 2x2 table

riwPCI * diabetes Crosstabulation

Universitas Sumatera Utara

.019

73

diabetes
1
riwPCI

1

2

Count

Total

5

6

11

Expected Count

4.0

7.0

11.0

Count

10

20

30

11.0

19.0

30.0

15

26

41

15.0

26.0

41.0

Expected Count
Total

2

Count
Expected Count

Chi-Square Tests
Value
Pearson Chi-Square
Continuity Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear Association
N of Valid Cases

Asymp. Sig. (2sided)

df

Exact Sig. (2sided)

.510a
.121
.501

1
1
1

.475
.728
.479

.497
41

1

.481

Exact Sig. (1sided)

.491

a. 1 cells (25,0%) have expected count less than 5. The minimum expected count is 4,02.
b. Computed only for a 2x2 table
NPar Tests
Two-Sample Kolmogorov-Smirnov Test

Frequencies
diabetes
riwPCI

N

1

15

2

26

Total

41
Test Statisticsa
riwPCI

Most Extreme Differences

Absolute

.103

Positive

.000

Negative
Kolmogorov-Smirnov Z

-.103
.316

Asymp. Sig. (2-tailed)

1.000

a. Grouping Variable: diabetes

aspirin * diabetes Crosstabulation
diabetes
1
aspirin

1

Count
Expected Count

2

Count

2

Total

7

11

18

6.6

11.4

18.0

8

15

23

Universitas Sumatera Utara

.359

74

Total

Expected Count

8.4

14.6

23.0

Count

15

26

41

15.0

26.0

41.0

Expected Count

Chi-Square Tests
Value
Pearson Chi-Square
Continuity Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear Association
N of Valid Cases

Asymp. Sig. (2sided)

df

Exact Sig. (2sided)

.073a
.000
.073

1
1
1

.786
1.000
.787

.072
41

1

.789

Exact Sig. (1sided)

1.000

.521

a. 0 cells (,0%) have expected count less than 5. The minimum expected count is 6,59.
b. Computed only for a 2x2 table
Crosstabs
Case Processing Summary
Cases
Valid
N
clopidogrel * diabetes

Missing
Percent

41

N

100.0%

Total

Percent

N

0

.0%

2

Total

Percent
41

100.0%

clopidogrel * diabetes Crosstabulation
diabetes
1
clopidogrel

1

Count
Expected Count

2
Total

7

9

16

5.9

10.1

16.0

Count

8

17

25

Expected Count

9.1

15.9

25.0

Count

15

26

41

15.0

26.0

41.0

Expected Count

Chi-Square Tests
Value
Pearson Chi-Square
Continuity Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear Association
N of Valid Cases

Asymp. Sig. (2sided)

df

.581a
.185
.577

1
1
1

.446
.667
.448

.566
41

1

.452

Exact Sig. (2sided)

Exact Sig. (1sided)

.517

a. 0 cells (,0%) have expected count less than 5. The minimum expected count is 5,85.
b. Computed only for a 2x2 table

Universitas Sumatera Utara

.332

75

statin * diabetes Crosstabulation
diabetes
1
statin

1

2

Total

5

6

11

Expected Count

4.0

7.0

11.0

Count

10

20

30

11.0

19.0

30.0

Expected Count
Total

2

Count

Count
Expected Count

15

26

41

15.0

26.0

41.0

Chi-Square Tests
Value

Asymp. Sig. (2sided)

df

.510a
.121
.501

Pearson Chi-Square
Continuity Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear Association
N of Valid Cases

1
1
1

Exact Sig. (2sided)

Exact Sig. (1sided)

.475
.728
.479
.491

.497
41

1

.359

.481

a. 1 cells (25,0%) have expected count less than 5. The minimum expected count is 4,02.
b. Computed only for a 2x2 table

Tests of Normality
Kolmogorov-Smirnova
diabetes
hb

Statistic

1

df

.160

2

Shapiro-Wilk
Sig.

15

.101

26

Statistic

df

Sig.

.200

*

.918

15

.178

.200

*

.963

26

.444

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
T-Test
Group Statistics
diabetes
hb

N

Mean

Std. Deviation

Std. Error Mean

1

15

13.0467

1.90108

.49086

2

26

14.7654

1.36057

.26683

Independent Samples Test
Levene's Test for Equality of
Variances
F
hb

Equal variances assumed

t-test for Equality of Means

Sig.
3.034

Equal variances not assumed

t
.089

df
-3.363

39

-3.076

22.401

Independent Samples Test

Universitas Sumatera Utara

76

t-test for Equality of Means

Sig. (2-tailed)
hb

Std. Error
Difference

Mean Difference

Equal variances assumed

.002

-1.71872

.51102

Equal variances not assumed

.005

-1.71872

.55869

Independent Samples Test
t-test for Equality of Means
95% Confidence Interval of the
Difference
Lower
hb

Upper

Equal variances assumed

-2.75235

-.68509

Equal variances not assumed

-2.87617

-.56126

Tests of Normality
Kolmogorov-Smirnova
diabetes
leukosit

Statistic

df

Shapiro-Wilk
Sig.

1

.169

15

2

.153

26

Statistic

df

Sig.

*

.929

15

.261

.118

.908

26

.024

.200

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
Mann-Whitney Test
Ranks
diabetes
leukosit

N

Mean Rank

Sum of Ranks

1

15

22.20

333.00

2

26

20.31

528.00

Total

41

Test Statisticsb
leukosit
Mann-Whitney U
Wilcoxon W
Z
Asymp. Sig. (2-tailed)
Exact Sig. [2*(1-tailed Sig.)]

177.000
528.000
-.487
.626
.640a

a. Not corrected for ties.
b. Grouping Variable: diabetes

Tests of Normality
Kolmogorov-Smirnova
diabetes
platelet

1

Statistic
.151

df

Shapiro-Wilk
Sig.

15

.200

Statistic
*

df

.910

Sig.
15

.133

Universitas Sumatera Utara

77

2

.130

.200*

26

.968

26

.583

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
Group Statistics
diabetes
platelet

N

Mean

Std. Deviation

Std. Error Mean

1

15

311600.0000

1.06793E5

27573.93524

2

26

244000.0000

45128.26165

8850.38026

Independent Samples Test
Levene's Test for Equality of
Variances
F
platelet

Equal variances assumed

t-test for Equality of Means

Sig.
19.328

t
.000

Equal variances not assumed

df
2.837

39

2.334

16.933

Independent Samples Test
t-test for Equality of Means

Sig. (2-tailed)
platelet

Mean Difference

Std. Error
Difference

Equal variances assumed

.007

67600.00000

23825.25359

Equal variances not assumed

.032

67600.00000

28959.47402

Independent Samples Test
t-test for Equality of Means
95% Confidence Interval of the
Difference
Lower
platelet

Equal variances assumed
Equal variances not assumed

Upper

19408.87589

1.15791E5

6482.30258

1.28718E5

diabetes
Tests of Normality
Kolmogorov-Smirnova
diabetes
ureum

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.236

15

.025

.815

15

.006

2

.183

26

.024

.865

26

.003

a. Lilliefors Significance Correction
Mann-Whitney Test
Ranks
diabetes
ureum

N

Mean Rank

Sum of Ranks

1

15

25.77

386.50

2

26

18.25

474.50

Universitas Sumatera Utara

78

Ranks
diabetes
ureum

N

Mean Rank

Sum of Ranks

1

15

25.77

386.50

2

26

18.25

474.50

Total

41

Test Statisticsb
ureum
Mann-Whitney U
Wilcoxon W
Z
Asymp. Sig. (2-tailed)
Exact Sig. [2*(1-tailed Sig.)]

123.500
474.500
-1.935
.053
.052a

a. Not corrected for ties.
b. Grouping Variable: diabetes

Tests of Normality
Kolmogorov-Smirnova
diabetes
kreatinin

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.169

15

.200*

.863

15

.027

2

.183

26

.025

.893

26

.011

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
Mann-Whitney Test
Ranks
diabetes
kreatinin

N

Mean Rank

Sum of Ranks

1

15

20.33

305.00

2

26

21.38

556.00

Total

41

Test Statisticsb
kreatinin
Mann-Whitney U
Wilcoxon W
Z
Asymp. Sig. (2-tailed)
Exact Sig. [2*(1-tailed Sig.)]

185.000
305.000
-.271
.787
.799a

a. Not corrected for ties.
b. Grouping Variable: diabetes

Tests of Normality
Kolmogorov-Smirnova
diabetes
kgd

1

Statistic
.236

df

Shapiro-Wilk
Sig.

15

Statistic
.024

.840

df

Sig.
15

.013

Universitas Sumatera Utara

79

2

.179

26

.031

.899

26

.015

a. Lilliefors Significance Correction
Mann-Whitney Test
Ranks
diabetes
kgd

N

Mean Rank

Sum of Ranks

1

15

30.87

463.00

2

26

15.31

398.00

Total

41

Test Statisticsb
kgd
Mann-Whitney U
Wilcoxon W
Z
Asymp. Sig. (2-tailed)
Exact Sig. [2*(1-tailed Sig.)]

47.000
398.000
-4.006
.000
.000a

a. Not corrected for ties.
b. Grouping Variable: diabetes

Report
diabetes
1

sex
Mean

HR

BMI

merokok

56.80

127.00

76.07

25.4367

1.20

15

15

15

15

15

15

Std. Deviation

.414

9.428

18.689

16.180

3.79212

.414

Mean

1.08

56.46

131.81

72.35

25.5288

1.08

N
Total

TDS

1.20

N
2

usia

26

26

26

26

26

26

Std. Deviation

.272

6.243

19.291

12.435

3.29004

.272

Mean

1.12

56.59

130.05

73.71

25.4951

1.12

N
Std. Deviation

41

41

41

41

41

41

.331

7.450

18.983

13.841

3.43516

.331

clopidogrel

statin

Report
diabetes
1

hipertensi
Mean

aspirin

1.27

1.67

1.53

1.53

1.67

15

15

15

15

15

15

Std. Deviation

.488

.458

.488

.516

.516

.488

Mean

1.27

1.65

1.77

1.58

1.65

1.77

26

26

26

26

26

26

Std. Deviation

.452

.485

.430

.504

.485

.430

Mean

1.29

1.51

1.73

1.56

1.61

1.73

41

41

41

41

41

41

.461

.506

.449

.502

.494

.449

N
Total

riwPCI

1.33

N
2

riwACS

N
Std. Deviation

Report
diabetes

hb

leukosit

platelet

ureum

Universitas Sumatera Utara

80

1

Mean

13.0467

N
2

311600.0000

37.8200

15

15

15

15

Std. Deviation

1.90108

2806.33762

1.06793E5

21.50775

Mean

14.7654

8884.2308

244000.0000

26.4731

N
Total

9518.6000

26

26

26

26

Std. Deviation

1.36057

2088.84690

45128.26165

12.12127

Mean

14.1366

9116.3171

268731.7073

30.6244

41

41

41

41

1.76759

2362.02987

79694.73772

16.86269

N
Std. Deviation
Report
diabetes
1

kreatinin
Mean

1.2047

204.9933

15

15

Std. Deviation

.51687

111.89970

Mean

1.1327

103.0192

N
2

N
Total

kgd

26

26

Std. Deviation

.31102

21.33997

Mean

1.1590

140.3268

N
Std. Deviation

41

41

.39395

84.49868

Tests of Normality
Kolmogorov-Smirnova
diabetes
TDD

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.290

15

.001

.771

15

.002

2

.167

26

.061

.924

26

.057

a. Lilliefors Significance Correction
Mann-Whitney Test

Ranks
diabetes
TDD

N

Mean Rank

Sum of Ranks

1

15

18.87

283.00

2

26

22.23

578.00

Total

41

NPar Tests

Test Statisticsb
TDD
Mann-Whitney U
Wilcoxon W
Z
Asymp. Sig. (2-tailed)

163.000
283.000
-.904
.366

Universitas Sumatera Utara

81

.398a

Exact Sig. [2*(1-tailed Sig.)]
a. Not corrected for ties.
b. Grouping Variable: diabetes

Tests of Normality
Kolmogorov-Smirnova
diabetes
PT

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.131

15

.200*

.939

15

.368

2

.110

26

.200*

.946

26

.186

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.

Group Statistics
diabetes
PT

N

Mean

Std. Deviation

Std. Error Mean

1

15

.9667

.09194

.02374

2

26

.9812

.08515

.01670

Independent Samples Test
Levene's Test for Equality of
Variances

F
PT

Equal variances assumed

t-test for Equality of Means

Sig.
.039

t
.845

Equal variances not assumed

df
-.510

39

-.499

27.512

Independent Samples Test
t-test for Equality of Means

Std. Error
Sig. (2-tailed)
PT

Mean Difference

Difference

Equal variances assumed

.613

-.01449

.02842

Equal variances not assumed

.622

-.01449

.02902

Independent Samples Test

Universitas Sumatera Utara

82

t-test for Equality of Means
95% Confidence Interval of the
Difference
Lower
PT

Upper

Equal variances assumed

-.07197

.04299

Equal variances not assumed

-.07399

.04501

Tests of Normality
Kolmogorov-Smirnova
diabetes
APTT

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.322

15

.000

.787

15

.002

2

.122

26

.200*

.968

26

.564

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
APTT
Mann-Whitney Test
Ranks
diabetes
APTT

N

Mean Rank

Sum of Ranks

1

15

18.60

279.00

2

26

22.38

582.00

Total

41

Test Statisticsb
APTT
Mann-Whitney U

159.000

Wilcoxon W

279.000

Z

-.975

Asymp. Sig. (2-tailed)

.329

Exact Sig. [2*(1-tailed Sig.)]

.341a

a. Not corrected for ties.
b. Grouping Variable: diabetes

Tests of Normality

Universitas Sumatera Utara

83

Kolmogorov-Smirnova
diabetes
TT

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.303

15

.001

.668

15

.000

2

.134

26

.200*

.940

26

.132

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
TT
Mann-Whitney Test
Ranks
diabetes
TT

N

Mean Rank

Sum of Ranks

1

15

23.73

356.00

2

26

19.42

505.00

Total

41

Test Statisticsb
TT
Mann-Whitney U

154.000

Wilcoxon W

505.000

Z

-1.112

Asymp. Sig. (2-tailed)

.266

Exact Sig. [2*(1-tailed Sig.)]

.277a

a. Not corrected for ties.
b. Grouping Variable: diabetes

Tests of Normality
Kolmogorov-Smirnova
diabetes
TEGR

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.200

15

.110

.930

15

.274

2

.128

26

.200*

.973

26

.700

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
TEGR
Group Statistics

Universitas Sumatera Utara

84

diabetes
TEGR

N

Mean

Std. Deviation

Std. Error Mean

1

15

4.9067

1.14297

.29511

2

26

6.0808

1.52683

.29944

Independent Samples Test
Levene's Test for Equality of
Variances

F
TEGR

t-test for Equality of Means

Sig.

Equal variances assumed

t

1.519

.225

Equal variances not assumed

df
-2.584

39

-2.793

36.187

Independent Samples Test
t-test for Equality of Means

Std. Error
Sig. (2-tailed)
TEGR

Mean Difference

Difference

Equal variances assumed

.014

-1.17410

.45431

Equal variances not assumed

.008

-1.17410

.42042

Independent Samples Test
t-test for Equality of Means
95% Confidence Interval of the
Difference
Lower
TEGR

Upper

Equal variances assumed

-2.09304

-.25517

Equal variances not assumed

-2.02660

-.32160

Tests of Normality
Kolmogorov-Smirnova
diabetes
TEGangle

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.124

15

.200*

.978

15

.952

2

.100

26

.200*

.957

26

.340

a. Lilliefors Significance Correction

Universitas Sumatera Utara

85

Tests of Normality
Kolmogorov-Smirnova
diabetes
TEGangle

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.124

15

.200*

.978

15

.952

2

.100

26

.200*

.957

26

.340

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
TEGangle
Group Statistics
diabetes
TEGangle

N

Mean

Std. Deviation

Std. Error Mean

1

15

69.9467

5.10166

1.31724

2

26

66.0192

5.37171

1.05348

Independent Samples Test
Levene's Test for Equality of
Variances

F
TEGangle

Equal variances assumed

t-test for Equality of Means

Sig.
.155

t
.696

Equal variances not assumed

df
2.296

39

2.328

30.621

Independent Samples Test
t-test for Equality of Means

Std. Error
Sig. (2-tailed)
TEGangle

Mean Difference

Difference

Equal variances assumed

.027

3.92744

1.71078

Equal variances not assumed

.027

3.92744

1.68670

Independent Samples Test
t-test for Equality of Means
95% Confidence Interval of the
Difference

Universitas Sumatera Utara

86

Lower
TEGangle

Upper

Equal variances assumed

.46706

7.38781

Equal variances not assumed

.48567

7.36920

Tests of Normality
Kolmogorov-Smirnova
diabetes
TEGK

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.113

15

.200*

.972

15

.889

2

.108

26

.200*

.973

26

.697

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
TEGK
Group Statistics
diabetes
TEGK

N

Mean

Std. Deviation

Std. Error Mean

1

15

1.3600

.35214

.09092

2

26

1.7769

.46674

.09154

Independent Samples Test
Levene's Test for Equality of
Variances

F
TEGK

Equal variances assumed

t-test for Equality of Means

Sig.
1.439

t
.237

Equal variances not assumed

df
-2.996

39

-3.232

36.033

Independent Samples Test
t-test for Equality of Means

Std. Error
Sig. (2-tailed)
TEGK

Mean Difference

Difference

Equal variances assumed

.005

-.41692

.13914

Equal variances not assumed

.003

-.41692

.12902

Universitas Sumatera Utara

87

Independent Samples Test
t-test for Equality of Means
95% Confidence Interval of the
Difference
Lower
TEGK

Upper

Equal variances assumed

-.69836

-.13548

Equal variances not assumed

-.67857

-.15527

Tests of Normality
Kolmogorov-Smirnova
diabetes
TEGMA

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.117

15

.200*

.969

15

.836

2

.149

26

.140

.965

26

.508

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
TEGMA
Group Statistics
diabetes
TEGMA

N

Mean

Std. Deviation

Std. Error Mean

1

15

69.2200

5.14215

1.32770

2

26

65.0615

5.50818

1.08024

Independent Samples Test
Levene's Test for Equality of
Variances

F
TEGMA

Equal variances assumed

t-test for Equality of Means

Sig.
.016

t
.901

Equal variances not assumed

df
2.384

39

2.430

31.051

Independent Samples Test
t-test for Equality of Means

Universitas Sumatera Utara

88

Std. Error
Sig. (2-tailed)
TEGMA

Mean Difference

Difference

Equal variances assumed

.022

4.15846

1.74427

Equal variances not assumed

.021

4.15846

1.71164

Independent Samples Test
t-test for Equality of Means
95% Confidence Interval of the
Difference
Lower
TEGMA

Upper

Equal variances assumed

.63034

7.68658

Equal variances not assumed

.66778

7.64914

Tests of Normality
Kolmogorov-Smirnova
diabetes
TEGG

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.152

15

.200*

.942

15

.412

2

.138

26

.200*

.945

26

.179

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
TEGG
Group Statistics
diabetes
TEGG

N

Mean

Std. Deviation

Std. Error Mean

1

15

11.7067

2.91828

.75350

2

26

9.6500

2.39136

.46898

Independent Samples Test
Levene's Test for Equality of
Variances

F
TEGG

Equal variances assumed
Equal variances not assumed

t-test for Equality of Means

Sig.
1.872

t
.179

df
2.446

39

2.317

24.859

Universitas Sumatera Utara

89

Independent Samples Test
t-test for Equality of Means

Std. Error
Sig. (2-tailed)
TEGG

Mean Difference

Difference

Equal variances assumed

.019

2.05667

.84070

Equal variances not assumed

.029

2.05667

.88753

Independent Samples Test
t-test for Equality of Means
95% Confidence Interval of the
Difference
Lower
TEGG

Upper

Equal variances assumed

.35620

3.75713

Equal variances not assumed

.22824

3.88509

Tests of Normality
Kolmogorov-Smirnova
diabetes
EPL

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.355

15

.000

.581

15

.000

2

.288

26

.000

.623

26

.000

a. Lilliefors Significance Correction
EPL
Mann-Whitney Test
Ranks
diabetes
EPL

N

Mean Rank

Sum of Ranks

1

15

21.93

329.00

2

26

20.46

532.00

Total

41

Test Statisticsb
EPL
Mann-Whitney U

181.000

Wilcoxon W

532.000

Universitas Sumatera Utara

90

Z

-.387

Asymp. Sig. (2-tailed)

.699

Exact Sig. [2*(1-tailed Sig.)]

.718a

a. Not corrected for ties.
b. Grouping Variable: diabetes

Descriptive Statistics
N

Minimum

Maximum

Mean

Std. Deviation

PT

41

.84

1.17

.9759

.08683

INR

41

.83

1.17

.9759

.08826

APTT

41

.58

1.73

.9546

.19818

TT

41

.71

1.62

.8888

.15012

TEGR

41

2.70

9.30

5.6512

1.49735

TEGangle

41

57.70

80.90

67.4561

5.55086

TEGK

41

.80

2.70

1.6244

.46999

TEGMA

41

53.90

77.40

66.5829

5.68590

TEGG

41

5.80

17.10

10.4024

2.74968

EPL

41

.00

11.80

1.3439

2.58041

Valid N (listwise)

41

Tests of Normality
Kolmogorov-Smirnova
diabetes
INR

Statistic

df

Shapiro-Wilk
Sig.

Statistic

df

Sig.

1

.122

15

.200*

.942

15

.411

2

.110

26

.200*

.943

26

.157

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
INR
Group Statistics
diabetes
INR

N

Mean

Std. Deviation

Std. Error Mean

1

15

.9653

.09395

.02426

2

26

.9819

.08612

.01689

Universitas Sumatera Utara

91

Independent Samples Test
Levene's Test for Equality of
Variances

F
INR

t-test for Equality of Means

Sig.

Equal variances assumed

t

.057

.812

Equal variances not assumed

df
-.575

39

-.561

27.273

Independent Samples Test
t-test for Equality of Means

Std. Error
Sig. (2-tailed)
INR

Mean Difference

Difference

Equal variances assumed

.569

-.01659

.02886

Equal variances not assumed

.579

-.01659

.02956

Independent Samples Test
t-test for Equality of Means
95% Confidence Interval of the
Difference
Lower
INR

Upper

Equal variances assumed

-.07496

.04178

Equal variances not assumed

-.07721

.04403

Universitas Sumatera Utara

92

LAMPIRAN 7
DAFTAR RIWAYAT HIDUP

DATA PRIBADI
Nama

: dr.Brama Ihsan Sazli

Tempat/Tgl. lahir

: Medan / 13 Agustus 1987

Jenis kelamin

: Pria

Agama

: Islam

Pekerjaan

: Dokter

NIP

:

Pangkat/Gol.

: Penata / IIIb

Alamat pekerjaan

: Fakultas Kedokteran Universitas Sumatera Utara

198708132012121003

Jl. dr. Mansyur no. 5 Medan
Departemen Ilmu Penyakit Dalam
RSUP. H. Adam Malik Medan
Jl. Bunga Lau no.17 Medan
Alamat rumah

: Jl.Gaperta No. 188
Kecamatan Medan JHelvetia
Medan

Telepon selular

: 085296630320

PENDIDIKAN
SD Swasta IKAL (1993-1998) di Medan – Sumatera Utara
SLTP Negeri 7 Medan (1998-2001) di Medan – Sumatera Utara
SMU Negeri 4 Medan (2001-2004) di Medan – Sumatera Utara
Fakultas Kedokteran USU (2004-2009) di Medan – Sumatera Utara
PPDS Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Sumatera Utara
(2011 - sekarang) di Medan-Sumatera Utara

RIWAYAT PEKERJAAN

Universitas Sumatera Utara

93

KEANGGOTAAN PROFESI
Ikatan Dokter Indonesia (IDI)
Perhimpunan Ahli Penyakit Dalam Indonesia (PAPDI)

KURSUS PENATARAN
Kursus Advanced Cardiac Life Support Course. PERKI, Medan 2010.

KARYA ILMIAH
Brama Ihsan Sazli, Halomoan Budi Santososo, Dharma Lindarto. Pengaruh Pola
Hidup Medis dengan dan tanpa Metformin Terhadap Kadar Adiponektin pada
PAsien Obesitas. SUMETSU. Surabaya. 2012
Brama Ihsan Sazli, Abdurrahim R. Lubis. Gangguan Fungsi Ginjal Pada
Keracunan Paraquat. PIT PERNEFRI. Denpasar. 2012

Universitas Sumatera Utara

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