Formulasi dan Uji Efektivitas Sedian Krim yang Mengandung Minyak Biji Anggur (Grapeseed Oil)

Lampiran 1. Bagan alir proses pembuatan dasar krim

Fase minyak

Fase air

- asam stearat

- sorbitol

- setil alkohol

- propilenglikol

- dimasukkan ke dalam cawan
penguap

- trietanolamin
- nipagin

- dilebur di atas penangas air pada suhu 70°C - dicukupkan dengan

akuades
- dipanaskan pada suhu
70°C
Fase minyak + fase air
- digerus konstan di dalam lumpang panas
- ditambahkan 3 tetes ol lavender
Dasar krim

48

Lampiran 2. Bagan alir proses pembuatan sediaan krim anti-aging
Fase minyak

Fase air

- asam stearat

- sorbitol

- setil alkohol


- propilenglikol

- dimasukkan ke dalam cawan
penguap

- trietanolamin
- nipagin

- dilebur di atas penangas air pada suhu

- dicukupkan dengan
akuades
- dipanaskan pada suhu
70°C

70°C

Fase minyak + Fase air
- digerus konstan di dalam lumpang panas

- ditambahkan minyak biji anggur
- ditambahkan 3 tetes ol lavender
Krim anti-aging

49

Lampiran 3. Gambar alat-alat penelitian

Keterangan:

A

B

C

D

A = Moisture Checker (Aramo)
B = Timbangan analitik (Dickson)

C = Skin Analyzer (Aramo)
D = pH meter (Hanna Instrument)

50

Lampiran 4. Gambar minyak biji anggur

51

Lampiran 5. Gambar sediaan krim anti-aging yang disimpan selama 90 hari
dalam suhu kamar
- Setelah dibuat dalam wadah

F1

F2

F3

F4


F5

- Setelah 90 hari

F1

F2

F3

F4

F5

Keterangan: F1 = blanko (tanpa minyak) dan krim anti-aging minyak biji anggur
F2 = 5%, F3 = 10%, F4 = 15%, F5 = 20%

52


Lampiran 6. Gambar hasil uji tipe emulsi dan homogenitas sediaan krim

a. tipe emulsi

A

B

C

D

E

Keterangan: Hasil penentuan tipe emulsi krim A= blanko, krim minyak biji
anggur B = 5%, C = 10%, D = 15%, E = 20%
b. homogenitas

A


B

C

D

E

Keterangan: Hasil penentuan homogenitas krim A = blanko, krim minyak biji
anggur B = 5%, C = 10%, D = 15%, E = 20%

53

Lampiran 7. Contoh hasil pengukuran menggunakan alat skin analyzer aramoSG pada kulit punggung tangan sukarelawan.
- Moisture (Kadar Air)

54

Lampiran 7. (Lanjutan)


55

Lampiran 7. (Lanjutan)
- Evenness/Pore (Kehalusan/Pori)

56

Lampiran 7. (Lanjutan)

57

Lampiran 7. (Lanjutan)

58

Lampiran 7. (Lanjutan)
- Spot (Noda)

59


Lampiran 7. (Lanjutan)

60

Lampiran 7. (Lanjutan)

61

Lampiran 7. (Lanjutan)
- Wrinkle (Keriput)

62

Lampiran 7. (Lanjutan)

63

Lampiran 7. (Lanjutan)

64


Lampiran 8. Data Hasil Uji Statistik


Kadar air (Moisture)
ANOVA
Sum of Squares

Sebelu Between Groups

df

Mean Square

3.600

4

.900


Within Groups

3.333

10

.333

Total

6.933

14

14.933

4

3.733

4.000

10

.400

18.933

14

11.333

4

2.833

2.667

10

.267

14.000

14

Minggu Between Groups

8.667

4

2.167

III

2.667

10

.267

11.333

14

18.667

4

4.667

4.667

10

.467

23.333

14

m

Minggu Between Groups
I

Within Groups
Total

Minggu Between Groups
II

Within Groups
Total

Within Groups
Total

Minggu Between Groups
IV

Within Groups
Total

F

Sig.

2.700

.092

9.333

.006

10.625

.003

8.125

.002

10.000

.000

Sebelum
Subset for alpha = 0.05
PEMULIHAN
a

Tukey HSD

N

1

2

Formula A

3

30.00

Formula B

3

27.33

Formula C

3

28.33

Formula D

3

28.33

Formula E

3

Sig.

27.30
.200

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

65

1.000

Lampiran 8. (Lanjutan)
MingguI
Subset for alpha = 0.05
PEMULIHAN
a

Tukey HSD

N

1

2

Formula A

3

30.00

Formula B

3

29.00

29.00

Formula C

3

30.00

30.00

Formula D

3

30.67

Formula E

3

31.33

Sig.

.283

.102

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

MingguII
Subset for alpha = 0.05
PEMULIHAN
a

Tukey HSD

N

1

2

3

Formula A

3

30.00

Formula B

3

30.33

30.33

Formula C

3

30.67

30.67

Formula D

3

Formula E

3

Sig.

31.67

32.33
.539

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

66

31.67

.061

.539

Lampiran 8. (Lanjutan)
MingguIII
Subset for alpha = 0.05
PEMULIHAN
a

Tukey HSD

N

1

2

Formula A

3

30.33

Formula B

3

31.00

Formula C

3

Formula D

3

Formula E

3

3

4

31.00
31.67

31.67
32.33

32.33
33.00

Sig.

.411

.411

.411

.411

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

MingguIV
Subset for alpha = 0.05
PEMULIHAN
a

Tukey HSD

N

1

2

3

Formula A

3

30.33

Formula B

3

31.67

Formula C

3

32.67

Formula D

3

33.00

Formula E

3

Sig.

a. Uses Harmonic Mean Sample Size = 3.000.

67

33.00
34.33

.061

Means for groups in homogeneous subsets are displayed.

31.67

.061

.061

Lampiran 8. (Lanjutan)


Kehalusan (Evenness)
ANOVA
Sum of Squares
Sebelu Between Groups
m

16.100

Within Groups

15.333

10

1.533

Total

79.733

14

142.267

4

35.567

16.667

10

1.667

158.933

14

144.667

4

36.167

18.667

10

1.867

163.333

14

169.733

4

42.433

14.000

10

1.400

183.733

14

217.067

4

54.267

16.667

10

1.667

233.733

14

Within Groups

Minggu Between Groups
Within Groups
Total
Minggu Between Groups
III

Within Groups
Total

Minggu Between Groups
IV

F

4

Total

II

Mean Square

64.400

Minggu Between Groups
I

df

Within Groups
Total

Sig.

10.500 .011

21.340 .010

19.375 .007

30.310 .000

32.560 .000

Sebelum
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

3

Formula E

3

35.67

Formula D

3

37.67

37.67

Formula C

3

38.00

38.00

Formula B

3

Formula A

3

Sig.

39.00

42.00
.219

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

68

39.00

.687

.082

Lampiran 8. (Lanjutan)
MingguI
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

34.00

Formula D

3

34.00

Formula C

3

36.33

Formula B

3

Formula A

3

3

36.33
39.00

39.00
42.00

Sig.

.250

.159

.099

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

MingguII
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

33.67

Formula D

3

33.00

Formula C

3

35.33

Formula B

3

Formula A

3

Sig.

a. Uses Harmonic Mean Sample Size = 3.000.

69

35.33
38.67

38.67
42.00

.294

Means for groups in homogeneous subsets are displayed.

3

.126

.126

Lampiran 8. (Lanjutan)
MingguIII
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

32.33

Formula D

3

32.67

Formula C

3

34.00

Formula B

3

Formula A

3

3

34.00
37.00
42.00

Sig.

.462

.067

1.000

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

MingguIV
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

30.00

Formula D

3

31.00

Formula C

3

33.33

Formula B

3

Formula A

3

Sig.

a. Uses Harmonic Mean Sample Size = 3.000.

70

33.33
37.33
41.67

.061

Means for groups in homogeneous subsets are displayed.

3

.061

1.000

Lampiran 8. (Lanjutan)


Pori (Pore)
ANOVA
Sum of Squares

Sebelum Between Groups

df

Mean Square

155.333

4

38.833

Within Groups

118.000

10

11.800

Total

273.333

14

Between Groups

86.400

4

21.600

Within Groups

99.333

10

9.933

Total

185.733

14

MingguII Between Groups

56.000

4

14.000

54.000

10

5.400

Total

110.000

14

MingguIII Between Groups

41.067

4

10.267

Within Groups

34.667

10

3.467

Total

75.733

14

MingguIV Between Groups

57.600

4

14.400

Within Groups

21.333

10

2.133

Total

78.933

14

MingguI

Within Groups

F

Sig.

3.291 .075

2.174 .058

2.593 .021

2.962 .015

6.750 .007

Sebelum

Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

Formula E

3

28.67

Formula D

3

28.33

Formula C

3

27.67

Formula B

3

27.00

Formula A

3

20.00

Sig.

.068

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

71

Lampiran 8. (Lanjutan)
MingguI

Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

Formula E

3

24.67

Formula D

3

24.33

Formula C

3

25.33

Formula B

3

26.00

Formula A

3

18.67

Sig.

.146

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

MingguII

Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

Formula E

3

18.67

Formula D

3

22.67

Formula C

3

22.00

Formula B

3

23.00

Formula A

3

18.67

Sig.

.227

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

72

Lampiran 8. (Lanjutan)
MingguIII
Subset for alpha = 0.05
PEMULIHAN
a

Tukey HSD

N

1

2

Formula E

3

15.33

Formula D

3

18.00

18.00

Formula C

3

19.33

19.33

Formula B

3

21.33

21.33

Formula A

3

18.67

Sig.

.200

.342

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

MingguIV
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

Formula D

3

15.33

Formula C

3

16.00

Formula B

3

18.67

Formula A

3

18.67

Sig.

12.00

1.000

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

73

.794

Lampiran 8. (Lanjutan)


Noda (Spot)
ANOVA
Sum of Squares

Sebelum

Between Groups

4

29.100

17.333

10

1.733

Total

133.733

14

Between Groups

206.267

4

51.567

25.333

10

2.533

Total

231.600

14

Between Groups

337.333

4

84.333

18.000

10

1.800

Total

355.333

14

Between Groups

428.400

4

107.100

9.333

10

.933

Total

437.733

14

Between Groups

508.933

4

127.233

12.667

10

1.267

521.600

14

Within Groups

MingguII

Within Groups

MingguIII

Within Groups

MingguIV

Mean Square

116.400

Within Groups

MingguI

df

Within Groups
Total

F

Sig.

16.788 .008

20.355 .007

46.852 .006

114.750 .000

100.447 .000

Sebelum
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

31.33

Formula D

3

32.00

Formula C

3

34.33

Formula B

3

Formula A

3

Sig.

a. Uses Harmonic Mean Sample Size = 3.000.

74

34.33
36.00

36.00
38.67

.108

Means for groups in homogeneous subsets are displayed.

3

.556

.108

Lampiran 8. (Lanjutan)
MingguI
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

28.33

Formula D

3

29.67

Formula C

3

32.67

Formula B

3

Formula A

3

3

32.67
35.33

35.33
38.67

Sig.

.151

.219

.070

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

MingguII
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

25.00

Formula D

3

27.00

Formula C

3

Formula B

3

Formula A

3

3

4

27.00
30.00
35.00
38.67

Sig.

.411

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

75

.183

1.000

1.000

Lampiran 8. (Lanjutan)
MingguIII
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

3

Formula E

3

Formula D

3

25.33

Formula C

3

28.33

Formula B

3

Formula A

3

4

22.33

34.33
38.67

Sig.

1.000

.158

1.000

1.000

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

MingguIV
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

3

Formula E

3

Formula D

3

23.67

Formula C

3

26.67

Formula B

3

Formula A

3

4

20.67

33.00
38.33

Sig.

1.000

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

76

.157

1.000

1.000

Lampiran 8. (Lanjutan)


Keriput (Wrinkle)
ANOVA
Sum of Squares

Sebelum

MingguI

MingguII

MingguIII

MingguIV

df

Mean Square

Between Groups

11.333

4

2.833

Within Groups

14.667

10

1.467

Total

26.000

14

Between Groups

28.267

4

7.067

Within Groups

24.667

10

2.467

Total

52.933

14

Between Groups

60.400

4

15.100

Within Groups

21.333

10

2.133

Total

81.733

14

Between Groups

83.600

4

20.900

Within Groups

12.000

10

1.200

Total

95.600

14

115.733

4

28.933

10.000

10

1.000

125.733

14

Between Groups
Within Groups
Total

F

Sig.

1.932 .182

2.865 .081

7.078 .006

17.417 .000

28.933 .000

Sebelum

Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

Formula E

3

26.33

Formula D

3

26.33

Formula C

3

27.00

Formula B

3

26.67

Formula A

3

28.67

Sig.

.204

77

Lampiran 8. (Lanjutan)
a. Uses Harmonic Mean Sample Size = 3.000.

MingguI

Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

Formula E

3

24.33

Formula D

3

25.00

Formula C

3

25.67

Formula B

3

26.33

Formula A

3

28.33

Sig.

.065

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

MingguII
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

22.33

Formula D

3

24.00

Formula C

3

25.00

25.00

Formula B

3

26.00

26.00

Formula A

3

Sig.

28.33
.070

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

78

.107

Lampiran 8. (Lanjutan)
MingguIII
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

3

Formula E

3

21.33

Formula D

3

23.00

23.00

Formula C

3

24.00

24.00

Formula B

3

Formula A

3

25.33
28.33

Sig.

.081

.142

1.000

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

MingguIV
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

3

Formula E

3

20.00

Formula D

3

22.33

Formula C

3

23.67

Formula B

3

25.00

Formula A

3

Sig.

28.33
.098

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

79

22.33

.052

1.000

Lampiran 8. (Lanjutan)


Kedalaman Keriput (Wrinkle’s Depth)
ANOVA
Sum of Squares

Sebelum

MingguI

MingguII

Between Groups

4

12.233

Within Groups

106.000

10

10.600

Total

154.933

14

Between Groups

95.333

4

23.833

Within Groups

94.667

10

9.467

Total

190.000

14

Between Groups

119.067

4

29.767

42.667

10

4.267

Total

161.733

14

Between Groups

271.333

4

67.833

54.667

10

5.467

Total

326.000

14

Between Groups

292.267

4

73.067

42.667

10

4.267

334.933

14

Within Groups

MingguIV

Mean Square

48.933

Within Groups

MingguIII

df

Within Groups
Total

80

F

Sig.

1.154

.387

2.518

.108

6.977

.006

12.409

.001

17.125

.000

Lampiran 8. (Lanjutan)
Sebelum

Subset for alpha = 0.05
PEMULIHAN
a

Tukey HSD

N

1

Formula E

3

32.00

Formula D

3

34.67

Formula C

3

37.00

Formula B

3

36.33

Formula A

3

34.00

Sig.

.095

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

MingguI

Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

Formula E

3

29.33

Formula D

3

33.33

Formula C

3

35.67

Formula B

3

35.67

Formula A

3

34.00

Sig.

.133

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

81

Lampiran 8. (Lanjutan)
MingguII
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

27.00

Formula D

3

31.33

Formula C

3

34.67

Formula B

3

34.33

Formula A

3

33.33

Sig.

31.33

.150

.342

Means for groups in homogeneous subsets are displayed.
a.

Uses Harmonic Mean Sample Size = 3.000.

MingguIII
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

Formula D

3

29.67

Formula C

3

31.33

Formula B

3

33.67

Formula A

3

33.33

Sig.

22.00

1.000

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

82

.293

Lampiran 8. (Lanjutan)
Minggu IV
Subset for alpha = 0.05
PEMULIHAN
a

TukeyHSD

N

1

2

Formula E

3

Formula D

3

28.67

Formula C

3

28.67

Formula B

3

31.33

Formula A

3

33.33

Sig.

20.00

1.000

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3.000.

83

.200

Lampiran 9. Surat Pernyataan Sukarelawan

84