Pengaruh Pemberian Curcuminoid Terhadap Konsentrasi Hidrogen Peroksida (H2O2) Serum Dan Ekspresi Malondialdehid (MDA) Fibroblas Koklea Pada Rattus Norvegicus Model Diabetes Mellitus
DAFTAR PUSTAKA
AACE/ACE Diabetes Guidelines, (2015). American association of clinical
endocrinologists and american college of endocrinology – clinical
practice guidelines for developing a diabetes mellitus
comprehensive care plan – 2015. Endocr Pract.;21(Suppl 1).
Abeeleh M.A., Bani Ismail Z., Alzaben K.R., Abu-Halaweh S.A., Al-Essa
M.K., Abuabeeleh J.A., Alsmady M.M., 2009. Induction of Diabetes
Mellitus in Rats Using Intraperitoneal Streptozotocin: A
Comparison between 2 Strains of Rats. European Journal of
Scientific Research. 32(3). Pp.398-402.
ADA (American Diabetes Association). (2016). Standard of medical care in
diabetes (2016). Diabetes care 34(1): 511-561.
Aggarwal, B.B. and Harikumar, K.B. 2009. Potential therapeutic effects of
curcumin, the anti-inflammatory agent, against neurodegenerative,
cardiovascular, pulmonary, metabolic, autoimmune and neoplastic
diseases. International Journal of Biochemical Cell Biology, 41(1),
pp.40-59.
Aladag I., Eyibilen A., Guven M., Atis O & Erkokmaz U., 2009. Role of
oxidative stress in hearing impairment in patients with type two
diabetes mellitus. The Journal of Laryngology & Otology . 123
pp.957–963.
Antunes, L.M.G., Araujo, M.C.P., Dias, F.L. and Takahashi, C.S., 2005.
Effects of H2O2, Fe2+ and Fe3+ on curcumin-induced
chromosomal aberrations in CHO cells. Genet Mo. Biol, 28(1),
pp.161-4.
Aronson D. 2008. Hyperglycemia and the Pathobiology of Diabetic
Complications : Fisman EZ, Tenenbaum A (eds): Cardiovascular
Diabetology: Clinical, Metabolic and Inflammatory Facets. Adv
Cardiol. Basel, Karger, vol 45, pp 1–16.
Ayala, A., Munoz, M.F. and Arguelles, S., 2014. Lipid peroxidation:
Production, metabolism, and signaling mechanisms of
malondialdehyde and 4-hydroxy-2-nonenal. Oxidative Medicine
and Cellular Longevity, 2014, pp.1-31.
Bainridge K.E., Cheng Y.J., and Cowie C.C., 2010. Potential mediators of
diabetes-related hearing impairment in the U.S. population:
National Health and Nutrition Examination Survey 1999-2004.
Diabetes Care 33(4):811-6
Banerjee A., Kunwar A., Mishra B., Priyadarsini K.I., 2008. Concentration
dependent antioxidant/pro-oxidant activity of curcumin studies from
AAPH induced hemolysis of RBC’s. Chem Biol Interact
;174(2):134Barbusinski, K., 2009. Fenton reaction - Controversy concerning the
chemistry. Ecological Chemistry and Engineerings, 16(3), pp. 34758.
Bolisetty, S. and Jaimes, E.A., 2013. Mitochondria and reactive oxygen
species: Physiology and pathophysiology. Int J Mol Sci,14(3),
pp.6306-44.
116
Universitas Sumatera Utara
Bravard A., Bonnard C., Durrand A., Chauvin M. A., Favier R., Vidal H. &
Rieusset J. Inhibition of xanthine oxidase reduces hyperglycemiainduced oxidative stress and improves mitochondrial alterations in
skeletal muscle of diabetic mice. Am J Physiol Endocrinol Metab.
2011; 300: pp581–591.
Calaf, G.M., Echiburu-Chau, C., Roy, D., Chai, Y., Wen, G. and Balajee,
A.S., 2011. Protective role of curcumin in oxidative stress of breast
cells. Oncol Rep, 26(4), pp.1029-35.
Chemoprevention Branch and Agent Development Committee., 1996.
Clinical development plan: curcumin. Journal of Cellular
Biochemistry, 265, pp.72-85.
Chen S, Hong SW, Iglesias-de la Cruz MC, Isono M, Casaretto A,
Ziyadeh FN, 2001. The key role of the transforming growth factor-b
system in the pathogenesis of diabetic nephropathy. Renal Failure,
23(3&4), 471–81.
Christen, Y., 2000. Oxidative stress and Alzheimer disease. Am J Clin
Nutr, 71(2), pp.621S-629S.
Chong S.J.F., Low I.C.C. & Pervaiz S., 2014. Mitochondrial ROS and
involvement oc Bcl-2 as a mitochondrial ROS regulator.
Mitochondrion 00933.
Ciorba, A., Chicca, M., Bianchini, C., Aimoni, C. and Pastore, A., 2012.
Sensorineural hearing loss and endothelial dysfunction due to
oxidative stress: Is there a connection?. Int Adv Otol, 8(1), pp.1620.
Cohly, H.H., Taylor, A., Angel, M.F. and Salahudeen, A.K., 1998. Effect of
turmeric, turmerin and curcumin on H2O2-induced renal epithelial
(LLC-PK1) cell injury. Free Radic Biol Med, 24(1), pp.49-54.
Cookson, M. and Shaw, P., 1999. Oxidative stress and motor neurone
disease. Brain Pathol, 9(1), pp.165-86.
Cullen JR, Cinnamond MJ. (1993) Hearing loss in diabetics. Journal of
Laryngology and Otology 107:179-182.
Davi, G., Falco, A. and Patrono, C., 2005. Lipid peroxidation in diabetes
mellitus. Antioxid Redox Signal, 7(1–2), pp.256-68.
D'Autreaux, B., and Toledano, M.B. (2007). ROS as signaling molecules:
mechanisms that generate specificity in ROS homeostasis. Nat.
Rev. Mol. Cell Biol. 8, 813-824.
Deeds M.C., Anderson J.M., Armstrong A.S., Gastineau D.A., Hiddinga
H.J., Jahangir
Despopoulos, A. and Silbernagl, S. 2008. Central nervous system and
senses. In: Despopoulus, A., Silbernagl, S. 6th ed, 2008. Color
Atlas of Physiology. New York: Thieme, pp.368-76.
Dehne, N., Lautermann, J., ten Cate, W.J., Rauen, U. an d de Groot, H.,
2000. In vitro effects of hydrogen peroxide on the cochlear
neurosensory epithelium of the guinea pig. Hear Res, 143(1-2),
pp.162-70.
De Zwart, L.I., Meerman, J.H.N., Commandeur, J.N.M. and Vermeulen,
N.P.E., 1999. Biomarkers of free radical damage: Applications in
Universitas Sumatera Utara
experimental animals and in humans. Free Radical Biology &
Medicine, 26(1), pp.202-26.
Evans, P. and Halliwell, B., 1999. Free radicals and hearing: Cause,
consequence, and criteria. Ann NY Acad Sci, 884, pp.19-40.
FAO, 2011. Legislative and regulatory options for animal welfare. [online]
Available at:
[Accessed 15 February 2015].
Filho, A.C.M., Hoffmann, M.E. and Meneghini, R., 1984. Cell killing and
DNA damage by hydrogen peroxide are mediated by intracellular
iron. Biochem J, 218, pp.273-5.
Fukushima H, Cureoglu S, Schachern PA, Paparella MM, Harada T, Oktay
MF, 2006. Effects of type 2 diabetes mellitus on cochlear structure
in humans. Arch Otolaryngol Head Neck Surg 132:934-938.
Gacek, R. R., 2009. Anatomy of the auditory and vestibular system. In:
Snow, Jr.JB. and Wackym, P.A. Ballenger,s. otorhinolaryngology
head and neck surgery 17. Centennial edition. Peoples Medical
Publishing House. Philadhelpia, pp.1-157.
Gaetani, G., Ferraris, A., Rolfo, M., Mangerini, R., Arena, S. and Kirkman,
H., 1996. Predominant role of catalase in the disposal of hydrogen
peroxide within human erythrocytes. Blood, 87(4), pp.1595-9.
Ghosh S., Bhattacharayya S., Rashid K., Sil P.C., 2015. Curcumin
protects
rat
liver
from
streptozotocin-induceddiabetic
pathophysiology by counteracting reactive oxygenspecies and
inhibiting the activation of p53 and MAPKsmediated stress
response pathways. Toxicology Reports 2; 365–376
Goldfarb S, 2001. TGF-β: A crucial component of the pathogenesis of
diabetic nephropathy. Transactions of the American Clinical and
Climatological Association 112:27-33.
Goodsell, D.S., 2007. Molecule of the month: Superoxide dismutase.
[online].Availableat:
AACE/ACE Diabetes Guidelines, (2015). American association of clinical
endocrinologists and american college of endocrinology – clinical
practice guidelines for developing a diabetes mellitus
comprehensive care plan – 2015. Endocr Pract.;21(Suppl 1).
Abeeleh M.A., Bani Ismail Z., Alzaben K.R., Abu-Halaweh S.A., Al-Essa
M.K., Abuabeeleh J.A., Alsmady M.M., 2009. Induction of Diabetes
Mellitus in Rats Using Intraperitoneal Streptozotocin: A
Comparison between 2 Strains of Rats. European Journal of
Scientific Research. 32(3). Pp.398-402.
ADA (American Diabetes Association). (2016). Standard of medical care in
diabetes (2016). Diabetes care 34(1): 511-561.
Aggarwal, B.B. and Harikumar, K.B. 2009. Potential therapeutic effects of
curcumin, the anti-inflammatory agent, against neurodegenerative,
cardiovascular, pulmonary, metabolic, autoimmune and neoplastic
diseases. International Journal of Biochemical Cell Biology, 41(1),
pp.40-59.
Aladag I., Eyibilen A., Guven M., Atis O & Erkokmaz U., 2009. Role of
oxidative stress in hearing impairment in patients with type two
diabetes mellitus. The Journal of Laryngology & Otology . 123
pp.957–963.
Antunes, L.M.G., Araujo, M.C.P., Dias, F.L. and Takahashi, C.S., 2005.
Effects of H2O2, Fe2+ and Fe3+ on curcumin-induced
chromosomal aberrations in CHO cells. Genet Mo. Biol, 28(1),
pp.161-4.
Aronson D. 2008. Hyperglycemia and the Pathobiology of Diabetic
Complications : Fisman EZ, Tenenbaum A (eds): Cardiovascular
Diabetology: Clinical, Metabolic and Inflammatory Facets. Adv
Cardiol. Basel, Karger, vol 45, pp 1–16.
Ayala, A., Munoz, M.F. and Arguelles, S., 2014. Lipid peroxidation:
Production, metabolism, and signaling mechanisms of
malondialdehyde and 4-hydroxy-2-nonenal. Oxidative Medicine
and Cellular Longevity, 2014, pp.1-31.
Bainridge K.E., Cheng Y.J., and Cowie C.C., 2010. Potential mediators of
diabetes-related hearing impairment in the U.S. population:
National Health and Nutrition Examination Survey 1999-2004.
Diabetes Care 33(4):811-6
Banerjee A., Kunwar A., Mishra B., Priyadarsini K.I., 2008. Concentration
dependent antioxidant/pro-oxidant activity of curcumin studies from
AAPH induced hemolysis of RBC’s. Chem Biol Interact
;174(2):134Barbusinski, K., 2009. Fenton reaction - Controversy concerning the
chemistry. Ecological Chemistry and Engineerings, 16(3), pp. 34758.
Bolisetty, S. and Jaimes, E.A., 2013. Mitochondria and reactive oxygen
species: Physiology and pathophysiology. Int J Mol Sci,14(3),
pp.6306-44.
116
Universitas Sumatera Utara
Bravard A., Bonnard C., Durrand A., Chauvin M. A., Favier R., Vidal H. &
Rieusset J. Inhibition of xanthine oxidase reduces hyperglycemiainduced oxidative stress and improves mitochondrial alterations in
skeletal muscle of diabetic mice. Am J Physiol Endocrinol Metab.
2011; 300: pp581–591.
Calaf, G.M., Echiburu-Chau, C., Roy, D., Chai, Y., Wen, G. and Balajee,
A.S., 2011. Protective role of curcumin in oxidative stress of breast
cells. Oncol Rep, 26(4), pp.1029-35.
Chemoprevention Branch and Agent Development Committee., 1996.
Clinical development plan: curcumin. Journal of Cellular
Biochemistry, 265, pp.72-85.
Chen S, Hong SW, Iglesias-de la Cruz MC, Isono M, Casaretto A,
Ziyadeh FN, 2001. The key role of the transforming growth factor-b
system in the pathogenesis of diabetic nephropathy. Renal Failure,
23(3&4), 471–81.
Christen, Y., 2000. Oxidative stress and Alzheimer disease. Am J Clin
Nutr, 71(2), pp.621S-629S.
Chong S.J.F., Low I.C.C. & Pervaiz S., 2014. Mitochondrial ROS and
involvement oc Bcl-2 as a mitochondrial ROS regulator.
Mitochondrion 00933.
Ciorba, A., Chicca, M., Bianchini, C., Aimoni, C. and Pastore, A., 2012.
Sensorineural hearing loss and endothelial dysfunction due to
oxidative stress: Is there a connection?. Int Adv Otol, 8(1), pp.1620.
Cohly, H.H., Taylor, A., Angel, M.F. and Salahudeen, A.K., 1998. Effect of
turmeric, turmerin and curcumin on H2O2-induced renal epithelial
(LLC-PK1) cell injury. Free Radic Biol Med, 24(1), pp.49-54.
Cookson, M. and Shaw, P., 1999. Oxidative stress and motor neurone
disease. Brain Pathol, 9(1), pp.165-86.
Cullen JR, Cinnamond MJ. (1993) Hearing loss in diabetics. Journal of
Laryngology and Otology 107:179-182.
Davi, G., Falco, A. and Patrono, C., 2005. Lipid peroxidation in diabetes
mellitus. Antioxid Redox Signal, 7(1–2), pp.256-68.
D'Autreaux, B., and Toledano, M.B. (2007). ROS as signaling molecules:
mechanisms that generate specificity in ROS homeostasis. Nat.
Rev. Mol. Cell Biol. 8, 813-824.
Deeds M.C., Anderson J.M., Armstrong A.S., Gastineau D.A., Hiddinga
H.J., Jahangir
Despopoulos, A. and Silbernagl, S. 2008. Central nervous system and
senses. In: Despopoulus, A., Silbernagl, S. 6th ed, 2008. Color
Atlas of Physiology. New York: Thieme, pp.368-76.
Dehne, N., Lautermann, J., ten Cate, W.J., Rauen, U. an d de Groot, H.,
2000. In vitro effects of hydrogen peroxide on the cochlear
neurosensory epithelium of the guinea pig. Hear Res, 143(1-2),
pp.162-70.
De Zwart, L.I., Meerman, J.H.N., Commandeur, J.N.M. and Vermeulen,
N.P.E., 1999. Biomarkers of free radical damage: Applications in
Universitas Sumatera Utara
experimental animals and in humans. Free Radical Biology &
Medicine, 26(1), pp.202-26.
Evans, P. and Halliwell, B., 1999. Free radicals and hearing: Cause,
consequence, and criteria. Ann NY Acad Sci, 884, pp.19-40.
FAO, 2011. Legislative and regulatory options for animal welfare. [online]
Available at:
[Accessed 15 February 2015].
Filho, A.C.M., Hoffmann, M.E. and Meneghini, R., 1984. Cell killing and
DNA damage by hydrogen peroxide are mediated by intracellular
iron. Biochem J, 218, pp.273-5.
Fukushima H, Cureoglu S, Schachern PA, Paparella MM, Harada T, Oktay
MF, 2006. Effects of type 2 diabetes mellitus on cochlear structure
in humans. Arch Otolaryngol Head Neck Surg 132:934-938.
Gacek, R. R., 2009. Anatomy of the auditory and vestibular system. In:
Snow, Jr.JB. and Wackym, P.A. Ballenger,s. otorhinolaryngology
head and neck surgery 17. Centennial edition. Peoples Medical
Publishing House. Philadhelpia, pp.1-157.
Gaetani, G., Ferraris, A., Rolfo, M., Mangerini, R., Arena, S. and Kirkman,
H., 1996. Predominant role of catalase in the disposal of hydrogen
peroxide within human erythrocytes. Blood, 87(4), pp.1595-9.
Ghosh S., Bhattacharayya S., Rashid K., Sil P.C., 2015. Curcumin
protects
rat
liver
from
streptozotocin-induceddiabetic
pathophysiology by counteracting reactive oxygenspecies and
inhibiting the activation of p53 and MAPKsmediated stress
response pathways. Toxicology Reports 2; 365–376
Goldfarb S, 2001. TGF-β: A crucial component of the pathogenesis of
diabetic nephropathy. Transactions of the American Clinical and
Climatological Association 112:27-33.
Goodsell, D.S., 2007. Molecule of the month: Superoxide dismutase.
[online].Availableat: