Pembuatan Sediaan Gastroretentif Ranitidin Hidroklorida Sebagai Antiulkus Menggunakan Polimer Alginat-Kitosan
DAFTAR PUSTAKA
Allen, V. L., (2013). Dalam: Remington The Science and Practice of Pharmacy.
Edisi ke- 22. Pharmaceutical Press London Philadelphia. Hal. 989998.
Arora, S., Ali, J., Ahuja, A., Khar, R.K.,,dan Baboota, S. (2005). Floating Drug
Delivery Systems: A Review. AAPS PharmSciTech, 6(3): 372-390.
Ami, M., Krunal,S., Heja, P., dan Yogi, P. (2012). Advancements in Controlled
Release Gastroretentive Drug Delivery System: A Review. Journal of
Drug Delivery & Therapeutics. 2(3): 12-21.
Amandeep, K., Robin, S., Ramica, S., dan Sunil, K., (2012). Peptic Ulcer: A
Review on Etiology and Pathogenesis, International Research Journal of
Pharmacy, 3(6):34-38.
Bangun, H., dan Arianto, A.(1995). Karakteristik Pelepasan Kloramfenikol dari
Butir Gel Alginat yang Dibuat dengan Cara Mengempa. Media Farmasi,
3(1): 13-22.
Bangun, H., dan Arianto, A (1996). Pengaruh Amylum dan Ukuran Partikel
Obat Terhadap Laju Pelepasan Obat dari Butir Gel Alginat. J. Agrokimia.
2: 31-48.
Bangun, H., dan Arianto, A. (1999). Pembuatan Sediaan Nifedipin Sustained
Release dengan Menggunakan Gel Alginat sebagai Matriks. Media
Farmasi 7(1): 59-71.
Bangun, H., Simanjuntak, M.T., dan Khairiah. 2005. Perbandingan Disolusi
Obat pada Kapsul Alginat dengan Kapsul Gelatin. Media Farmasi 13(2):
182-188.
Bangun, H., Tarigan, P., Simanjuntak, M.T., dan Pakpahan, C. (2006).
Pembuatan dan Karakterisasi Kapsul Alginat Tipe Matriks yang Tahan
Terhadap Asam Lambung. Media Farmasi. 14(1): 11-21.
Bae, D.K., Park, D., Lee, S.H., Yang, G., Yang, Y.H., Kim, T.K., Choi, Y.J.,
Kim, J.J., Jeon, J.H., Jang, M.J., Choi E.K., Hwang, S.Y., dan Kim Y.B.
(2011). Different Antiulcer Activities of Pantoprazole in Stres, Alkohol
and Pylorus Ligation-Induced Ulcer Models. Lab Anim Res. 27(1): 47-52.
Basit, A.W., dan Lacey, L.F. (2001). Colonic Metabolism of Ranitidine:
Implications for Its delivery and Absorption. Int. J. Pharm. 227(1-2): 15765.
143
Brunton, L.L., Chabner, B.A., dan Knollmann, B.C., (2011). Goodman &
Gilman’s The Pharmacological Basis of Therapeutics. Edisi ke-12.
McGraw-Hill Companies. Newyork. Hal. 1313-1322.
Chickering, D.E., Jacob, J.S., Desai, T.A. Harrison, M., Harris, W.P., Morcel,
C.N., Chaturvendi, P., and Mathiwitz, E., (1997). Bioadhesive
microspheres: An in vivo transit and bioavailability study of drug loaded
alginate and poly (fumaric-co-sebaic anhydrate) microsphere, J. Controlled
Release 48: 35-46.
Choudhury, A., Das, S., Bahadur, S., dan Saha, S., (2009). Development and
Characterization Extended Release Gastroretentive Drug Delivery. Journal
of Pharmacy Research 2(10): 1557- 1560.
Costa, P. dan Lobo. J.M.S. (2001). Modeling and Comparison of Disolution
Profiles. European Journal of Pharmaceutical Sciences.13: 123-133.
Dhankar, V., Garg, F., Dharmija, K., dan Awasthi, R. (2014). Preparation.
Characterization and Evaluation of Ranitidine Hydrochlorida-Loaded
Mucoadhesive Microspheres. Polim.Med.44(2): 75-81.
Das, R., Ali, A.K., dan Bandyopadhyay, K.A. (2011). Mucoadhesion and
Mucoahesive Tablets-A Review. Int. J. Pharm. Sci. Tech. 6(1): 64-115.
Dash, S., Murthy, P.N., Nath. L., dan Chowdhury, P. (2010). Review: Kinetic
Modeling on Drug Release from Controlled Drug Delivery System. Acta
Poloniae Pharmaceutica. 67(3): 217-223.
DitJen POM. (1995). Farmakope Indonesia. Edisi Ke-4. Jakarta: Departemen
Kesehatan Republik Indonesia. Hal. 375-379. 733. 1124. 1137.
Dhawan, S., Singla, A.K., and Sinha, V.R. (2004). Evaluation of mucoadhesive
properties of chitosan microsphere prepared by different method, AAPS
PharmSciTech, 5(4): 1-7.
Deghan, H.G.M., dan Khan, N.F. (2009). Gastroretentive Drug Delivery Systems:
A Patent Perspective. International Journal of Health Research. 2(1): 2344.
Donatus, L.A. dan Nurlaila (1986). Obat Tradisional dan Fitoterapi Uji
Toksikologi. Yogyakarta. Fakultas Farmasi Universitas Gajah Mada: Hal.
12-21.
Dua, K., dan Trivedi, P., (2013). Formulation and Evaluation of Mucoadhesive
Microsphere Ranitdine Hydrochloride using Chitosan and Sodium Carboxy
144
Methyl Cellulose as Polymers. International Journal of Pharmaceutical and
Biomedical Research 4(2): 140-144.
Felt, O., Buri, P., dan Gurny. R. (1998). Chitosan: A Unique Polysaccharide for
Drug Delivery. Drug Development and Industrial Pharmacy. 24(11): 979993..
Grant, S.M., Langtry, H.D., dan Brogden, R.N. (1989). Ranitidine. An Updated
Review of Its Pharmacodynamic And Pharmacokinetic Properties And
Therapeutic Use In Peptic Ulcer Disease And Other Allied Diseases. Drugs.
37(6): 801-870.
Grassi, M dan Grassi, G. (2005). Mathematical Modelling and Controlled Drug
Delivery: Matrix Systems. Current Drug Delivery. 2: 97-116.
Gierszewska-Druzynska, M.. dan Ostrowska-Czubenko. J. (2012). Mechanism of
Water Diffusion into Noncrosslinked and Ionically Crosslinked Chitosan
Membranes. Progress on Chemistry and Application of Chitin and Its 12:
59-66.
Gennaro, R.A. (2000).The Science and Practice of Pharmacy Edisi Ke-20. New
York: Lippincott Williams & Wilkin. Hal. 1225
Garg, R., dan Gupta, DG., (2008). Progress in Controlled Gastroretentive
Delivery Systems. Tropical Journal of Pharmaceutical Research. 7(3):
1055-1066.
Gunarso, W. (1989). Bahan Pengajaran Mikroteknik. Bogor, Departemen
Pendidikan dan Kebudayaan Direktorat Jenderal Pendidikan Tinggi Pusat
Antar Universitas Ilmu Hayat Institut Pertanian Bogor. Hal.80-81
Hoffman, A. (1998). Pharmacodynamic aspects of Sustained release preparations.
Adv Drug Del Rev. 33(3): 186-199.
Humason, G.L. (1967). Animal Tissue Technique. San Fransisco: W.H.Freeman
and Company. Hal.33-67.
th
Junquiera L.C, Carneiro J. (2005). Basic Histology. 11 edition, New York,
McGraw-Hill. Hal.
Katzung, B.G. (2004). Farmakologi Dasar dan Klinik. Edisi Ke-8. Jilid Ketiga.
Penerjemah: Bagian Farmakologi Fakultas Kedokteran Universitas
Airlangga. Jakarta: Penerbit Salemba Medika. Hal. 544-545.
Kharia, A.A., dan Singhai, K.A., (2013). Formulation and Evaluation of
Gastroretentive Drug Delivey System of Acyclovir as Mucoadhesive
145
Nanoparticles. International Journal of PharmTech Research 5(4): 15381545.
Knill, C.J., Kennedy,J.F., Mistry, J., Miraftab, M., Smart, G., Groocock, M.R.,
and William, H.J. (2004). Alginate Fibres Modified with Unhydrolysed and
Hydrolysed Chitosans for Wound Dressings. Carbohydrate Polymers, 55:
65-76.
Kumar, D.B.N., Sundaramoorthy, K., Vetrichelvan, T., (2010). Formulation and
In-Vitro Evaluation of Gastroretentive Floating Microspheres of Ranitidine
Hydrochloride. An International Journal of Advances In Pharmaceutical
Sciences 1(2): 298-306.
Kurniasih, M., dan Kartika, D. (2011). Sintesis dan Karakterisasi Fisika-Kinia
Kitosan. Jurnal Inovasi. 5(1): 42-48.
Lauritsen, K. (1990). Clinical Pharmacokinetics of Drugs Used in the Treatment
of Gastrointestinal Diseases. Clin Pharmacokinet. 19:11-31. 94-125.
Lachman, L., Lieberman, H.A., and Kanig, J.L. (2012).Teori dan Praktek
Farmasi Industri II. Edisi ke-3. UI Press. Hal. 934-937.
Lehr, M.C.. Bouwstra, A.J., Schacht, H.E., dan Junginger, E.H. (1992). In Vitro
Evaluation of Mucoadhesive properties of chitosan and some other natural
polymers. International Journal of Pharmaceutics 78: 43-48.natural
polymers
Li, P., Dai, Ya-Ni, Zhang. Jun-Ping. Wang. Ai-Qin. dan Wei, Q. (2008).
Chitosan-Alginate Nanoparticles as a Novel Drug Delivery System for
Nifedipine. International Journal of Biomedical Science. 4(3): 221-228.
Liao, S.K., Hung, C.C., dan Lin, F.M. (2004). A Kinetic Study of Thermal
Degradations of Chitosan/Polycaprolacton Blends. Macromolecular
Research. 12(5): 466-473.
Lohani, A., dan Chaudhary, P.G. (2012). Mucoadhesive Microsphere: A Novel
Approach to Increase Gastroretention. Chronicles of Young Scientists 3(2):
121-128.
Marabathuni,J.V., Deveswaran, R., Bharath, S., Basavaraj, V.B., dan Madhavan,
V. (2012). Design and Optimization of Multiparticulate Gastroretentive
Delivery System of Ranitidine Hydrochloride. International Journal of
Pharmacy and Pharmaceutical Siences. 4(2): 597-603
Meng X., Tian F., dan Yang J., (2010). Chitosan and Alginate Polyelectrolyte
Complex Membranes and Their Properties for Wound Dressing
Applications. J. Mater Sci: Mater Med 21: 1751-1759.
146
Morris, E.R., Rees, D.A., dan Thom, D. (1978). Chiroptical and Stoichiometry
Evidence of a Specific Primary Dimerisation in Alginate Gelation.
Carbohydrate Research. 11(2): 272-277.
Murthy, K.S.. dan Ghebre-Selasie, I. (1993). Current Perspectives on the
Dissolution Stability of Solid Oral Dosage Forms. Journal of
Pharmaceutical Sciences. 82(2):113-126.
Nayak, A.K., Maji. R., Das. B. (2010). Gastroretentive Drug Delivery Systems: A
Review. Asian Journal of Pharmaceutical And Clinical Research. 3(1): 210.
Nayak, P.K., Upadhyay, P., Valera, R.A.D.J.. dan Chauhan. P.N. (2012).
Gastroretentive Drug Delivery Systems and Recent Approaches: A Review.
Journal of Pharmaceutical Research and Opinion. 2(1): 1-8.
Pandit, V., Suresh, S., dan Joshi, H., Gastroretentif drug delivery system of
Amoxycillin: Formulation and In Vitro Evaluation, (2010). International
Journal of Pharma and Bio Sciences, 1(2):1-10.
Parmar, N.S., dan Prakash, S., (2006). Screening Methods in Pharmacology. India
Alpha Science International Ltd. Hal 262-263.
Patil, J.S., Kamalapur, M.V., Marapur, S.C., dan Kadam, D.V. (2010). Ionotropic
Gelation and Polyelectrolyte Complexation: The Novel Techniques to
Design Hydrogel Particulate Sustained. Modulated Drug Delivery System:
A Review. Digest Journal of Nanomaterials and Biostructures 5(1): 241248.
Patil, S.V., Gaikwad, P.D., Bankar, P.H., dan Pawar, S.P., (2010). Formulation
and evaluation of floating matrix tablet of locally acting H2-Antagonist.
International Journal Of Pharmacy & Technology 2(3):528-540.
Peppas, N.A., Buri, P.A., (1985). Surface. interfacial and molecular aspects of
polymer bioadhesion on soft tissues. J. Control Release. 2: 257-275.
Peppas, N.A., Bures, P,. Leobandung, W, dan Ichikawa. (2000). Hydrogels in
Pharmaceutical Formulations. European Journal of Pharmaceutics and
Biopharmaceutics. 50: 27-46.
Perigard, C.J. (2000). Clinical Analysis, Gastric Analysis. Dalam: Remington: The
Science and Practice of Pharmacy. Volume I. Editor: Alfonso Gennaro.
London: Lippincott William & Wilkins. Hal. 580-581.
147
Pratima, N.A., Tiwari. S., dan Kamble, S. (2012). Mucoadhesive: As Oral
Controlled Gastroretentive Drug Delivery System. International Journal of
Research in Pharmacy and Science. 2(3):32-59.
Price, A.S., dan Wilson, M.L., (2006) Patofisiologi Konsep Klinis Proses-Proses
Penyakit. Jakarta, Penerbit Buku Kedokteran EGC. Hal. 417-435.
Rajabi-Siahboomi, A.R., Rane, M.S., dan Felton, L.A. (2013) Oral ModifiedRelease Systems. Dalam: Allen. L.V.. Adejare. A.. Desselle. S.P.. Felton.
A.A.. Moffat. A.C. Remington The Science and Practice of Pharmacy. 22nd
Edition. London-Philadelphia Pharmaceutical Press. Hal. 989-997.
Rajput, G., Majmudar, F., Patel. J., Thakor, R., dan Rajgor, N.B. (2010).
Stomach-Specific Mucoadhesive Microsphere As A Controlled Drug
Delivery System. Systematic Reviews In Pharmacy. 1(1): 70-78.
Ramachandran, S., Thirumurugan. G., dan Dhanaraju, M.D. (2011). Development
and Evaluation of Biodegradable Chitosan Microspheres Loaded with
Ranitidine and Cross Linked with Glutaraldehyde. American Journal of
Drug Discovery and Development. 1(2): 105-120.
Rehm, B.H.A. (2009). Alginates: Biology and Applications. NewYork: Springer
Dordrecht Heidelberg. Hal. 21.
Sabiu, S., Garuba, T., Sunmonu, T., Ajani, E., Sulyman, A., Nurain, I., Balogun,
A., (2015). Indomethacin-induced gastric ulceration in rats: Protectiveroles
of Spondias mombin and Ficus exasperate Saheed. Toxicology Reports 2:
261–267.
Sachan. N.K.. Pushkar. S., Jha. A.,dan Bhattcharya. A.. (2009). Sodium Alginate:
The Wonder Polymer for Controlled Drug Delivery. Journal of Pharmacy
Reseach 2(8): 1191-1199.
Sahasathian, T., Praphairaksit, N., dan Muangsin, N., (2010). Mucoadhesive and
Floating chitosan- coated Alginate Beads for the Controlled Gastric Release
of Amoxicillin. Arch Pharm Res. 33(6): 889-899.
Sahoo, S., Chakraborti, K.C., dan Bebera, K.P., (2012). Development and
Evaluation of Gastroretentive Controlled Release Polymeric Suspension
Containing Ciprofloxacin and Carbopol Polymers. Journal of Chemical and
Pharmaceutical Research 4(4): 2268-2284.
Sarmento, B., Ferreira, D., Veiga, F., Ribeiro, A., (2006). Characterization of
Insulin-loaded Alginate Nanoparticles Produced by Ionotropic Pre-gelation
Through DSC and FTIR Studies. Carbohydrate Polymers. 66: 1-7.
148
Sanjay, S., Vaibhav, J., Kumar, B.P. (2009). Gastroretentive Drug Delivery
System. Current Approaches Journal of Pharmacy Reseach 2(5):881-886.
Siepmann, J., dan Peppas, N.A. (2001). Modelling of Drug Release from Delivery
Systems Based on Hydroxypropyl Methylcellulose (HPMC). Advance Drug
Delivery Reviews 48:139-157.
Sinko,J.P., (2011). Martin’s Physical Pharmacy and Pharmaceutical Sciences,
Sixth Edition, Walters Kluwer, Philadelphia, Hal. 248-250.
Singh, A., Singh, D., Irchhaiya, R. (2013). Mucoahesive Microsphere: A Review.
Journal of Pharmaceutical and Biomedical Analysis Letters.
Silverstein, M.R., Bassier C.G., dan Morrill, C.T. (1991). Spectrometrik
Identification of Organic Compounds. Edisi ke-5. New York. John Willey &
Sons, Inc. Hal. 121-128.
Soares, J.P.,Santos, J.E., Chierice, G.O., dan Cavalheiro, E.T.G., (2004). Thermal
Behavior of Alginic Acid and Its Sodium Salt. Ecl. Quim., Sao Paulo, 29(2):
53-56.
Solanki, P.D. (2012). Formulation. Evaluation and Optimization of Bilayer
Floating Tablet of Repaglinide and Glipizide. International Journal for
Pharmaceutical Research Scholars 1(I-3): 123-134.
Swetha, S., Allena T.R., dan Gowda, D.V., (2012). A Comprehensive Review on
Gastroretentive Drug Delivery Systems. International Journal of Research
in Pharmaceutical and Biomedical Sciences 3(3): 1285-1293.
Surana, S.A., dan Kotecha, K.R., (2010). An Overview on Various Approaches to
Oral Controlled Drug Delivery System Via Gastroretentention.
International Journal of Pharmaceutical Sciences Review and Research
2(2): 68-72.
Takahashi, T., Takayama, K., Machida.,Y., an Nagai, T. (1990). Characteristic of
Polyion Complexes of Chitosan with Sodium Alginat and Sodium
Polyacrylate. Int J Pharm. 61: 35-41.
Tarigan, P., (2006). Tukak Gaster, Chapter 78. Dalam: Buku Ajar Ilmu Penyakit
Dalam. Jilid I Edisi IV. Editor: Aru W.Sudoyo, Bambang Setiyohadi, Idrus
Alwi, Marcellus Simadibrata K, Siti Setiati. Jakarta: Pusat Penerbitan
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas
Indonesia. Halaman 338-344.
149
Tolman, K.G. (2000). Gastrointestinal and Liver. Dalam: Remington: The Science
and Practice of Pharmacy. Volume II. Editor: Alfonso Gennaro. London:
Lippincott Williams & Wilkins. Halaman 1219-1220.
Thom, D., Grant, G.T. Morris. E.R.. dan Ress.D.A. (1982). Characterisation of
Cation Binding and Gelation of Polyuronates by Circular Divhroism.
Carbohydrate Research. 100:29-42.
Tonnesen, H.H., dan Karisen, J. (2002). Alginate in Drug Delivery Systems. Drug
Development and Industrial Pharmacy. 28(6): 621-630.
Underwood, J.C.E.,(1994). Patologi Umum dan Sistematik (1994). Patologi dan
sistematik, Pathogi Umum dan Sistemik, Edisi ke 2. Halaman 436-437.
Wilson, L.M. dan Lester, L.B. (1994). Patofisiologi, Proses-proses penyakit, Jilid
I, Jakarta, EGC Penerbit Buku Kedokteran, hal. 371-385.
Yadav, K.M., Gupta, A.B., Kumar, R., Yadaf, S.J., Kumar, B., (2010).
Mucoadhesive Polymers: Means of Improving the Mucoadhesive Properties
of Drug Delivery System. Journal of Chemical and Pharmaceutical
Research 2(5): 418-432.
Yamazaki, S., Kamamura, M., Kitsukawa, M., Ando, K., Nitta, I., Tobe, A., dan
Okabe, S. (1991). Effects of MCI-727, a New Antiulcer Agent, Various
Gastric and Duodenal Lesions in Experimental Animals. Japan. J.
Pharmacol. 55: 415-424.
Yellanki, K.S., Singh, J., Syed, A.J., Bigala, R., Goranti, S., dan Nerella, K.N.
(2010). Design and Characterization of Amoxicillin Trihydrate
Mucoadhesive Microspheres for Prolonged Gastric Retention. International
of Pharmaceutical Sciences and Drug Research 2(2): 112-114.
150
Allen, V. L., (2013). Dalam: Remington The Science and Practice of Pharmacy.
Edisi ke- 22. Pharmaceutical Press London Philadelphia. Hal. 989998.
Arora, S., Ali, J., Ahuja, A., Khar, R.K.,,dan Baboota, S. (2005). Floating Drug
Delivery Systems: A Review. AAPS PharmSciTech, 6(3): 372-390.
Ami, M., Krunal,S., Heja, P., dan Yogi, P. (2012). Advancements in Controlled
Release Gastroretentive Drug Delivery System: A Review. Journal of
Drug Delivery & Therapeutics. 2(3): 12-21.
Amandeep, K., Robin, S., Ramica, S., dan Sunil, K., (2012). Peptic Ulcer: A
Review on Etiology and Pathogenesis, International Research Journal of
Pharmacy, 3(6):34-38.
Bangun, H., dan Arianto, A.(1995). Karakteristik Pelepasan Kloramfenikol dari
Butir Gel Alginat yang Dibuat dengan Cara Mengempa. Media Farmasi,
3(1): 13-22.
Bangun, H., dan Arianto, A (1996). Pengaruh Amylum dan Ukuran Partikel
Obat Terhadap Laju Pelepasan Obat dari Butir Gel Alginat. J. Agrokimia.
2: 31-48.
Bangun, H., dan Arianto, A. (1999). Pembuatan Sediaan Nifedipin Sustained
Release dengan Menggunakan Gel Alginat sebagai Matriks. Media
Farmasi 7(1): 59-71.
Bangun, H., Simanjuntak, M.T., dan Khairiah. 2005. Perbandingan Disolusi
Obat pada Kapsul Alginat dengan Kapsul Gelatin. Media Farmasi 13(2):
182-188.
Bangun, H., Tarigan, P., Simanjuntak, M.T., dan Pakpahan, C. (2006).
Pembuatan dan Karakterisasi Kapsul Alginat Tipe Matriks yang Tahan
Terhadap Asam Lambung. Media Farmasi. 14(1): 11-21.
Bae, D.K., Park, D., Lee, S.H., Yang, G., Yang, Y.H., Kim, T.K., Choi, Y.J.,
Kim, J.J., Jeon, J.H., Jang, M.J., Choi E.K., Hwang, S.Y., dan Kim Y.B.
(2011). Different Antiulcer Activities of Pantoprazole in Stres, Alkohol
and Pylorus Ligation-Induced Ulcer Models. Lab Anim Res. 27(1): 47-52.
Basit, A.W., dan Lacey, L.F. (2001). Colonic Metabolism of Ranitidine:
Implications for Its delivery and Absorption. Int. J. Pharm. 227(1-2): 15765.
143
Brunton, L.L., Chabner, B.A., dan Knollmann, B.C., (2011). Goodman &
Gilman’s The Pharmacological Basis of Therapeutics. Edisi ke-12.
McGraw-Hill Companies. Newyork. Hal. 1313-1322.
Chickering, D.E., Jacob, J.S., Desai, T.A. Harrison, M., Harris, W.P., Morcel,
C.N., Chaturvendi, P., and Mathiwitz, E., (1997). Bioadhesive
microspheres: An in vivo transit and bioavailability study of drug loaded
alginate and poly (fumaric-co-sebaic anhydrate) microsphere, J. Controlled
Release 48: 35-46.
Choudhury, A., Das, S., Bahadur, S., dan Saha, S., (2009). Development and
Characterization Extended Release Gastroretentive Drug Delivery. Journal
of Pharmacy Research 2(10): 1557- 1560.
Costa, P. dan Lobo. J.M.S. (2001). Modeling and Comparison of Disolution
Profiles. European Journal of Pharmaceutical Sciences.13: 123-133.
Dhankar, V., Garg, F., Dharmija, K., dan Awasthi, R. (2014). Preparation.
Characterization and Evaluation of Ranitidine Hydrochlorida-Loaded
Mucoadhesive Microspheres. Polim.Med.44(2): 75-81.
Das, R., Ali, A.K., dan Bandyopadhyay, K.A. (2011). Mucoadhesion and
Mucoahesive Tablets-A Review. Int. J. Pharm. Sci. Tech. 6(1): 64-115.
Dash, S., Murthy, P.N., Nath. L., dan Chowdhury, P. (2010). Review: Kinetic
Modeling on Drug Release from Controlled Drug Delivery System. Acta
Poloniae Pharmaceutica. 67(3): 217-223.
DitJen POM. (1995). Farmakope Indonesia. Edisi Ke-4. Jakarta: Departemen
Kesehatan Republik Indonesia. Hal. 375-379. 733. 1124. 1137.
Dhawan, S., Singla, A.K., and Sinha, V.R. (2004). Evaluation of mucoadhesive
properties of chitosan microsphere prepared by different method, AAPS
PharmSciTech, 5(4): 1-7.
Deghan, H.G.M., dan Khan, N.F. (2009). Gastroretentive Drug Delivery Systems:
A Patent Perspective. International Journal of Health Research. 2(1): 2344.
Donatus, L.A. dan Nurlaila (1986). Obat Tradisional dan Fitoterapi Uji
Toksikologi. Yogyakarta. Fakultas Farmasi Universitas Gajah Mada: Hal.
12-21.
Dua, K., dan Trivedi, P., (2013). Formulation and Evaluation of Mucoadhesive
Microsphere Ranitdine Hydrochloride using Chitosan and Sodium Carboxy
144
Methyl Cellulose as Polymers. International Journal of Pharmaceutical and
Biomedical Research 4(2): 140-144.
Felt, O., Buri, P., dan Gurny. R. (1998). Chitosan: A Unique Polysaccharide for
Drug Delivery. Drug Development and Industrial Pharmacy. 24(11): 979993..
Grant, S.M., Langtry, H.D., dan Brogden, R.N. (1989). Ranitidine. An Updated
Review of Its Pharmacodynamic And Pharmacokinetic Properties And
Therapeutic Use In Peptic Ulcer Disease And Other Allied Diseases. Drugs.
37(6): 801-870.
Grassi, M dan Grassi, G. (2005). Mathematical Modelling and Controlled Drug
Delivery: Matrix Systems. Current Drug Delivery. 2: 97-116.
Gierszewska-Druzynska, M.. dan Ostrowska-Czubenko. J. (2012). Mechanism of
Water Diffusion into Noncrosslinked and Ionically Crosslinked Chitosan
Membranes. Progress on Chemistry and Application of Chitin and Its 12:
59-66.
Gennaro, R.A. (2000).The Science and Practice of Pharmacy Edisi Ke-20. New
York: Lippincott Williams & Wilkin. Hal. 1225
Garg, R., dan Gupta, DG., (2008). Progress in Controlled Gastroretentive
Delivery Systems. Tropical Journal of Pharmaceutical Research. 7(3):
1055-1066.
Gunarso, W. (1989). Bahan Pengajaran Mikroteknik. Bogor, Departemen
Pendidikan dan Kebudayaan Direktorat Jenderal Pendidikan Tinggi Pusat
Antar Universitas Ilmu Hayat Institut Pertanian Bogor. Hal.80-81
Hoffman, A. (1998). Pharmacodynamic aspects of Sustained release preparations.
Adv Drug Del Rev. 33(3): 186-199.
Humason, G.L. (1967). Animal Tissue Technique. San Fransisco: W.H.Freeman
and Company. Hal.33-67.
th
Junquiera L.C, Carneiro J. (2005). Basic Histology. 11 edition, New York,
McGraw-Hill. Hal.
Katzung, B.G. (2004). Farmakologi Dasar dan Klinik. Edisi Ke-8. Jilid Ketiga.
Penerjemah: Bagian Farmakologi Fakultas Kedokteran Universitas
Airlangga. Jakarta: Penerbit Salemba Medika. Hal. 544-545.
Kharia, A.A., dan Singhai, K.A., (2013). Formulation and Evaluation of
Gastroretentive Drug Delivey System of Acyclovir as Mucoadhesive
145
Nanoparticles. International Journal of PharmTech Research 5(4): 15381545.
Knill, C.J., Kennedy,J.F., Mistry, J., Miraftab, M., Smart, G., Groocock, M.R.,
and William, H.J. (2004). Alginate Fibres Modified with Unhydrolysed and
Hydrolysed Chitosans for Wound Dressings. Carbohydrate Polymers, 55:
65-76.
Kumar, D.B.N., Sundaramoorthy, K., Vetrichelvan, T., (2010). Formulation and
In-Vitro Evaluation of Gastroretentive Floating Microspheres of Ranitidine
Hydrochloride. An International Journal of Advances In Pharmaceutical
Sciences 1(2): 298-306.
Kurniasih, M., dan Kartika, D. (2011). Sintesis dan Karakterisasi Fisika-Kinia
Kitosan. Jurnal Inovasi. 5(1): 42-48.
Lauritsen, K. (1990). Clinical Pharmacokinetics of Drugs Used in the Treatment
of Gastrointestinal Diseases. Clin Pharmacokinet. 19:11-31. 94-125.
Lachman, L., Lieberman, H.A., and Kanig, J.L. (2012).Teori dan Praktek
Farmasi Industri II. Edisi ke-3. UI Press. Hal. 934-937.
Lehr, M.C.. Bouwstra, A.J., Schacht, H.E., dan Junginger, E.H. (1992). In Vitro
Evaluation of Mucoadhesive properties of chitosan and some other natural
polymers. International Journal of Pharmaceutics 78: 43-48.natural
polymers
Li, P., Dai, Ya-Ni, Zhang. Jun-Ping. Wang. Ai-Qin. dan Wei, Q. (2008).
Chitosan-Alginate Nanoparticles as a Novel Drug Delivery System for
Nifedipine. International Journal of Biomedical Science. 4(3): 221-228.
Liao, S.K., Hung, C.C., dan Lin, F.M. (2004). A Kinetic Study of Thermal
Degradations of Chitosan/Polycaprolacton Blends. Macromolecular
Research. 12(5): 466-473.
Lohani, A., dan Chaudhary, P.G. (2012). Mucoadhesive Microsphere: A Novel
Approach to Increase Gastroretention. Chronicles of Young Scientists 3(2):
121-128.
Marabathuni,J.V., Deveswaran, R., Bharath, S., Basavaraj, V.B., dan Madhavan,
V. (2012). Design and Optimization of Multiparticulate Gastroretentive
Delivery System of Ranitidine Hydrochloride. International Journal of
Pharmacy and Pharmaceutical Siences. 4(2): 597-603
Meng X., Tian F., dan Yang J., (2010). Chitosan and Alginate Polyelectrolyte
Complex Membranes and Their Properties for Wound Dressing
Applications. J. Mater Sci: Mater Med 21: 1751-1759.
146
Morris, E.R., Rees, D.A., dan Thom, D. (1978). Chiroptical and Stoichiometry
Evidence of a Specific Primary Dimerisation in Alginate Gelation.
Carbohydrate Research. 11(2): 272-277.
Murthy, K.S.. dan Ghebre-Selasie, I. (1993). Current Perspectives on the
Dissolution Stability of Solid Oral Dosage Forms. Journal of
Pharmaceutical Sciences. 82(2):113-126.
Nayak, A.K., Maji. R., Das. B. (2010). Gastroretentive Drug Delivery Systems: A
Review. Asian Journal of Pharmaceutical And Clinical Research. 3(1): 210.
Nayak, P.K., Upadhyay, P., Valera, R.A.D.J.. dan Chauhan. P.N. (2012).
Gastroretentive Drug Delivery Systems and Recent Approaches: A Review.
Journal of Pharmaceutical Research and Opinion. 2(1): 1-8.
Pandit, V., Suresh, S., dan Joshi, H., Gastroretentif drug delivery system of
Amoxycillin: Formulation and In Vitro Evaluation, (2010). International
Journal of Pharma and Bio Sciences, 1(2):1-10.
Parmar, N.S., dan Prakash, S., (2006). Screening Methods in Pharmacology. India
Alpha Science International Ltd. Hal 262-263.
Patil, J.S., Kamalapur, M.V., Marapur, S.C., dan Kadam, D.V. (2010). Ionotropic
Gelation and Polyelectrolyte Complexation: The Novel Techniques to
Design Hydrogel Particulate Sustained. Modulated Drug Delivery System:
A Review. Digest Journal of Nanomaterials and Biostructures 5(1): 241248.
Patil, S.V., Gaikwad, P.D., Bankar, P.H., dan Pawar, S.P., (2010). Formulation
and evaluation of floating matrix tablet of locally acting H2-Antagonist.
International Journal Of Pharmacy & Technology 2(3):528-540.
Peppas, N.A., Buri, P.A., (1985). Surface. interfacial and molecular aspects of
polymer bioadhesion on soft tissues. J. Control Release. 2: 257-275.
Peppas, N.A., Bures, P,. Leobandung, W, dan Ichikawa. (2000). Hydrogels in
Pharmaceutical Formulations. European Journal of Pharmaceutics and
Biopharmaceutics. 50: 27-46.
Perigard, C.J. (2000). Clinical Analysis, Gastric Analysis. Dalam: Remington: The
Science and Practice of Pharmacy. Volume I. Editor: Alfonso Gennaro.
London: Lippincott William & Wilkins. Hal. 580-581.
147
Pratima, N.A., Tiwari. S., dan Kamble, S. (2012). Mucoadhesive: As Oral
Controlled Gastroretentive Drug Delivery System. International Journal of
Research in Pharmacy and Science. 2(3):32-59.
Price, A.S., dan Wilson, M.L., (2006) Patofisiologi Konsep Klinis Proses-Proses
Penyakit. Jakarta, Penerbit Buku Kedokteran EGC. Hal. 417-435.
Rajabi-Siahboomi, A.R., Rane, M.S., dan Felton, L.A. (2013) Oral ModifiedRelease Systems. Dalam: Allen. L.V.. Adejare. A.. Desselle. S.P.. Felton.
A.A.. Moffat. A.C. Remington The Science and Practice of Pharmacy. 22nd
Edition. London-Philadelphia Pharmaceutical Press. Hal. 989-997.
Rajput, G., Majmudar, F., Patel. J., Thakor, R., dan Rajgor, N.B. (2010).
Stomach-Specific Mucoadhesive Microsphere As A Controlled Drug
Delivery System. Systematic Reviews In Pharmacy. 1(1): 70-78.
Ramachandran, S., Thirumurugan. G., dan Dhanaraju, M.D. (2011). Development
and Evaluation of Biodegradable Chitosan Microspheres Loaded with
Ranitidine and Cross Linked with Glutaraldehyde. American Journal of
Drug Discovery and Development. 1(2): 105-120.
Rehm, B.H.A. (2009). Alginates: Biology and Applications. NewYork: Springer
Dordrecht Heidelberg. Hal. 21.
Sabiu, S., Garuba, T., Sunmonu, T., Ajani, E., Sulyman, A., Nurain, I., Balogun,
A., (2015). Indomethacin-induced gastric ulceration in rats: Protectiveroles
of Spondias mombin and Ficus exasperate Saheed. Toxicology Reports 2:
261–267.
Sachan. N.K.. Pushkar. S., Jha. A.,dan Bhattcharya. A.. (2009). Sodium Alginate:
The Wonder Polymer for Controlled Drug Delivery. Journal of Pharmacy
Reseach 2(8): 1191-1199.
Sahasathian, T., Praphairaksit, N., dan Muangsin, N., (2010). Mucoadhesive and
Floating chitosan- coated Alginate Beads for the Controlled Gastric Release
of Amoxicillin. Arch Pharm Res. 33(6): 889-899.
Sahoo, S., Chakraborti, K.C., dan Bebera, K.P., (2012). Development and
Evaluation of Gastroretentive Controlled Release Polymeric Suspension
Containing Ciprofloxacin and Carbopol Polymers. Journal of Chemical and
Pharmaceutical Research 4(4): 2268-2284.
Sarmento, B., Ferreira, D., Veiga, F., Ribeiro, A., (2006). Characterization of
Insulin-loaded Alginate Nanoparticles Produced by Ionotropic Pre-gelation
Through DSC and FTIR Studies. Carbohydrate Polymers. 66: 1-7.
148
Sanjay, S., Vaibhav, J., Kumar, B.P. (2009). Gastroretentive Drug Delivery
System. Current Approaches Journal of Pharmacy Reseach 2(5):881-886.
Siepmann, J., dan Peppas, N.A. (2001). Modelling of Drug Release from Delivery
Systems Based on Hydroxypropyl Methylcellulose (HPMC). Advance Drug
Delivery Reviews 48:139-157.
Sinko,J.P., (2011). Martin’s Physical Pharmacy and Pharmaceutical Sciences,
Sixth Edition, Walters Kluwer, Philadelphia, Hal. 248-250.
Singh, A., Singh, D., Irchhaiya, R. (2013). Mucoahesive Microsphere: A Review.
Journal of Pharmaceutical and Biomedical Analysis Letters.
Silverstein, M.R., Bassier C.G., dan Morrill, C.T. (1991). Spectrometrik
Identification of Organic Compounds. Edisi ke-5. New York. John Willey &
Sons, Inc. Hal. 121-128.
Soares, J.P.,Santos, J.E., Chierice, G.O., dan Cavalheiro, E.T.G., (2004). Thermal
Behavior of Alginic Acid and Its Sodium Salt. Ecl. Quim., Sao Paulo, 29(2):
53-56.
Solanki, P.D. (2012). Formulation. Evaluation and Optimization of Bilayer
Floating Tablet of Repaglinide and Glipizide. International Journal for
Pharmaceutical Research Scholars 1(I-3): 123-134.
Swetha, S., Allena T.R., dan Gowda, D.V., (2012). A Comprehensive Review on
Gastroretentive Drug Delivery Systems. International Journal of Research
in Pharmaceutical and Biomedical Sciences 3(3): 1285-1293.
Surana, S.A., dan Kotecha, K.R., (2010). An Overview on Various Approaches to
Oral Controlled Drug Delivery System Via Gastroretentention.
International Journal of Pharmaceutical Sciences Review and Research
2(2): 68-72.
Takahashi, T., Takayama, K., Machida.,Y., an Nagai, T. (1990). Characteristic of
Polyion Complexes of Chitosan with Sodium Alginat and Sodium
Polyacrylate. Int J Pharm. 61: 35-41.
Tarigan, P., (2006). Tukak Gaster, Chapter 78. Dalam: Buku Ajar Ilmu Penyakit
Dalam. Jilid I Edisi IV. Editor: Aru W.Sudoyo, Bambang Setiyohadi, Idrus
Alwi, Marcellus Simadibrata K, Siti Setiati. Jakarta: Pusat Penerbitan
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas
Indonesia. Halaman 338-344.
149
Tolman, K.G. (2000). Gastrointestinal and Liver. Dalam: Remington: The Science
and Practice of Pharmacy. Volume II. Editor: Alfonso Gennaro. London:
Lippincott Williams & Wilkins. Halaman 1219-1220.
Thom, D., Grant, G.T. Morris. E.R.. dan Ress.D.A. (1982). Characterisation of
Cation Binding and Gelation of Polyuronates by Circular Divhroism.
Carbohydrate Research. 100:29-42.
Tonnesen, H.H., dan Karisen, J. (2002). Alginate in Drug Delivery Systems. Drug
Development and Industrial Pharmacy. 28(6): 621-630.
Underwood, J.C.E.,(1994). Patologi Umum dan Sistematik (1994). Patologi dan
sistematik, Pathogi Umum dan Sistemik, Edisi ke 2. Halaman 436-437.
Wilson, L.M. dan Lester, L.B. (1994). Patofisiologi, Proses-proses penyakit, Jilid
I, Jakarta, EGC Penerbit Buku Kedokteran, hal. 371-385.
Yadav, K.M., Gupta, A.B., Kumar, R., Yadaf, S.J., Kumar, B., (2010).
Mucoadhesive Polymers: Means of Improving the Mucoadhesive Properties
of Drug Delivery System. Journal of Chemical and Pharmaceutical
Research 2(5): 418-432.
Yamazaki, S., Kamamura, M., Kitsukawa, M., Ando, K., Nitta, I., Tobe, A., dan
Okabe, S. (1991). Effects of MCI-727, a New Antiulcer Agent, Various
Gastric and Duodenal Lesions in Experimental Animals. Japan. J.
Pharmacol. 55: 415-424.
Yellanki, K.S., Singh, J., Syed, A.J., Bigala, R., Goranti, S., dan Nerella, K.N.
(2010). Design and Characterization of Amoxicillin Trihydrate
Mucoadhesive Microspheres for Prolonged Gastric Retention. International
of Pharmaceutical Sciences and Drug Research 2(2): 112-114.
150