Pengaruh Pemberian Ramuan Ekstrak Daun Jati Belanda (Guazuma ulmifolia Lamk.) dan Rimpang Bangle (Zingiber purpureum Roxb.) terhadap Bobot Badan dan Lemak Tikus Jantan Dewasa

PENGARUH PEMBERIAN RAMUAN EKSTRAK
DAUN JATI BELANDA (Guazuma ulmifolia Lamk.) DAN
RIMPANG BANGLE (Zingiber purpureum Roxb.) TERHADAP
BOBOT BADAN DAN LEMAK TIKUS JANTAN DEWASA

GUSMAYANTI

FAKULTAS KEDOKTERAN HEWAN
INSTITUT PERTANIAN BOGOR
2008

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ABSTRAK
Gusmayanti. Pengaruh Pemberian Ramuan Ekstrak Daun Jati Belanda (Guazuma
ulmifolia Lamk.) dan Rimpang Bangle (Zingber purpureum Roxb.) terhadap
Bobot Badan dan Lemak Tikus Jantan Dewasa. Dibimbing oleh Min Rahminiwati
dan Eva Harlina.
Jati belanda (Guazuma ulmifolia Lamk.) dan Bangle (Zingber purpureum
Roxb.) telah banyak digunakan sebagai bahan obat tradisional. Beberapa
penelitian membuktikan kedua tanaman ini dapat menurunkan aktivitas enzim

lipase. Penelitan ini bertujuan untuk mengetahui pengaruh pemberian ramuan
ekstrak daun jati belanda dan rimpang bangle dengan dosis berbeda terhadap
bobot badan dan bobot jaringan lemak testis, ginjal dan omentum, dan
membandingkan gambaran histopatologi lemak omentum. Sebanyak 40 ekor tikus
dewasa galur Sprague Dawley umur 56 hari atau yang memiliki bobot badan
diatas 236 g dibagi menjadi 4 kelompok yaitu kelompok kontrol negatif (pakan
normal, rendah lemak), kelompok kontrol positif (pakan kaya lemak), kelompok
uji dosis rendah ekstrak alkohol daun jati belanda dan rimpang bangle (302,4
mg/200g BB) dan kelompok uji dosis tinggi ekstrak alkohol daun jati belanda dan
rimpang bangle (604,8 mg/200 g BB). Penelitian dilakukan dalam dua tahap yaitu
tahap penggemukan dan tahap uji dosis, masing-masing selama 4 minggu. Hasil
penelitian menunjukkan bahwa pemberian ekstrak alkohol daun jati belanda dan
rimpang bangle dosis rendah maupun dosis tinggi menyebabkan persentase
pertambahan bobot badan yang lebih kecil namun tidak berbeda nyata (p>0,05)
dibandingkan kelompok pakan kaya lemak (kontrol positif). Pemberian ekstrak
dosis rendah cenderung menghambat persentase pertambahan bobot badan.
Pemberian ekstrak juga tidak mempengaruhi persentase bobot jaringan lemak
ginjal, testis maupun omentum, namun memperkecil ukuran sel lemak omentum.

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ABSTRACT
Gusmayanti. Influence of Extract of Jati Belanda’s (Guazuma ulmifolia Lamk.)
leaves and Bangle’s (Zingiber purpureum Roxb.) Rhizomes on Body Weight and
Mass of Adipose Tissues of Male Rats (Rattus novergicus). Under the direction of
Min Rahminiwati and Eva Harlina.
Jati belanda (Guazuma ulmifolia Lamk.) and Bangle (Zingiber purpureum
Roxb.) had been used as traditional medicine. Many researches have proved that
both of these plants could decrease lipase activities. The aim of the research was
to study the effect of low and high dose of alcohol extract of jati belanda leaves
and bangle rhizomes on reducing body weight and renal, testicle and mesenteric
adipose tissue mass and comparing the size of mesenteric adipose cells.
Fourty male rats, 56 days old or minimum body weight are 236 g were
divided into 4 groups, one group as a negative control received normal feed, the
second group as a positive control received high fat diet (25%), the third group
was treated by high fat diet and low dose of alcohol extract of jati belanda leaves
and bangle rhizomes (302,4 mg/200g BW) and the last group was treated by high
fat diet with high dose of alcohol extract of jati belanda leaves and bangle
rhizomes (604,8 mg/200 g BW). The research was conducted in two steps,
fattening step and dose test step, and in 4 weeks for each step. The result showed

that low and high dose of alcohol extract of jati belanda leaves and bangle
rhizomes decreased percentage of body weight gain but not significantly different
(p0,05)
dibandingkan kelompok pakan kaya lemak (kontrol positif). Pemberian ekstrak
dosis rendah cenderung menghambat persentase pertambahan bobot badan.
Pemberian ekstrak juga tidak mempengaruhi persentase bobot jaringan lemak
ginjal, testis maupun omentum, namun memperkecil ukuran sel lemak omentum.

5

ABSTRACT
Gusmayanti. Influence of Extract of Jati Belanda’s (Guazuma ulmifolia Lamk.)
leaves and Bangle’s (Zingiber purpureum Roxb.) Rhizomes on Body Weight and
Mass of Adipose Tissues of Male Rats (Rattus novergicus). Under the direction of
Min Rahminiwati and Eva Harlina.
Jati belanda (Guazuma ulmifolia Lamk.) and Bangle (Zingiber purpureum
Roxb.) had been used as traditional medicine. Many researches have proved that
both of these plants could decrease lipase activities. The aim of the research was
to study the effect of low and high dose of alcohol extract of jati belanda leaves
and bangle rhizomes on reducing body weight and renal, testicle and mesenteric

adipose tissue mass and comparing the size of mesenteric adipose cells.
Fourty male rats, 56 days old or minimum body weight are 236 g were
divided into 4 groups, one group as a negative control received normal feed, the
second group as a positive control received high fat diet (25%), the third group
was treated by high fat diet and low dose of alcohol extract of jati belanda leaves
and bangle rhizomes (302,4 mg/200g BW) and the last group was treated by high
fat diet with high dose of alcohol extract of jati belanda leaves and bangle
rhizomes (604,8 mg/200 g BW). The research was conducted in two steps,
fattening step and dose test step, and in 4 weeks for each step. The result showed
that low and high dose of alcohol extract of jati belanda leaves and bangle
rhizomes decreased percentage of body weight gain but not significantly different
(p