Model Rapid Application Development RAD Pengembangan Evolusioner
2. Analyst mencatat semua data pengujian dalam formulir record of analysis dan melampirkan kromatogram yang diperoleh selama proses validasi
3. Analyst memasukkan semua data pengujian ke formulir data of method developmentvalidation with internal standard lalu melaporkannya pada
analytical supervisor. 4. Analytical
supervisor melakukan
perhitungan statistik
dan membandingkannya terhadap kriteria penerimaan tiap parameter.
5. Analytical supervisor lalu memindahkannya ke dalam formulir report of analytical method validation with internal standard lalu melaporkannya
kepada technical manager. 6. Setelah diperiksa dan disahkan oleh technical manager report of analytical
method validation with internal standard lalu di periksa dan disahkan oleh QA manager.
Flowmap sistem validasi tersebut dapat dilihat pada gambar III.1.
Analytical Supervisor
Analyst
Keterangan : A1 : Record of analysis
A2 : Kromatogram A3 : Data of method developmentvalidation with internal standard
A4 : Report of analytical method validation with internal standard Technical Manager
QA Manager
Formulir analytical method validation programme
Formulir analytical method validation programme
Validasi metode Kromatogram
Record of analysis
Pengisian data
Perhitungan data Report analytical
method validation with internal standard
Pemeriksaan dan pengesahan
Pemeriksaan dan pengesahan
Memenuhi syarat?
Y
A4
Memenuhi syarat?
A2 A1
A3
Kromatogram Record of analysis
Data of method development validation with internal standard
Kromatogram Record of analysis
Data of method development validation with internal standard
Kromatogram Record of analysis
Data of method development validation with internal
standard
Report analytical method validation with
internal standard Kromatogram
Record of analysis Data of method development
validation with internal standard Report analytical
method validation with internal standard
Kromatogram Record of analysis
Data of method development validation with internal standard
Report analytical method validation with
internal standard Kromatogram
Record of analysis Data of method development
validation with internal standard
Report analytical method validation with
internal standard Kromatogram
Record of analysis Data of method development
validation with internal standard
Y T
T
Gambar III.1 Flowmap validasi metode analisis uji bioequivalensi