95 – 96. 806 – 808. This is produced in exactly the same way
FURTHER READING
285 Continued
Danazol and gestrinone Figure 5.141 are inhibitors of pituitary gonadotrophin release,
combining weak androgenic activity with antioestrogenic and antiprogestogenic activity. These highly modified structures bear one or more of the features we have already noted
in discussions of androgens, progestogens and oestrogens, possibly accounting for their complex activity. These compounds are used particularly to treat endometriosis, where
endometrial tissue grows outside the uterus.
FURTHER READING Biosynthesis, General
Bochar DA, Friesen JA, Stauffacher CV and Rodwell VW 1999 Biosynthesis of mevalonic acid from
acetyl-CoA. Comprehensive Natural Products Chem- istry
, Vol 2. Elsevier, Amsterdam, pp 15 – 44. Chappell J 1995 Biochemistry and molecular biology
of the isoprenoid biosynthetic pathway in plants. Annu Rev Plant Physiol Plant Mol Biol 46
, 521 – 547. Dewick PM 1999 The biosynthesis of C
5
– C
25
ter-
penoid compounds. Nat Prod Rep 16, 97 – 130. Ear- lier reviews
: 1997, 14, 111 – 141; 1995, 12, 507 – 534.
Eisenreich W, Schwarz M, Cartayrade A, Arigoni D, Zenk MH and Bacher A 1998 The deoxyxy-
lulose phosphate pathway of terpenoid biosynthe- sis in plants and microorganisms. Chem Biol 5,
R221 – R233.
Lichtenhaler HK 1999 The 1-deoxy-D-xylulose-5- phosphate pathway of isoprenoid biosynthesis in
plants. Annu Rev Plant Physiol Plant Mol Biol 50, 47 – 65.
McGarvey DJ and Croteau R 1995 Terpenoid
metabolism. Plant Cell 7, 1015 – 1026.
Rohmer M 1998 Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for
antibacterial drugs? Prog Drug Res 50, 135 – 154.
Rohmer M 1999 The discovery of the mevalonate- independent pathway for isoprenoid biosynthesis in
bacteria, algae and higher plants. Nat Prod Rep 16, 565 – 574.
Rohmer M 1999 A mevalonate-independent route to isopentenyl diphosphate. Comprehensive Natural
Products Chemistry , Vol 2. Elsevier, Amsterdam, pp
45 – 67.
Monoterpenoids
Croteau R 1991 Metabolism of monoterpenes in mint
Mentha species. Planta Med 57, S10-S14. Grayson DH 2000 Monoterpenoids. Nat Prod Rep 17,
385 – 419. Earlier reviews: 1998, 15, 439 – 475; 1997, 14, 477 – 522.
Wise ML and Croteau R 1999 Monoterpene biosyn- thesis. Comprehensive Natural Products Chemistry,
Vol 2. Elsevier, Amsterdam, pp 97 – 153.
Volatile Oils
Mookherjee BD and Wilson RA 1996 Oils, essential. Kirk–Othmer Encyclopedia of Chemical Technology
, 4th edn, Vol 17. Wiley, New York, pp 603 – 674.
Pyrethrins
Metcalf RL 1995 Insect control technology. Kirk– Othmer Encyclopedia of Chemical Technology
, 4th edn, Vol 14. Wiley, New York, pp 524– 602.
Ramos Tombo GM and Bellus D 1991 Chirality
and crop protection. Angew Chem Int Edn Engl 30, 1193 – 1215.
Iridoids
Houghton P 1994 Herbal products: valerian. Pharm J