209 – 219. 289 – 337. This is produced in exactly the same way

286 THE MEVALONATE AND DEOXYXYLULOSE PHOSPHATE PATHWAYS Fraga BM 2000 Natural sesquiterpenoids. Nat Prod Rep 17 , 483 – 504. Earlier reviews: 1999, 16, 711 – 730; 1999, 16, 21 – 38. Groenewegen WA, Knight DA and Heptinstall S 1992 Progress in the medicinal chemistry of the herb feverfew. Prog Med Chem 29, 217 – 238. Knight DW 1995 Feverfew: chemistry and biological activity. Nat Prod Rep 12, 271 – 276. Robles M, Aregullin M, West J and Rodriguez E 1995 Recent studies on the zoopharmacognosy, pharmacology and neurotoxicology of sesquiterpene lactones. Planta Med 61, 199 – 203. Artemisinin Bhattacharya AK and Sharma RP 1999 Recent devel- opments on the chemistry and biological activity of artemisinin and related antimalarials – an update. Heterocycles 51 , 1681 – 1745. Casteel DA 1999 Peroxy natural products. Nat Prod Rep 16 , 55 – 73. Haynes RK and Vonwiller SC 1997 From qinghao, marvelous herb of antiquity, to the antimalarial tri- oxane qinghaosu – and some remarkable new chem- istry. Account Chem Res 30, 73 – 79. Klayman DL 1992 Antiparasitic agents antipro- tozoals. Kirk–Othmer Encyclopedia of Chemical Technology , 4th edn, Vol 3. Wiley, New York, pp 489 – 526. Robert A and Meunier B 1998 Is alkylation the main mechanism of action of the antimalarial drug artemisinin? Chem Soc Rev 27, 273 – 279. van Geldre E, Vergauwe A and van den Eeckhout E 1997 State of the art of the production of the antimalarial compound artemisinin in plants. Plant Mol Biol 33 , 199 – 209. Ziffer H, Highet RJ and Klayman DL 1997 Artemisinin: an endoperoxidic antimalarial from Artemisia annua L. Prog Chem Org Nat Prod 72, 121 – 214. Gossypol Jaroszewski JW, Strom-Hansen T, Hansen SH, Thastrup O and Kofod H 1992 On the botanical distribu- tion of chiral forms of gossypol. Planta Med 58, 454 – 458. Trichothecenes Grove JF 1993 Macrocyclic trichothecenes. Nat Prod Rep 10 , 429 – 448. Grove JF 1996 Non-macrocyclic trichothecenes, part 2. Prog Chem Org Nat Prod 69 , 1 – 70. Diterpenoids Hanson JR 2001 Diterpenoids. Nat Prod Rep 18, 88 – 94. Earlier reviews: 2000, 17, 165 – 174; 1999,

16, 209 – 219.

MacMillan J and Beale MH 1999 Diterpene biosyn- thesis. Comprehensive Natural Products Chemistry, Vol 2. Elsevier, Amsterdam, pp 217 – 243. San Feliciano A, Gordaliza M, Salinero MA and del Corral JMM 1993 Abietane acids: sources, biolog- ical activities, and therapeutic uses. Planta Med 59, 485 – 490. Taxol Amos LA and L¨owe J 1999 How Taxol  stabilizes microtubule structure. Chem Biol 6, R65 – R69. Appendino G 1995 The phytochemistry of the yew tree. Nat Prod Rep 12, 349 – 360. Appendino G 1996 Taxine. Alkaloids, Chemical and Biological Perspectives ed Pelletier SW Vol 11. Elsevier, Amsterdam, pp 237 – 268. Baloglu E and Kingston DGI 1999 The taxane diter- penoids. J Nat Prod 62, 1448 – 1472. Gu´enard D, Gu´eritte-Voegelein F and Potier P 1993 Taxol and taxotere: discovery, chemistry, and structure-activity relationships. Account Chem Res 26, 160 – 167. Heinstein PF and Chang C-j 1994 Taxol. Annu Rev Plant Physiol Plant Mol Biol 45 , 663 – 674. Jaziri M, Zhiri A, Guo Y-W, Dupont J-P, Shimo- mura K, Hamada H, Vanhaelen M and Homes J 1996 Taxus sp. cell, tissue and organ cultures as alternative sources for taxoids production: a liter- ature survey. Plant Cell Tissue Organ Culture 44, 59 – 75. Jenkins P 1996 Taxol branches out. Chem Brit 32 11, 43 – 46. Kapoor VK and Mahindroo 1997 Recent advances in structure modifications of taxol paclitaxel. Ind J Chem 36B , 639 – 652. Kingston DGI 2000 Recent advances in the chemistry of taxol. J Nat Prod 63, 726 – 734. Nicolaou KC, Dai W-M and Guy RK 1994 Chemistry and biology of taxol. Angew Chem Int Edn Engl 33, 15 – 44. van Rozendaal ELM, Leylveld GP and van Beek TA 2000 Screening of the needles of different yew species and cultivars for paclitaxel and related tax- oids. Phytochemistry 53, 383 – 389. Vyas DM and Kadow JF 1995 Paclitaxel: a unique tubulin interacting anticancer agent. Prog Med Chem

32, 289 – 337.

FURTHER READING 287 Ginkgo Braquet P, Esanu A, Buisine E, Hosford D, Broquet C and Koltai M 1991 Recent progress in ginkgolide research. Med Res Rev 11, 295 – 355. Braquet P and Hosford D 1991 Ethnopharmacology and the development of natural PAF antagonists as therapeutic agents. J Ethnopharmacol 32, 135 – 139. Houghton P 1994 Herbal products: Ginkgo. Pharm J

253, 122 – 123.