TR Band and Genesis Hematoma

106 PROCEEDING BOOK The 2 nd International Conference on Health Science 2015

2. Multivariate Analysis

Based on the results of the bivariate analysis with chi-square of five variables administration of medication types, sheath size, systolic blood pressure values, frequency puncture and TR Band obtained pvalue 0.05 means that fi ve variables can continue to do the analysis for the logistic regression model determine the most dominant factor to the incidence of hematoma of these fi ve factors. Based on the results of the results of multivariate logistic regression analysis of the fi ve variables signifi cantly infl uence the incidence of hematoma, these fi ve variables are the number of drug types, sheath size, blood pressure, puncture frequency, size TR Brand. Logistic regression analysis results of fi ve variables that affect the occurrence of hematoma in patients undergoing transradial Cardiac Catheterization action at Hospital Dr. Sardjito is the amount of anticoagulant drug administration. This means that after fi ve factors that infl uence the incidence of hematoma tested simultaneously then showed that patients given anticoagulant drugs two or more kinds 19 .115 times have infl uence on the incidence of hematoma in patients undergoing transradial cardiac catheterization in Hospital Dr. Sardjito compared to other variables. While the smallest effect on multivariate phase is the frequency puncture. During cardiac catheterization action has been correlated unfractionated heparin, the dose and increased partial thromboplastin time to improve vaskular 17 complications. Anticoagulation drugs used during cardiac catheterization action is unfractionated heparin UFH 21 . Heparin is aprimary anticoagulant where the effect is to disable thrombin and inhibits factor X via antithrombin, by inactivating thrombin, the heparin not only prevents the formation of fi brin but also inhibits the activation of thrombin-induced platelet and factors V and VIII, UFH is thrombin inhibitor indirectly, and requires the presence of cofactor antithrombin to be effective. Heparin is a specifi c action and nonlinear, and each patient responds differently to heparin doses 13 . Active Heparin sometimes free to do more work on antithrombin. Heparin worksare in the same lane at work clotting factors XIIa, Xa, and IXa serine protease others. Binding of heparin on coagulation factors and antithrombin both very important in enhancing antithrombin. Work heparin on factor Xa are also mediated by increased affi nity of antithrombin for clotting factors but did not bind factor Xa heparin. Factor Xa inhibiting improvement compared with lower levels of heparin that has been measured to inhibit thrombin. Heparin reduces platelet agresasi secondary to the reduction in thrombin a potent cause of platelet aggregation. An increase in lipases cause increased plasma free fatty acids. UFH anticoagulation and antiplatelet group aims to improve Activated Cloting Time ACT and Activated Thromboplastin Time APTT. Improved ACT and APTT is required when the patient underwent cardiac catheterization to prevent blood clotting and thrombus occurrence, on the other hand with an increase in ACT may increase the risk of bleeding in patients post cardiac catheterization 11 . Patients who underwent cardiac catheterization have already got the drug Aspilet or clopidogrel or class of antiplatelet, this class of drugs prevents adhesion and aggregation of platelets by inhibiting a receptor on the membrane of platelets, preventing the interaction of platelets or the interaction of platelets premises chemicals blood clotting another 14 . The impact of these drugs is going to increase bleeding and increase the risk of hematoma.