Efek Pemberian Ekstrak Buah Andaliman (Zanthoxylum acanthopodium) Terhadap Penurunan Kadar Gula Darah pada Mencit Model Diabetes Mellitus Tipe 1 Appendix
41
CURRICULUM VITAE
Nama
: M. Ridho
Alamat
: Taman Setiabudi Indah II Blok IV
No. 96 Medan Sumatera Utara.
: ridho110196@gmail.com
Tempat/ tanggal lahir
: Medan, sumatera utara / 11 januari 1996
Riwayat Pendidikan
Sekolah Dasar
SD Kemala Bhayangkari Medan 2001-2007
Sekolah Menengah Pertama
SMP Negeri 1 Medan 2007-2010
Sekolah Menengah Atas
SMA Negeri 15 Medan 2010-2013
Pendidikan Sarjana
Fakultas Kedokteran Universitas Sumatera Utara Tahun
2013 Sampai Dengan Sekarang
Riwayat Organisasi
1. PEMA FK USU Periode 2014
2. PEMA FK USU Periode 2015
3. PEMA FK USU Periode 2016
Riwayat Kepanitiaan
1.Koor Seksi Publikasi dan Dokumentasi MMB FK USU Tahun 2014
2.Koor Seksi Publikasi dan Dokumentasi Medical Humanity Day Tahun
2014
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3. Anggota Seksi Administrasi dan Kesekretariatan TRY OUT SBMPTN
FK USU Tahun 2014
4. Anggota Seksi Publikasi dan Dokumentasi LKMM FK USU Tahun 2014
5. Koor Seksi Publikasi dan Dokumentasi Porseni FK USU 2015
6. Anggota Seksi Publikasi dan Dokumentasi PM AKBAR PEMA FK USU Tahun 2015
7. Anggota Seksi Dana LKMM FK USU Tahun 2015
8. Anggota Seksi Dana Islamic Medicine 3 Tahun 2015
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Lampiran 1. Hasil identifikasi tumbuhan
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Lampiran 2. Surat persetujuan etik penelitian
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Lampiran 3. Surat izin penelitian di laboratorium Fakultas Farmasi USU
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Lampiran 4. Surat izin penelitian di laboratorium Fakultas MIPA USU
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Lampiran 5. Gambar buah andaliman
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Lampiran 6. Gambar hewan uji
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Lampiran 7. Perlakuan hewan uji pada saat penelitian
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Lampiran 8. Proses Pembuatan Ekstrak
Buah Andaliman
Dicuci dan dikeringkan
Simplisia buah andaliman
Dihaluskan dengan blender
Serbuk simplisia buah andaliman 770 gr
Maserasi dengan etanol 70% dan
disaring dengan kertas saring
Ampas
Maserasi dengan
Etanol 70% dan
Disaring dengan
Kertas saring
Maserat I
Maserat II
Maserat I dan II digabung
dan dipekatkan dengan
rotary evaporator
Ekstrak buah andaliman 60,424 gr
Lampiran 9. Perhitungan dosis
a. Dosis Metformin
Tabel konversi antara hewan dengan manusia
Mencit 20
g
Tikus 200
g
Marmut
400 g
Kelinci 1,2
g
Mencit
Tikus
Marmut
Kelinci
Kera
Anjing
Manusia
20 g
200 g
400 g
1,2 g
4 kg
12 kg
70 kg
1,0
7,0
12,25
27,8
64,1
124,2
387,9
0,14
1,0
1,74
3,9
9,2
17,8
56,0
0,08
0,57
1,0
2,25
5,2
10,2
31,5
0,04
0,25
0,44
1,0
2,4
4,5
14,2
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Kera 4 kg
Anjing 12
kg
Manusia
70 kg
0,016
0,11
0,19
0,42
1,0
1,9
6,1
0,008
0,06
0,10
0,22
0,52
1,0
3,1
0,0026
0,018
0,031
0,07
0,16
0,32
1,0
1. Tiap tablet metformin mengandung 500 mg metformin-HCl,
2. Dosis untuk manusia dewasa adalah 500 mg - 3000 mg
3. Konversi dosis manusia (70 kg) ke dosis untuk hewan uji mencit dikali 0,0026
4. Dosis metformin untuk mencit (20 g) = (500 mg – 300 mg) x 0,0026 = 1,3 mg –
7,8 mg
5. Metformin yang digunakan = 1,3 mg untuk mencit 20 g
6. Dosis metformin yang diberikan
7. x =
!,! !"
!" !
!" !"
!" !
=
!
! !"
× 1 �� = 65 ��.
8. Dosis metformin = 65 mg/kg bb
9. 65 mg/kg bb = 65/1000 g x 20 g = 1,3 g
10. Volume larutan yang diberikan adalah 1,3 mg/ 5 mg x 1 ml = 0,26 ml
b. Dosis Aloksan
1. Dosis pemberian secara intravena = 65 mg/kg bb
2. Dosis pemberian secara intraperitoneal = 2-3 kali dosis intravena
3. Perhitungan dosis untuk mencit berat 20 g dengan dosis 125 mg/kg bb =
125 ��
× 20 � = 2,5 �
1000 �
4. Volume aloksan yang diberikan
2,5 ��
�� = 0,35 ��
10
��
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c. Dosis Ekstrak Buah Andaliman
1. Dosis suspensi ekstrak buah andaliman yang akan dibuat adalah 100 mg/kg bb,
200 mg/kg bb dan 300 mg/kg bb
2. Cara pembuatan suspensi ekstrak buah andaliman :
Timbang 100 mg, 20 mg dan 300 mg ekstrak buah andaliman, masing-masing
dilarutkan dalam 10 ml suspensi CMC 0,5%
3. Volume suspensi ekstrak buah andaliman yang diberikan kepada mencit
a. Jumlah ekstrak buah andaliman dosis 100 mg/kg bb =
Volume larutan yang diberikan =
! !"
!"" !"
! !"
!"" !"
! !"
!"" !"
× 20 � = 2 ��
!"" !"
!""" !
× 20 � = 4 ��
× 10 �� = 0,2 ��
c. Jumlah ekstrak buah andaliman dosis 300 mg/kg bb =
Volume larutan yang diberikan =
!""" !
× 10 �� = 0,2 ��
b. Jumlah ekstrak buah andaliman dosis 200 mg/kg bb =
Volume larutan yang diberikan =
!"" !"
!"" !"
!""" !
× 20 � = 6 ��
× 10 �� = 0,2 ��
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Lampiran 10. Tabel hasil pengukuran KGD
hari ke-
Kelomp
Perulang
KGD
KGD
ok
an
normal
aloksan
3
6
9
12
15
1
107
224
292
472
592
191
181
2
118
236
242
360
205
186
118
3
96
258
297
273
207
178
156
4
130
335
364
398
465
443
385
5
112
237
298
315
353
276
209
112.6
258
298.
363.
364.
254.
209.
6
6
4
8
8
1
72
320
275
220
176
120
104
2
75
405
374
228
184
105
89
3
52
258
216
154
134
126
81
4
92
520
436
328
243
188
125
5
57
241
205
186
178
127
86
69.6
348.8
301.
223.
2
2
1
91
245
181
170
132
95
84
2
79
583
476
379
201
156
114
3
33
286
271
229
185
142
107
4
67
363
321
294
226
197
126
5
67
422
398
371
306
264
113
67.4
379.8
329.
288.
170.
108.
4
6
8
8
1
81
415
569
285
216
193
122
2
63
234
306
209
194
173
165
3
130
310
565
527
321
274
185
4
83
284
273
239
187
177
169
5
113
279
253
239
225
202
189
Aquades
rata-rata
EBA
100
mg/kg
bb
rata-rata
EBA
200
mg/kg
bb
rata-rata
EBA
300
mg/kg
bb
183
210
133.
2
97
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rata-rata
94
304.4
393.
299.
228.
203.
2
8
6
8
166
metform
1
75
527
491
382
275
172
113
in dosis
2
138
515
463
296
250
185
118
65
3
116
246
175
166
158
143
110
mg/kg
4
136
327
279
218
167
116
97
bb
5
108
367
285
203
183
152
108
114.6
396.4
206.
153.
109.
6
6
2
rata-rata
338.
6
253
Lampiran 11. Tabel persen penurunan KGD
Kelompok
Aquades
Perulangan
6
9
12
15
-30.35
-110.71 -164.2
14.73
19.19
2
-2.54
-52.54
13.13
21.18
50
3
-15.11
-5.81
19.76
31
39.5
4
-8.65
-18.8
-38.8
-32.2
-14.92
5
-25.73
-32.91
-48.94
-16.45
11.81
-16.476 -44.154 -43.81
3.652
21.116
1
14
31.25
45
62.5
67.5
2
7.65
43.7
54.56
74.07
78
3
16.27
40.31
48
51.16
68.6
4
16.15
36.92
53.26
63.84
75.96
5
14.93
22.82
26.14
47.3
64.31
13.8
35
1
26.12
30.61
46.12
61.22
65.71
2
18.35
34.99
65.52
73.24
80.44
Rata-rata
EBA 200 mg/kg bb
3
1
Rata-rata
EBA 100 mg/kg bb
hari ke-
45.392 59.774 70.874
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3
5.24
19.93
35.31
50.34
62.58
4
11.57
19
37.74
45.73
65.28
5
5.68
12.08
27.48
37.44
73.22
13.392
23.322
42.434 53.594 69.446
1
-37.1
31.32
47.95
53.49
70.6
2
-30.76
10.68
17.09
26.06
29.48
3
-82.25
-70
-3.54
11.61
40.32
4
3.87
15.84
34.15
37.67
40.49
5
9.31
14.33
19.35
27.59
32.25
-27.386
0.434
23
1
5.69
27.51
47.81
67.36
78.55
2
10.09
42.42
51.45
64.07
77.08
3
28.86
32.52
35.77
41.86
55.28
4
14.67
33.33
48.92
64.52
70.33
5
22.34
44.68
50.13
58.58
70.57
16.33
36.092
46.816 59.278 70.362
Rata-rata
EBA 300 mg/kg bb
Rata-rata
Metformin dosis 65
mg/kg bb
Rata-rata
31.284 42.628
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Lampiran 12. Hasil analisis statistik
a. Perbandingan KGD sebelum dan sesudah induksi aloksan 125 mg/kg bb
T-Test kelompok kontrol negatif
Paired Samples Statistics
Mean
N
Std. Deviation
Std. Error Mean
KGD_Normal
112.6000
5
12.64120
5.65332
KGD_Aloksan
258.0000
5
44.74930
20.01250
Pair 1
Paired Samples Correlations
N
Pair 1
KGD_Normal &
Correlation
5
Sig.
.629
.255
KGD_Aloksan
Paired Samples Test
Paired Differences
Mean
Std.
Std. Error
95% Confidence Interval
Deviation
Mean
of the Difference
Lower
Pair
KGD_Normal -
-
1
KGD_Aloksan
145.40000
38.08280
17.03115
-192.68605
Paired Samples Test
Paired Differences
t
df
Sig. (2tailed)
95% Confidence Interval of the
Difference
Upper
Pair
KGD_Normal -
1
KGD_Aloksan
-98.11395
-
4
.001
8.537
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T-Test kelompok uji dosis 100
Paired Samples Statistics
Mean
N
Std. Deviation
Std. Error Mean
KGD_Normal
69.6000
5
15.85244
7.08943
KGD_Aloksan
348.8000
5
115.28530
51.55715
Pair 1
Paired Samples Correlations
N
Pair 1
KGD_Normal &
Correlation
5
Sig.
.961
.009
KGD_Aloksan
Paired Samples Test
Paired Differences
Mean
Std.
Std. Error
95% Confidence Interval
Deviation
Mean
of the Difference
Lower
Pair
KGD_Normal -
-
1
KGD_Aloksan
279.20000
100.14589
44.78661
-403.54755
Paired Samples Test
Paired Differences
t
df
Sig. (2tailed)
95% Confidence Interval of the
Difference
Upper
Pair
KGD_Normal -
1
KGD_Aloksan
-154.85245
-
4
.003
6.234
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T-Test kelompok uji dosis 200
Paired Samples Statistics
Mean
N
Std. Deviation
Std. Error Mean
KGD_Normal
67.4000
5
21.65179
9.68297
KGD_Aloksan
379.8000
5
132.59223
59.29705
Pair 1
Paired Samples Correlations
N
Pair 1
KGD_Normal &
Correlation
5
Sig.
.208
.737
KGD_Aloksan
Paired Samples Test
Paired Differences
Mean
Std.
Std. Error
95% Confidence Interval
Deviation
Mean
of the Difference
Lower
Pair
KGD_Normal -
-
1
KGD_Aloksan
312.40000
129.82026
58.05739
-473.59314
Paired Samples Test
Paired Differences
t
df
Sig. (2tailed)
95% Confidence Interval of the
Difference
Upper
Pair
KGD_Normal -
1
KGD_Aloksan
-151.20686
-
4
.006
5.381
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T-Test kelompok uji dosis 300
Paired Samples Statistics
Mean
N
Std. Deviation
Std. Error Mean
KGD_Normal
94.0000
5
26.96294
12.05819
KGD_Aloksan
304.4000
5
67.60399
30.23343
Pair 1
Paired Samples Correlations
N
Pair 1
KGD_Normal &
Correlation
5
Sig.
.094
.880
KGD_Aloksan
Paired Samples Test
Paired Differences
Mean
Std.
Std. Error
95% Confidence Interval
Deviation
Mean
of the Difference
Lower
Pair
KGD_Normal -
-
1
KGD_Aloksan
210.40000
70.37968
31.47475
-297.78792
Paired Samples Test
Paired Differences
t
df
Sig. (2tailed)
95% Confidence Interval of the
Difference
Upper
Pair
KGD_Normal -
1
KGD_Aloksan
-123.01208
-
4
.003
6.685
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T-Test kelompok kontrol positif
Paired Samples Statistics
Mean
N
Std. Deviation
Std. Error Mean
KGD_Normal
114.6000
5
25.58906
11.44378
KGD_Aloksan
396.4000
5
121.88437
54.50835
Pair 1
Paired Samples Correlations
N
Pair 1
KGD_Normal &
Correlation
5
Sig.
-.312
.609
KGD_Aloksan
Paired Samples Test
Paired Differences
Mean
Std.
Std. Error
95% Confidence Interval
Deviation
Mean
of the Difference
Lower
Pair
KGD_Normal -
-
1
KGD_Aloksan
281.80000
132.13516
59.09264
-445.86747
Paired Samples Test
Paired Differences
t
df
Sig. (2tailed)
95% Confidence Interval of the
Difference
Upper
Pair
KGD_Normal -
1
KGD_Aloksan
-117.73253
-
4
.009
4.769
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b. KGD setelah perlakuan
Tests of Normality
Hari_ke Kolmogorov-Smirnov
Statistic
Aquades
df
a
Sig.
Shapiro-Wilk
Statistic df Sig.
3
.306
5
.143
.905
5 .438
6
.137
5
.200
*
.986
5 .965
*
.909
5 .464
9
.226
5
.200
12
.315
5
.118
.774
5 .049
15
.303
5
.150
.845
5 .179
5
.200
*
.903
5 .428
*
.920
5 .533
3
.203
6
.271
5
.200
Dosis_100 9
.290
5
.197
.910
5 .470
.377
5
.019
.796
5 .075
5
.200
*
.886
5 .335
.200
*
.994
5 .992
.200
*
.920
5 .528
.200
*
.969
5 .870
.200
*
.976
5 .911
*
.914
5 .492
12
15
3
6
Dosis_200 9
12
.273
.129
.219
.201
.192
5
5
5
5
15
.254
5
.200
3
.307
5
.138
.770
5 .046
6
.345
5
.051
.733
5 .021
Dosis_300 9
.327
5
.087
.801
5 .082
.318
5
.111
.797
5 .077
5
.200
*
.859
5 .225
.900
5 .413
12
15
.285
3
.255
5
.200
*
6
.257
5
.200
*
.925
5 .565
.866
5 .249
Metformin 9
12
15
.273
5
.200
*
.155
5
.200
*
.979
5 .931
.200
*
.947
5 .716
.239
5
Test of Homogeneity of Variances
Levene Statistic
df1
df2
Sig.
Aquades
2.096
4
20
.119
Dosis_100
4.091
4
20
.014
Dosis_200
2.492
4
20
.076
Dosis_300
6.479
4
20
.002
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Metformin
9.297
4
20
.000
df
Mean Square
ANOVA
Sum of
F
Sig.
1.939
.143
6.701
.001
Squares
Between Groups
Aquades
Dosis_200
91789.360
4
22947.340
Within Groups
236697.200
20
11834.860
Total
328486.560
24
Between Groups
157744.240
4
39436.060
Within Groups
117698.000
20
5884.900
Total
275442.240
24
Kruskal-Wallis Test
Test Statistics
dosis100
Chi-Square
a,b
dosis300
metformin
18.388
16.090
17.479
4
4
4
.001
.003
.002
df
Asymp. Sig.
a. Kruskal Wallis Test
b. Grouping Variable: Hari_ke
c. Perbandingan KGD sebelum induksi aloksan, hari ke-0 dan hari ke-15
setelah perlakuan
Tests of Normality
KGD
Kolmogorov-Smirnov
Statistic
Akuades
df
Sig.
a
Shapiro-Wilk
Statistic df Sig.
Sebelum
.135
5
.200
*
.998
5 .998
Hari 0
.300
5
.161
.781
5 .056
Hari 15
.303
5
.150
.845
5 .179
5
.200
*
.952
5 .749
.200
*
.918
5 .517
*
.886
5 .335
.916
5 .505
Sebelum
Dosis_100 Hari 0
Hari 15
Dosis_200 Sebelum
.187
.199
5
.273
5
.200
.293
5
.187
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Hari 0
.175
Hari 15
.254
Sebelum
.258
Dosis_300 Hari 0
.267
Hari 15
.285
Sebelum
Metformin Hari 0
Hari 15
5
5
5
5
5
.200
*
.943
5 .685
.200
*
.914
5 .492
.200
*
.939
5 .659
.200
*
.893
5 .373
.200
*
.859
5 .225
.903
5 .426
.199
5
.200
*
.235
5
.200
*
.907
5 .449
.200
*
.947
5 .716
.239
5
*. This is a lower bound of the true significance.
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
Levene Statistic
df1
df2
Sig.
Akuades
2.630
2
12
.113
Dosis_100
9.826
2
12
.003
Dosis_200
6.294
2
12
.014
Dosis_300
1.553
2
12
.251
Metformin
14.564
2
12
.001
ANOVA
Sum of Squares df Mean Square
Akuades
Between Groups
54853.733
2
27426.867
Within Groups
51496.000 12
4291.333
Total
106349.733 14
Between Groups
114344.533
Dosis_300 Within Groups
2
24025.200 12
Total
F
Sig.
6.391 .013
57172.267 28.556 .000
2002.100
138369.733 14
Kruskal-Wallis Test
Test Statistics
Dosis_100
Chi-Square
df
Asymp. Sig.
Dosis_200
a
Metformin
11.180
12.042
9.572
2
2
2
.004
.002
.008
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d. Persentase penurunan KGD
Tests of Normality
hari_ke Kolmogorov-Smirnov
Statistic
3
6
Akuades
9
12
.188
.219
.272
.260
df
5
5
5
5
a
Sig.
Shapiro-Wilk
Statistic df Sig.
.200
*
.954
5 .769
.200
*
.900
5 .408
.200
*
.863
5 .239
.200
*
.910
5 .469
*
.970
5 .872
15
.166
5
.200
3
.322
5
.098
.769
5 .044
5
.200
*
.956
5 .779
.200
*
.833
5 .146
.200
*
.949
5 .731
.200
*
.911
5 .472
.200
*
.908
5 .456
.200
*
.940
5 .665
.200
*
.923
5 .549
*
.975
5 .906
6
dosis_100 9
12
15
3
6
dosis_200 9
.192
.286
.201
.252
.207
.242
.227
5
5
5
5
5
5
12
.192
5
.200
15
.295
5
.177
.890
5 .357
*
.920
5 .530
3
.202
5
.200
6
.401
5
.009
.729
5 .019
5
.200
*
.980
5 .936
*
.976
5 .911
dosis_300 9
.180
12
.194
5
.200
15
.352
5
.042
.801
5 .083
.968
5 .864
3
.171
5
.200
*
6
.249
5
.200
*
.916
5 .507
Metformin 9
.362
5
.031
.754
5 .033
*
.805
5 .089
.860
5 .230
12
.280
5
.200
15
.299
5
.166
*. This is a lower bound of the true significance.
a. Lilliefors Significance Correction
Universitas Sumatera Utara
65
Test of Homogeneity of Variances
Levene Statistic
df1
df2
Sig.
Akuades
1.859
4
20
.157
dosis_100
1.381
4
20
.276
dosis_200
.823
4
20
.526
dosis_300
1.327
4
20
.294
Metformin
.304
4
20
.872
ANOVA
Sum of Squares df Mean Square
Akuades
Between Groups
16650.237
4
4162.559
Within Groups
34531.951 20
1726.598
Total
51182.188 24
Between Groups
9806.617
dosis_100 Within Groups
4
1438.732 20
Total
11245.349 24
Between Groups
10214.860
dosis_200 Within Groups
4
2495.686 20
Total
12710.546 24
Between Groups
15480.680
dosis_300 Within Groups
Total
F
Sig.
2.411 .083
2451.654 34.081 .000
71.937
2553.715 20.465 .000
124.784
4
3870.170
15423.896 20
771.195
5.018 .006
30904.576 24
Between Groups
8743.519
Metformin Within Groups
4
1475.066 20
Total
2185.880 29.638 .000
73.753
10218.584 24
e. Perbedaan antar perlakuan
Tests of Normality
Kelompok Kolmogorov-Smirnov
Statistic
hari_3
df
a
Sig.
Shapiro-Wilk
Statistic df Sig.
*
.954
5 .769
Aquades
.188
5
.200
100
.322
5
.098
.769
5 .044
.908
5 .456
200
.207
5
.200
*
300
.202
5
.200
*
.920
5 .530
.200
*
.968
5 .864
Metformin
.171
5
Universitas Sumatera Utara
66
Aquades
.219
100
hari_6
.192
5
.200
*
.900
5 .408
.200
*
.956
5 .779
*
.940
5 .665
200
.242
5
.200
300
.401
5
.009
.729
5 .019
5
.200
*
.916
5 .507
.200
*
.863
5 .239
.200
*
.833
5 .146
.200
*
.923
5 .549
*
.980
5 .936
Metformin
.249
Aquades
.272
100
hari_9
5
.286
200
.227
5
5
5
300
.180
5
.200
Metformin
.362
5
.031
.754
5 .033
5
.200
*
.910
5 .469
.200
*
.949
5 .731
.200
*
.975
5 .906
.200
*
.976
5 .911
.200
*
.805
5 .089
.970
5 .872
Aquades
.260
100
.201
hari_12 200
.192
300
.194
Metformin
.280
5
5
5
5
Aquades
.166
5
.200
*
100
.252
5
.200
*
.911
5 .472
hari_15 200
.295
5
.177
.890
5 .357
300
.352
5
.042
.801
5 .083
Metformin
.299
5
.166
.860
5 .230
*. This is a lower bound of the true significance.
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
Levene Statistic
df1
df2
Sig.
hari_3
4.542
4
20
.009
hari_6
3.108
4
20
.038
hari_9
3.396
4
20
.028
hari_12
3.249
4
20
.033
hari_15
2.396
4
20
.085
ANOVA
Sum of Squares df Mean Square
Between Groups
9988.939
4
hari_15 Within Groups
4323.605 20
Total
14312.544 24
F
Sig.
2497.235 11.552 .000
216.180
Universitas Sumatera Utara
67
Kruskal-Wallis Test
Test Statistics
hari_3
Chi-Square
hari_6
a,b
hari_9
hari_12
15.707
17.110
14.880
15.759
4
4
4
4
.003
.002
.005
.003
df
Asymp. Sig.
a. Kruskal Wallis Test
b. Grouping Variable: Kelompok
Post Hoc Tests
Multiple Comparisons
Tukey HSD
Dependent
(I)
(J)
Variable
Kelompok
Kelompok
Mean
Std.
Difference (I-
Error
Sig.
95% Confidence
Interval
J)
Lower
Upper
Bound
Bound
100
-30.27600 11.56668
.105
-64.8878
4.3358
200
-29.86800 11.56668
.112
-64.4798
4.7438
300
10.91000 11.56668
.877
-23.7018
45.5218
Metformin
-32.80600 11.56668
.069
-67.4178
1.8058
Aquades
30.27600 11.56668
.105
-4.3358
64.8878
.40800 11.56668 1.000
-34.2038
35.0198
Aquades
200
100
300
hari_3
11.56668
.015
6.5742
75.7978
Metformin
-2.53000 11.56668
.999
-37.1418
32.0818
Aquades
29.86800 11.56668
.112
-4.7438
64.4798
-.40800 11.56668 1.000
-35.0198
34.2038
100
41.18600
200
300
*
11.56668
.016
6.1662
75.3898
Metformin
-2.93800 11.56668
.999
-37.5498
31.6738
Aquades
-10.91000 11.56668
.877
-45.5218
23.7018
100
40.77800
-41.18600
*
11.56668
.015
-75.7978
-6.5742
-40.77800
*
11.56668
.016
-75.3898
-6.1662
-43.71600
*
11.56668
.009
-78.3278
-9.1042
32.80600 11.56668
.069
-1.8058
67.4178
300
200
Metformin
Metformin
*
Aquades
Universitas Sumatera Utara
68
100
2.53000 11.56668
.999
-32.0818
37.1418
200
2.93800 11.56668
.999
-31.6738
37.5498
43.71600
*
11.56668
.009
9.1042
78.3278
-79.15400
*
16.74127
.001 -129.2502
-29.0578
200
-67.47600
*
16.74127
.005 -117.5722
-17.3798
300
-44.58800 16.74127
300
100
Aquades
-94.6842
5.5082
16.74127
.001 -130.3422
-30.1498
16.74127
.001
29.0578
129.2502
200
11.67800 16.74127
.955
-38.4182
61.7742
300
34.56600 16.74127
.273
-15.5302
84.6622
Metformin
-1.09200 16.74127 1.000
-51.1882
49.0042
-80.24600
*
Aquades
79.15400
*
Metformin
100
hari_6
200
300
Aquades
67.47600
16.74127
.005
17.3798
117.5722
100
-11.67800 16.74127
.955
-61.7742
38.4182
300
22.88800 16.74127
.654
-27.2082
72.9842
Metformin
-12.77000 16.74127
.938
-62.8662
37.3262
Aquades
44.58800 16.74127
.096
-5.5082
94.6842
100
-34.56600 16.74127
.273
-84.6622
15.5302
200
-22.88800 16.74127
.654
-72.9842
27.2082
Metformin
-35.65800 16.74127
.247
-85.7542
14.4382
.001
30.1498
130.3422
1.09200 16.74127 1.000
-49.0042
51.1882
Aquades
Metformin
100
.938
-37.3262
62.8662
300
35.65800 16.74127
.247
-14.4382
85.7542
200
300
Aquades
hari_9
200
300
-89.20200
*
22.29543
.006 -155.9183
-22.4857
-86.24400
*
22.29543
.008 -152.9603
-19.5277
-66.81000
*
22.29543
.050 -133.5263
-.0937
-90.62600
*
22.29543
.005 -157.3423
-23.9097
89.20200
*
22.29543
.006
22.4857
155.9183
2.95800 22.29543 1.000
-63.7583
69.6743
300
22.39200 22.29543
.850
-44.3243
89.1083
Metformin
-1.42400 22.29543 1.000
-68.1403
65.2923
.008
19.5277
152.9603
100
-2.95800 22.29543 1.000
-69.6743
63.7583
300
19.43400 22.29543
.904
-47.2823
86.1503
Metformin
-4.38200 22.29543 1.000
-71.0983
62.3343
Aquades
200
16.74127
12.77000 16.74127
Metformin
100
80.24600
*
200
100
Aquades
*
.096
86.24400
*
*
22.29543
Aquades
66.81000
22.29543
.050
.0937
133.5263
100
-22.39200 22.29543
.850
-89.1083
44.3243
200
-19.43400 22.29543
.904
-86.1503
47.2823
Metformin
-23.81600 22.29543
.820
-90.5323
42.9003
Universitas Sumatera Utara
69
Aquades
Metformin
23.9097
157.3423
100
1.42400 22.29543 1.000
-65.2923
68.1403
200
4.38200 22.29543 1.000
-62.3343
71.0983
.820
-42.9003
90.5323
10.47329
.000
-87.4620
-24.7820
200
-49.94200
*
10.47329
.001
-81.2820
-18.6020
300
-27.63200 10.47329
.101
-58.9720
3.7080
-55.62600
*
10.47329
.000
-86.9660
-24.2860
56.12200
*
10.47329
.000
24.7820
87.4620
200
6.18000 10.47329
.975
-25.1600
37.5200
300
28.49000 10.47329
.086
-2.8500
59.8300
.49600 10.47329 1.000
-30.8440
31.8360
Aquades
Metformin
Aquades
hari_12
200
300
49.94200
*
10.47329
.001
18.6020
81.2820
100
-6.18000 10.47329
.975
-37.5200
25.1600
300
22.31000 10.47329
.246
-9.0300
53.6500
Metformin
-5.68400 10.47329
.982
-37.0240
25.6560
Aquades
27.63200 10.47329
.101
-3.7080
58.9720
100
-28.49000 10.47329
.086
-59.8300
2.8500
200
-22.31000 10.47329
.246
-53.6500
9.0300
Metformin
-27.99400 10.47329
.094
-59.3340
3.3460
.000
24.2860
86.9660
100
-.49600 10.47329 1.000
-31.8360
30.8440
200
5.68400 10.47329
.982
-25.6560
37.0240
300
27.99400 10.47329
.094
-3.3460
59.3340
Aquades
Metformin
23.81600 22.29543
-56.12200
Metformin
100
22.29543
*
100
Aquades
*
.005
300
90.62600
55.62600
*
10.47329
100
-49.75800
*
200
-48.33000
*
9.29904
.000
-76.1562
-20.5038
300
-21.51200
9.29904
.182
-49.3382
6.3142
Metformin
-49.24600
*
9.29904
.000
-77.0722
-21.4198
49.75800
*
9.29904
.000
21.9318
77.5842
9.29904 1.000
-26.3982
29.2542
.046
.4198
56.0722
9.29904 1.000
-27.3142
28.3382
.000
20.5038
76.1562
-29.2542
26.3982
.062
-1.0082
54.6442
9.29904 1.000
-28.7422
26.9102
-6.3142
49.3382
9.29904
.000
-77.5842
-21.9318
Aquades
Aquades
200
1.42800
300
*
100
hari_15
Metformin
Aquades
28.24600
.51200
48.33000
*
9.29904
9.29904
100
-1.42800
9.29904 1.000
300
26.81800
9.29904
200
Metformin
300
Aquades
-.91600
21.51200
9.29904
.182
Universitas Sumatera Utara
70
100
-28.24600
*
9.29904
.046
-56.0722
-.4198
200
-26.81800
9.29904
.062
-54.6442
1.0082
Metformin
-27.73400
9.29904
.051
-55.5602
.0922
Aquades
49.24600
*
9.29904
.000
21.4198
77.0722
100
-.51200
9.29904 1.000
-28.3382
27.3142
200
.91600
9.29904 1.000
-26.9102
28.7422
300
27.73400
-.0922
55.5602
Metformin
9.29904
.051
*. The mean difference is significant at the 0.05 level.
Homogeneous Subsets
hari_3
Tukey HSD
a
Kelompok
N
Subset for alpha = 0.05
1
2
300
5
-27.3860
Aquades
5
-16.4760
200
5
13.3920
100
5
13.8000
Metformin
5
-16.4760
16.3300
Sig.
.877
.069
Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
hari_6
Tukey HSD
Kelompok
a
N
Subset for alpha = 0.05
1
2
Aquades
5
-44.1540
300
5
.4340
200
5
23.3220
100
5
35.0000
Metformin
5
36.0920
Sig.
.096
.4340
.247
Universitas Sumatera Utara
71
Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
hari_9
Tukey HSD
a
Kelompok
N
Subset for alpha = 0.05
1
2
Aquades
5
-43.8100
300
5
23.0000
200
5
42.4340
100
5
45.3920
Metformin
5
46.8160
Sig.
1.000
.820
Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
hari_12
Tukey HSD
a
Kelompok N Subset for alpha = 0.05
1
2
Aquades
5
3.6520
300
5
31.2840
200
5
53.5940
Metformin
5
59.2780
100
5
59.7740
Sig.
.101
31.2840
.086
Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
Universitas Sumatera Utara
72
hari_15
Tukey HSD
a
Kelompok N
Subset for alpha = 0.05
1
2
3
Aquades
5 21.1160
300
5 42.6280 42.6280
200
5
69.4460 69.4460
Metformin
5
70.3620 70.3620
100
5
70.8740
Sig.
.182
.051
1.000
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
Universitas Sumatera Utara