Formulasi Sediaan Krim Sari Tomat (Solanum Lycopersicum L.) Dan Uji Efek Anti-Aging

LAMPIRAN 1. Bagan pembuatan sediaan krim

Fase minyak

Fase air

-

asam stearat
setil alkoho
gliseril monostearat
Vaselin
BHT
dimasukkan ke dalam cawan
penguap
- dilebur di atas penangas air pada suhu 70°C

-

Nipagin
Natrium edetat

propilen glikol
trietanolamin
aquadest

- dilarutkan dalam air
panas yg telah ditakar
pada suhu 70°C

Fase minyak + Fase air
- digerus konstan di dalam lumpang panas
- ditambahkan 3 tetes pewangi
Dasar Krim

Sari tomat
- ditimbang masing-masing konsentrasi
- dimasukkan bahan dasar krim ke dalam lumpang
- ditambahkan sari tomat yang telah ditimbang sedikit
demi sedikit hingga homogen
Krim sari tomat


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Lampiran 2. Hasil identifikasi tumbuhan

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Lampiran 3. Gambar buah tomat, tomat setelah di potong, tomat di juice dan sari
tomat yang telah di freeze drying

Buah tomat

Tomat setelah dipotong kecil - kecil

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Lampiran 3. (Lanjutan)


Tomat di juice

Sari tomat yang telah di freeze drying

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Lampiran 4. Gambar alat-alat penelitian

A

B

C
Keterangan: A: Juicer yang berisi sampel (Miyako), B: Skin analyzer (Aramo),
C: Moisturizer checker (Aramo), D: pH meter (Hanna Instrumen).

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Lampiran 5. Gambar sediaan setelah dimasukkan kedalam wadah dan gambar
sediaan setelah penyimpanan hari ke–90
a. Gambar sediaan setelah dimasukkan kedalam wadah

Keterangan : Formula A : Blanko (dasar krim tanpa sampel).
Formula B : krim sari tomat 5%
Formula C : krim sari tomat 7,5%
Formula D : krim sari tomat 10%
Formula E : krim sari tomat 12%

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Lampiran 5. (Lanjutan)
b. Gambar sediaan setelah penyimpanan hari ke - 90

Keterangan : Formula A : Blanko (dasar krim tanpa sampel).
Formula B : krim sari tomat 5%
Formula C : krim sari tomat 7,5%
Formula D : krim sari tomat 10%

Formula E : krim sari tomat 12%

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Lampiran 6. Gambar hasil uji homogenitas dan tipe emulsi
a. Uji homogenitas

FA

FB

FC

FD

FE

FF


b. Tipe emulsi

FA

FB

FC

FD

FE

FF

Keterangan : Formula A : Blanko (dasar krim tanpa sampel).
Formula B : krim sari tomat 5%
Formula C : krim sari tomat 7,5%
Formula D : krim sari tomat 10%
Formula E : krim sari tomat 12%


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Lampiran 7. Salah satu contoh hasil uji efektivitas anti-aging pada sukarelawan
a.. Hasil pengukuran kadar air (Moisture)
- Kondisi awal

- Pemulihan minggu pertama (Minggu1)

- Pemulihan minggu kedua (Minggu 2)

- Pemulihan minggu ketiga (Minggu 3)

- Pemulihan minggu ke empat (Minggu 4)

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Lampiran 7. (Lanjutan)
a. Hasil pengukuran kehalusan dan besar pori (Evenness/pore)

- Kondisi awal

- Pemulihan minggu pertama (Minggu1)

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Lampiran 7. (Lanjutan)
- Pemulihan minggu kedua (Minggu 2)

- Pemulihan minggu ketiga (Minggu 3)

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Lampiran 7. (Lanjutan)
- Pemulihan minggu ke empat (Minggu 4)

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Lampiran 7. (Lanjutan)
b. Hasil pengukuran banyak noda (spot)
- Kondisi awal

- Pemulihan minggu pertama (Minggu1)

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Lampiran 7. (Lanjutan)
- Pemulihan minggu pertama (Minggu2)

- Pemulihan minggu pertama (Minggu3)

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Lampiran 7. (Lanjutan)
- Pemulihan minggu pertama (Minggu4)


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Lampiran 8. Hasil variansi (ANAVA) dan Tukey untuk
sukarelawan selama 4 minggu

pemulihan kulit

a. Kadar air (Moisture)
ANOVA
Sum of
Squares
minggu0

minggu1

minggu2

minggu3


minggu4

Between Groups

df

Mean Square

2.000

5

.400

Within Groups

12.000

12

1.000

Total

14.000

17

Between Groups

12.944

5

2.589

Within Groups

18.667

12

1.556

Total

31.611

17

Between Groups

42.944

5

8.589

Within Groups

12.667

12

1.056

Total

55.611

17

Between Groups

57.778

5

11.556

Within Groups

10.000

12

.833

Total

67.778

17

125.611

5

25.122

11.333

12

.944

136.944

17

Between Groups
Within Groups
Total

F

Sig.
.400

.840

1.664

.217

8.137

.001

13.867

.000

26.600

.000

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minggu0
TukeyHSDa
Subset for alpha =
0.05
Formula

N

1

Blanko

3

28.00

KST 5%

3

27.67

KST 7,5%

3

28.00

KST 10%

3

27.67

KST 12%

3

28.67

Olay

3

28.00

Sig.

.817

Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

minggu1
TukeyHSDa
Subset for alpha =
0.05
Formula

N

1

Blanko

3

28.00

KST 5%

3

28.33

KST 7,5%

3

29.33

KST 10%

3

29.67

KST 12%

3

30.00

OLAY

3

30.33

Sig.

.269

Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

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minggu2
TukeyHSDa
Subset for alpha = 0.05
Formula

N

1

2

3

Blanko

3

28.00

KST 5%

3

29.33

KST 7,5%

3

31.33

31.33

KST 10%

3

31.33

31.33

KST 12%

3

32.00

32.00

OLAY

3

29.33

32.33

Sig.

.620

.067

.833

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

minggu3
TukeyHSDa
Subset for alpha = 0.05
Formula

N

1

2

3

Blanko

3

29.00

KST 5%

3

30.00

KST 7,5%

3

KST 10%

3

32.67

KST 12%

3

33.33

OLAY

3

34.00

Sig.

30.00
32.33

.758

.073

32.33

.290

Means for groups in homogeneous subsets are displayed.
a.

Uses Harmonic Mean Sample Size = 3,000.

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minggu4
TukeyHSDa
Subset for alpha = 0.05
Formula

N

1

2

3

Blanko

3

29.33

KST 5%

3

30.00

KST 7,5%

3

33.33

KST 10%

3

33.67

KST 12%

3

35.33

OLAY

3

Sig.

35.33
36.67

.954

.192

.567

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

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Lampiran 8. (Lanjutan)
b. Kehalusan (Evenness)
ANOVA
Sum of
Squares
minggu0

minggu2

minggu3

minggu4

Mean Square

Between Groups

4.667

5

.933

Within Groups

9.333

12

.778

14.000

17

9.333

5

1.867

Within Groups

12.667

12

1.056

Total

22.000

17

Between Groups

37.111

5

7.422

Within Groups

10.000

12

.833

Total

47.111

17

Between Groups

78.278

5

15.656

Within Groups

18.000

12

1.500

Total

96.278

17

Between Groups

98.278

5

19.656

8.667

12

.722

106.944

17

Total
minggu1

df

Between Groups

Within Groups
Total

F

Sig.

1.200

.366

1.768

.194

8.907

.001

10.437

.000

27.215

.000

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minggu0
TukeyHSDa
Subset for alpha =
0.05
Formula

N

1

Olay

3

35.67

KST 12%

3

34.67

KST 10%

3

35.67

KST 7,5%

3

35.67

KST 5%

3

36.33

Blanko

3

36.00

Sig.

.260

Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

minggu1
TukeyHSDa
Subset for alpha =
0.05
Formula

N

1

OLAY

3

34.00

KST 12%

3

34.33

KST 10%

3

34.67

KST 7,5%

3

35.33

Blanko

3

35.67

KST 5%

3

36.00

Sig.

.235

Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

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minggu2
TukeyHSDa
Subset for alpha = 0.05
Formula

N

1

2

3

OLAY

3

32.00

KST 12%

3

32.33

32.33

KST 10%

3

33.00

33.00

KST 5%

3

34.67

34.67

KST 7,5%

3

34.67

34.67

Blanko

3

36.00

Sig.

.758

.073

.506

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

minggu3
TukeyHSDa
Subset for alpha = 0.05
Formula

N

1

2

KST 12%

3

30.00

KST 10%

3

31.00

OLAY

3

31.00

KST 7,5%

3

33.33

KST 5%

3

34.67

Blanko

3

35.67

Sig.

33.33

.052

.253

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

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minggu4

TukeyHSDa
Subset for alpha = 0.05
Formula

N

1

2

3

OLAY

3

28.00

KST 12%

3

29.00

29.00

KST 10%

3

30.00

30.00

KST 7,5%

3

KST 5%

3

Blanko

3

Sig.

31.00

4

31.00
32.67
35.00

.110

.110

.229

1.000

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

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Lampiran 8. (Lanjutan)
c. pori (pore)
ANOVA
Sum of
Squares
minggu0

minggu1

47.611

5

9.522

Within Groups

62.000

12

5.167

Total

109.611

17

Between Groups

104.500

5

20.900

78.000

12

6.500

Total

182.500

17

Between Groups

277.111

5

55.422

72.667

12

6.056

Total

349.778

17

Between Groups

445.778

5

89.156

70.000

12

5.833

Total

515.778

17

Between Groups

625.833

5

125.167

96.667

12

8.056

722.500

17

Within Groups

minggu3

Within Groups

minggu4

Mean Square

Between Groups

Within Groups

minggu2

df

Within Groups
Total

F

Sig.

1.843

.179

3.215

.045

9.152

.001

15.284

.000

15.538

.000

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minggu0
Tukey HSDa
Subset for alpha =
0.05
Formula

N

1

Olay

3

31.33

KST 12%

3

32.33

KST 10%

3

32.33

KST 7,5%

3

32.67

KST 5%

3

32.33

Blanko

3

35.33

Sig.

.253

Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

minggu1
Tukey HSDa
Subset for alpha = 0.05
Formula

N

1

2

OLAY

3

28.33

KST 12%

3

32.00

32.00

KST 10%

3

31.00

31.00

KST 7,5%

3

31.33

31.33

KST 5%

3

35.00

35.00

Blanko

3

Sig.

35.33
.065

.357

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

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minggu2
Tukey HSDa
Subset foralpha = 0.05
Formula

N

1

OLAY

3

23.00

KST 12%

3

28.67

28.67

KST 10%

3

29.00

29.00

KST 7,5%

3

29.67

29.67

KST 5%

3

35.33

Blanko

3

35.33

Sig.

.054

.093

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

minggu3
Tukey HSDa
Subset for alpha = 0.05
Formula

N

1

2

3

4

OLAY

3

KST 12%

3

25.00

KST 10%

3

26.67

26.67

KST 7,5%

3

27.00

27.00

KST 5%

3

Blanko

3

Sig.

18.33

32.00

32.00
33.67

1.000

.904

.145

.953

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

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minggu4
Tukey HSDa
Subset for alpha = 0.05
Formula

N

1

2

3

4

OLAY

3

15.67

KST 12%

3

22.33

KST 10%

3

24.00

24.00

KST 7,5%

3

26.00

26.00

26.00

KST 5%

3

31.67

31.67

Blanko

3

Sig.

22.33

33.33
.111

.624

.054

.069

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

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Lampiran 8. (Lanjutan)
d. Noda (spot)
ANOVA
Sum of
Squares
minggu0

minggu1

minggu2

minggu3

Mean Square

Between Groups

10.500

5

2.100

Within Groups

28.000

12

2.333

Total

38.500

17

Between Groups

37.833

5

7.567

Within Groups

34.667

12

2.889

Total

72.500

17

Between Groups

81.333

5

16.267

Within Groups

32.667

12

2.722

Total

114.000

17

Between Groups

203.111

5

40.622

38.667

12

3.222

Total

241.778

17

Between Groups

379.167

5

75.833

55.333

12

4.611

434.500

17

Within Groups

minggu4

df

Within Groups
Total

F

Sig.
.900

.512

2.619

.080

5.976

.005

12.607

.000

16.446

.000

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minggu0
TukeyHSDa
Subset for alpha =
0.05
Formula

N

1

OLAY

3

29.67

KST 7,5%

3

31.00

KST 10%

3

31.00

KST 5%

3

31.67

KST 12%

3

31.67

Blanko

3

32.00

Sig.

.462

Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

minggu1
TukeyHSDa
Subset for alpha =
0.05
Formula

N

1

OLAY

3

28.33

KST 12%

3

28.33

KST 10%

3

30.00

KST 7,5%

3

30.67

KST 5%

3

31.67

Blanko

3

32.00

Sig.

.160

Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

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minggu2
TukeyHSDa
Subset for alpha = 0.05
Formula

N

1

2

KST 12%

3

26.33

OLAY

3

26.67

KST 10%

3

28.67

28.67

KST 7,5%

3

29.00

29.00

KST 5%

3

31.33

Blanko

3

32.00

Sig.

.406

.206

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

minggu3
TukeyHSDa
Subset for alpha = 0.05
Formula

N

1

2

3

4

OLAY

3

22.33

KST 12%

3

24.33

24.33

KST 10%

3

25.67

25.67

25.67

KST 7,5%

3

28.00

28.00

28.00

KST 5%

3

30.33

30.33

Blanko

3

Sig.

32.00
.275

.198

.067

.140

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

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minggu4
TukeyHSDa
Subset for alpha = 0.05
Formula

N

1

2

3

OLAY

3

19.33

KST 12%

3

21.33

KST 10%

3

23.00

KST 7,5%

3

KST 5%

3

30.33

Blanko

3

31.67

Sig.

23.00
27.33

.352

.207

27.33

.207

Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 3,000.

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SURAT PERNYATAAN PERSETUJUAN IKUT SERTA
DALAM PENELITIAN

Nama lengkap

:……………………………………………..

Usia

:…………………………………………….

Jenis kelamin

:…………………………………………….

Alamat

:…………………………………………….

Bersedia menjadi sukarelawan untuk test anti-aging ?………….

Telah mendapat penjelasan secukupnya bahwa tangan saya akan digunakan sebagai
daerah yang akan dianalisis. Setelah mendapat penjelasan secukupnya tentang
manfaat penelitian ini maka saya menyatakan SETUJU untuk ikut serta dalam
penelitian DARA YUNITA dengan judul “FORMULASI SEDIAAN KRIM SARI
TOMAT (Solanum lycopersicum L.) DAN UJI EFEK ANTI-AGING
” sebagai usaha untuk mengetahui apakah sediaan krim yang dihasilkan mampu
memberikan efek anti penuaan dini. Saya menyatakan sukarela dan bersedia untuk
mengikuti prosedur penelitian yang telah ditetapkan.
Persetujuan ini saya buat dengan penuh kesadaran dan tanpa paksaan dari pihak
manapun. Demikian surat pernyataan ini dibuat untuk dapat dipergunakan
sebagaimana mestinya.

Peneliti ,

Medan,

September 2015

Dara Yunita
NIM 101501008

NIM

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