Perbandingan Ekspresi Kiss 1 Pada Tumor Ganas Ovarium Tipe Epitel Dengan Tumor Jinak Ovarium Tipe Epitel
DAFTAR PUSTAKA
1.
American Cancer Society. Cancer Facts and Figures 2011,
(http://www.cancer.org/Cancer/OvarianCancer/DetailedGuide/ovariancancer-eystatistics), diakses 6 Juni, (2015).
2.
Aziz MF. Current management and trend of ovarian cancer. In
Saifudddin AB, Affandi B and Winknjosastro GH. Womens Health. The
proceeding of the Xvth. Asian and Ocenia Congress of Obstetrics and
Gynecology. Jakarta : Yayasan Bina Pustaka. S. Prawihardjo, 1995.p.
321-334.
3.
Nuranna L. Tumor ganas ovarium tipe epitel. Jakaarta : Sub Bagian
Onkologi Kebidanan dan Kandungan FKUI/RSCM; 1992.
4.
Tumor
markers
for
Ovarian
Cancer.
1994.
(http://www.oncolink.org/includes/print_article.cfm?Page=2&id=7143&
section=cancer_types), diakses 6 Juni (2015).
5.
Kanda S, Oka Y. Structure, Synthesis, and Phylogenyof Kisspeptin
and its Receptor, Kauffman AS, Smith JT,In: Kisspeptin Signaling in
Reproductive Biology,Advances in Experimental Medicine and
Biology. Springer Science Business Media, LLC; 2013; p 9-26.
6.
Sonigo C, Binart N. Overview of the impact of Kisspeptin on
reproductive function. Annales d’Endocrinologie 2012;73:448–458
7.
Dova, Golfinopoulos V, Pentheroudakis G, et al. Systemic
Dissemination in Cancer of Unknown Primaryis Independent of
Mutational Inactivation of the KiSS1Metastasis-suppressor Gene.
Pathol Oncol Res 2008;14:239–241.
8.
Cunningham FG, Gant NF, Leveno KJ, Gilstrap LC, Hauth JC,
Wenstrom KD. Obstetri Williams Edisi ke-21 Vol. 2. Jakarta : ECG;
2004. p. 934, 1035-7. 2.
9.
Kotani M Detheux M, Vandebogaerde A, Communi D, Vanderwinden
JM, Le Poul E, Brezilien S, Tyldesley R, Suarez-Huerta N, Vandeput
F, et al. (2001) The metastasi suppressor gene KiSS1 encodes
Kisspeptins, the natural ligands of the orphan G protein-coupled
receptor GPR54. J Biol Chem 276: 34631-34636
10. Jemal A, Murray T, Samuels A et al. Cancer statistics, 2003. CA
Cancer J Clin 2003; 53: 5–26.
56
11. Saifuddin, Abdul Bari, dkk. 2010. Ilmu Kebidanan Sarwono
Prawirohardjo. Jakarta : PT Bina Pustaka Sarwono Prawirohardjo.
12. Prabhu VV, Sakhtivel KM, Guruvayoorappan C. Kisspeptin (KiSS1):
essential player in supressing tumor metastasis. Asian Pac J Cancer
Prev, 14 (11), 6215-6220
13. Smith JT, Clifton DK, Steiner RA (2006). Regulation of the
neuroendocrine reproductive axis by Kisspeptin-GPR54 signaling.
Reproduction, 131, 623-30.
14. Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ,
Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, et al.
(2001) AXOR12, a novel human G protein-coupled receptor, activated
by the peptide KiSS1. J Biol Chem 276: 28969-28975.
15. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K,
Terao Y, Kumano S, Takatsu Y, Masuda Y, et al. (2001) Metastasis
suppressor gene KiSS1 encodes peptide ligand of a G-proteincoupled receptor. Nature 411: 613-617
16. Welch DR, Chen P, Miele ME, McGary CT, Bower JM, Stanbridge EJ,
and Weissman BE (1994) Microcell-mediated transfer of chromosome
6 into metastatic human C8161 melanoma cells suppresses
metastasis but does not inhibit tumorigenicity. Oncogene 9: 255-262.
17. Mechaly AS, Vinas J, Murphy C, Reith M & Piferrer. Gene structure of
the KiSS1 receptor-2 in the atlantic halibut: insights into the evolution
and regulation of KiSS1r genes. Mol Cel Endocrin 2010; 317: 78-89.
18. Hata K, Dhar DK, Watanabe Y, et al (2007). Expression of metastin
and a G-protein-coupled receptor (AXOR12) in epithelial ovarian
cancer. Eur J Cancer, 43, 1452-9.
19. Stafford LJ, Xia C, Ma W, Cai Y, Liu M (2002). Identification and
characterization of mouse metastasis-suppressor KiSS1 and its Gprotein coupled receptor. Cancer Res, 62, 5399-404.
20. Weipei Z, Aihua G, Xin C, Feng L, Jiang N & Hong Z. Expression of
KiSS1 in epithelial ovarian cancer and its role in metastasis. Applied
Mech & Mat 2012; 140: 142-151.
21. Gupta GP and Massagué J (2006) Cancer metastasis: building a
framework. Cell 127: 679-695.
22. Sastrawinata, Sulaiman. dkk. 2004. Ilmu Kesehatan Reproduksi:
Obstetri Patologi.Edisi 2. Jakarta: EGC hal :104.
57
23. DeChemey AH, Pernoll ML. Current Obstetric and Gynecologic
Diagnosis and Treatment 8th edition. Norwalk : Appleton & Lange;
1994. p. 744-51.
24. Helm, CW. Ovarian Cyst. 19 maret 2008. (Available at :
http://.emedicine.com/med/topic1699.htm, accessed on 15 Juni 2013)
25. Moeloek FA, Nuranna L, Wibowo N, Purbadi S. Standar Pelayanan
Medik Obstetri dan Ginekologi. Jakarta : Perkumpulan Obstetri dan
Ginekologi Indonesia; 2006. p.130-1 6. Ovarian Cyst. 6 April 2008.
(Available at http://en.wikipedia.org/wiki/Ovarian_cyst, accessed on 15
Juni 2013)
26. Steeg PS. Metastasis suppressors alter the signal transduction of
cancer cells. Nat Rev Cancer 2003; 3: 55–63.
27. Welch DR, Hunter KW. A new member of the growing family of
metastasis suppressors identified in prostate cancer. J Natl Cancer
Inst 2003; 95: 839–41.
28. Bari R, Zhang YH, Zhang F, et al (2009). Transmembrane interactions
are needed for KAI1/CD82-mediated suppression of cancer invasion
and metastasis. Am J Pathol, 174, 647-60.
29. Prabhu VV, Siddikuzzaman, Grace VM, Guruvayoorappan C (2012).
Targeting tumor metastasis by regulating Nm23 gene expression.
Asian Pac J Cancer Prev, 13, 3539-48.
30. Welch, D. R. (1996) J. Natl. Cancer Inst. 88,1731–1737
31. Lee, J. H., Miele, M. E., Hicks, D. J., Phillips, K. K., Trent, J. M.,
Weissman, B. E., and Welch, D. R. (1996). KiSS1, a novel human
malignant melanoma metastasis-suppressor gene. J Natl Cancer Inst
88, 1731-1737.
32. Lee, J. H., and Welch, D. R. (1997). Suppression of metastasis in
human breast carcinoma MDA-MB-435 cells after transfection with
the metastasis suppressor gene, KiSS1. Cancer Res 57, 2384-2387.
33. Xavier d‟Anglemont de Tassigny and William Henry Colledge (2010).
“The Role of Kisspeptin Signaling in Reproduction”. PHYSIOLOGY;
25: 207–217.
34. Bilban M, Ghaffari-Tabrizi N, Hintermann E, et al (2004). Kisspeptin10, a KiSS1/metasin-derived decapeptide, is a physiological invasion
inhibitor of primary human trophoblast. J Cell Sci, 117, 1319-28.
58
35. Tena-Sempere M, Felip A, Gómez A, Zanuy S, Carrillo M (2012).
Comparative insights of the Kisspeptin/Kisspeptin receptor system:
lessons from non-mammalian vertebrates. Gen Comp Endocrinol, 175,
234-43.
36. Cho, S. G., Yi, Z., Pang, X., Yi, T., Wang, Y., Luo, J., Wu, Z., Li, D.,
and Liu, M. (2009b). Kisspeptin-10, a KISS1-derived decapeptide,
inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF
expression and FAK/Rho GTPase activation. Cancer Res 69, 70627070.
37. Navenot JM, Fujii N & Peiper SC. KiSS1 metastasis supressor gene
product induces suppression of tyrosine kinase receptor signaling to
Akt, tumor necrosis factor family ligand expression, and apoptosis.
38. Becker JA, Mirjolet JF, Bernard J, Burgeon E, Simons MJ, Vassart G,
Parmentier M, and Libert F (2005) Activation of GPR54 promotes cell
cycle arrest and apoptosis of human tumor cells through a specific
transcriptional program not shared by other Gq-coupled
receptors.Biochem Biophys Res Commun 326: 677-686.
39. Hori A, Honda S, Asada M, Ohtaki T, Oda K, Watanabe T, Shintani Y,
Yamada T, Suenaga M, Kitada C, et al. (2001) Metastin suppresses
the motility and growth of CHO cells transfected with its
receptor. Biochem Biophys Res Commun 286: 958-963
40. Gao GL, Liu LD, Zou XS, et al. Expression of KiSS1, matrix
metalloproteinase-9, nuclear factor-kappaBp65 in ovarian tumour.
Zhonghua Fu Chan Ke Za Zhi. (2007)42(1):34-38
41. Takino T, Koshikawa N, Miyamori H, et al. Cleavage of metastasis
suppressor gene product KiSS1 protein/metastin by matrix
metalloproteinases. Oncogene (2003), 22(30):4617-4626
42. Makri A, Pissimissis N, Lembessis P,et al. The Kisspeptin
(KiSS1)/GPR54 system in cancer biology.Cancer Treat Rev.
(2008);34(8):682-692.
43. Nagai K, Doi R, Katagiri F, et al. Prognostic value of metastin
expression in human pancreatic cancer.J Exp Clin Cancer Res. (2009)
;21;28-29
44. Schmid K, Wang X, Haitel A,et al.KiSS1 overexpression as an
independent prognostic marker in hepatocellular carcinoma: an
immunohistochemical study. Virchows Arch.( 2007); 450 (2) : 143-149.
45. Oakley AE, Clifton DK, Steiner RA (2009). Kisspeptin signaling in the
brain. Endocr Rev, 30, 713-43.
59
46. Martin TA, Watkins G, Jiang WG (2005). KiSS1 expression in human
breast cancer. Clin Exp Metastas, 22, 503-11.
47. Liang S, Yang ZL (2007). Expression of KiSS1 mRNA in pancreatic
ductal adenocarcinoma and non-cancerous pancreatic tissues in SD
rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 32, 109-13.
48. Dhar DK, Naora H, Kubota H, et al (2004). Downregulation of KiSS1
expression is responsible for tumor invasion and worse prognosis in
gastriccarcinoma. Int J Cancer, 10, 868-72.
49. Babwah AV, Pampillo M, Min L, et al (2012). Single-cell analyses
reveal that KiSS1-R-expressing cells undergo sustained Kisspeptininduced signaling that is dependent upon an influx of extracellular Ca
+. Endocrinol, 153, 5875-87.
50. Sanchez-Carbayo M, Capodieci P, Cordon-Cardo C (2003). Tumor
suppressor role of KiSS1 in bladder cancer: loss of KiSS1 expression
is associated with bladder cancer progression and clinical outcome.
Am J Pathol, 162, 609
51. Goldberg SF, Miele ME, Hatta N, et al (2003). Melanoma metastasis
suppression by chromosome 6: evidence for a pathway regulated by
CRSP3 and TXNIP. Cancer Res, 63:432-40.
52. Nash KT, Welch DR (2006). The KiSS1 metastasis suppressor:
mechanistic insights and clinical utility. Front Biosci, 1;647-59.
53. Mitchell DC, Abdelrahim M, Weng J, Stafford LJ, Safe S, Bar-Eli M, Liu
M (2006). “Regulation of KiSS1 metastasis
suppressor gene
expression in breast cancer cells by direct interaction of transcription
factors activator protein-2alpha and specificity protein-1”. Journal
Biology Chemistry; 281: 51–58.
54. Ying J, Berk M, Singh LS, Tan H, Yin L, Powell CT, et al. KiSS1
supresses metastasis in human ovarian cancer via inhibition of protein
kinase C alpha. Clin Exp Metastasis 2005; 22: 369-376.
55. Harms JF, Welch DR, Miele ME. KISS1 metastasis suppression and
emergent pathways. Clin Exp Metast 2003; 20: 11–8.
56. Jiang Y, Berk M, Singh LS, et al. KiSS1 suppresses metastasis in
human ovarian cancer via inhibition of protein kinase C alpha. Clin Exp
Metast 2005;22:369–76.
57. Zhang SL, Yu Y, Jiang T, Lin B, Gao H: Expression and significance of
KiSS1 and its receptor GPR54 mRNA in epithelial ovarian cancer.
Zhonghua Fu Chan Ke Za Zhi 2005, 40:689-692.
60
58. Prentice LM, Klausen C, Kalloger S, Kobel M, McKineey S, Santos JL,
et al. Kisspeptin and GPR54 immunoreactivity in a cohort of 518
patients defines favourable prognosis and clear cell subtype in ovarian
carcinoma. BMC Medicine 2007; 5: 33.
59. Krajewski SJ, Burke MC, Anderson MJ, McMullen NT, Rance NE
(2010). “Forebrain projections of arcuate neurokinin B neurons
demonstrated by anterograde tracttracingand monosodium glutamate
lesions in the rat”. Neuroscience; 166(2):680–697.
60. Makri A, Pissimissis N, Lembessis P, Poluchronakos C, Koutsillieris M.
The Kisspeptin (KiSS1)/GPR54 system in cancer biology. Cancer
Treatment Reviews (2008) 34, 682-692.
61. Simerly RB (2002) Wired for reproduction: organization and
development of sexually dimorphic circuits in the mammalian
forebrain. Annu Rev Neurosci 25:507–536.
62. Matsui H, Takatsu Y, Kumano S, Matsumoto H, Ohtaki
T (2004) Peripheral administration of metastin induces marked
gonadotropin release and ovulation in the rat. Biochem Biophys Res
Commun 320:383–388
63. Panidis D, Rousso D, Koliakos G, et al. Plasma metastin levels are
negatively correlated with insulin resistance and free androgens in
women with polycystic ovary syndrome. Fertil Steril 2006;85:1778–83.
64. Montes AF, Gomez JG, Viejo MN, Bermejo MA, Urrutia SA & Mata JG.
Epidemiology and etiology of ovarian cancer. Interchopen, 2012.
61
1.
American Cancer Society. Cancer Facts and Figures 2011,
(http://www.cancer.org/Cancer/OvarianCancer/DetailedGuide/ovariancancer-eystatistics), diakses 6 Juni, (2015).
2.
Aziz MF. Current management and trend of ovarian cancer. In
Saifudddin AB, Affandi B and Winknjosastro GH. Womens Health. The
proceeding of the Xvth. Asian and Ocenia Congress of Obstetrics and
Gynecology. Jakarta : Yayasan Bina Pustaka. S. Prawihardjo, 1995.p.
321-334.
3.
Nuranna L. Tumor ganas ovarium tipe epitel. Jakaarta : Sub Bagian
Onkologi Kebidanan dan Kandungan FKUI/RSCM; 1992.
4.
Tumor
markers
for
Ovarian
Cancer.
1994.
(http://www.oncolink.org/includes/print_article.cfm?Page=2&id=7143&
section=cancer_types), diakses 6 Juni (2015).
5.
Kanda S, Oka Y. Structure, Synthesis, and Phylogenyof Kisspeptin
and its Receptor, Kauffman AS, Smith JT,In: Kisspeptin Signaling in
Reproductive Biology,Advances in Experimental Medicine and
Biology. Springer Science Business Media, LLC; 2013; p 9-26.
6.
Sonigo C, Binart N. Overview of the impact of Kisspeptin on
reproductive function. Annales d’Endocrinologie 2012;73:448–458
7.
Dova, Golfinopoulos V, Pentheroudakis G, et al. Systemic
Dissemination in Cancer of Unknown Primaryis Independent of
Mutational Inactivation of the KiSS1Metastasis-suppressor Gene.
Pathol Oncol Res 2008;14:239–241.
8.
Cunningham FG, Gant NF, Leveno KJ, Gilstrap LC, Hauth JC,
Wenstrom KD. Obstetri Williams Edisi ke-21 Vol. 2. Jakarta : ECG;
2004. p. 934, 1035-7. 2.
9.
Kotani M Detheux M, Vandebogaerde A, Communi D, Vanderwinden
JM, Le Poul E, Brezilien S, Tyldesley R, Suarez-Huerta N, Vandeput
F, et al. (2001) The metastasi suppressor gene KiSS1 encodes
Kisspeptins, the natural ligands of the orphan G protein-coupled
receptor GPR54. J Biol Chem 276: 34631-34636
10. Jemal A, Murray T, Samuels A et al. Cancer statistics, 2003. CA
Cancer J Clin 2003; 53: 5–26.
56
11. Saifuddin, Abdul Bari, dkk. 2010. Ilmu Kebidanan Sarwono
Prawirohardjo. Jakarta : PT Bina Pustaka Sarwono Prawirohardjo.
12. Prabhu VV, Sakhtivel KM, Guruvayoorappan C. Kisspeptin (KiSS1):
essential player in supressing tumor metastasis. Asian Pac J Cancer
Prev, 14 (11), 6215-6220
13. Smith JT, Clifton DK, Steiner RA (2006). Regulation of the
neuroendocrine reproductive axis by Kisspeptin-GPR54 signaling.
Reproduction, 131, 623-30.
14. Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ,
Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, et al.
(2001) AXOR12, a novel human G protein-coupled receptor, activated
by the peptide KiSS1. J Biol Chem 276: 28969-28975.
15. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K,
Terao Y, Kumano S, Takatsu Y, Masuda Y, et al. (2001) Metastasis
suppressor gene KiSS1 encodes peptide ligand of a G-proteincoupled receptor. Nature 411: 613-617
16. Welch DR, Chen P, Miele ME, McGary CT, Bower JM, Stanbridge EJ,
and Weissman BE (1994) Microcell-mediated transfer of chromosome
6 into metastatic human C8161 melanoma cells suppresses
metastasis but does not inhibit tumorigenicity. Oncogene 9: 255-262.
17. Mechaly AS, Vinas J, Murphy C, Reith M & Piferrer. Gene structure of
the KiSS1 receptor-2 in the atlantic halibut: insights into the evolution
and regulation of KiSS1r genes. Mol Cel Endocrin 2010; 317: 78-89.
18. Hata K, Dhar DK, Watanabe Y, et al (2007). Expression of metastin
and a G-protein-coupled receptor (AXOR12) in epithelial ovarian
cancer. Eur J Cancer, 43, 1452-9.
19. Stafford LJ, Xia C, Ma W, Cai Y, Liu M (2002). Identification and
characterization of mouse metastasis-suppressor KiSS1 and its Gprotein coupled receptor. Cancer Res, 62, 5399-404.
20. Weipei Z, Aihua G, Xin C, Feng L, Jiang N & Hong Z. Expression of
KiSS1 in epithelial ovarian cancer and its role in metastasis. Applied
Mech & Mat 2012; 140: 142-151.
21. Gupta GP and Massagué J (2006) Cancer metastasis: building a
framework. Cell 127: 679-695.
22. Sastrawinata, Sulaiman. dkk. 2004. Ilmu Kesehatan Reproduksi:
Obstetri Patologi.Edisi 2. Jakarta: EGC hal :104.
57
23. DeChemey AH, Pernoll ML. Current Obstetric and Gynecologic
Diagnosis and Treatment 8th edition. Norwalk : Appleton & Lange;
1994. p. 744-51.
24. Helm, CW. Ovarian Cyst. 19 maret 2008. (Available at :
http://.emedicine.com/med/topic1699.htm, accessed on 15 Juni 2013)
25. Moeloek FA, Nuranna L, Wibowo N, Purbadi S. Standar Pelayanan
Medik Obstetri dan Ginekologi. Jakarta : Perkumpulan Obstetri dan
Ginekologi Indonesia; 2006. p.130-1 6. Ovarian Cyst. 6 April 2008.
(Available at http://en.wikipedia.org/wiki/Ovarian_cyst, accessed on 15
Juni 2013)
26. Steeg PS. Metastasis suppressors alter the signal transduction of
cancer cells. Nat Rev Cancer 2003; 3: 55–63.
27. Welch DR, Hunter KW. A new member of the growing family of
metastasis suppressors identified in prostate cancer. J Natl Cancer
Inst 2003; 95: 839–41.
28. Bari R, Zhang YH, Zhang F, et al (2009). Transmembrane interactions
are needed for KAI1/CD82-mediated suppression of cancer invasion
and metastasis. Am J Pathol, 174, 647-60.
29. Prabhu VV, Siddikuzzaman, Grace VM, Guruvayoorappan C (2012).
Targeting tumor metastasis by regulating Nm23 gene expression.
Asian Pac J Cancer Prev, 13, 3539-48.
30. Welch, D. R. (1996) J. Natl. Cancer Inst. 88,1731–1737
31. Lee, J. H., Miele, M. E., Hicks, D. J., Phillips, K. K., Trent, J. M.,
Weissman, B. E., and Welch, D. R. (1996). KiSS1, a novel human
malignant melanoma metastasis-suppressor gene. J Natl Cancer Inst
88, 1731-1737.
32. Lee, J. H., and Welch, D. R. (1997). Suppression of metastasis in
human breast carcinoma MDA-MB-435 cells after transfection with
the metastasis suppressor gene, KiSS1. Cancer Res 57, 2384-2387.
33. Xavier d‟Anglemont de Tassigny and William Henry Colledge (2010).
“The Role of Kisspeptin Signaling in Reproduction”. PHYSIOLOGY;
25: 207–217.
34. Bilban M, Ghaffari-Tabrizi N, Hintermann E, et al (2004). Kisspeptin10, a KiSS1/metasin-derived decapeptide, is a physiological invasion
inhibitor of primary human trophoblast. J Cell Sci, 117, 1319-28.
58
35. Tena-Sempere M, Felip A, Gómez A, Zanuy S, Carrillo M (2012).
Comparative insights of the Kisspeptin/Kisspeptin receptor system:
lessons from non-mammalian vertebrates. Gen Comp Endocrinol, 175,
234-43.
36. Cho, S. G., Yi, Z., Pang, X., Yi, T., Wang, Y., Luo, J., Wu, Z., Li, D.,
and Liu, M. (2009b). Kisspeptin-10, a KISS1-derived decapeptide,
inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF
expression and FAK/Rho GTPase activation. Cancer Res 69, 70627070.
37. Navenot JM, Fujii N & Peiper SC. KiSS1 metastasis supressor gene
product induces suppression of tyrosine kinase receptor signaling to
Akt, tumor necrosis factor family ligand expression, and apoptosis.
38. Becker JA, Mirjolet JF, Bernard J, Burgeon E, Simons MJ, Vassart G,
Parmentier M, and Libert F (2005) Activation of GPR54 promotes cell
cycle arrest and apoptosis of human tumor cells through a specific
transcriptional program not shared by other Gq-coupled
receptors.Biochem Biophys Res Commun 326: 677-686.
39. Hori A, Honda S, Asada M, Ohtaki T, Oda K, Watanabe T, Shintani Y,
Yamada T, Suenaga M, Kitada C, et al. (2001) Metastin suppresses
the motility and growth of CHO cells transfected with its
receptor. Biochem Biophys Res Commun 286: 958-963
40. Gao GL, Liu LD, Zou XS, et al. Expression of KiSS1, matrix
metalloproteinase-9, nuclear factor-kappaBp65 in ovarian tumour.
Zhonghua Fu Chan Ke Za Zhi. (2007)42(1):34-38
41. Takino T, Koshikawa N, Miyamori H, et al. Cleavage of metastasis
suppressor gene product KiSS1 protein/metastin by matrix
metalloproteinases. Oncogene (2003), 22(30):4617-4626
42. Makri A, Pissimissis N, Lembessis P,et al. The Kisspeptin
(KiSS1)/GPR54 system in cancer biology.Cancer Treat Rev.
(2008);34(8):682-692.
43. Nagai K, Doi R, Katagiri F, et al. Prognostic value of metastin
expression in human pancreatic cancer.J Exp Clin Cancer Res. (2009)
;21;28-29
44. Schmid K, Wang X, Haitel A,et al.KiSS1 overexpression as an
independent prognostic marker in hepatocellular carcinoma: an
immunohistochemical study. Virchows Arch.( 2007); 450 (2) : 143-149.
45. Oakley AE, Clifton DK, Steiner RA (2009). Kisspeptin signaling in the
brain. Endocr Rev, 30, 713-43.
59
46. Martin TA, Watkins G, Jiang WG (2005). KiSS1 expression in human
breast cancer. Clin Exp Metastas, 22, 503-11.
47. Liang S, Yang ZL (2007). Expression of KiSS1 mRNA in pancreatic
ductal adenocarcinoma and non-cancerous pancreatic tissues in SD
rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 32, 109-13.
48. Dhar DK, Naora H, Kubota H, et al (2004). Downregulation of KiSS1
expression is responsible for tumor invasion and worse prognosis in
gastriccarcinoma. Int J Cancer, 10, 868-72.
49. Babwah AV, Pampillo M, Min L, et al (2012). Single-cell analyses
reveal that KiSS1-R-expressing cells undergo sustained Kisspeptininduced signaling that is dependent upon an influx of extracellular Ca
+. Endocrinol, 153, 5875-87.
50. Sanchez-Carbayo M, Capodieci P, Cordon-Cardo C (2003). Tumor
suppressor role of KiSS1 in bladder cancer: loss of KiSS1 expression
is associated with bladder cancer progression and clinical outcome.
Am J Pathol, 162, 609
51. Goldberg SF, Miele ME, Hatta N, et al (2003). Melanoma metastasis
suppression by chromosome 6: evidence for a pathway regulated by
CRSP3 and TXNIP. Cancer Res, 63:432-40.
52. Nash KT, Welch DR (2006). The KiSS1 metastasis suppressor:
mechanistic insights and clinical utility. Front Biosci, 1;647-59.
53. Mitchell DC, Abdelrahim M, Weng J, Stafford LJ, Safe S, Bar-Eli M, Liu
M (2006). “Regulation of KiSS1 metastasis
suppressor gene
expression in breast cancer cells by direct interaction of transcription
factors activator protein-2alpha and specificity protein-1”. Journal
Biology Chemistry; 281: 51–58.
54. Ying J, Berk M, Singh LS, Tan H, Yin L, Powell CT, et al. KiSS1
supresses metastasis in human ovarian cancer via inhibition of protein
kinase C alpha. Clin Exp Metastasis 2005; 22: 369-376.
55. Harms JF, Welch DR, Miele ME. KISS1 metastasis suppression and
emergent pathways. Clin Exp Metast 2003; 20: 11–8.
56. Jiang Y, Berk M, Singh LS, et al. KiSS1 suppresses metastasis in
human ovarian cancer via inhibition of protein kinase C alpha. Clin Exp
Metast 2005;22:369–76.
57. Zhang SL, Yu Y, Jiang T, Lin B, Gao H: Expression and significance of
KiSS1 and its receptor GPR54 mRNA in epithelial ovarian cancer.
Zhonghua Fu Chan Ke Za Zhi 2005, 40:689-692.
60
58. Prentice LM, Klausen C, Kalloger S, Kobel M, McKineey S, Santos JL,
et al. Kisspeptin and GPR54 immunoreactivity in a cohort of 518
patients defines favourable prognosis and clear cell subtype in ovarian
carcinoma. BMC Medicine 2007; 5: 33.
59. Krajewski SJ, Burke MC, Anderson MJ, McMullen NT, Rance NE
(2010). “Forebrain projections of arcuate neurokinin B neurons
demonstrated by anterograde tracttracingand monosodium glutamate
lesions in the rat”. Neuroscience; 166(2):680–697.
60. Makri A, Pissimissis N, Lembessis P, Poluchronakos C, Koutsillieris M.
The Kisspeptin (KiSS1)/GPR54 system in cancer biology. Cancer
Treatment Reviews (2008) 34, 682-692.
61. Simerly RB (2002) Wired for reproduction: organization and
development of sexually dimorphic circuits in the mammalian
forebrain. Annu Rev Neurosci 25:507–536.
62. Matsui H, Takatsu Y, Kumano S, Matsumoto H, Ohtaki
T (2004) Peripheral administration of metastin induces marked
gonadotropin release and ovulation in the rat. Biochem Biophys Res
Commun 320:383–388
63. Panidis D, Rousso D, Koliakos G, et al. Plasma metastin levels are
negatively correlated with insulin resistance and free androgens in
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