Pembuatan dan Evaluasi Sediaan Gastroretentif Metronidazol dari Film Alginat-Kitosan yang Ditambahkan HPMC
LAMPIRAN
Lampiran 1. Data spesifikasi sediaan gastroretentif metronidazol dari film alginatkitosan yang ditambahkan HPMC
No
Formula
Gambar Film
Komposisi
Berat (g)
Berat
Ratarata
± SD
F1
5
gram
larutan
Alginat 4% + 250 mg
metronidazol + 8
tetes gliserin
0,990
0,995
0,985
0,940
±0,005
F3
1,25 gram larutan
Alginat 4% + 3,75
gram larutan kitosan
+
250
mg
metronidazol + 8
tetes gliserin
0,952
0,955
0,952
0,930
±0,007
F4
1,67 gram larutan
Alginat 4% + 3,37
gram larutan kitosan
+
250
mg
metronidazol + 8
tetes gliserin
0,943
0,945
0,941
0,941
±0,002
F5
2
gram
larutan
Alginat 4% + 3 gram
larutan kitosan + 250
mg metronidazol + 8
tetes gliserin
0,946
0,947
0,947
0,947
±0,001
5
F6
2,5 gram larutan
Alginat 4% + 2,5
gram larutan kitosan
+
250
mg
metronidazol + 8
tetes gliserin
0,950
0,955
0,950
0,952
±0,003
6
F7
3
gram
larutan
Alginat 4% + 2 gram
0,956
0,958
0,957
±0,001
1
2
3
4
Universitas Sumatera Utara
larutan kitosan + 250
mg metronidazol + 8
tetes gliserin
7
8
9
10
11
0,958
F8
3,34 gram larutan
Alginat 4% + 1,67
gram larutan kitosan
+
250
mg
metronidazol + 8
tetes gliserin
0,926
0,925
0,921
0,924
±0,003
F9
3,75 gram larutan
Alginat 4% + 1,25
gram larutan kitosan
+
250
mg
metronidazol + 8
tetes gliserin
0,910
0,915
0,913
0,913
±0,003
F10
3,34 gram larutan
Alginat 4% + 1,16
gram larutan kitosan
+ 50 mg HPMC +
250 mg metronidazol
+ 8 tetes gliserin
0,935
0,945
0,935
0,938
±0,006
F11
3,34 gram larutan
Alginat 4% + 1,16
gram larutan kitosan
+ 100 mg HPMC +
250 mg metronidazol
+ 8 tetes gliserin
0,980
0,985
0,980
0,982
±0,003
F12
3,34 gram larutan
Alginat 4% + 1,16
gram larutan kitosan
+ 150 mg HPMC +
250 mg metronidazol
+ 8 tetes gliserin
1,035
1,040
1,045
1,040
±0,005
Universitas Sumatera Utara
12
F13
3,34 gram larutan
Alginat 4% + 1,16
gram larutan kitosan
+ 200 mg HPMC +
250 mg metronidazol
+ 8 tetes gliserin
1,085
1,090
1,090
1,008
±0,003
Ket.
P = Panjang film; L = Lebar film
Universitas Sumatera Utara
Lampiran 2. Data sifat pembentangan (unfolding behaviour)
Pembentangan
Ratio
Keterangan
Waktu
RataFormula
(Alginat :
rata
Kitosan)
F1
A
B
C
F3
A
B
C
F4
A
B
C
F5
F6
0
0.3
0,5
> 3jam
> 3 jam
> 3 jam
> 3 jam
Tidak dapat
membentang
kembali
0,967 menit
0,933 menit
0,983 menit
0,961
±0,025
menit
Membentang
kembali
1,983 menit
1,867 menit
1,145 menit
1,767
±0,20
menit
Membentang
kembali
2,572
±0,106
menit
Membentang
kembali
A
B
C
0,667
2,450 menit
2,633 menit
2,633 menit
A
B
C
1
3,317 menit
3,067 menit
3,483 menit
3,289
±0,210
menit
Membentang
kembali
3,383 menit
3,444
Membentang
A
Gambar Film setelah 3 jam
Universitas Sumatera Utara
B
C
F7
3,400 menit
3,550 menit
±0,092
menit
kembali
3,450
±0,076
menit
Membentang
kembali
1,5
A
B
C
2
3,433 menit
3,533 menit
3,383 menit
A
B
C
2 + 50 mg
HPMC
5,217 menit
5,400 menit
5,517 menit
5,378
±0,151
menit
Membentang
kembali
F11
A
B
C
2 + 100 mg
HPMC
5,767 menit
5,850 menit
6,433 menit
6,017
±0,363
menit
Membentang
kembali
F12
A
B
C
2 + 150 mg
HPMC
6,617 menit
6,250 menit
6,600 menit
6,489
±0,217
menit
Membentang
kembali
F8
F10
Universitas Sumatera Utara
Lampiran 3. Data pengujian sifat integritas film
No
Formula
Waktu hancur
F3
F4
F5
F6
F7
F8
F10
F11
F12
F3a
F3b
F3c
F3
F4a
F4b
F4c
F4
F5a
F5b
F5c
F5
F6a
F6b
F6c
F6
F7a
F7b
F7c
F7
F8a
F8b
F8c
F8
F10a
F10b
F10c
F10
F11a
F11b
F11c
F11
F12a
F12b
F12c
F12
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
Lampiran 4. Data pengujian sifat pengembangan film
1. Pengujian sifat pengembangan film F3
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,850
7,220
7,580
7,630
7,680
7,650
7,630
7,4
7,231
lebar ( cm)
1,770
2,440
2,490
2,650
2,740
2,730
2,630
2,61
2,54
luas (cm2)
8,585
17,617
18,874
20,220
21,043
20,885
20,067
19,314
18,367
% swelling
0,000
105,216
119,864
135,535
145,130
143,281
133,744
124,974
113,940
berat (g)
0,952
2,957
3,260
3,575
3,475
3,475
3,395
3,2
3,155
% swelling
0,000
210,609
242,437
275,525
265,021
265,021
256,618
236,134
231,408
panjang(cm)
4,880
7,197
7,557
7,607
7,657
7,627
7,607
7,377
7,208
lebar ( cm)
1,760
2,428
2,478
2,638
2,728
2,718
2,618
2,598
2,528
luas (cm2)
8,589
17,474
18,726
20,067
20,888
20,730
19,915
19,165
18,222
% swelling
0,000
103,455
118,026
133,639
143,198
141,357
131,868
123,139
112,153
berat (g)
0,955
2,960
3,330
3,450
3,500
3,510
3,400
3,195
3
% swelling
0,000
209,948
248,691
261,257
266,492
267,539
256,021
234,555
214,136
panjang(cm)
4,850
7,174
7,534
7,584
7,634
7,604
7,584
7,354
7,185
lebar ( cm)
1,780
2,415
2,465
2,625
2,715
2,705
2,605
2,585
2,515
luas (cm2)
8,633
17,322
18,568
19,905
20,723
20,566
19,753
19,007
18,067
% swelling
0,000
100,653
115,085
130,568
140,047
138,223
128,811
120,169
109,283
berat (g)
0,952
2,955
3,225
3,445
3,480
3,475
3,400
3,285
3,095
% swelling
0,000
210,399
238,761
261,870
265,546
265,021
257,143
245,063
225,105
%swelling (berat)
0,000
210,319
243,296
266,217
265,686
265,860
256,594
238,584
223,550
SD
0,000
0,338
5,021
8,067
0,746
1,454
0,561
5,666
8,740
%swelling (luas)
0,000
103,108
117,658
133,247
142,792
140,954
131,474
122,761
111,792
SD
0,000
2,302
2,410
2,506
2,566
2,553
2,490
2,425
2,349
F3
Lampiran 4. (Lanjutan)
2. Pengujian sifat pengembangan film F4
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,470
6,100
6,270
6,430
6,480
6,500
6,450
6,290
6,200
lebar ( cm)
1,750
2,380
2,510
2,630
2,680
2,680
2,570
2,530
2,455
luas (cm2)
7,823
14,518
15,738
16,911
17,366
17,420
16,577
15,914
15,221
% swelling
0,000
85,593
101,185
116,183
122,006
122,691
111,908
103,435
94,580
berat (g)
0,943
2,723
3,026
3,285
3,241
3,241
3,161
2,966
2,821
% swelling
0,000
188,759
220,891
248,356
243,690
243,690
235,207
214,528
199,152
panjang(cm)
4,480
6,120
6,290
6,450
6,480
6,490
6,400
6,280
6,200
lebar ( cm)
1,760
2,625
2,755
2,875
2,925
2,925
2,815
2,775
2,700
luas (cm2)
7,885
16,065
17,329
18,544
18,954
18,983
18,016
17,427
16,740
% swelling
0,000
103,741
119,771
135,178
140,380
140,751
128,484
121,015
112,302
berat (g)
0,945
2,801
3,104
3,363
3,319
3,319
3,239
3,044
2,899
% swelling
0,000
196,402
228,466
255,873
251,217
251,217
242,751
222,116
206,772
panjang(cm)
4,470
6,110
6,270
6,440
6,480
6,480
6,400
6,300
6,150
lebar ( cm)
1,750
2,385
2,510
2,630
2,690
2,690
2,650
2,500
2,450
luas (cm2)
7,823
14,572
15,738
16,937
17,431
17,431
16,960
15,750
15,068
% swelling
0,000
86,276
101,172
116,505
122,820
122,820
116,797
101,329
92,605
berat (g)
0,941
2,821
3,124
3,383
3,339
3,339
3,259
3,064
2,919
% swelling
0,000
199,785
231,985
259,509
254,833
254,833
246,332
225,609
210,200
%swelling (berat)
0,000
194,982
227,114
254,579
249,913
249,913
241,430
220,751
205,375
SD
0,000
5,648
5,669
5,688
5,685
5,685
5,679
5,665
5,655
%swelling (luas)
0,000
91,870
107,376
122,622
128,402
128,754
119,063
108,593
99,829
SD
0,000
10,287
10,734
10,875
10,382
10,390
8,517
10,809
10,847
F4
Lampiran 4. (Lanjutan)
3. Pengujian sifat pengembangan film F5
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,284
5,914
6,084
6,244
6,294
6,314
6,264
6,104
6,014
lebar ( cm)
1,644
2,279
2,329
2,500
2,579
2,569
2,469
2,449
2,379
luas (cm2)
7,043
13,476
14,167
15,610
16,230
16,218
15,463
14,946
14,305
% swelling
0,000
83,542
92,961
112,612
121,053
120,895
110,614
103,572
94,837
berat (g)
0,925
2,570
2,873
3,132
3,088
3,088
3,008
2,813
2,668
% swelling
0,000
171,670
203,700
231,078
226,427
226,427
217,970
197,357
182,030
panjang(cm)
4,208
5,838
6,008
6,168
6,218
6,238
6,188
6,028
5,938
lebar ( cm)
1,623
2,258
2,308
2,479
2,558
2,548
2,448
2,428
2,358
luas (cm2)
6,830
13,180
13,864
15,290
15,903
15,892
15,146
14,634
13,999
% swelling
0,000
79,513
88,832
108,260
116,605
116,452
106,289
99,313
90,676
berat (g)
0,921
2,566
2,869
3,128
3,084
3,084
3,004
2,809
2,664
% swelling
0,000
171,247
203,277
230,655
226,004
226,004
217,548
196,934
181,607
panjang(cm)
4,267
5,897
6,067
6,227
6,277
6,297
6,247
6,087
5,997
lebar ( cm)
1,619
2,254
2,304
2,475
2,554
2,544
2,444
2,424
2,354
luas (cm2)
6,908
13,289
13,976
15,412
16,029
16,017
15,265
14,752
14,115
% swelling
0,000
81,006
90,356
109,913
118,319
118,156
107,916
100,932
92,244
berat (g)
0,918
2,563
2,866
3,125
3,081
3,081
3,001
2,806
2,661
% swelling
0,000
170,962
202,992
230,370
225,719
225,719
217,262
196,649
181,321
%swelling (berat)
0,000
171,293
203,323
230,701
226,050
226,050
217,593
196,980
181,653
SD
0,000
0,356
0,356
0,356
0,356
0,356
0,356
0,356
0,356
%swelling (luas)
0,000
81,354
90,716
110,262
118,659
118,501
108,273
101,272
92,585
SD
0,000
2,037
2,088
2,197
2,243
2,242
2,185
2,150
2,101
F5
Lampiran 4. (Lanjutan)
4. Pengujian sifat pengembangan film F6
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,560
5,800
5,970
6,130
6,180
6,200
5,987
5,990
5,900
lebar ( cm)
1,610
2,182
2,232
2,403
2,482
2,472
2,400
2,352
2,282
luas (cm2)
7,342
12,653
13,323
14,730
15,336
15,324
14,369
14,086
13,461
% swelling
0,000
72,341
81,458
100,632
108,884
108,716
95,707
91,856
83,348
berat (g)
0,952
2,408
2,711
2,970
2,926
2,926
2,846
2,651
2,506
% swelling
0,000
152,941
184,769
211,975
207,353
207,353
198,950
178,466
163,235
panjang(cm)
4,550
5,767
5,937
6,097
6,147
6,167
6,070
5,957
5,867
lebar ( cm)
1,580
2,140
2,190
2,361
2,440
2,430
2,358
2,310
2,240
luas (cm2)
7,189
12,338
12,999
14,394
14,996
14,983
14,312
13,758
13,139
% swelling
0,000
71,630
80,819
100,228
108,591
108,412
99,088
91,371
82,767
berat (g)
0,955
2,487
2,790
3,049
3,005
3,005
2,925
2,730
2,585
% swelling
0,000
160,387
192,115
219,236
214,628
214,628
206,251
185,832
170,649
panjang(cm)
4,550
5,711
5,881
6,041
6,091
6,111
6,014
5,901
5,811
lebar ( cm)
1,560
2,172
2,222
2,393
2,472
2,462
2,390
2,342
2,272
luas (cm2)
7,098
12,403
13,067
14,458
15,056
15,044
14,375
13,819
13,202
% swelling
0,000
74,745
84,089
103,685
112,116
111,951
102,521
94,691
85,991
berat (g)
0,950
2,482
2,785
3,044
3,000
3,000
2,920
2,725
2,580
% swelling
0,000
159,937
191,665
218,785
214,178
214,178
205,801
185,382
170,199
%swelling (berat)
0,000
157,755
189,516
216,665
212,053
212,053
203,667
183,227
168,028
SD
0,000
4,175
4,118
4,068
4,077
4,077
4,092
4,129
4,157
%swelling (luas)
0,000
72,905
82,122
101,515
109,864
109,693
99,105
92,640
84,036
SD
0,000
1,632
1,733
1,890
1,956
1,962
3,407
1,793
1,718
F6
Lampiran 4. (Lanjutan)
5. Pengujian sifat pengembangan film F7
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,560
5,440
6,140
6,150
6,160
6,090
6,020
5,9
5,8
lebar ( cm)
1,610
2,260
2,280
2,400
2,440
2,380
2,310
2,23
2,16
luas (cm2)
7,342
12,294
13,999
14,760
15,030
14,494
13,906
13,157
12,528
% swelling
0,000
67,453
90,673
101,035
104,718
97,415
89,406
79,202
70,635
berat (g)
0,946
2,425
2,680
2,690
2,695
2,685
2,665
2,6
2,47
% swelling
0,000
156,342
183,298
184,355
184,884
183,827
181,712
174,841
161,099
panjang(cm)
4,550
5,410
6,110
6,120
6,130
6,060
6,040
5,870
5,770
lebar ( cm)
1,580
2,260
2,280
2,400
2,440
2,380
2,210
2,19
2,16
luas (cm2)
7,189
12,227
13,931
14,688
14,957
14,423
13,348
12,855
12,463
% swelling
0,000
66,530
89,741
100,054
103,721
96,442
81,809
75,093
69,752
berat (g)
0,947
2,425
2,680
2,690
2,695
2,685
2,665
2,5587
2,48
% swelling
0,000
156,342
183,298
184,355
184,884
183,827
181,712
170,476
162,156
panjang(cm)
4,550
5,440
6,140
5,800
6,160
6,090
6,050
5,9
5,8
lebar ( cm)
1,600
2,226
2,246
2,366
2,406
2,346
2,176
2,156
2,126
luas (cm2)
7,280
12,109
13,790
13,723
14,821
14,287
13,165
12,720
12,331
% swelling
0,000
64,934
87,829
86,908
101,865
94,595
79,308
73,255
67,949
berat (g)
0,947
2,407
2,662
2,672
2,677
2,667
2,647
2,582
2,452
% swelling
0,000
154,440
181,395
182,452
182,981
181,924
179,810
172,939
159,197
%swelling (berat)
0,000
155,708
182,664
183,721
184,249
183,192
181,078
172,752
160,817
SD
0,000
1,099
1,099
1,099
1,099
1,099
1,099
2,189
1,500
%swelling (luas)
0,000
66,305
89,415
95,999
103,435
96,151
83,508
75,850
69,445
SD
0,000
1,274
1,450
7,888
1,448
1,433
5,259
3,045
1,369
F7
Lampiran 4. (Lanjutan)
6. Pengujian sifat pengembangan film F8
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,510
5,244
5,944
5,954
5,964
5,894
5,824
5,704
5,604
lebar ( cm)
1,545
2,162
2,182
2,302
2,342
2,282
2,212
2,132
2,062
luas (cm2)
6,968
11,339
12,971
13,707
13,969
13,451
12,884
12,162
11,557
% swelling
0,000
62,724
86,151
96,718
100,472
93,044
84,900
74,542
65,852
berat (g)
0,925
2,219
2,474
2,484
2,489
2,479
2,459
2,394
2,264
% swelling
0,000
139,892
167,459
168,541
169,081
168,000
165,838
158,811
144,757
panjang(cm)
4,510
5,166
5,866
5,876
5,886
5,816
5,746
5,626
5,526
lebar ( cm)
1,550
2,106
2,126
2,246
2,286
2,226
2,156
2,076
2,006
luas (cm2)
6,991
10,881
12,472
13,199
13,457
12,948
12,390
11,681
11,086
% swelling
0,000
55,638
78,405
88,795
92,484
85,204
77,221
67,082
58,579
berat (g)
0,926
2,207
2,462
2,472
2,477
2,467
2,447
2,382
2,252
% swelling
0,000
138,337
165,875
166,955
167,495
166,415
164,255
157,235
143,197
panjang(cm)
4,500
5,212
5,912
5,922
5,932
5,862
5,792
5,672
5,572
lebar ( cm)
1,570
2,111
2,131
2,251
2,291
2,231
2,161
2,081
2,011
luas (cm2)
7,065
11,000
12,596
13,328
13,588
13,075
12,514
11,801
11,203
% swelling
0,000
55,840
78,427
88,786
92,463
85,215
77,267
67,175
58,709
berat (g)
0,921
2,214
2,469
2,479
2,484
2,474
2,454
2,389
2,259
% swelling
0,000
142,708
170,669
171,765
172,314
171,217
169,024
161,897
147,643
%swelling (berat)
0,000
140,312
168,001
169,087
169,630
168,544
166,372
159,314
145,199
SD
0,000
2,216
2,443
2,451
2,456
2,447
2,429
2,371
2,256
%swelling (luas)
0,000
58,067
80,994
91,433
95,140
87,821
79,796
69,600
61,047
SD
0,000
4,034
4,466
4,577
4,618
4,523
4,420
4,280
4,162
F8
Lampiran 4. (Lanjutan)
7. Pengujian sifat pengembangan film F10
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,490
5,177
5,877
5,887
5,897
5,827
5,757
5,637
5,537
lebar ( cm)
1,560
2,088
2,108
2,228
2,268
2,208
2,138
2,058
1,988
luas (cm2)
7,004
10,811
12,390
13,117
13,376
12,867
12,310
11,602
11,009
% swelling
0,000
54,349
76,897
87,285
90,971
83,712
75,751
65,649
57,177
berat (g)
0,910
2,033
2,288
2,298
2,303
2,293
2,273
2,208
2,078
% swelling
0,000
123,407
151,429
152,527
153,077
151,978
149,780
142,637
128,352
panjang(cm)
4,480
5,101
5,801
5,811
5,821
5,751
5,681
5,561
5,461
lebar ( cm)
1,550
2,043
2,063
2,183
2,223
2,163
2,093
2,013
1,943
luas (cm2)
6,944
10,422
11,969
12,687
12,941
12,441
11,891
11,195
10,612
% swelling
0,000
50,092
72,359
82,698
86,366
79,156
71,248
61,224
52,820
berat (g)
0,915
2,008
2,263
2,273
2,278
2,268
2,248
2,183
2,053
% swelling
0,000
119,410
147,279
148,372
148,918
147,825
145,639
138,536
124,328
panjang(cm)
4,460
5,177
5,877
5,887
5,897
5,827
5,757
5,637
5,537
lebar ( cm)
1,550
2,050
2,070
2,190
2,230
2,170
2,100
2,020
1,950
luas (cm2)
6,913
10,612
12,165
12,892
13,150
12,644
12,089
11,386
10,797
% swelling
0,000
53,513
75,970
86,488
90,217
82,902
74,875
64,707
56,178
berat (g)
0,913
2,031
2,286
2,296
2,301
2,291
2,271
2,206
2,076
% swelling
0,000
122,453
150,383
151,479
152,026
150,931
148,740
141,621
127,382
%swelling (berat)
0,000
121,757
149,697
150,793
151,340
150,245
148,053
140,931
126,687
SD
0,000
2,088
2,158
2,161
2,163
2,160
2,154
2,136
2,100
%swelling (luas)
0,000
52,651
75,076
85,490
89,185
81,923
73,958
63,860
55,392
SD
0,000
2,256
2,398
2,451
2,470
2,431
2,388
2,331
2,282
F10
Lampiran 4. (Lanjutan)
8. Pengujian sifat pengembangan film F11
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,570
5,134
5,834
5,844
5,854
5,784
5,714
5,594
5,494
lebar ( cm)
1,510
2,034
2,054
2,174
2,214
2,154
2,084
2,004
1,934
luas (cm2)
6,901
10,444
11,984
12,706
12,962
12,460
11,909
11,211
10,626
% swelling
0,000
51,334
73,659
84,119
87,827
80,552
72,571
62,462
53,985
berat (g)
0,980
1,999
2,254
2,264
2,269
2,259
2,239
2,174
2,044
% swelling
0,000
103,980
130,000
131,020
131,531
130,510
128,469
121,837
108,571
panjang(cm)
4,460
5,111
5,811
5,821
5,831
5,761
5,691
5,571
5,471
lebar ( cm)
1,540
2,000
2,020
2,140
2,180
2,120
2,050
1,970
1,900
luas (cm2)
6,868
10,221
11,737
12,456
12,711
12,212
11,666
10,974
10,394
% swelling
0,000
47,353
69,429
79,893
83,601
76,346
68,386
58,315
49,871
berat (g)
0,985
1,986
2,241
2,251
2,256
2,246
2,226
2,161
2,031
% swelling
0,000
101,584
127,472
128,487
128,995
127,980
125,949
119,350
106,152
panjang(cm)
4,540
5,077
5,777
5,787
5,797
5,727
5,657
5,537
5,437
lebar ( cm)
1,530
1,946
1,966
2,086
2,126
2,066
1,996
1,916
1,846
luas (cm2)
6,9462
9,879
11,357
12,071
12,324
11,831
11,291
10,608
10,036
% swelling
0,000
42,227
63,501
73,781
77,420
70,330
62,548
52,723
44,486
berat (g)
0,980
1,930
2,185
2,195
2,200
2,190
2,170
2,105
1,975
% swelling
0,000
96,898
122,918
123,939
124,449
123,429
121,388
114,755
101,490
%swelling (berat)
0,000
100,820
126,797
127,815
128,325
127,306
125,269
118,647
105,405
SD
0,000
3,602
3,589
3,588
3,588
3,589
3,590
3,593
3,600
%swelling (luas)
0,000
46,971
68,863
79,264
82,949
75,743
67,835
57,833
49,447
SD
0,000
4,566
5,102
5,197
5,234
5,137
5,034
4,887
4,764
F11
Lampiran 4. (Lanjutan)
9. Pengujian sifat pengembangan film F12
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,510
5,078
5,778
5,788
5,798
5,728
5,658
5,538
5,438
lebar ( cm)
1,500
1,889
1,909
2,029
2,069
2,009
1,939
1,859
1,789
luas (cm2)
6,765
9,593
11,031
11,745
11,997
11,509
10,972
10,296
9,730
% swelling
0,000
41,809
63,065
73,614
77,343
70,121
62,188
52,199
43,824
berat (g)
1,035
2,102
2,277
2,287
2,292
2,282
2,262
2,197
2,067
% swelling
0,000
103,092
120,000
120,966
121,449
120,483
118,551
112,271
99,710
panjang(cm)
4,580
5,073
5,773
5,783
5,793
5,723
5,653
5,533
5,433
lebar ( cm)
1,490
1,885
1,905
2,025
2,065
2,005
1,935
1,855
1,785
luas (cm2)
6,824
9,560
10,995
11,708
11,960
11,472
10,936
10,261
9,696
% swelling
0,000
40,099
61,124
71,571
75,263
68,114
60,259
50,371
42,080
berat (g)
1,040
2,068
2,243
2,253
2,258
2,248
2,228
2,163
2,033
% swelling
0,000
98,798
115,625
116,587
117,067
116,106
114,183
107,933
95,433
panjang(cm)
4,540
5,063
5,763
5,773
5,783
5,713
5,643
5,523
5,423
lebar ( cm)
1,490
1,881
1,901
2,021
2,061
2,001
1,931
1,851
1,781
luas (cm2)
6,765
9,524
10,956
11,668
11,920
11,433
10,898
10,224
9,659
% swelling
0,000
40,788
61,958
72,479
76,197
68,998
61,088
51,131
42,784
berat (g)
1,050
2,054
2,229
2,239
2,244
2,234
2,214
2,149
2,019
% swelling
0,000
95,619
112,286
113,238
113,714
112,762
110,857
104,667
92,286
%swelling (berat)
0,000
99,170
115,970
116,930
117,410
116,450
114,530
108,290
95,810
SD
0,000
3,750
3,869
3,875
3,879
3,872
3,859
3,815
3,727
%swelling (luas)
0,000
40,899
62,049
72,555
76,268
69,078
61,178
51,234
42,896
SD
0,000
0,860
0,974
1,024
1,041
1,006
0,967
0,918
0,877
F12
Lampiran 5. Kurva serapan larutan metronidazol dalam medium lambung buatan
pH 1,2
a. Kurva serapan metronidazol dalam medium lambung buatan pada
konsentrasi 12 ppm
Universitas Sumatera Utara
b. Tabel pengukuran serapan metronidazol dalam medium lambung buatan
pH 1,2 konsentrasi 12 ppm
Universitas Sumatera Utara
Lampiran 6. Kurva kalibrasi larutan metronidazol dalam medium lambung
buatan pH 1,2
a. Tabel kalibrasi larutan metronidazol dalam medium lambung buatan pH
1,2 pada panjang gelombang 277,30 nm
b. Kurva kalibrasi larutan metronidazol dalam medium lambung buatan pH
1,2 pada panjang gelombang 277,30 nm
Universitas Sumatera Utara
Lampiran 7. Data hasil pengujian disolusi sediaan gastroretentif metronidazol
dari film alginat kitosan yang ditambahkan HPMC
Co = 250 mg, FP (faktor pengenceran) = 12,5, [] = konsentrasi
1. Disolusi Film F3
a. Disolusi F3(1)
Faktor
Waktu
[] dalam 900
[] dalam
Penambaha
%
(menit)
Absorbansi
[]
[] x FP
ml
2 ml
n
Total Obat
Kumulatif
0
0,000
0,000
0,000
0,000
0,000
0,000
0,000
0,000
5
0,147
2,435
30,438
27393,750
60,875
0,000
27393,750
10,958
10
0,260
4,337
54,213
48791,250
108,425
60,875
48852,125
19,541
15
0,439
7,335
91,688
82518,750
183,375
169,300
82688,050
33,075
30
0,798
13,382
167,275
150547,500
334,550
352,675
150900,175
60,360
60
0,953
15,986
199,825
179842,500
399,650
687,225
180529,725
72,212
90
1,030
17,276
215,950
194355,000
431,900
1086,875
195441,875
78,177
120
1,054
17,678
220,975
198877,500
441,950
1518,775
200396,275
80,159
150
1,088
18,244
228,050
205245,000
456,100
1960,725
207205,725
82,882
180
1,131
18,967
237,088
213378,750
474,175
2416,825
215795,575
86,318
210
1,140
19,123
239,038
215133,750
478,075
2891,000
218024,750
87,210
240
1,147
19,233
240,413
216371,250
480,825
3369,075
219740,325
87,896
270
1,145
19,211
240,138
216123,750
480,275
3849,900
219973,650
87,989
300
1,155
19,371
242,138
217923,750
484,275
4330,175
222253,925
88,902
330
1,148
19,256
240,700
216630,000
481,400
4814,450
221444,450
88,578
360
1,148
19,255
240,688
216618,750
481,375
5295,850
221914,600
88,766
390
1,148
19,261
240,763
216686,250
481,525
5777,225
222463,475
88,985
420
1,143
19,166
239,575
215617,500
479,150
6258,750
221876,250
88,751
450
1,149
19,267
240,838
216753,750
481,675
6737,900
223491,650
89,397
480
1,150
19,289
241,113
217001,250
482,225
7219,575
224220,825
89,688
510
1,151
19,311
241,388
217248,750
482,775
7701,800
224950,550
89,980
540
1,150
19,298
241,225
217102,500
482,450
8184,575
225287,075
90,115
570
1,149
19,278
240,975
216877,500
481,950
8667,025
225544,525
90,218
600
1,149
19,279
240,988
216888,750
481,975
9148,975
226037,725
90,415
630
1,151
19,314
241,425
217282,500
482,850
9630,950
226913,450
90,765
660
1,152
19,319
241,488
217338,750
482,975
10113,800
227452,550
90,981
690
1,158
19,418
242,725
218452,500
485,450
10596,775
229049,275
91,620
720
1,163
19,501
243,763
219386,250
487,525
11082,225
230468,475
92,187
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
b. Disolusi F3(2)
Waktu
(menit)
Absorbansi
Konsentrasi
[] x FP
[] dalam
900 ml
[]
dalam 2
ml
Faktor
Penambahan
Total Obat
%
Kumulatif
0
0,000
0,000
0,000
0,000
0,000
0,000
0,000
0,000
5
0,148
2,443
30,538
27483,750
61,075
0,000
27483,750
10,994
10
0,261
4,342
54,275
48847,500
108,550
61,075
48908,575
19,563
15
0,438
7,327
91,588
82428,750
183,175
169,625
82598,375
33,039
30
0,798
13,381
167,263
150536,250
334,525
352,800
150889,050
60,356
60
0,940
15,768
197,100
177390,000
394,200
687,325
178077,325
71,231
90
1,030
17,268
215,850
194265,000
431,700
1081,525
195346,525
78,139
120
1,054
17,671
220,888
198798,750
441,775
1513,225
200311,975
80,125
150
1,088
18,254
228,175
205357,500
456,350
1955,000
207312,500
82,925
180
1,131
18,977
237,213
213491,250
474,425
2411,350
215902,600
86,361
210
1,140
19,125
239,063
215156,250
478,125
2885,775
218042,025
87,217
240
1,146
19,231
240,388
216348,750
480,775
3363,900
219712,650
87,885
270
1,149
19,276
240,950
216855,000
481,900
3844,675
220699,675
88,280
300
1,156
19,384
242,300
218070,000
484,600
4326,575
222396,575
88,959
330
1,144
19,197
239,963
215966,250
479,925
4811,175
220777,425
88,311
360
1,148
19,255
240,688
216618,750
481,375
5291,100
221909,850
88,764
390
1,149
19,269
240,863
216776,250
481,725
5772,475
222548,725
89,019
420
1,143
19,167
239,588
215628,750
479,175
6254,200
221882,950
88,753
450
1,149
19,276
240,950
216855,000
481,900
6733,375
223588,375
89,435
480
1,150
19,293
241,163
217046,250
482,325
7215,275
224261,525
89,705
510
1,147
19,234
240,425
216382,500
480,850
7697,600
224080,100
89,632
540
1,151
19,310
241,375
217237,500
482,750
8178,450
225415,950
90,166
570
1,151
19,310
241,375
217237,500
482,750
8661,200
225898,700
90,359
600
1,151
19,311
241,388
217248,750
482,775
9143,950
226392,700
90,557
630
1,151
19,314
241,425
217282,500
482,850
9626,725
226909,225
90,764
660
1,152
19,319
241,488
217338,750
482,975
10109,575
227448,325
90,979
690
1,158
19,418
242,725
218452,500
485,450
10592,550
229045,050
91,618
720
1,163
19,501
243,763
219386,250
487,525
11078,000
230464,250
92,186
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
c. Disolusi F3(3)
Waktu
(menit)
Absorbansi
Konsentrasi
[] x FP
[] dalam
900 ml
[]
dalam 2
ml
Faktor
Penambahan
Total Obat
%
Kumulatif
0
0,000
0,000
0,000
0,000
0,000
0,000
0,000
0,000
5
0,154
2,543
31,788
28608,750
63,575
0,000
28608,750
11,444
10
0,253
4,217
52,713
47441,250
105,425
63,575
47504,825
19,002
15
0,439
7,341
91,763
82586,250
183,525
169,000
82755,250
33,102
30
0,799
13,388
167,350
150615,000
334,700
352,525
150967,525
60,387
60
0,983
16,478
205,975
185377,500
411,950
687,225
186064,725
74,426
90
1,030
17,278
215,975
194377,500
431,950
1099,175
195476,675
78,191
120
1,054
17,672
220,900
198810,000
441,800
1531,125
200341,125
80,136
150
1,088
18,252
228,150
205335,000
456,300
1972,925
207307,925
82,923
180
1,131
18,971
237,138
213423,750
474,275
2429,225
215852,975
86,341
210
1,141
19,135
239,188
215268,750
478,375
2903,500
218172,250
87,269
240
1,146
19,231
240,388
216348,750
480,775
3381,875
219730,625
87,892
270
1,146
19,222
240,275
216247,500
480,550
3862,650
220110,150
88,044
300
1,155
19,378
242,225
218002,500
484,450
4343,200
222345,700
88,938
330
1,147
19,244
240,550
216495,000
481,100
4827,650
221322,650
88,529
360
1,147
19,235
240,438
216393,750
480,875
5308,750
221702,500
88,681
390
1,148
19,259
240,738
216663,750
481,475
5789,625
222453,375
88,981
420
1,143
19,166
239,575
215617,500
479,150
6271,100
221888,600
88,755
450
1,149
19,270
240,875
216787,500
481,750
6750,250
223537,750
89,415
480
1,151
19,311
241,388
217248,750
482,775
7232,000
224480,750
89,792
510
1,152
19,323
241,538
217383,750
483,075
7714,775
225098,525
90,039
540
1,149
19,278
240,975
216877,500
481,950
8197,850
225075,350
90,030
570
1,149
19,278
240,975
216877,500
481,950
8679,800
225557,300
90,223
600
1,149
19,279
240,988
216888,750
481,975
9161,750
226050,500
90,420
630
1,151
19,299
241,238
217113,750
482,475
9643,725
226757,475
90,703
660
1,152
19,317
241,463
217316,250
482,925
10126,200
227442,450
90,977
690
1,158
19,421
242,763
218486,250
485,525
10609,125
229095,375
91,638
720
1,162
19,500
243,750
219375,000
487,500
11094,650
230469,650
92,188
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
d. Rata-rata Disolusi F3
Waktu
(menit)
0
5
10
15
30
60
90
120
150
180
210
240
270
300
330
360
390
420
450
480
510
540
570
600
630
660
690
720
I
0
10,958
19,541
33,075
60,36
72,212
78,177
80,159
82,882
86,318
87,21
87,896
87,989
88,902
88,578
88,766
88,985
88,751
89,397
89,688
89,98
90,115
90,218
90,415
90,765
90,981
91,62
92,187
%Kumulatif
II
0
10,994
19,563
33,039
60,356
71,231
78,139
80,125
82,925
86,361
87,217
87,885
88,28
88,959
88,311
88,764
89,019
88,753
89,435
89,705
89,632
90,166
90,359
90,557
90,764
90,979
91,618
92,186
III
0
11,444
19,002
33,102
60,387
74,426
78,191
80,136
82,923
86,341
87,269
87,892
88,044
88,938
88,529
88,681
88,981
88,755
89,415
89,792
90,039
90,03
90,223
90,42
90,703
90,977
91,638
92,188
Rata-rata
0,000
11,132
19,369
33,072
60,368
72,623
78,169
80,140
82,910
86,340
87,232
87,891
88,104
88,933
88,473
88,737
88,995
88,753
89,416
89,728
89,884
90,104
90,267
90,464
90,744
90,979
91,625
92,187
SD
0,000
0,007
0,318
0,030
0,016
0,009
0,023
0,018
0,023
0,023
0,028
0,006
0,157
0,030
0,139
0,053
0,025
0,004
0,021
0,051
0,216
0,073
0,083
0,084
0,040
0,007
0,006
0,004
600
700
e. Grafik %Kumulatif Vs Waktu (F3)
100
80
60
40
20
0
0
100
200
300
400
500
800
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
2.
Disolusi Film F4
a. Disolusi F4 (1)
[] dalam
[] dalam
Faktor
%
900 ml
2 ml
Penambahan
Total Obat
Kumulatif
Waktu
Absorbansi
Konsentrasi
[] x FP
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,095
1,554
19,425
17482,500
38,850
0,000
17482,500
6,993
10
0,188
3,123
39,038
35133,750
78,075
37,650
35171,400
14,069
15
0,283
4,724
59,050
53145,000
118,100
80,975
53225,975
21,290
30
0,752
12,6
157,500
141750,000
315,000
207,175
141957,175
56,783
60
0,914
15,322
191,525
172372,500
383,050
528,975
172901,475
69,161
90
0,947
15,877
198,463
178616,250
396,925
883,275
179499,525
71,800
120
0,981
16,444
205,550
184995,000
411,100
1263,700
186258,700
74,503
150
1,027
17,215
215,188
193668,750
430,375
1657,375
195326,125
78,130
180
1,054
17,675
220,938
198843,750
441,875
2065,625
200909,375
80,364
210
1,072
17,984
224,800
202320,000
449,600
2487,100
204807,100
81,923
240
1,086
18,219
227,738
204963,750
455,475
2922,975
207886,725
83,155
270
1,098
18,412
230,150
207135,000
460,300
3367,650
210502,650
84,201
300
1,104
18,523
231,538
208383,750
463,075
3844,725
212228,475
84,891
330
1,111
18,635
232,938
209643,750
465,875
4325,700
213969,450
85,588
360
1,112
18,647
233,088
209778,750
466,175
4801,775
214580,525
85,832
390
1,112
18,652
233,150
209835,000
466,300
5279,950
215114,950
86,046
420
1,113
18,668
233,350
210015,000
466,700
5758,175
215773,175
86,309
450
1,113
18,669
233,363
210026,250
466,725
6232,000
216258,250
86,503
480
1,113
18,66
233,250
209925,000
466,500
6710,475
216635,475
86,654
510
1,113
18,662
233,275
209947,500
466,550
7189,400
217136,900
86,855
540
1,113
18,666
233,325
209992,500
466,650
7666,850
217659,350
87,064
570
1,113
18,667
233,338
210003,750
466,675
8146,100
218149,850
87,260
600
1,113
18,669
233,363
210026,250
466,725
8624,750
218651,000
87,460
630
1,113
18,673
233,413
210071,250
466,825
9101,400
219172,650
87,669
660
1,113
18,67
233,375
210037,500
466,750
9581,050
219618,550
87,847
690
1,113
18,674
233,425
210082,500
466,850
10060,725
220143,225
88,057
720
1,113
18,675
233,438
210093,750
466,875
10540,850
220634,600
88,254
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
b. Disolusi F4 (2)
[] dalam
[] dalam
Faktor
900 ml
2 ml
Penambahan
Total Obat
%
Waktu
Absorbansi
Konsentrasi
[] x FP
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,100
1,645
20,563
18506,250
41,125
0,000
18506,250
7,403
10
0,180
2,987
37,338
33603,750
74,675
41,125
33644,875
13,458
15
0,282
4,701
58,763
52886,250
117,525
115,800
53002,050
21,201
30
0,753
12,617
157,713
141941,250
315,425
233,325
142174,575
56,870
60
0,824
13,818
172,725
155452,500
345,450
548,750
156001,250
62,401
90
0,874
14,651
183,138
164823,750
366,275
894,200
165717,950
66,287
120
0,935
15,670
195,875
176287,500
391,750
1260,475
177547,975
71,019
150
0,977
16,376
204,700
184230,000
409,400
1652,225
185882,225
74,353
180
1,066
17,877
223,463
201116,250
446,925
2061,625
203177,875
81,271
210
1,084
18,186
227,325
204592,500
454,650
2508,550
207101,050
82,840
240
1,098
18,421
230,263
207236,250
460,525
2963,200
210199,450
84,080
270
1,110
18,614
232,675
209407,500
465,350
3423,725
212831,225
85,132
300
1,116
18,725
234,063
210656,250
468,125
3889,075
214545,325
85,818
330
1,123
18,837
235,463
211916,250
470,925
4357,200
216273,450
86,509
360
1,124
18,849
235,613
212051,250
471,225
4828,125
216879,375
86,752
390
1,124
18,854
235,675
212107,500
471,350
5299,350
217406,850
86,963
420
1,125
18,870
235,875
212287,500
471,750
5770,700
218058,200
87,223
450
1,125
18,871
235,888
212298,750
471,775
6242,450
218541,200
87,416
480
1,125
18,862
235,775
212197,500
471,550
6714,225
218911,725
87,565
510
1,125
18,864
235,800
212220,000
471,600
7185,775
219405,775
87,762
540
1,125
18,868
235,850
212265,000
471,700
7657,375
219922,375
87,969
570
1,125
18,869
235,863
212276,250
471,725
8129,075
220405,325
88,162
600
1,125
18,871
235,888
212298,750
471,775
8600,800
220899,550
88,360
630
1,125
18,875
235,938
212343,750
471,875
9072,575
221416,325
88,567
660
1,125
18,872
235,900
212310,000
471,800
9544,450
221854,450
88,742
690
1,125
18,876
235,950
212355,000
471,900
10016,250
222371,250
88,949
720
1,125
18,877
235,963
212366,250
471,925
10488,150
222854,400
89,142
Kumulatif
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
c. Disolusi F4 (3)
[] dalam
[] dalam
Faktor
900 ml
2 ml
Penambahan
Total Obat
%
Waktu
Absorbansi
Konsentrasi
[] x FP
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,097
1,597
19,963
17966,250
39,925
0,000
17966,250
7,187
10
0,188
3,129
39,113
35201,250
78,225
39,925
35241,175
14,096
15
0,273
4,545
56,813
51131,250
113,625
118,150
51249,400
20,500
30
0,734
12,296
153,700
138330,000
307,400
231,775
138561,775
55,425
60
0,813
13,631
170,388
153348,750
340,775
539,175
153887,925
61,555
90
0,865
14,495
181,188
163068,750
362,375
879,950
163948,700
65,579
120
0,915
15,349
191,863
172676,250
383,725
1242,325
173918,575
69,567
150
0,973
16,322
204,025
183622,500
408,050
1626,050
185248,550
74,099
180
1,073
18,003
225,038
202533,750
450,075
2034,100
204567,850
81,827
210
1,092
18,312
228,900
206010,000
457,800
2484,175
208494,175
83,398
240
1,106
18,547
231,838
208653,750
463,675
2941,975
211595,725
84,638
270
1,117
18,740
234,250
210825,000
468,500
3405,650
214230,650
85,692
300
1,124
18,851
235,638
212073,750
471,275
3874,150
215947,900
86,379
330
1,131
18,963
237,038
213333,750
474,075
4345,425
217679,175
87,072
360
1,131
18,975
237,188
213468,750
474,375
4819,500
218288,250
87,315
390
1,132
18,980
237,250
213525,000
474,500
5293,875
218818,875
87,528
420
1,132
18,996
237,450
213705,000
474,900
5768,375
219473,375
87,789
450
1,133
18,997
237,463
213716,250
474,925
6243,275
219959,525
87,984
480
1,132
18,988
237,350
213615,000
474,700
6718,200
220333,200
88,133
510
1,132
18,990
237,375
213637,500
474,750
7192,900
220830,400
88,332
540
1,132
18,994
237,425
213682,500
474,850
7667,650
221350,150
88,540
570
1,132
18,995
237,438
213693,750
474,875
8142,500
221836,250
88,735
600
1,133
18,997
237,463
213716,250
474,925
8617,375
222333,625
88,933
630
1,133
19,001
237,513
213761,250
475,025
9092,300
222853,550
89,141
660
1,133
18,998
237,475
213727,500
474,950
9567,325
223294,825
89,318
690
1,133
19,002
237,525
213772,500
475,050
10042,275
223814,775
89,526
720
1,133
19,003
237,538
213783,750
475,075
10517,325
224301,075
89,720
Kumulatif
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
d. Rata-rata Disolusi F4
Waktu
I
0
5
10
15
30
60
90
120
150
180
210
240
270
300
330
360
390
420
450
480
510
540
570
600
630
660
690
720
0
6,993
14,069
21,29
56,783
69,161
71,8
74,503
78,13
80,364
81,923
83,155
84,201
84,891
85,588
85,832
86,046
86,309
86,503
86,654
86,855
87,064
87,26
87,46
87,669
87,847
88,057
88,254
%Kumulatif
II
0
7,403
13,458
21,201
56,87
62,401
66,287
71,019
74,353
81,271
82,84
84,08
85,132
85,818
86,509
86,752
86,963
87,223
87,416
87,565
87,762
87,969
88,162
88,36
88,567
88,742
88,949
89,142
III
0
7,187
14,096
20,5
55,425
61,555
65,579
69,567
74,099
81,827
83,398
84,638
85,692
86,379
87,072
87,315
87,528
87,789
87,984
88,133
88,332
88,54
88,735
88,933
89,141
89,318
89,526
89,72
Rata-rata
0,000
7,194
13,874
20,997
56,359
64,372
67,889
71,696
75,527
81,154
82,720
83,958
85,008
85,696
86,390
86,633
86,846
87,107
87,301
87,451
87,650
87,858
88,052
88,251
88,459
88,636
88,844
89,039
SD
0,000
0,205
0,361
0,433
0,810
4,169
3,406
2,537
2,258
0,738
0,745
0,749
0,753
0,751
0,749
0,749
0,748
0,747
0,747
0,746
0,745
0,744
0,744
0,743
0,742
0,741
0,740
0,738
e. Grafik %Kumulatif Vs Waktu (F4)
100
80
60
40
20
0
0
100
200
300
400
500
600
700
800
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
3.
Disolusi Film F5
a. Disolusi F5 (1)
[]
Waktu
[] dalam
dalam 2
Faktor
%
(menit)
Absorbansi
Konsentrasi
[] x FP
900 ml
ml
Penambahan
Total Obat
Kumulatif
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,071
1,162
14,525
13072,500
29,050
0,000
13072,500
5,229
10
0,093
1,522
19,025
17122,500
38,050
29,050
17151,550
6,861
15
0,259
4,308
53,850
48465,000
107,700
67,100
48532,100
19,413
30
0,676
11,332
141,650
127485,000
283,300
174,800
127659,800
51,064
60
0,795
13,319
166,488
149838,750
332,975
458,100
150296,850
60,119
90
0,848
14,208
177,600
159840,000
355,200
791,075
160631,075
64,252
120
0,895
15,006
187,575
168817,500
375,150
1146,275
169963,775
67,986
150
0,947
15,877
198,463
178616,250
396,925
1521,425
180137,675
72,055
180
0,986
16,532
206,650
185985,000
413,300
1918,350
187903,350
75,161
210
1,021
17,115
213,938
192543,750
427,875
2331,650
194875,400
77,950
240
1,045
17,522
219,025
197122,500
438,050
2759,525
199882,025
79,953
270
1,086
18,208
227,600
204840,000
455,200
3197,575
208037,575
83,215
300
1,100
18,458
230,725
207652,500
461,450
3652,775
211305,275
84,522
330
1,106
18,555
231,938
208743,750
463,875
4114,225
212857,975
85,143
360
1,106
18,556
231,950
208755,000
463,900
4578,100
213333,100
85,333
390
1,103
18,505
231,313
208181,250
462,625
5042,000
213223,250
85,289
420
1,110
18,622
232,775
209497,500
465,550
5504,625
215002,125
86,001
450
1,110
18,626
232,825
209542,500
465,650
5970,175
215512,675
86,205
480
1,106
18,549
231,863
208676,250
463,725
6435,825
215112,075
86,045
510
1,111
18,631
232,888
209598,750
465,775
6899,550
216498,300
86,599
540
1,112
18,646
233,075
209767,500
466,150
7365,325
217132,825
86,853
570
1,122
18,826
235,325
211792,500
470,650
7831,475
219623,975
87,850
600
1,122
18,821
235,263
211736,250
470,525
8302,125
220038,375
88,015
630
1,122
18,823
235,288
211758,750
470,575
8772,650
220531,400
88,213
660
1,123
18,831
235,388
211848,750
470,775
9243,225
221091,975
88,437
690
1,123
18,833
235,413
211871,250
470,825
9714,000
221585,250
88,634
720
1,123
18,834
235,425
211882,500
470,850
10184,825
222067,325
88,827
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
b. Disolusi F5 (2)
Waktu
(menit)
Absorbansi
Konsentrasi
[] x FP
[] dalam
900 ml
[]
dalam 2
ml
Faktor
Penambahan
Total Obat
%
Kumulatif
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,068
1,097
13,713
12341,250
27,425
0,000
12341,250
4,937
10
0,090
1,477
18,463
16616,250
36,925
27,425
16643,675
6,657
15
0,255
4,254
53,175
47857,500
106,350
64,350
47921,850
19,169
30
0,673
11,267
140,838
126753,750
281,675
170,700
126924,450
50,770
60
0,792
13,274
165,925
149332,500
331,850
452,375
149784,875
59,914
90
0,844
14,154
176,925
159232,500
353,850
784,225
160016,725
64,007
120
0,891
14,941
186,763
168086,250
373,525
1138,075
169224,325
67,690
150
0,944
15,832
197,900
178110,000
395,800
1511,600
179621,600
71,849
180
0,983
16,478
205,975
185377,500
411,950
1907,400
187284,900
74,914
210
1,017
17,05
213,125
191812,500
426,250
2319,350
194131,850
77,653
240
1,042
17,477
218,463
196616,250
436,925
2745,600
199361,850
79,745
270
1,082
18,154
226,925
204232,500
453,850
3182,525
207415,025
82,966
300
1,097
18,393
229,913
206921,250
459,825
3636,375
210557,625
84,223
330
1,104
18,51
231,375
208237,500
462,750
4096,200
212333,700
84,933
360
1,103
18,502
231,275
208147,500
462,550
4558,950
212706,450
85,083
390
1,099
18,44
230,500
207450,000
461,000
5021,500
212471,500
84,989
420
1,108
18,577
232,213
208991,250
464,425
5482,500
214473,750
85,790
450
1,107
18,572
232,150
208935,000
464,300
5946,925
214881,925
85,953
480
1,102
18,484
231,050
207945,000
462,100
6411,225
214356,225
85,742
510
1,108
18,586
232,325
209092,500
464,650
6873,325
215965,825
86,386
540
1,108
18,592
232,400
209160,000
464,800
7337,975
216497,975
86,599
570
1,119
18,761
234,513
211061,250
469,025
7802,775
218864,025
87,546
600
1,119
18,776
234,700
211230,000
469,400
8271,800
219501,800
87,801
630
1,119
18,769
234,613
211151,250
469,225
8741,200
219892,450
87,957
660
1,119
18,766
234,575
211117,500
469,150
9210,425
220327,925
88,131
690
1,120
18,788
234,850
211365,000
469,700
9679,575
221044,575
88,418
720
1,120
18,78
234,750
211275,000
469,500
10149,275
221424,275
88,570
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
c. Disolusi F5 (3)
Waktu
(menit)
Absorbansi
Konsentrasi
[] x FP
[] dalam
900 ml
[]
dalam 2
ml
Faktor
Penambahan
Total Obat
%
Kumulatif
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,075
1,218
15,225
13702,500
30,450
0,000
13702,500
5,481
10
0,149
2,464
30,800
27720,000
61,600
30,450
27750,450
11,100
15
0,314
5,241
65,513
58961,250
131,025
92,050
59053,300
23,621
30
0,680
11,388
142,350
128115,000
284,700
223,075
128338,075
51,335
60
0,851
14,261
178,263
160436,250
356,525
507,775
160944,025
64,378
90
0,903
15,141
189,263
170336,250
378,525
864,300
171200,550
68,480
120
0,953
15,987
199,838
179853,750
399,675
1242,825
181096,575
72,439
150
1,003
16,819
210,238
189213,750
420,475
1642,500
190856,250
76,343
180
1,041
17,465
218,313
196481,250
436,625
2062,975
198544,225
79,418
210
1,060
17,778
222,225
200002,500
444,450
2499,600
202502,100
81,001
240
1,101
18,464
230,800
207720,000
461,600
2944,050
210664,050
84,266
270
1,086
18,221
227,763
204986,250
455,525
3405,650
208391,900
83,357
300
1,093
18,332
229,150
206235,000
458,300
3861,175
210096,175
84,038
330
1,097
18,4
230,000
207000,000
460,000
4319,475
211319,475
84,528
360
1,092
18,312
228,900
206010,000
457,800
4779,475
210789,475
84,316
390
1,093
18,328
229,100
206190,000
458,200
5237,275
211427,275
84,571
420
1,101
18,465
230,813
207731,250
461,625
5695,475
213426,725
85,371
450
1,100
18,448
230,600
207540,000
461,200
6157,100
213697,100
85,479
480
1,096
18,375
229,688
206718,750
459,375
6618,300
213337,050
85,335
510
1,105
18,532
231,650
208485,000
463,300
7077,675
215562,675
86,225
540
1,104
18,518
231,475
208327,500
462,950
7540,975
215868,475
86,347
570
1,098
18,419
230,238
207213,750
460,475
8003,925
215217,675
86,087
600
1,105
18,541
231,763
208586,250
463,525
8464,400
217050,650
86,820
630
1,105
18,538
231,725
208552,500
463,450
8927,925
217480,425
86,992
660
1,115
18,696
233,700
210330,000
467,400
9391,375
219721,375
87,889
690
1,117
18,731
234,138
210723,750
468,275
9858,775
220582,525
88,233
720
1,116
18,715
233,938
210543,750
467,875
10327,050
220870,800
88,348
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
d. Rata-rata Disolusi F5
Waktu
(menit)
0
5
10
15
30
60
90
120
150
180
210
240
270
300
330
360
390
420
450
480
510
540
570
600
630
660
690
720
I
0
5,229
6,861
19,413
51,064
60,119
64,252
67,986
72,055
75,161
77,95
79,953
83,215
84,522
85,143
85,333
85,289
86,001
86,205
86,045
86,599
86,853
87,85
88,015
88,213
88,437
88,634
88,827
%Kumulatif
II
0
4,937
6,657
19,169
50,77
59,914
64,007
67,69
71,849
74,914
77,653
79,745
82,966
84,223
84,933
85,083
84,989
85,79
85,953
85,742
86,386
86,599
87,546
87,801
87,957
88,131
88,418
88,57
III
0
5,481
11,1
23,621
51,335
64,378
68,48
72,439
76,343
79,418
81,001
84,266
83,357
84,038
84,528
84,316
84,571
85,371
85,479
85,335
86,225
86,347
86,087
86,82
86,992
87,889
88,233
88,348
Rata-rata
0,000
5,216
8,206
20,734
51,056
61,470
65,580
69,372
73,416
76,498
78,868
81,321
83,179
84,261
84,868
84,911
84,950
85,721
85,879
85,707
86,403
86,600
87,161
87,545
87,721
88,152
88,428
88,582
SD
0,000
0,272
2,508
2,503
0,283
2,520
2,515
2,661
2,537
2,532
1,853
2,552
0,198
0,244
0,313
0,530
0,361
0,321
0,369
0,356
0,188
0,253
0,942
0,637
0,644
0,275
0,201
0,240
e. Grafik %Kumulatif Vs Waktu (F5)
100
80
60
40
20
0
0
100
200
300
400
500
600
700
800
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
4.
Disolusi Film F6
a. Disolusi F6 (1)
[]
Waktu
[] dalam
dalam 2
Faktor
%
(menit)
Absorbansi
Konsentrasi
[] x FP
900 ml
ml
Penambahan
Total Obat
Kumulatif
0
0,000
0,000
0,000
0,000
0,000
0,000
0,000
0,000
5
0,044
0,700
8,750
7875,000
17,500
0,000
7875,000
3,150
10
0,062
1,000
12,500
11250,000
25,000
17,500
11267,500
4,507
15
0,232
3,869
48,363
43526,250
96,725
42,500
43568,750
17,428
30
0,649
10,870
135,875
122287,500
271,750
139,225
122426,725
48,971
60
0,762
12,767
159,588
143628,750
319,175
410,975
144039,725
57,616
90
0,817
13,686
171,075
153967,500
342,150
730,150
154697,650
61,879
120
0,874
14,645
183,063
164756,250
366,125
1072,300
165828,550
66,331
150
0,919
15,415
192,688
173418,750
385,375
1438,425
174857,175
69,943
180
0,953
15,980
199,750
179775,000
399,500
1823,800
181598,800
72,640
210
0,995
16,683
208,538
187683,750
417,075
2223,300
189907,050
75,963
240
1,019
17,083
213,538
192183,750
427,075
2640,375
194824,125
77,930
270
1,058
17,746
221,825
199642,500
443,650
3067,450
202709,950
81,084
300
1,073
17,996
224,950
202455,000
449,900
3511,100
205966,100
82,386
330
1,075
18,033
225,413
202871,250
450,825
3961,000
206832,250
82,733
360
1,080
18,117
226,463
203816,250
452,925
4411,825
208228,075
83,291
390
1,081
18,133
226,663
203996,250
453,325
4864,750
208861,000
83,544
420
1,077
18,070
225,875
203287,500
451,750
5318,075
208605,575
83,442
450
1,079
18,104
226,300
203670,000
452,600
5769,825
209439,825
83,776
480
1,085
18,200
227,500
204750,000
455,000
6222,425
210972,425
84,389
510
1,083
18,169
227,113
204401,250
454,225
6677,425
211078,675
84,431
540
1,087
18,234
227,925
205132,500
455,850
7131,650
212264,150
84,906
570
1,097
18,394
229,925
206932,500
459,850
7587,500
214520,000
85,808
600
1,103
18,493
231,163
208046,250
462,325
8047,350
216093,600
86,437
630
1,102
18,491
231,138
208023,750
462,275
8509,675
216533,425
86,613
660
1,097
18,401
230,013
207011,250
460,025
8971,950
215983,200
86,393
690
1,098
18,423
230,288
207258,750
460,575
9431,975
216690,725
86,676
720
1,107
18,567
232,088
208878,750
464,175
9892,550
218771,300
87,509
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
b. Disolusi F6 (2)
Waktu
(menit)
Absorbansi
Konsentrasi
[] x FP
[] dalam
900 ml
[]
dalam 2
ml
Faktor
Penambahan
Total Obat
%
Kumulatif
0
0,000
0,000
0,000
0,000
0,
Lampiran 1. Data spesifikasi sediaan gastroretentif metronidazol dari film alginatkitosan yang ditambahkan HPMC
No
Formula
Gambar Film
Komposisi
Berat (g)
Berat
Ratarata
± SD
F1
5
gram
larutan
Alginat 4% + 250 mg
metronidazol + 8
tetes gliserin
0,990
0,995
0,985
0,940
±0,005
F3
1,25 gram larutan
Alginat 4% + 3,75
gram larutan kitosan
+
250
mg
metronidazol + 8
tetes gliserin
0,952
0,955
0,952
0,930
±0,007
F4
1,67 gram larutan
Alginat 4% + 3,37
gram larutan kitosan
+
250
mg
metronidazol + 8
tetes gliserin
0,943
0,945
0,941
0,941
±0,002
F5
2
gram
larutan
Alginat 4% + 3 gram
larutan kitosan + 250
mg metronidazol + 8
tetes gliserin
0,946
0,947
0,947
0,947
±0,001
5
F6
2,5 gram larutan
Alginat 4% + 2,5
gram larutan kitosan
+
250
mg
metronidazol + 8
tetes gliserin
0,950
0,955
0,950
0,952
±0,003
6
F7
3
gram
larutan
Alginat 4% + 2 gram
0,956
0,958
0,957
±0,001
1
2
3
4
Universitas Sumatera Utara
larutan kitosan + 250
mg metronidazol + 8
tetes gliserin
7
8
9
10
11
0,958
F8
3,34 gram larutan
Alginat 4% + 1,67
gram larutan kitosan
+
250
mg
metronidazol + 8
tetes gliserin
0,926
0,925
0,921
0,924
±0,003
F9
3,75 gram larutan
Alginat 4% + 1,25
gram larutan kitosan
+
250
mg
metronidazol + 8
tetes gliserin
0,910
0,915
0,913
0,913
±0,003
F10
3,34 gram larutan
Alginat 4% + 1,16
gram larutan kitosan
+ 50 mg HPMC +
250 mg metronidazol
+ 8 tetes gliserin
0,935
0,945
0,935
0,938
±0,006
F11
3,34 gram larutan
Alginat 4% + 1,16
gram larutan kitosan
+ 100 mg HPMC +
250 mg metronidazol
+ 8 tetes gliserin
0,980
0,985
0,980
0,982
±0,003
F12
3,34 gram larutan
Alginat 4% + 1,16
gram larutan kitosan
+ 150 mg HPMC +
250 mg metronidazol
+ 8 tetes gliserin
1,035
1,040
1,045
1,040
±0,005
Universitas Sumatera Utara
12
F13
3,34 gram larutan
Alginat 4% + 1,16
gram larutan kitosan
+ 200 mg HPMC +
250 mg metronidazol
+ 8 tetes gliserin
1,085
1,090
1,090
1,008
±0,003
Ket.
P = Panjang film; L = Lebar film
Universitas Sumatera Utara
Lampiran 2. Data sifat pembentangan (unfolding behaviour)
Pembentangan
Ratio
Keterangan
Waktu
RataFormula
(Alginat :
rata
Kitosan)
F1
A
B
C
F3
A
B
C
F4
A
B
C
F5
F6
0
0.3
0,5
> 3jam
> 3 jam
> 3 jam
> 3 jam
Tidak dapat
membentang
kembali
0,967 menit
0,933 menit
0,983 menit
0,961
±0,025
menit
Membentang
kembali
1,983 menit
1,867 menit
1,145 menit
1,767
±0,20
menit
Membentang
kembali
2,572
±0,106
menit
Membentang
kembali
A
B
C
0,667
2,450 menit
2,633 menit
2,633 menit
A
B
C
1
3,317 menit
3,067 menit
3,483 menit
3,289
±0,210
menit
Membentang
kembali
3,383 menit
3,444
Membentang
A
Gambar Film setelah 3 jam
Universitas Sumatera Utara
B
C
F7
3,400 menit
3,550 menit
±0,092
menit
kembali
3,450
±0,076
menit
Membentang
kembali
1,5
A
B
C
2
3,433 menit
3,533 menit
3,383 menit
A
B
C
2 + 50 mg
HPMC
5,217 menit
5,400 menit
5,517 menit
5,378
±0,151
menit
Membentang
kembali
F11
A
B
C
2 + 100 mg
HPMC
5,767 menit
5,850 menit
6,433 menit
6,017
±0,363
menit
Membentang
kembali
F12
A
B
C
2 + 150 mg
HPMC
6,617 menit
6,250 menit
6,600 menit
6,489
±0,217
menit
Membentang
kembali
F8
F10
Universitas Sumatera Utara
Lampiran 3. Data pengujian sifat integritas film
No
Formula
Waktu hancur
F3
F4
F5
F6
F7
F8
F10
F11
F12
F3a
F3b
F3c
F3
F4a
F4b
F4c
F4
F5a
F5b
F5c
F5
F6a
F6b
F6c
F6
F7a
F7b
F7c
F7
F8a
F8b
F8c
F8
F10a
F10b
F10c
F10
F11a
F11b
F11c
F11
F12a
F12b
F12c
F12
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
>12 jam
> 12 jam
> 12 jam
> 12 jam
Lampiran 4. Data pengujian sifat pengembangan film
1. Pengujian sifat pengembangan film F3
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,850
7,220
7,580
7,630
7,680
7,650
7,630
7,4
7,231
lebar ( cm)
1,770
2,440
2,490
2,650
2,740
2,730
2,630
2,61
2,54
luas (cm2)
8,585
17,617
18,874
20,220
21,043
20,885
20,067
19,314
18,367
% swelling
0,000
105,216
119,864
135,535
145,130
143,281
133,744
124,974
113,940
berat (g)
0,952
2,957
3,260
3,575
3,475
3,475
3,395
3,2
3,155
% swelling
0,000
210,609
242,437
275,525
265,021
265,021
256,618
236,134
231,408
panjang(cm)
4,880
7,197
7,557
7,607
7,657
7,627
7,607
7,377
7,208
lebar ( cm)
1,760
2,428
2,478
2,638
2,728
2,718
2,618
2,598
2,528
luas (cm2)
8,589
17,474
18,726
20,067
20,888
20,730
19,915
19,165
18,222
% swelling
0,000
103,455
118,026
133,639
143,198
141,357
131,868
123,139
112,153
berat (g)
0,955
2,960
3,330
3,450
3,500
3,510
3,400
3,195
3
% swelling
0,000
209,948
248,691
261,257
266,492
267,539
256,021
234,555
214,136
panjang(cm)
4,850
7,174
7,534
7,584
7,634
7,604
7,584
7,354
7,185
lebar ( cm)
1,780
2,415
2,465
2,625
2,715
2,705
2,605
2,585
2,515
luas (cm2)
8,633
17,322
18,568
19,905
20,723
20,566
19,753
19,007
18,067
% swelling
0,000
100,653
115,085
130,568
140,047
138,223
128,811
120,169
109,283
berat (g)
0,952
2,955
3,225
3,445
3,480
3,475
3,400
3,285
3,095
% swelling
0,000
210,399
238,761
261,870
265,546
265,021
257,143
245,063
225,105
%swelling (berat)
0,000
210,319
243,296
266,217
265,686
265,860
256,594
238,584
223,550
SD
0,000
0,338
5,021
8,067
0,746
1,454
0,561
5,666
8,740
%swelling (luas)
0,000
103,108
117,658
133,247
142,792
140,954
131,474
122,761
111,792
SD
0,000
2,302
2,410
2,506
2,566
2,553
2,490
2,425
2,349
F3
Lampiran 4. (Lanjutan)
2. Pengujian sifat pengembangan film F4
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,470
6,100
6,270
6,430
6,480
6,500
6,450
6,290
6,200
lebar ( cm)
1,750
2,380
2,510
2,630
2,680
2,680
2,570
2,530
2,455
luas (cm2)
7,823
14,518
15,738
16,911
17,366
17,420
16,577
15,914
15,221
% swelling
0,000
85,593
101,185
116,183
122,006
122,691
111,908
103,435
94,580
berat (g)
0,943
2,723
3,026
3,285
3,241
3,241
3,161
2,966
2,821
% swelling
0,000
188,759
220,891
248,356
243,690
243,690
235,207
214,528
199,152
panjang(cm)
4,480
6,120
6,290
6,450
6,480
6,490
6,400
6,280
6,200
lebar ( cm)
1,760
2,625
2,755
2,875
2,925
2,925
2,815
2,775
2,700
luas (cm2)
7,885
16,065
17,329
18,544
18,954
18,983
18,016
17,427
16,740
% swelling
0,000
103,741
119,771
135,178
140,380
140,751
128,484
121,015
112,302
berat (g)
0,945
2,801
3,104
3,363
3,319
3,319
3,239
3,044
2,899
% swelling
0,000
196,402
228,466
255,873
251,217
251,217
242,751
222,116
206,772
panjang(cm)
4,470
6,110
6,270
6,440
6,480
6,480
6,400
6,300
6,150
lebar ( cm)
1,750
2,385
2,510
2,630
2,690
2,690
2,650
2,500
2,450
luas (cm2)
7,823
14,572
15,738
16,937
17,431
17,431
16,960
15,750
15,068
% swelling
0,000
86,276
101,172
116,505
122,820
122,820
116,797
101,329
92,605
berat (g)
0,941
2,821
3,124
3,383
3,339
3,339
3,259
3,064
2,919
% swelling
0,000
199,785
231,985
259,509
254,833
254,833
246,332
225,609
210,200
%swelling (berat)
0,000
194,982
227,114
254,579
249,913
249,913
241,430
220,751
205,375
SD
0,000
5,648
5,669
5,688
5,685
5,685
5,679
5,665
5,655
%swelling (luas)
0,000
91,870
107,376
122,622
128,402
128,754
119,063
108,593
99,829
SD
0,000
10,287
10,734
10,875
10,382
10,390
8,517
10,809
10,847
F4
Lampiran 4. (Lanjutan)
3. Pengujian sifat pengembangan film F5
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,284
5,914
6,084
6,244
6,294
6,314
6,264
6,104
6,014
lebar ( cm)
1,644
2,279
2,329
2,500
2,579
2,569
2,469
2,449
2,379
luas (cm2)
7,043
13,476
14,167
15,610
16,230
16,218
15,463
14,946
14,305
% swelling
0,000
83,542
92,961
112,612
121,053
120,895
110,614
103,572
94,837
berat (g)
0,925
2,570
2,873
3,132
3,088
3,088
3,008
2,813
2,668
% swelling
0,000
171,670
203,700
231,078
226,427
226,427
217,970
197,357
182,030
panjang(cm)
4,208
5,838
6,008
6,168
6,218
6,238
6,188
6,028
5,938
lebar ( cm)
1,623
2,258
2,308
2,479
2,558
2,548
2,448
2,428
2,358
luas (cm2)
6,830
13,180
13,864
15,290
15,903
15,892
15,146
14,634
13,999
% swelling
0,000
79,513
88,832
108,260
116,605
116,452
106,289
99,313
90,676
berat (g)
0,921
2,566
2,869
3,128
3,084
3,084
3,004
2,809
2,664
% swelling
0,000
171,247
203,277
230,655
226,004
226,004
217,548
196,934
181,607
panjang(cm)
4,267
5,897
6,067
6,227
6,277
6,297
6,247
6,087
5,997
lebar ( cm)
1,619
2,254
2,304
2,475
2,554
2,544
2,444
2,424
2,354
luas (cm2)
6,908
13,289
13,976
15,412
16,029
16,017
15,265
14,752
14,115
% swelling
0,000
81,006
90,356
109,913
118,319
118,156
107,916
100,932
92,244
berat (g)
0,918
2,563
2,866
3,125
3,081
3,081
3,001
2,806
2,661
% swelling
0,000
170,962
202,992
230,370
225,719
225,719
217,262
196,649
181,321
%swelling (berat)
0,000
171,293
203,323
230,701
226,050
226,050
217,593
196,980
181,653
SD
0,000
0,356
0,356
0,356
0,356
0,356
0,356
0,356
0,356
%swelling (luas)
0,000
81,354
90,716
110,262
118,659
118,501
108,273
101,272
92,585
SD
0,000
2,037
2,088
2,197
2,243
2,242
2,185
2,150
2,101
F5
Lampiran 4. (Lanjutan)
4. Pengujian sifat pengembangan film F6
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,560
5,800
5,970
6,130
6,180
6,200
5,987
5,990
5,900
lebar ( cm)
1,610
2,182
2,232
2,403
2,482
2,472
2,400
2,352
2,282
luas (cm2)
7,342
12,653
13,323
14,730
15,336
15,324
14,369
14,086
13,461
% swelling
0,000
72,341
81,458
100,632
108,884
108,716
95,707
91,856
83,348
berat (g)
0,952
2,408
2,711
2,970
2,926
2,926
2,846
2,651
2,506
% swelling
0,000
152,941
184,769
211,975
207,353
207,353
198,950
178,466
163,235
panjang(cm)
4,550
5,767
5,937
6,097
6,147
6,167
6,070
5,957
5,867
lebar ( cm)
1,580
2,140
2,190
2,361
2,440
2,430
2,358
2,310
2,240
luas (cm2)
7,189
12,338
12,999
14,394
14,996
14,983
14,312
13,758
13,139
% swelling
0,000
71,630
80,819
100,228
108,591
108,412
99,088
91,371
82,767
berat (g)
0,955
2,487
2,790
3,049
3,005
3,005
2,925
2,730
2,585
% swelling
0,000
160,387
192,115
219,236
214,628
214,628
206,251
185,832
170,649
panjang(cm)
4,550
5,711
5,881
6,041
6,091
6,111
6,014
5,901
5,811
lebar ( cm)
1,560
2,172
2,222
2,393
2,472
2,462
2,390
2,342
2,272
luas (cm2)
7,098
12,403
13,067
14,458
15,056
15,044
14,375
13,819
13,202
% swelling
0,000
74,745
84,089
103,685
112,116
111,951
102,521
94,691
85,991
berat (g)
0,950
2,482
2,785
3,044
3,000
3,000
2,920
2,725
2,580
% swelling
0,000
159,937
191,665
218,785
214,178
214,178
205,801
185,382
170,199
%swelling (berat)
0,000
157,755
189,516
216,665
212,053
212,053
203,667
183,227
168,028
SD
0,000
4,175
4,118
4,068
4,077
4,077
4,092
4,129
4,157
%swelling (luas)
0,000
72,905
82,122
101,515
109,864
109,693
99,105
92,640
84,036
SD
0,000
1,632
1,733
1,890
1,956
1,962
3,407
1,793
1,718
F6
Lampiran 4. (Lanjutan)
5. Pengujian sifat pengembangan film F7
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,560
5,440
6,140
6,150
6,160
6,090
6,020
5,9
5,8
lebar ( cm)
1,610
2,260
2,280
2,400
2,440
2,380
2,310
2,23
2,16
luas (cm2)
7,342
12,294
13,999
14,760
15,030
14,494
13,906
13,157
12,528
% swelling
0,000
67,453
90,673
101,035
104,718
97,415
89,406
79,202
70,635
berat (g)
0,946
2,425
2,680
2,690
2,695
2,685
2,665
2,6
2,47
% swelling
0,000
156,342
183,298
184,355
184,884
183,827
181,712
174,841
161,099
panjang(cm)
4,550
5,410
6,110
6,120
6,130
6,060
6,040
5,870
5,770
lebar ( cm)
1,580
2,260
2,280
2,400
2,440
2,380
2,210
2,19
2,16
luas (cm2)
7,189
12,227
13,931
14,688
14,957
14,423
13,348
12,855
12,463
% swelling
0,000
66,530
89,741
100,054
103,721
96,442
81,809
75,093
69,752
berat (g)
0,947
2,425
2,680
2,690
2,695
2,685
2,665
2,5587
2,48
% swelling
0,000
156,342
183,298
184,355
184,884
183,827
181,712
170,476
162,156
panjang(cm)
4,550
5,440
6,140
5,800
6,160
6,090
6,050
5,9
5,8
lebar ( cm)
1,600
2,226
2,246
2,366
2,406
2,346
2,176
2,156
2,126
luas (cm2)
7,280
12,109
13,790
13,723
14,821
14,287
13,165
12,720
12,331
% swelling
0,000
64,934
87,829
86,908
101,865
94,595
79,308
73,255
67,949
berat (g)
0,947
2,407
2,662
2,672
2,677
2,667
2,647
2,582
2,452
% swelling
0,000
154,440
181,395
182,452
182,981
181,924
179,810
172,939
159,197
%swelling (berat)
0,000
155,708
182,664
183,721
184,249
183,192
181,078
172,752
160,817
SD
0,000
1,099
1,099
1,099
1,099
1,099
1,099
2,189
1,500
%swelling (luas)
0,000
66,305
89,415
95,999
103,435
96,151
83,508
75,850
69,445
SD
0,000
1,274
1,450
7,888
1,448
1,433
5,259
3,045
1,369
F7
Lampiran 4. (Lanjutan)
6. Pengujian sifat pengembangan film F8
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,510
5,244
5,944
5,954
5,964
5,894
5,824
5,704
5,604
lebar ( cm)
1,545
2,162
2,182
2,302
2,342
2,282
2,212
2,132
2,062
luas (cm2)
6,968
11,339
12,971
13,707
13,969
13,451
12,884
12,162
11,557
% swelling
0,000
62,724
86,151
96,718
100,472
93,044
84,900
74,542
65,852
berat (g)
0,925
2,219
2,474
2,484
2,489
2,479
2,459
2,394
2,264
% swelling
0,000
139,892
167,459
168,541
169,081
168,000
165,838
158,811
144,757
panjang(cm)
4,510
5,166
5,866
5,876
5,886
5,816
5,746
5,626
5,526
lebar ( cm)
1,550
2,106
2,126
2,246
2,286
2,226
2,156
2,076
2,006
luas (cm2)
6,991
10,881
12,472
13,199
13,457
12,948
12,390
11,681
11,086
% swelling
0,000
55,638
78,405
88,795
92,484
85,204
77,221
67,082
58,579
berat (g)
0,926
2,207
2,462
2,472
2,477
2,467
2,447
2,382
2,252
% swelling
0,000
138,337
165,875
166,955
167,495
166,415
164,255
157,235
143,197
panjang(cm)
4,500
5,212
5,912
5,922
5,932
5,862
5,792
5,672
5,572
lebar ( cm)
1,570
2,111
2,131
2,251
2,291
2,231
2,161
2,081
2,011
luas (cm2)
7,065
11,000
12,596
13,328
13,588
13,075
12,514
11,801
11,203
% swelling
0,000
55,840
78,427
88,786
92,463
85,215
77,267
67,175
58,709
berat (g)
0,921
2,214
2,469
2,479
2,484
2,474
2,454
2,389
2,259
% swelling
0,000
142,708
170,669
171,765
172,314
171,217
169,024
161,897
147,643
%swelling (berat)
0,000
140,312
168,001
169,087
169,630
168,544
166,372
159,314
145,199
SD
0,000
2,216
2,443
2,451
2,456
2,447
2,429
2,371
2,256
%swelling (luas)
0,000
58,067
80,994
91,433
95,140
87,821
79,796
69,600
61,047
SD
0,000
4,034
4,466
4,577
4,618
4,523
4,420
4,280
4,162
F8
Lampiran 4. (Lanjutan)
7. Pengujian sifat pengembangan film F10
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,490
5,177
5,877
5,887
5,897
5,827
5,757
5,637
5,537
lebar ( cm)
1,560
2,088
2,108
2,228
2,268
2,208
2,138
2,058
1,988
luas (cm2)
7,004
10,811
12,390
13,117
13,376
12,867
12,310
11,602
11,009
% swelling
0,000
54,349
76,897
87,285
90,971
83,712
75,751
65,649
57,177
berat (g)
0,910
2,033
2,288
2,298
2,303
2,293
2,273
2,208
2,078
% swelling
0,000
123,407
151,429
152,527
153,077
151,978
149,780
142,637
128,352
panjang(cm)
4,480
5,101
5,801
5,811
5,821
5,751
5,681
5,561
5,461
lebar ( cm)
1,550
2,043
2,063
2,183
2,223
2,163
2,093
2,013
1,943
luas (cm2)
6,944
10,422
11,969
12,687
12,941
12,441
11,891
11,195
10,612
% swelling
0,000
50,092
72,359
82,698
86,366
79,156
71,248
61,224
52,820
berat (g)
0,915
2,008
2,263
2,273
2,278
2,268
2,248
2,183
2,053
% swelling
0,000
119,410
147,279
148,372
148,918
147,825
145,639
138,536
124,328
panjang(cm)
4,460
5,177
5,877
5,887
5,897
5,827
5,757
5,637
5,537
lebar ( cm)
1,550
2,050
2,070
2,190
2,230
2,170
2,100
2,020
1,950
luas (cm2)
6,913
10,612
12,165
12,892
13,150
12,644
12,089
11,386
10,797
% swelling
0,000
53,513
75,970
86,488
90,217
82,902
74,875
64,707
56,178
berat (g)
0,913
2,031
2,286
2,296
2,301
2,291
2,271
2,206
2,076
% swelling
0,000
122,453
150,383
151,479
152,026
150,931
148,740
141,621
127,382
%swelling (berat)
0,000
121,757
149,697
150,793
151,340
150,245
148,053
140,931
126,687
SD
0,000
2,088
2,158
2,161
2,163
2,160
2,154
2,136
2,100
%swelling (luas)
0,000
52,651
75,076
85,490
89,185
81,923
73,958
63,860
55,392
SD
0,000
2,256
2,398
2,451
2,470
2,431
2,388
2,331
2,282
F10
Lampiran 4. (Lanjutan)
8. Pengujian sifat pengembangan film F11
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,570
5,134
5,834
5,844
5,854
5,784
5,714
5,594
5,494
lebar ( cm)
1,510
2,034
2,054
2,174
2,214
2,154
2,084
2,004
1,934
luas (cm2)
6,901
10,444
11,984
12,706
12,962
12,460
11,909
11,211
10,626
% swelling
0,000
51,334
73,659
84,119
87,827
80,552
72,571
62,462
53,985
berat (g)
0,980
1,999
2,254
2,264
2,269
2,259
2,239
2,174
2,044
% swelling
0,000
103,980
130,000
131,020
131,531
130,510
128,469
121,837
108,571
panjang(cm)
4,460
5,111
5,811
5,821
5,831
5,761
5,691
5,571
5,471
lebar ( cm)
1,540
2,000
2,020
2,140
2,180
2,120
2,050
1,970
1,900
luas (cm2)
6,868
10,221
11,737
12,456
12,711
12,212
11,666
10,974
10,394
% swelling
0,000
47,353
69,429
79,893
83,601
76,346
68,386
58,315
49,871
berat (g)
0,985
1,986
2,241
2,251
2,256
2,246
2,226
2,161
2,031
% swelling
0,000
101,584
127,472
128,487
128,995
127,980
125,949
119,350
106,152
panjang(cm)
4,540
5,077
5,777
5,787
5,797
5,727
5,657
5,537
5,437
lebar ( cm)
1,530
1,946
1,966
2,086
2,126
2,066
1,996
1,916
1,846
luas (cm2)
6,9462
9,879
11,357
12,071
12,324
11,831
11,291
10,608
10,036
% swelling
0,000
42,227
63,501
73,781
77,420
70,330
62,548
52,723
44,486
berat (g)
0,980
1,930
2,185
2,195
2,200
2,190
2,170
2,105
1,975
% swelling
0,000
96,898
122,918
123,939
124,449
123,429
121,388
114,755
101,490
%swelling (berat)
0,000
100,820
126,797
127,815
128,325
127,306
125,269
118,647
105,405
SD
0,000
3,602
3,589
3,588
3,588
3,589
3,590
3,593
3,600
%swelling (luas)
0,000
46,971
68,863
79,264
82,949
75,743
67,835
57,833
49,447
SD
0,000
4,566
5,102
5,197
5,234
5,137
5,034
4,887
4,764
F11
Lampiran 4. (Lanjutan)
9. Pengujian sifat pengembangan film F12
Universitas Sumatera Utara
waktu (menit)
Formula
Spesifikasi
0
10
15
30
60
120
180
240
300
panjang(cm)
4,510
5,078
5,778
5,788
5,798
5,728
5,658
5,538
5,438
lebar ( cm)
1,500
1,889
1,909
2,029
2,069
2,009
1,939
1,859
1,789
luas (cm2)
6,765
9,593
11,031
11,745
11,997
11,509
10,972
10,296
9,730
% swelling
0,000
41,809
63,065
73,614
77,343
70,121
62,188
52,199
43,824
berat (g)
1,035
2,102
2,277
2,287
2,292
2,282
2,262
2,197
2,067
% swelling
0,000
103,092
120,000
120,966
121,449
120,483
118,551
112,271
99,710
panjang(cm)
4,580
5,073
5,773
5,783
5,793
5,723
5,653
5,533
5,433
lebar ( cm)
1,490
1,885
1,905
2,025
2,065
2,005
1,935
1,855
1,785
luas (cm2)
6,824
9,560
10,995
11,708
11,960
11,472
10,936
10,261
9,696
% swelling
0,000
40,099
61,124
71,571
75,263
68,114
60,259
50,371
42,080
berat (g)
1,040
2,068
2,243
2,253
2,258
2,248
2,228
2,163
2,033
% swelling
0,000
98,798
115,625
116,587
117,067
116,106
114,183
107,933
95,433
panjang(cm)
4,540
5,063
5,763
5,773
5,783
5,713
5,643
5,523
5,423
lebar ( cm)
1,490
1,881
1,901
2,021
2,061
2,001
1,931
1,851
1,781
luas (cm2)
6,765
9,524
10,956
11,668
11,920
11,433
10,898
10,224
9,659
% swelling
0,000
40,788
61,958
72,479
76,197
68,998
61,088
51,131
42,784
berat (g)
1,050
2,054
2,229
2,239
2,244
2,234
2,214
2,149
2,019
% swelling
0,000
95,619
112,286
113,238
113,714
112,762
110,857
104,667
92,286
%swelling (berat)
0,000
99,170
115,970
116,930
117,410
116,450
114,530
108,290
95,810
SD
0,000
3,750
3,869
3,875
3,879
3,872
3,859
3,815
3,727
%swelling (luas)
0,000
40,899
62,049
72,555
76,268
69,078
61,178
51,234
42,896
SD
0,000
0,860
0,974
1,024
1,041
1,006
0,967
0,918
0,877
F12
Lampiran 5. Kurva serapan larutan metronidazol dalam medium lambung buatan
pH 1,2
a. Kurva serapan metronidazol dalam medium lambung buatan pada
konsentrasi 12 ppm
Universitas Sumatera Utara
b. Tabel pengukuran serapan metronidazol dalam medium lambung buatan
pH 1,2 konsentrasi 12 ppm
Universitas Sumatera Utara
Lampiran 6. Kurva kalibrasi larutan metronidazol dalam medium lambung
buatan pH 1,2
a. Tabel kalibrasi larutan metronidazol dalam medium lambung buatan pH
1,2 pada panjang gelombang 277,30 nm
b. Kurva kalibrasi larutan metronidazol dalam medium lambung buatan pH
1,2 pada panjang gelombang 277,30 nm
Universitas Sumatera Utara
Lampiran 7. Data hasil pengujian disolusi sediaan gastroretentif metronidazol
dari film alginat kitosan yang ditambahkan HPMC
Co = 250 mg, FP (faktor pengenceran) = 12,5, [] = konsentrasi
1. Disolusi Film F3
a. Disolusi F3(1)
Faktor
Waktu
[] dalam 900
[] dalam
Penambaha
%
(menit)
Absorbansi
[]
[] x FP
ml
2 ml
n
Total Obat
Kumulatif
0
0,000
0,000
0,000
0,000
0,000
0,000
0,000
0,000
5
0,147
2,435
30,438
27393,750
60,875
0,000
27393,750
10,958
10
0,260
4,337
54,213
48791,250
108,425
60,875
48852,125
19,541
15
0,439
7,335
91,688
82518,750
183,375
169,300
82688,050
33,075
30
0,798
13,382
167,275
150547,500
334,550
352,675
150900,175
60,360
60
0,953
15,986
199,825
179842,500
399,650
687,225
180529,725
72,212
90
1,030
17,276
215,950
194355,000
431,900
1086,875
195441,875
78,177
120
1,054
17,678
220,975
198877,500
441,950
1518,775
200396,275
80,159
150
1,088
18,244
228,050
205245,000
456,100
1960,725
207205,725
82,882
180
1,131
18,967
237,088
213378,750
474,175
2416,825
215795,575
86,318
210
1,140
19,123
239,038
215133,750
478,075
2891,000
218024,750
87,210
240
1,147
19,233
240,413
216371,250
480,825
3369,075
219740,325
87,896
270
1,145
19,211
240,138
216123,750
480,275
3849,900
219973,650
87,989
300
1,155
19,371
242,138
217923,750
484,275
4330,175
222253,925
88,902
330
1,148
19,256
240,700
216630,000
481,400
4814,450
221444,450
88,578
360
1,148
19,255
240,688
216618,750
481,375
5295,850
221914,600
88,766
390
1,148
19,261
240,763
216686,250
481,525
5777,225
222463,475
88,985
420
1,143
19,166
239,575
215617,500
479,150
6258,750
221876,250
88,751
450
1,149
19,267
240,838
216753,750
481,675
6737,900
223491,650
89,397
480
1,150
19,289
241,113
217001,250
482,225
7219,575
224220,825
89,688
510
1,151
19,311
241,388
217248,750
482,775
7701,800
224950,550
89,980
540
1,150
19,298
241,225
217102,500
482,450
8184,575
225287,075
90,115
570
1,149
19,278
240,975
216877,500
481,950
8667,025
225544,525
90,218
600
1,149
19,279
240,988
216888,750
481,975
9148,975
226037,725
90,415
630
1,151
19,314
241,425
217282,500
482,850
9630,950
226913,450
90,765
660
1,152
19,319
241,488
217338,750
482,975
10113,800
227452,550
90,981
690
1,158
19,418
242,725
218452,500
485,450
10596,775
229049,275
91,620
720
1,163
19,501
243,763
219386,250
487,525
11082,225
230468,475
92,187
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
b. Disolusi F3(2)
Waktu
(menit)
Absorbansi
Konsentrasi
[] x FP
[] dalam
900 ml
[]
dalam 2
ml
Faktor
Penambahan
Total Obat
%
Kumulatif
0
0,000
0,000
0,000
0,000
0,000
0,000
0,000
0,000
5
0,148
2,443
30,538
27483,750
61,075
0,000
27483,750
10,994
10
0,261
4,342
54,275
48847,500
108,550
61,075
48908,575
19,563
15
0,438
7,327
91,588
82428,750
183,175
169,625
82598,375
33,039
30
0,798
13,381
167,263
150536,250
334,525
352,800
150889,050
60,356
60
0,940
15,768
197,100
177390,000
394,200
687,325
178077,325
71,231
90
1,030
17,268
215,850
194265,000
431,700
1081,525
195346,525
78,139
120
1,054
17,671
220,888
198798,750
441,775
1513,225
200311,975
80,125
150
1,088
18,254
228,175
205357,500
456,350
1955,000
207312,500
82,925
180
1,131
18,977
237,213
213491,250
474,425
2411,350
215902,600
86,361
210
1,140
19,125
239,063
215156,250
478,125
2885,775
218042,025
87,217
240
1,146
19,231
240,388
216348,750
480,775
3363,900
219712,650
87,885
270
1,149
19,276
240,950
216855,000
481,900
3844,675
220699,675
88,280
300
1,156
19,384
242,300
218070,000
484,600
4326,575
222396,575
88,959
330
1,144
19,197
239,963
215966,250
479,925
4811,175
220777,425
88,311
360
1,148
19,255
240,688
216618,750
481,375
5291,100
221909,850
88,764
390
1,149
19,269
240,863
216776,250
481,725
5772,475
222548,725
89,019
420
1,143
19,167
239,588
215628,750
479,175
6254,200
221882,950
88,753
450
1,149
19,276
240,950
216855,000
481,900
6733,375
223588,375
89,435
480
1,150
19,293
241,163
217046,250
482,325
7215,275
224261,525
89,705
510
1,147
19,234
240,425
216382,500
480,850
7697,600
224080,100
89,632
540
1,151
19,310
241,375
217237,500
482,750
8178,450
225415,950
90,166
570
1,151
19,310
241,375
217237,500
482,750
8661,200
225898,700
90,359
600
1,151
19,311
241,388
217248,750
482,775
9143,950
226392,700
90,557
630
1,151
19,314
241,425
217282,500
482,850
9626,725
226909,225
90,764
660
1,152
19,319
241,488
217338,750
482,975
10109,575
227448,325
90,979
690
1,158
19,418
242,725
218452,500
485,450
10592,550
229045,050
91,618
720
1,163
19,501
243,763
219386,250
487,525
11078,000
230464,250
92,186
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
c. Disolusi F3(3)
Waktu
(menit)
Absorbansi
Konsentrasi
[] x FP
[] dalam
900 ml
[]
dalam 2
ml
Faktor
Penambahan
Total Obat
%
Kumulatif
0
0,000
0,000
0,000
0,000
0,000
0,000
0,000
0,000
5
0,154
2,543
31,788
28608,750
63,575
0,000
28608,750
11,444
10
0,253
4,217
52,713
47441,250
105,425
63,575
47504,825
19,002
15
0,439
7,341
91,763
82586,250
183,525
169,000
82755,250
33,102
30
0,799
13,388
167,350
150615,000
334,700
352,525
150967,525
60,387
60
0,983
16,478
205,975
185377,500
411,950
687,225
186064,725
74,426
90
1,030
17,278
215,975
194377,500
431,950
1099,175
195476,675
78,191
120
1,054
17,672
220,900
198810,000
441,800
1531,125
200341,125
80,136
150
1,088
18,252
228,150
205335,000
456,300
1972,925
207307,925
82,923
180
1,131
18,971
237,138
213423,750
474,275
2429,225
215852,975
86,341
210
1,141
19,135
239,188
215268,750
478,375
2903,500
218172,250
87,269
240
1,146
19,231
240,388
216348,750
480,775
3381,875
219730,625
87,892
270
1,146
19,222
240,275
216247,500
480,550
3862,650
220110,150
88,044
300
1,155
19,378
242,225
218002,500
484,450
4343,200
222345,700
88,938
330
1,147
19,244
240,550
216495,000
481,100
4827,650
221322,650
88,529
360
1,147
19,235
240,438
216393,750
480,875
5308,750
221702,500
88,681
390
1,148
19,259
240,738
216663,750
481,475
5789,625
222453,375
88,981
420
1,143
19,166
239,575
215617,500
479,150
6271,100
221888,600
88,755
450
1,149
19,270
240,875
216787,500
481,750
6750,250
223537,750
89,415
480
1,151
19,311
241,388
217248,750
482,775
7232,000
224480,750
89,792
510
1,152
19,323
241,538
217383,750
483,075
7714,775
225098,525
90,039
540
1,149
19,278
240,975
216877,500
481,950
8197,850
225075,350
90,030
570
1,149
19,278
240,975
216877,500
481,950
8679,800
225557,300
90,223
600
1,149
19,279
240,988
216888,750
481,975
9161,750
226050,500
90,420
630
1,151
19,299
241,238
217113,750
482,475
9643,725
226757,475
90,703
660
1,152
19,317
241,463
217316,250
482,925
10126,200
227442,450
90,977
690
1,158
19,421
242,763
218486,250
485,525
10609,125
229095,375
91,638
720
1,162
19,500
243,750
219375,000
487,500
11094,650
230469,650
92,188
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
d. Rata-rata Disolusi F3
Waktu
(menit)
0
5
10
15
30
60
90
120
150
180
210
240
270
300
330
360
390
420
450
480
510
540
570
600
630
660
690
720
I
0
10,958
19,541
33,075
60,36
72,212
78,177
80,159
82,882
86,318
87,21
87,896
87,989
88,902
88,578
88,766
88,985
88,751
89,397
89,688
89,98
90,115
90,218
90,415
90,765
90,981
91,62
92,187
%Kumulatif
II
0
10,994
19,563
33,039
60,356
71,231
78,139
80,125
82,925
86,361
87,217
87,885
88,28
88,959
88,311
88,764
89,019
88,753
89,435
89,705
89,632
90,166
90,359
90,557
90,764
90,979
91,618
92,186
III
0
11,444
19,002
33,102
60,387
74,426
78,191
80,136
82,923
86,341
87,269
87,892
88,044
88,938
88,529
88,681
88,981
88,755
89,415
89,792
90,039
90,03
90,223
90,42
90,703
90,977
91,638
92,188
Rata-rata
0,000
11,132
19,369
33,072
60,368
72,623
78,169
80,140
82,910
86,340
87,232
87,891
88,104
88,933
88,473
88,737
88,995
88,753
89,416
89,728
89,884
90,104
90,267
90,464
90,744
90,979
91,625
92,187
SD
0,000
0,007
0,318
0,030
0,016
0,009
0,023
0,018
0,023
0,023
0,028
0,006
0,157
0,030
0,139
0,053
0,025
0,004
0,021
0,051
0,216
0,073
0,083
0,084
0,040
0,007
0,006
0,004
600
700
e. Grafik %Kumulatif Vs Waktu (F3)
100
80
60
40
20
0
0
100
200
300
400
500
800
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
2.
Disolusi Film F4
a. Disolusi F4 (1)
[] dalam
[] dalam
Faktor
%
900 ml
2 ml
Penambahan
Total Obat
Kumulatif
Waktu
Absorbansi
Konsentrasi
[] x FP
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,095
1,554
19,425
17482,500
38,850
0,000
17482,500
6,993
10
0,188
3,123
39,038
35133,750
78,075
37,650
35171,400
14,069
15
0,283
4,724
59,050
53145,000
118,100
80,975
53225,975
21,290
30
0,752
12,6
157,500
141750,000
315,000
207,175
141957,175
56,783
60
0,914
15,322
191,525
172372,500
383,050
528,975
172901,475
69,161
90
0,947
15,877
198,463
178616,250
396,925
883,275
179499,525
71,800
120
0,981
16,444
205,550
184995,000
411,100
1263,700
186258,700
74,503
150
1,027
17,215
215,188
193668,750
430,375
1657,375
195326,125
78,130
180
1,054
17,675
220,938
198843,750
441,875
2065,625
200909,375
80,364
210
1,072
17,984
224,800
202320,000
449,600
2487,100
204807,100
81,923
240
1,086
18,219
227,738
204963,750
455,475
2922,975
207886,725
83,155
270
1,098
18,412
230,150
207135,000
460,300
3367,650
210502,650
84,201
300
1,104
18,523
231,538
208383,750
463,075
3844,725
212228,475
84,891
330
1,111
18,635
232,938
209643,750
465,875
4325,700
213969,450
85,588
360
1,112
18,647
233,088
209778,750
466,175
4801,775
214580,525
85,832
390
1,112
18,652
233,150
209835,000
466,300
5279,950
215114,950
86,046
420
1,113
18,668
233,350
210015,000
466,700
5758,175
215773,175
86,309
450
1,113
18,669
233,363
210026,250
466,725
6232,000
216258,250
86,503
480
1,113
18,66
233,250
209925,000
466,500
6710,475
216635,475
86,654
510
1,113
18,662
233,275
209947,500
466,550
7189,400
217136,900
86,855
540
1,113
18,666
233,325
209992,500
466,650
7666,850
217659,350
87,064
570
1,113
18,667
233,338
210003,750
466,675
8146,100
218149,850
87,260
600
1,113
18,669
233,363
210026,250
466,725
8624,750
218651,000
87,460
630
1,113
18,673
233,413
210071,250
466,825
9101,400
219172,650
87,669
660
1,113
18,67
233,375
210037,500
466,750
9581,050
219618,550
87,847
690
1,113
18,674
233,425
210082,500
466,850
10060,725
220143,225
88,057
720
1,113
18,675
233,438
210093,750
466,875
10540,850
220634,600
88,254
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
b. Disolusi F4 (2)
[] dalam
[] dalam
Faktor
900 ml
2 ml
Penambahan
Total Obat
%
Waktu
Absorbansi
Konsentrasi
[] x FP
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,100
1,645
20,563
18506,250
41,125
0,000
18506,250
7,403
10
0,180
2,987
37,338
33603,750
74,675
41,125
33644,875
13,458
15
0,282
4,701
58,763
52886,250
117,525
115,800
53002,050
21,201
30
0,753
12,617
157,713
141941,250
315,425
233,325
142174,575
56,870
60
0,824
13,818
172,725
155452,500
345,450
548,750
156001,250
62,401
90
0,874
14,651
183,138
164823,750
366,275
894,200
165717,950
66,287
120
0,935
15,670
195,875
176287,500
391,750
1260,475
177547,975
71,019
150
0,977
16,376
204,700
184230,000
409,400
1652,225
185882,225
74,353
180
1,066
17,877
223,463
201116,250
446,925
2061,625
203177,875
81,271
210
1,084
18,186
227,325
204592,500
454,650
2508,550
207101,050
82,840
240
1,098
18,421
230,263
207236,250
460,525
2963,200
210199,450
84,080
270
1,110
18,614
232,675
209407,500
465,350
3423,725
212831,225
85,132
300
1,116
18,725
234,063
210656,250
468,125
3889,075
214545,325
85,818
330
1,123
18,837
235,463
211916,250
470,925
4357,200
216273,450
86,509
360
1,124
18,849
235,613
212051,250
471,225
4828,125
216879,375
86,752
390
1,124
18,854
235,675
212107,500
471,350
5299,350
217406,850
86,963
420
1,125
18,870
235,875
212287,500
471,750
5770,700
218058,200
87,223
450
1,125
18,871
235,888
212298,750
471,775
6242,450
218541,200
87,416
480
1,125
18,862
235,775
212197,500
471,550
6714,225
218911,725
87,565
510
1,125
18,864
235,800
212220,000
471,600
7185,775
219405,775
87,762
540
1,125
18,868
235,850
212265,000
471,700
7657,375
219922,375
87,969
570
1,125
18,869
235,863
212276,250
471,725
8129,075
220405,325
88,162
600
1,125
18,871
235,888
212298,750
471,775
8600,800
220899,550
88,360
630
1,125
18,875
235,938
212343,750
471,875
9072,575
221416,325
88,567
660
1,125
18,872
235,900
212310,000
471,800
9544,450
221854,450
88,742
690
1,125
18,876
235,950
212355,000
471,900
10016,250
222371,250
88,949
720
1,125
18,877
235,963
212366,250
471,925
10488,150
222854,400
89,142
Kumulatif
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
c. Disolusi F4 (3)
[] dalam
[] dalam
Faktor
900 ml
2 ml
Penambahan
Total Obat
%
Waktu
Absorbansi
Konsentrasi
[] x FP
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,097
1,597
19,963
17966,250
39,925
0,000
17966,250
7,187
10
0,188
3,129
39,113
35201,250
78,225
39,925
35241,175
14,096
15
0,273
4,545
56,813
51131,250
113,625
118,150
51249,400
20,500
30
0,734
12,296
153,700
138330,000
307,400
231,775
138561,775
55,425
60
0,813
13,631
170,388
153348,750
340,775
539,175
153887,925
61,555
90
0,865
14,495
181,188
163068,750
362,375
879,950
163948,700
65,579
120
0,915
15,349
191,863
172676,250
383,725
1242,325
173918,575
69,567
150
0,973
16,322
204,025
183622,500
408,050
1626,050
185248,550
74,099
180
1,073
18,003
225,038
202533,750
450,075
2034,100
204567,850
81,827
210
1,092
18,312
228,900
206010,000
457,800
2484,175
208494,175
83,398
240
1,106
18,547
231,838
208653,750
463,675
2941,975
211595,725
84,638
270
1,117
18,740
234,250
210825,000
468,500
3405,650
214230,650
85,692
300
1,124
18,851
235,638
212073,750
471,275
3874,150
215947,900
86,379
330
1,131
18,963
237,038
213333,750
474,075
4345,425
217679,175
87,072
360
1,131
18,975
237,188
213468,750
474,375
4819,500
218288,250
87,315
390
1,132
18,980
237,250
213525,000
474,500
5293,875
218818,875
87,528
420
1,132
18,996
237,450
213705,000
474,900
5768,375
219473,375
87,789
450
1,133
18,997
237,463
213716,250
474,925
6243,275
219959,525
87,984
480
1,132
18,988
237,350
213615,000
474,700
6718,200
220333,200
88,133
510
1,132
18,990
237,375
213637,500
474,750
7192,900
220830,400
88,332
540
1,132
18,994
237,425
213682,500
474,850
7667,650
221350,150
88,540
570
1,132
18,995
237,438
213693,750
474,875
8142,500
221836,250
88,735
600
1,133
18,997
237,463
213716,250
474,925
8617,375
222333,625
88,933
630
1,133
19,001
237,513
213761,250
475,025
9092,300
222853,550
89,141
660
1,133
18,998
237,475
213727,500
474,950
9567,325
223294,825
89,318
690
1,133
19,002
237,525
213772,500
475,050
10042,275
223814,775
89,526
720
1,133
19,003
237,538
213783,750
475,075
10517,325
224301,075
89,720
Kumulatif
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
d. Rata-rata Disolusi F4
Waktu
I
0
5
10
15
30
60
90
120
150
180
210
240
270
300
330
360
390
420
450
480
510
540
570
600
630
660
690
720
0
6,993
14,069
21,29
56,783
69,161
71,8
74,503
78,13
80,364
81,923
83,155
84,201
84,891
85,588
85,832
86,046
86,309
86,503
86,654
86,855
87,064
87,26
87,46
87,669
87,847
88,057
88,254
%Kumulatif
II
0
7,403
13,458
21,201
56,87
62,401
66,287
71,019
74,353
81,271
82,84
84,08
85,132
85,818
86,509
86,752
86,963
87,223
87,416
87,565
87,762
87,969
88,162
88,36
88,567
88,742
88,949
89,142
III
0
7,187
14,096
20,5
55,425
61,555
65,579
69,567
74,099
81,827
83,398
84,638
85,692
86,379
87,072
87,315
87,528
87,789
87,984
88,133
88,332
88,54
88,735
88,933
89,141
89,318
89,526
89,72
Rata-rata
0,000
7,194
13,874
20,997
56,359
64,372
67,889
71,696
75,527
81,154
82,720
83,958
85,008
85,696
86,390
86,633
86,846
87,107
87,301
87,451
87,650
87,858
88,052
88,251
88,459
88,636
88,844
89,039
SD
0,000
0,205
0,361
0,433
0,810
4,169
3,406
2,537
2,258
0,738
0,745
0,749
0,753
0,751
0,749
0,749
0,748
0,747
0,747
0,746
0,745
0,744
0,744
0,743
0,742
0,741
0,740
0,738
e. Grafik %Kumulatif Vs Waktu (F4)
100
80
60
40
20
0
0
100
200
300
400
500
600
700
800
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
3.
Disolusi Film F5
a. Disolusi F5 (1)
[]
Waktu
[] dalam
dalam 2
Faktor
%
(menit)
Absorbansi
Konsentrasi
[] x FP
900 ml
ml
Penambahan
Total Obat
Kumulatif
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,071
1,162
14,525
13072,500
29,050
0,000
13072,500
5,229
10
0,093
1,522
19,025
17122,500
38,050
29,050
17151,550
6,861
15
0,259
4,308
53,850
48465,000
107,700
67,100
48532,100
19,413
30
0,676
11,332
141,650
127485,000
283,300
174,800
127659,800
51,064
60
0,795
13,319
166,488
149838,750
332,975
458,100
150296,850
60,119
90
0,848
14,208
177,600
159840,000
355,200
791,075
160631,075
64,252
120
0,895
15,006
187,575
168817,500
375,150
1146,275
169963,775
67,986
150
0,947
15,877
198,463
178616,250
396,925
1521,425
180137,675
72,055
180
0,986
16,532
206,650
185985,000
413,300
1918,350
187903,350
75,161
210
1,021
17,115
213,938
192543,750
427,875
2331,650
194875,400
77,950
240
1,045
17,522
219,025
197122,500
438,050
2759,525
199882,025
79,953
270
1,086
18,208
227,600
204840,000
455,200
3197,575
208037,575
83,215
300
1,100
18,458
230,725
207652,500
461,450
3652,775
211305,275
84,522
330
1,106
18,555
231,938
208743,750
463,875
4114,225
212857,975
85,143
360
1,106
18,556
231,950
208755,000
463,900
4578,100
213333,100
85,333
390
1,103
18,505
231,313
208181,250
462,625
5042,000
213223,250
85,289
420
1,110
18,622
232,775
209497,500
465,550
5504,625
215002,125
86,001
450
1,110
18,626
232,825
209542,500
465,650
5970,175
215512,675
86,205
480
1,106
18,549
231,863
208676,250
463,725
6435,825
215112,075
86,045
510
1,111
18,631
232,888
209598,750
465,775
6899,550
216498,300
86,599
540
1,112
18,646
233,075
209767,500
466,150
7365,325
217132,825
86,853
570
1,122
18,826
235,325
211792,500
470,650
7831,475
219623,975
87,850
600
1,122
18,821
235,263
211736,250
470,525
8302,125
220038,375
88,015
630
1,122
18,823
235,288
211758,750
470,575
8772,650
220531,400
88,213
660
1,123
18,831
235,388
211848,750
470,775
9243,225
221091,975
88,437
690
1,123
18,833
235,413
211871,250
470,825
9714,000
221585,250
88,634
720
1,123
18,834
235,425
211882,500
470,850
10184,825
222067,325
88,827
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
b. Disolusi F5 (2)
Waktu
(menit)
Absorbansi
Konsentrasi
[] x FP
[] dalam
900 ml
[]
dalam 2
ml
Faktor
Penambahan
Total Obat
%
Kumulatif
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,068
1,097
13,713
12341,250
27,425
0,000
12341,250
4,937
10
0,090
1,477
18,463
16616,250
36,925
27,425
16643,675
6,657
15
0,255
4,254
53,175
47857,500
106,350
64,350
47921,850
19,169
30
0,673
11,267
140,838
126753,750
281,675
170,700
126924,450
50,770
60
0,792
13,274
165,925
149332,500
331,850
452,375
149784,875
59,914
90
0,844
14,154
176,925
159232,500
353,850
784,225
160016,725
64,007
120
0,891
14,941
186,763
168086,250
373,525
1138,075
169224,325
67,690
150
0,944
15,832
197,900
178110,000
395,800
1511,600
179621,600
71,849
180
0,983
16,478
205,975
185377,500
411,950
1907,400
187284,900
74,914
210
1,017
17,05
213,125
191812,500
426,250
2319,350
194131,850
77,653
240
1,042
17,477
218,463
196616,250
436,925
2745,600
199361,850
79,745
270
1,082
18,154
226,925
204232,500
453,850
3182,525
207415,025
82,966
300
1,097
18,393
229,913
206921,250
459,825
3636,375
210557,625
84,223
330
1,104
18,51
231,375
208237,500
462,750
4096,200
212333,700
84,933
360
1,103
18,502
231,275
208147,500
462,550
4558,950
212706,450
85,083
390
1,099
18,44
230,500
207450,000
461,000
5021,500
212471,500
84,989
420
1,108
18,577
232,213
208991,250
464,425
5482,500
214473,750
85,790
450
1,107
18,572
232,150
208935,000
464,300
5946,925
214881,925
85,953
480
1,102
18,484
231,050
207945,000
462,100
6411,225
214356,225
85,742
510
1,108
18,586
232,325
209092,500
464,650
6873,325
215965,825
86,386
540
1,108
18,592
232,400
209160,000
464,800
7337,975
216497,975
86,599
570
1,119
18,761
234,513
211061,250
469,025
7802,775
218864,025
87,546
600
1,119
18,776
234,700
211230,000
469,400
8271,800
219501,800
87,801
630
1,119
18,769
234,613
211151,250
469,225
8741,200
219892,450
87,957
660
1,119
18,766
234,575
211117,500
469,150
9210,425
220327,925
88,131
690
1,120
18,788
234,850
211365,000
469,700
9679,575
221044,575
88,418
720
1,120
18,78
234,750
211275,000
469,500
10149,275
221424,275
88,570
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
c. Disolusi F5 (3)
Waktu
(menit)
Absorbansi
Konsentrasi
[] x FP
[] dalam
900 ml
[]
dalam 2
ml
Faktor
Penambahan
Total Obat
%
Kumulatif
0
0,000
0
0,000
0,000
0,000
0,000
0,000
0,000
5
0,075
1,218
15,225
13702,500
30,450
0,000
13702,500
5,481
10
0,149
2,464
30,800
27720,000
61,600
30,450
27750,450
11,100
15
0,314
5,241
65,513
58961,250
131,025
92,050
59053,300
23,621
30
0,680
11,388
142,350
128115,000
284,700
223,075
128338,075
51,335
60
0,851
14,261
178,263
160436,250
356,525
507,775
160944,025
64,378
90
0,903
15,141
189,263
170336,250
378,525
864,300
171200,550
68,480
120
0,953
15,987
199,838
179853,750
399,675
1242,825
181096,575
72,439
150
1,003
16,819
210,238
189213,750
420,475
1642,500
190856,250
76,343
180
1,041
17,465
218,313
196481,250
436,625
2062,975
198544,225
79,418
210
1,060
17,778
222,225
200002,500
444,450
2499,600
202502,100
81,001
240
1,101
18,464
230,800
207720,000
461,600
2944,050
210664,050
84,266
270
1,086
18,221
227,763
204986,250
455,525
3405,650
208391,900
83,357
300
1,093
18,332
229,150
206235,000
458,300
3861,175
210096,175
84,038
330
1,097
18,4
230,000
207000,000
460,000
4319,475
211319,475
84,528
360
1,092
18,312
228,900
206010,000
457,800
4779,475
210789,475
84,316
390
1,093
18,328
229,100
206190,000
458,200
5237,275
211427,275
84,571
420
1,101
18,465
230,813
207731,250
461,625
5695,475
213426,725
85,371
450
1,100
18,448
230,600
207540,000
461,200
6157,100
213697,100
85,479
480
1,096
18,375
229,688
206718,750
459,375
6618,300
213337,050
85,335
510
1,105
18,532
231,650
208485,000
463,300
7077,675
215562,675
86,225
540
1,104
18,518
231,475
208327,500
462,950
7540,975
215868,475
86,347
570
1,098
18,419
230,238
207213,750
460,475
8003,925
215217,675
86,087
600
1,105
18,541
231,763
208586,250
463,525
8464,400
217050,650
86,820
630
1,105
18,538
231,725
208552,500
463,450
8927,925
217480,425
86,992
660
1,115
18,696
233,700
210330,000
467,400
9391,375
219721,375
87,889
690
1,117
18,731
234,138
210723,750
468,275
9858,775
220582,525
88,233
720
1,116
18,715
233,938
210543,750
467,875
10327,050
220870,800
88,348
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
d. Rata-rata Disolusi F5
Waktu
(menit)
0
5
10
15
30
60
90
120
150
180
210
240
270
300
330
360
390
420
450
480
510
540
570
600
630
660
690
720
I
0
5,229
6,861
19,413
51,064
60,119
64,252
67,986
72,055
75,161
77,95
79,953
83,215
84,522
85,143
85,333
85,289
86,001
86,205
86,045
86,599
86,853
87,85
88,015
88,213
88,437
88,634
88,827
%Kumulatif
II
0
4,937
6,657
19,169
50,77
59,914
64,007
67,69
71,849
74,914
77,653
79,745
82,966
84,223
84,933
85,083
84,989
85,79
85,953
85,742
86,386
86,599
87,546
87,801
87,957
88,131
88,418
88,57
III
0
5,481
11,1
23,621
51,335
64,378
68,48
72,439
76,343
79,418
81,001
84,266
83,357
84,038
84,528
84,316
84,571
85,371
85,479
85,335
86,225
86,347
86,087
86,82
86,992
87,889
88,233
88,348
Rata-rata
0,000
5,216
8,206
20,734
51,056
61,470
65,580
69,372
73,416
76,498
78,868
81,321
83,179
84,261
84,868
84,911
84,950
85,721
85,879
85,707
86,403
86,600
87,161
87,545
87,721
88,152
88,428
88,582
SD
0,000
0,272
2,508
2,503
0,283
2,520
2,515
2,661
2,537
2,532
1,853
2,552
0,198
0,244
0,313
0,530
0,361
0,321
0,369
0,356
0,188
0,253
0,942
0,637
0,644
0,275
0,201
0,240
e. Grafik %Kumulatif Vs Waktu (F5)
100
80
60
40
20
0
0
100
200
300
400
500
600
700
800
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
4.
Disolusi Film F6
a. Disolusi F6 (1)
[]
Waktu
[] dalam
dalam 2
Faktor
%
(menit)
Absorbansi
Konsentrasi
[] x FP
900 ml
ml
Penambahan
Total Obat
Kumulatif
0
0,000
0,000
0,000
0,000
0,000
0,000
0,000
0,000
5
0,044
0,700
8,750
7875,000
17,500
0,000
7875,000
3,150
10
0,062
1,000
12,500
11250,000
25,000
17,500
11267,500
4,507
15
0,232
3,869
48,363
43526,250
96,725
42,500
43568,750
17,428
30
0,649
10,870
135,875
122287,500
271,750
139,225
122426,725
48,971
60
0,762
12,767
159,588
143628,750
319,175
410,975
144039,725
57,616
90
0,817
13,686
171,075
153967,500
342,150
730,150
154697,650
61,879
120
0,874
14,645
183,063
164756,250
366,125
1072,300
165828,550
66,331
150
0,919
15,415
192,688
173418,750
385,375
1438,425
174857,175
69,943
180
0,953
15,980
199,750
179775,000
399,500
1823,800
181598,800
72,640
210
0,995
16,683
208,538
187683,750
417,075
2223,300
189907,050
75,963
240
1,019
17,083
213,538
192183,750
427,075
2640,375
194824,125
77,930
270
1,058
17,746
221,825
199642,500
443,650
3067,450
202709,950
81,084
300
1,073
17,996
224,950
202455,000
449,900
3511,100
205966,100
82,386
330
1,075
18,033
225,413
202871,250
450,825
3961,000
206832,250
82,733
360
1,080
18,117
226,463
203816,250
452,925
4411,825
208228,075
83,291
390
1,081
18,133
226,663
203996,250
453,325
4864,750
208861,000
83,544
420
1,077
18,070
225,875
203287,500
451,750
5318,075
208605,575
83,442
450
1,079
18,104
226,300
203670,000
452,600
5769,825
209439,825
83,776
480
1,085
18,200
227,500
204750,000
455,000
6222,425
210972,425
84,389
510
1,083
18,169
227,113
204401,250
454,225
6677,425
211078,675
84,431
540
1,087
18,234
227,925
205132,500
455,850
7131,650
212264,150
84,906
570
1,097
18,394
229,925
206932,500
459,850
7587,500
214520,000
85,808
600
1,103
18,493
231,163
208046,250
462,325
8047,350
216093,600
86,437
630
1,102
18,491
231,138
208023,750
462,275
8509,675
216533,425
86,613
660
1,097
18,401
230,013
207011,250
460,025
8971,950
215983,200
86,393
690
1,098
18,423
230,288
207258,750
460,575
9431,975
216690,725
86,676
720
1,107
18,567
232,088
208878,750
464,175
9892,550
218771,300
87,509
Universitas Sumatera Utara
Lampiran 7. (Lanjutan)
b. Disolusi F6 (2)
Waktu
(menit)
Absorbansi
Konsentrasi
[] x FP
[] dalam
900 ml
[]
dalam 2
ml
Faktor
Penambahan
Total Obat
%
Kumulatif
0
0,000
0,000
0,000
0,000
0,