STUDI KOMPUTASI ISOPANDURATIN A, 4-HIDROKSIPANDURATIN A, KAEMPFERIDA DAN ETIL p-METOKSISINAMAT DARI TANAMAN SUKU ZINGIBERACEAE SEBAGAI INHIBITOR TIROSINASE DAN ALPHA MELANOCTYE STIMULATING HORMONE.
ABSTRAK
IV FA
ER KU
SI LT
TA A
S SF
PA A
D RM
JA A
D SI
JA
R
AN
Tirosinase dan alpha melanocyte stimulating hormone (α-MSH) berperan dalam
proses pigmentasi kulit. Isopanduratin A dan 4-hidroksipanduratin A rimpang
Kaempferia pandurata Roxb., kaempferida rimpang Alpinia officinarum Hance.
dan etil p-metoksisinamat (EPMS) rimpang Kaempferia galanga L. terbukti
memiliki aktivitas penghambatan tirosinase secara empiris dan in vitro. Studi
docking molekul dilakukan untuk memvisualisasikan interaksi tingkat molekul
keempat senyawa dengan tirosinase dan α-MSH kemudian aktivitasnya
dibandingkan dengan arbutin, asam kojik, dan hidrokuinon. Hasil menunjukkan
bahwa aktivitas penghambatan tirosinase dan α-MSH berturut-turut mulai dari
yang terbaik adalah kaempferida, isopanduratin A, 4-hidroksipanduratin A, dan
EPMS. Dapat disimpulkan senyawa tersebut lebih mudah berinteraksi dengan
tirosinase dibandingkan α-MSH. Keempat senyawa kecuali EPMS berpotensi
menghambat tirosinase lebih baik dibandingkan arbutin, asam kojik, dan
hidrokuinon.
U
N
Kata kunci: Isopanduratin A, 4-Hidroksipanduratin A, Kaempferida, EPMS,
Tirosinase, α-MSH, Docking molekul
iii
ABSTRACT
IV FA
ER KU
SI LT
TA A
S SF
PA A
D RM
JA A
D SI
JA
R
AN
Tyrosinase and alpha melanocyte stimulating hormone (α-MSH) involved in skin
pigmentation process. Isopanduratin A and 4-hydroxypanduratin A of Kaempferia
pandurata Roxb. rhizome, kaempferide of Alpinia officinarum Hance rhizome and
ethyl p-metoxycinnamate (EPMS) of Kaempferia galanga L. rhizhome have shown
inhibitory activity of tyrosinase both empirically and in vitro. Molecular docking
studies has been performed to visualize molecular interaction of these
compounds with tyrosinase and α-MSH then the activity was compared to arbutin,
kojic acid, and hidroquinon. The results indicate that the inhibitory activity of
tyrosinase and α-MSH in a row starting from the best are kaempferide,
isopanduratin A, 4-hydroxypanduratin A, and EPMS. In conclusion these
compounds interacted more easily with tyrosinase than α-MSH. These four
compounds except EPMS potentially inhibit tyrosinase better than arbutin, kojic
acid, and hydroquinone.
U
N
Key words: Isopanduratin A, 4-Hydroxypanduratin A, Kaempferide, EPMS,
Tyrosinase , α-MSH, Molecular docking
iv
IV FA
ER KU
SI LT
TA A
S SF
PA A
D RM
JA A
D SI
JA
R
AN
Tirosinase dan alpha melanocyte stimulating hormone (α-MSH) berperan dalam
proses pigmentasi kulit. Isopanduratin A dan 4-hidroksipanduratin A rimpang
Kaempferia pandurata Roxb., kaempferida rimpang Alpinia officinarum Hance.
dan etil p-metoksisinamat (EPMS) rimpang Kaempferia galanga L. terbukti
memiliki aktivitas penghambatan tirosinase secara empiris dan in vitro. Studi
docking molekul dilakukan untuk memvisualisasikan interaksi tingkat molekul
keempat senyawa dengan tirosinase dan α-MSH kemudian aktivitasnya
dibandingkan dengan arbutin, asam kojik, dan hidrokuinon. Hasil menunjukkan
bahwa aktivitas penghambatan tirosinase dan α-MSH berturut-turut mulai dari
yang terbaik adalah kaempferida, isopanduratin A, 4-hidroksipanduratin A, dan
EPMS. Dapat disimpulkan senyawa tersebut lebih mudah berinteraksi dengan
tirosinase dibandingkan α-MSH. Keempat senyawa kecuali EPMS berpotensi
menghambat tirosinase lebih baik dibandingkan arbutin, asam kojik, dan
hidrokuinon.
U
N
Kata kunci: Isopanduratin A, 4-Hidroksipanduratin A, Kaempferida, EPMS,
Tirosinase, α-MSH, Docking molekul
iii
ABSTRACT
IV FA
ER KU
SI LT
TA A
S SF
PA A
D RM
JA A
D SI
JA
R
AN
Tyrosinase and alpha melanocyte stimulating hormone (α-MSH) involved in skin
pigmentation process. Isopanduratin A and 4-hydroxypanduratin A of Kaempferia
pandurata Roxb. rhizome, kaempferide of Alpinia officinarum Hance rhizome and
ethyl p-metoxycinnamate (EPMS) of Kaempferia galanga L. rhizhome have shown
inhibitory activity of tyrosinase both empirically and in vitro. Molecular docking
studies has been performed to visualize molecular interaction of these
compounds with tyrosinase and α-MSH then the activity was compared to arbutin,
kojic acid, and hidroquinon. The results indicate that the inhibitory activity of
tyrosinase and α-MSH in a row starting from the best are kaempferide,
isopanduratin A, 4-hydroxypanduratin A, and EPMS. In conclusion these
compounds interacted more easily with tyrosinase than α-MSH. These four
compounds except EPMS potentially inhibit tyrosinase better than arbutin, kojic
acid, and hydroquinone.
U
N
Key words: Isopanduratin A, 4-Hydroxypanduratin A, Kaempferide, EPMS,
Tyrosinase , α-MSH, Molecular docking
iv