Antibiotics for very severe pneumonia

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13.11 Antibiotics for Meningitis

1. here is need for comparative studies on dose and frequency of cetriaxone, 2. Improved surveillance for antibiotic resistance among pathogens causing meningitis 3. he role and accuracy of rapid point of care diagnostic tests, that can be used in district hospitals that do not have culture facilities 4. Studies of the aetiology on meningoencephalitis in settings with high coverage of SPHib vaccine coverage

13.12 Antibiotics for Acute Otitis Media

1. RCTs in developing countries with pragmatic deinition of otitis 2. Follow up studies in developing countries to quantify complication rates, especially in high prevalence HIV settings 3. Systematic review of treatment of otorrhoea as may merit separate guidelines 4. RCT of diferent durations of antibiotic treatment including BD versus TID

13.13 Antibiotics for Typhoid Fever

1. Develop point of care diagnostic tests with higher speciicity than current tests 2. Deine local resistance patterns 3. Studies of basic epidemiology of typhoid in Africa 4. Continuing need for efective vaccine

13.14 Antibiotics for severe acute malnutrition

1. he role of metronidazole in controlling intestinal bacterial overgrowth in children with Severe Acute Malnutrition? here is currently one ongoing trial in Senegal 2. he efectiveness of diferent antibiotic regimens in the treatment of complicated SAM. 3. A randomised controlled trial on the role of antibiotics in uncomplicated SAM.

13.15 Oxygen systems and delivery methods

1. Large-scale efectiveness trials of improved oxygen systems on outcomes from pneumonia 2. Studies of alternative power supplies to run oxygen concentrators and pulse oximeters in remote settings where power supplies are unreliable 3. he role of inexpensive forms of CPAP in the management of severe pneumonia 4. Are there safe methods for cleaning and reuse of oxygen delivery equipment in high HIV prevalence settings?

13.16 Pulse oximetry

1. Studies of diferent types of pulse oximetry – such as hand-held devices – in ield settings