Appendix Keseragaman Kandungan Digoksin Dalam Sediaan Tablet Dengan Metode Kromatografi Cair Kinerja Tinggi (Kckt)
Lampiran 1
Alat Kromatografi Cair Kinerja Tinggi (KCKT)
Lampiran 2
Alat Ultrasonic Cleaner
Lampiran 3
Neraca Mikro
Neraca Makro
Lampiran 4
Lampiran 5
Lampiran 6
KK
Lu
=
Lb
×Kb
Bb Fu
× ×
Ke Fb
96,0304
-
KK2=
509211
×
-
KK3=
536276
×
4,274
-
KK4=
511422
×
4,274
-
KK5=
515407
×
4,274
-
KK6=
520505
×
4,274
-
KK7=
489712
×
-
KK8=
520136
×
4,274
-
KK9=
484756
×
4,274
-
KK10=
-
466989
466989
466989
466989
466989
466989
466989
466989
508593
466989
4,274
0,25
5
×97,545= 95,5957
5
×97,545= 91,3110
5
×97,545= 92,0197
×
5
×97,545= 92,9286
×
5
×97,545= 87,4338
5
×97,545= 92,8702
5
×97,545= 86,5499
100
×
100
×
100
×
0,25
100
100
4,274
0,25
0,25
100
×
100
×
4,274
×
466989
×97,545= 90,9191
0,25
0,25
537852
5
×
0,25
0,25
KK1=
0,25
100
×
5
×97,545= 90,8024
100
×
4,274
0,25
×
5
×97,545=
100
-
96,0304+90,9191+95,5957+91,3110+92,0197+92,9286+
87,4338+92,8702+86,5499+90,8024
KKrata-rata=
10
916,4688
=
SD
10
�
= ��
= 91,65
�����
(�−�)2
�1 �−1
�
96,03−91,64 2
90,91−91,64 2
⃓
�
� +�
� +
⃓
9
9
⃓
⃓
⃓
91,31−91,64 2
90,59−91,64 2
⃓
� +�
� +
�
⃓
9
9
⃓
⃓
92,92−91,64 2
⃓ 92,01−91,64 2
= ⃓�
+
�
� +
�
⃓
9
9
⃓
⃓
87,43−91,64 2
86,54−91,64 2
⃓
+
�
� +
�
�
⃓
9
9
⃓
⃓
⃓ 92,87−91,64 2
90,80−91,64 2
� +�
� +
�
9
9
⎷
2,14 + 0,05 + 1,73 + 0,01 + 0,01 + 0,18 +
1,96 + 2,89 + 0,16 + 9,20
=�
AV
= √9,20 = 3,03
AV
= 98,5 – 91,64 + (2 × 3,03) = 14,13
= 98,5 – KKrata-rata + K.S
Alat Kromatografi Cair Kinerja Tinggi (KCKT)
Lampiran 2
Alat Ultrasonic Cleaner
Lampiran 3
Neraca Mikro
Neraca Makro
Lampiran 4
Lampiran 5
Lampiran 6
KK
Lu
=
Lb
×Kb
Bb Fu
× ×
Ke Fb
96,0304
-
KK2=
509211
×
-
KK3=
536276
×
4,274
-
KK4=
511422
×
4,274
-
KK5=
515407
×
4,274
-
KK6=
520505
×
4,274
-
KK7=
489712
×
-
KK8=
520136
×
4,274
-
KK9=
484756
×
4,274
-
KK10=
-
466989
466989
466989
466989
466989
466989
466989
466989
508593
466989
4,274
0,25
5
×97,545= 95,5957
5
×97,545= 91,3110
5
×97,545= 92,0197
×
5
×97,545= 92,9286
×
5
×97,545= 87,4338
5
×97,545= 92,8702
5
×97,545= 86,5499
100
×
100
×
100
×
0,25
100
100
4,274
0,25
0,25
100
×
100
×
4,274
×
466989
×97,545= 90,9191
0,25
0,25
537852
5
×
0,25
0,25
KK1=
0,25
100
×
5
×97,545= 90,8024
100
×
4,274
0,25
×
5
×97,545=
100
-
96,0304+90,9191+95,5957+91,3110+92,0197+92,9286+
87,4338+92,8702+86,5499+90,8024
KKrata-rata=
10
916,4688
=
SD
10
�
= ��
= 91,65
�����
(�−�)2
�1 �−1
�
96,03−91,64 2
90,91−91,64 2
⃓
�
� +�
� +
⃓
9
9
⃓
⃓
⃓
91,31−91,64 2
90,59−91,64 2
⃓
� +�
� +
�
⃓
9
9
⃓
⃓
92,92−91,64 2
⃓ 92,01−91,64 2
= ⃓�
+
�
� +
�
⃓
9
9
⃓
⃓
87,43−91,64 2
86,54−91,64 2
⃓
+
�
� +
�
�
⃓
9
9
⃓
⃓
⃓ 92,87−91,64 2
90,80−91,64 2
� +�
� +
�
9
9
⎷
2,14 + 0,05 + 1,73 + 0,01 + 0,01 + 0,18 +
1,96 + 2,89 + 0,16 + 9,20
=�
AV
= √9,20 = 3,03
AV
= 98,5 – 91,64 + (2 × 3,03) = 14,13
= 98,5 – KKrata-rata + K.S