Saponin : uji busa + HCl

LAMPIRAN 1

54
Universitas Sumatera Utara

LAMPIRAN 2

HASIL PEMERIKSAAN
Menerangkan bahwa mahasiswa/peneliti yang namanya di bawah ini:

Peneliti

:

dr. Dwi Rita Anggraini, M.Kes.

Nama Instansi

:

Departemen Anatomi Fak. Kedokteran USU


Pada pemeriksaan karakterisasi simplisia/ekstrak Benalu Teh diperoleh hasil sebagai berikut:
No.

Pemeriksaan

1

Alkaloid
Reagen Meyer
Reagen Dragendorff
Reagen Bouchardat

2

3
4
5
6
7


8

Glikosida
Reagen Fehling A + B
Reagen Lieberman-Bouchard
Sianogenik : as. pikrat
Antrakinon : amonia
Tanin: FeCl3 4,5%
Triterpen/Steroid: as. Asetat
anhidrat + as. Sulfat p
Flavonoid
Zn/HCl p
Mg/HCl p
Saponin : uji busa + HCl

Hasil

Rujukan
Metode

MMI

Biaya (Rp)

MMI

160.000

MMI
MMI
MMI

45.000
110.000
20.000
35.000

MMI

105.000


MMI

25.000

120.000

End. Putih (+)
End. Coklat; lar.
Kuning (+)
End. Coklat; lar.
Coklat (+)
Lar. Merah (+)
ungu (+)
(-)
(-)
Hijau biru (+)
Hijau menjadi
ungu (+ triterpen)
kuning (+)

Merah jingga (+)
buih mantap (+)

Ket. MMI (Materia Medika Indonesia) Jilid V

55
Universitas Sumatera Utara

LAMPIRAN 3
Data baku penelitian

Kelompok

Waktu

Intervensi

K1- M1

3 mgg


0

K1-M2

3 mgg

0

K1-M3

3 mgg

0

K1-H1

3 mgg

0


K1-H2
P1-M1

3 mgg

0

3 mgg

Benalu teh 1.5g/kgBB

3 mgg

Benalu teh 1.5g/kgBB

3 mgg

Benalu teh 1.5g/kgBB


3 mgg

Benalu teh 1.5g/kgBB

3 mgg

Benalu teh 1.5g/kgBB

6 mgg

0

6 mgg

0

6 mgg

0


6 mgg

0

6 mgg

0

6 mgg

3 mgg 0 3 mgg Benalu teh 1.5g/kgBB

6 mgg

3 mgg 0 3 mgg Benalu teh 1.5g/kgBB

6 mgg

3 mgg 0 3 mgg Benalu teh 1.5g/kgBB


6 mgg

3 mgg 0 3 mgg Benalu teh 1.5g/kgBB

6 mgg

3 mgg 0 3 mgg Benalu teh 1.5g/kgBB

6 mgg

3 mgg 0 3 mgg Benalu teh 3g/kgBB

6 mgg

3 mgg 0 3 mgg Benalu teh 3g/kgBB

6 mgg

3 mgg 0 3 mgg Benalu teh 3g/kgBB


6 mgg

3 mgg 0 3 mgg Benalu teh 3g/kgBB

6 mgg

3 mgg 0 3 mgg Benalu teh 3g/kgBB

P1-M2
P1-M3
P1-H1
P1-H2
K2-M1
K2-M2
K2-H1
K2-H2
K2-H3
P2-M1
P2-M2
P2-M3
P2-M4
P2-H3
P3-M1
P3-M2
P3-M3
P3-H1
P3-H3

BB
awal

BB
akhir

Berat
massa

Ki-67 labelling index

152
150
157
169
143
148
147
128
156
161
137
139
151
116
172
143
174
146
145
164
145
125
180
156
131

174
183
168
188
147
153
145
186
176
179
155
152
164
134
180
196
161
167
160
204
158
139
206
175
168

1.37
3.09
0.76
0.1
0.42
0.22
0.55
0.09
0.38
0.34
0.68
0.26
0.37
0.29
0.32
0.31
0.21
0.64
0.26
0.37
0.32
0.15
0.24
0.14
0.16

1
3
1
1
1
1
3
0
1
0
1
0
3
1
1
1
1
0
0
1
0
0
1
1
0

Keterangan
:
0 = tak ada
1 = lemah
2 = sedang
3 = kuat

56
Universitas Sumatera Utara

LAMPIRAN 4
Explore
Uji normalitas seluruh kelompok
Descriptives
Statistic
BM

Mean

481.60

95% Confidence Interval for Lower Bound

231.01

Mean

Upper Bound

Std. Error
121.415

732.19

5% Trimmed Mean

377.44

Median

320.00

Variance

3.685E5

Std. Deviation

607.074

Minimum

90

Maximum

3090

Range

3000

Interquartile Range

270

Skewness
Kurtosis

3.675

.464

15.117

.902

Tests of Normality
a

Kolmogorov-Smirnov
Statistic
BM

.300

df

Shapiro-Wilk

Sig.
25

.000

Statistic
.542

df

Sig.
25

.000

a. Lilliefors Significance Correction
kesimpulan : distribusi tidak normal

57
Universitas Sumatera Utara

Explore
UJi noormalitas 1 dan 2
BM

Mean

732.00

95% Confidence Interval for Lower Bound
Mean

287.707

81.16

Upper Bound

1382.84

5% Trimmed Mean

636.67

Median

400.00

Variance

8.278E5

Std. Deviation

909.808

Minimum

90

Maximum

3090

Range

3000

Interquartile Range

722

Skewness

2.320

.687

Kurtosis

5.704

1.334

Tests of Normality
a

Kolmogorov-Smirnov
Statistic
BM

.288

df

Shapiro-Wilk

Sig.
10

.019

Statistic
.699

df

Sig.
10

.001

a. Lilliefors Significance Correction
kesimpulan : distribusi tidak normal

58
Universitas Sumatera Utara

Explore
Uji Normalitas kelompok 3, 4, dan 5
Descriptives
Statistic
BM

Mean

314.67

95% Confidence Interval for Lower Bound

227.08

Mean

Upper Bound

Std. Error
40.835

402.25

5% Trimmed Mean

304.07

Median

290.00

Variance

2.501E4

Std. Deviation

158.153

Minimum

140

Maximum

680

Range

540

Interquartile Range

160

Skewness

1.420

.580

Kurtosis

1.754

1.121

Tests of Normality
a

Kolmogorov-Smirnov
Statistic
BM

.230

df

Shapiro-Wilk

Sig.
15

.032

Statistic
.835

df

Sig.
15

.011

a. Lilliefors Significance Correction
kesimpulan: p value < alpha (Ho di tolak)distribusi tidak normal

59
Universitas Sumatera Utara

Kruskal-Wallis Test
Ranks
Kelompok
BM

N

Mean Rank

6 minggu tanpa intervensi

5

10.50

6mg,3mg benalu teh 1,5

5

9.20

6mg,3mg benalu teh 3gr

5

4.30

Total

15

Test Statistics

a,b

BM
Chi-Square

5.374

df

2

Asymp. Sig.

.068

a. Kruskal Wallis Test
b. Grouping Variable:
Kelompok

Explore
UJi Normalitas kelompok 4 dan 5
Descriptives
Statistic
BM

Mean

280.00

95% Confidence Interval for Lower Bound

173.90

Mean

Upper Bound

Std. Error
46.904

386.10

5% Trimmed Mean

267.78

Median

250.00

Variance

2.200E4

Std. Deviation

148.324

Minimum

140

Maximum

640

60
Universitas Sumatera Utara

Range

500

Interquartile Range

175

Skewness

1.719

.687

Kurtosis

3.673

1.334

Tests of Normality
a

Kolmogorov-Smirnov
Statistic
BM

.194

df

Shapiro-Wilk

Sig.

Statistic
*

10

.200

.835

df

Sig.
10

.038

a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
Kesimpulan : p value > alpha (Ho di terima)distribusi normal
T-Test
Group Statistics
Kelompok
BM

6mg,3mg
benalu teh 1,5
6mg,3mg
benalu teh 3gr

N

Mean

Std. Deviation

Std. Error Mean

5

358.00

168.434

75.326

5

202.00

76.942

34.409

61
Universitas Sumatera Utara

Independent Samples Test
Levene's Test for
Equality of
Variances

t-test for Equality of Means
95% Confidence Interval of the
Difference

Std. Error

B

F

Sig.

1.255

.295

t

df

Sig. (2-tailed) Mean Difference

Difference

Lower

Upper

Equal

M variance
s

1.884

8

.096

156.000

82.813

-34.967

346.967

1.884 5.600

.112

156.000

82.813

-50.200

362.200

assumed
Equal
variance
s not
assumed
Hasil : pada alpha 5% didapat tidak ada perbedaan yang signifikan rata-rata berat masa tumor
antara kelompok 4 dan kelompok 5

Uji normalitas berat badan
Case Processing Summary
Cases
Valid
N
selisihbb

Missing

Percent
25

N

100.0%

Total

Percent
0

.0%

N

Percent
25

100.0%

Descriptives
Statistic
selisihbb

Mean
95% Confidence Interval for
Mean

19.3200
Lower Bound

12.8362

Upper Bound

25.8038

5% Trimmed Mean

18.9000

Median

18.0000

Std. Error
3.14151

62
Universitas Sumatera Utara

Variance

246.727

Std. Deviation

1.57075E1

Minimum

-13.00

Maximum

58.00

Range

71.00

Interquartile Range

12.00

Skewness
Kurtosis

.705

.464

1.214

.902

Tests of Normality
a

Kolmogorov-Smirnov
Statistic
selisihbb

df

.192

Shapiro-Wilk

Sig.
25

Statistic

.018

df

.935

Sig.
25

.116

a. Lilliefors Significance Correction

Case Processing Summary
Cases
Valid
N
selisihbb

Missing

Percent
15

N

100.0%

Total

Percent
0

.0%

N

Percent
15

100.0%

Descriptives
Statistic
selisihbb

Mean
95% Confidence Interval for
Mean

19.6667
Lower Bound

11.2118

Upper Bound

28.1215

5% Trimmed Mean

19.6296

Median

18.0000

Variance

233.095

Std. Deviation
Minimum

Std. Error
3.94204

1.52675E1
-13.00

63
Universitas Sumatera Utara

Maximum

53.00

Range

66.00

Interquartile Range

13.00

Skewness
Kurtosis

.308

.580

1.615

1.121

Tests of Normality
a

Kolmogorov-Smirnov
Statistic
selisihbb

df

.199

Shapiro-Wilk

Sig.
15

Statistic

.115

df

.915

Sig.
15

.163

a. Lilliefors Significance Correction

kesimpulan : distribusi normal

Oneway
Notes
Output Created

13-Aug-2012 05:33:29

Comments
Input

Data

D:\dwi dkk\spss dwi.sav

Active Dataset

DataSet1

Filter

Kelompok > 2 (FILTER)

Weight



Split File



N of Rows in Working Data File
Missing Value Handling

Definition of Missing

15
User-defined missing values are treated as
missing.

Cases Used

Statistics for each analysis are based on
cases with no missing data for any variable
in the analysis.

64
Universitas Sumatera Utara

Syntax

ONEWAY selisihbb BY Kelompok
/STATISTICS DESCRIPTIVES
/MISSING ANALYSIS
/POSTHOC=BONFERRONI ALPHA(0.05).

Resources

Processor Time

00:00:00.078

Elapsed Time

00:00:00.048

[DataSet1] D:\dwi dkk\spss dwi.sav

Descriptives
selisihbb
95% Confidence Interval for Mean

Std.
N
6 minggu tanpa

Mean

Deviation

Std. Error

Lower Bound

Upper

5

14.0000

4.18330

1.87083

8.8057

6mg,3mg benalu teh 1,5

5

23.2000

25.26262

11.29779

-8.1677

6mg,3mg benalu teh 3gr

5

21.8000

9.93479

4.44297

9.4643

15

19.6667

15.26746

3.94204

11.2118

intervensi

Total

ANOVA
selisihbb
Sum of Squares
Between Groups

df

Mean Square

F

245.733

2

122.867

Within Groups

3017.600

12

251.467

Total

3263.333

14

Sig.
.489

.625

Post Hoc Tests
Multiple Comparisons
selisihbb
Bonferroni

95% Confidence Inte

Mean Difference (I(I) Kelompok

(J) Kelompok

J)

Std. Error

Sig.

Lower Bound

65
Universitas Sumatera Utara

Upper B

6 minggu tanpa intervensi

6mg,3mg
benalu teh 1,5
6mg,3mg
benalu teh 3gr

6mg,3mg benalu teh 1,5

6 minggu tanpa
intervensi
6mg,3mg
benalu teh 3gr

6mg,3mg benalu teh 3gr

6 minggu tanpa
intervensi
6mg,3mg
benalu teh 1,5

-9.20000

10.02929

1.000

-37.0761

-7.80000

10.02929

1.000

-35.6761

9.20000

10.02929

1.000

-18.6761

1.40000

10.02929

1.000

-26.4761

7.80000

10.02929

1.000

-20.0761

-1.40000

10.02929

1.000

-29.2761

kesimpulan : tidak ada perbedaan rata2 antar kelompok

Uji Ki-67
NPar Tests
Notes
Output Created

10-Sep-2012 09:52:10

Comments
Input

Data

D:\dwi dkk\spss dwi.sav

Active Dataset

DataSet1

Filter



Weight



Split File



N of Rows in Working Data

25

File
Missing Value Handling

Definition of Missing

User-defined missing values are treated
as missing.

Cases Used

Statistics for each test are based on all
cases with valid data for the variable(s)
used in that test.

66
Universitas Sumatera Utara

Syntax

NPAR TESTS
/M-W= Ki67baru BY Kelompok(4 5)
/MISSING ANALYSIS.

Resources

Processor Time

a

00:00:00.141

Elapsed Time

00:00:00.125

Number of Cases Allowed

112347

a. Based on availability of workspace memory.
Mann-Whitney Test
Ranks
Kelompok
Ki67baru

N

Mean Rank

Sum of Ranks

6mg,3mg benalu teh 1,5

5

6.00

30.00

6mg,3mg benalu teh 3gr

5

5.00

25.00

Total

Test Statistics

10

b

Ki67baru
Mann-Whitney U

10.000

Wilcoxon W

25.000

Z
Asymp. Sig. (2-tailed)
Exact Sig. [2*(1-tailed Sig.)]

-.600
.549
a

.690

a. Not corrected for ties.
b. Grouping Variable: Kelompok

67
Universitas Sumatera Utara

NPar Tests
Notes
Output Created

10-Sep-2012 09:51:48

Comments
Input

Data

D:\dwi dkk\spss dwi.sav

Active Dataset

DataSet1

Filter



Weight



Split File



N of Rows in Working Data File
Missing Value Handling

Definition of Missing

25
User-defined missing values are treated as
missing.

Cases Used

Statistics for each test are based on all
cases with valid data for the variable(s)
used in that test.

Syntax

NPAR TESTS
/M-W= Ki67baru BY Kelompok(3 5)
/MISSING ANALYSIS.

Resources

Processor Time

a

00:00:00.047

Elapsed Time

00:00:00.031

Number of Cases Allowed

112347

a. Based on availability of workspace memory.

Mann-Whitney Test
Ranks
Kelompok
Ki67baru

N

Mean Rank

Sum of Ranks

6 minggu tanpa intervensi

5

6.70

33.50

6mg,3mg benalu teh 3gr

5

4.30

21.50

Total

10

68
Universitas Sumatera Utara

Test Statistics

b

Ki67baru
Mann-Whitney U

6.500

Wilcoxon W

21.500

Z

-1.386

Asymp. Sig. (2-tailed)

.166

Exact Sig. [2*(1-tailed Sig.)]

.222

a

a. Not corrected for ties.
b. Grouping Variable: Kelompok

NPar Tests
Notes
Output Created

10-Sep-2012 09:51:28

Comments
Input

Data

D:\dwi dkk\spss dwi.sav

Active Dataset

DataSet1

Filter



Weight



Split File



N of Rows in Working Data File
Missing Value Handling

Definition of Missing

25
User-defined missing values are treated as
missing.

Cases Used

Statistics for each test are based on all
cases with valid data for the variable(s)
used in that test.

Syntax

NPAR TESTS
/M-W= Ki67baru BY Kelompok(3 4)
/MISSING ANALYSIS.

Resources

Processor Time

a

Elapsed Time
Number of Cases Allowed

00:00:00.062
00:00:00.031
112347

a. Based on availability of workspace memory.
[DataSet1] D:\dwi dkk\spss dwi.sav

69
Universitas Sumatera Utara

Mann-Whitney Test
Ranks
Kelompok
Ki67baru

N

Mean Rank

Sum of Ranks

6 minggu tanpa intervensi

5

6.30

31.50

6mg,3mg benalu teh 1,5

5

4.70

23.50

Total

Test Statistics

10

b

Ki67baru
Mann-Whitney U

8.500

Wilcoxon W

23.500

Z

-.956

Asymp. Sig. (2-tailed)

.339

Exact Sig. [2*(1-tailed Sig.)]

.421

a

a. Not corrected for ties.
b. Grouping Variable: Kelompok

NPar Tests
Notes
Output Created

10-Sep-2012 09:50:57

Comments
Input

Data

D:\dwi dkk\spss dwi.sav

Active Dataset

DataSet1

Filter



Weight



Split File



N of Rows in Working Data File
Missing Value Handling

Definition of Missing

25
User-defined missing values are treated as
missing.

Cases Used

Statistics for each test are based on all
cases with valid data for the variable(s)
used in that test.

70
Universitas Sumatera Utara

Syntax

NPAR TESTS
/M-W= Ki67baru BY Kelompok(1 2)
/MISSING ANALYSIS.

Resources

Processor Time

a

00:00:00.031

Elapsed Time

00:00:00.015

Number of Cases Allowed

112347

a. Based on availability of workspace memory.

Mann-Whitney Test
Ranks
Kelompok
Ki67baru

N

Mean Rank

Sum of Ranks

3 minggu tanpa intervensi

5

6.30

31.50

3 minggu benalu teh 1,5g

5

4.70

23.50

Total
Test Statistics

10
b

Ki67baru
Mann-Whitney U

8.500

Wilcoxon W

23.500

Z

-.949

Asymp. Sig. (2-tailed)

.343

Exact Sig. [2*(1-tailed Sig.)]

.421

a

a. Not corrected for ties.
b. Grouping Variable: Kelompok

NPar Tests
Notes
Output Created

10-Sep-2012 09:50:27

Comments
Input

Data

D:\dwi dkk\spss dwi.sav

Active Dataset

DataSet1

Filter



Weight



Split File



71
Universitas Sumatera Utara

N of Rows in Working Data File
Missing Value Handling

Definition of Missing

25
User-defined missing values are treated as
missing.

Cases Used

Statistics for each test are based on all
cases with valid data for the variable(s)
used in that test.

Syntax

NPAR TESTS
/K-W=Ki67baru BY Kelompok(3 5)
/MISSING ANALYSIS.

Resources

Processor Time

a

00:00:00.047

Elapsed Time

00:00:00.032

Number of Cases Allowed

112347

a. Based on availability of workspace memory.

Kruskal-Wallis Test
Ranks
Kelompok
Ki67baru

N

Mean Rank

6 minggu tanpa intervensi

5

10.00

6mg,3mg benalu teh 1,5

5

7.70

6mg,3mg benalu teh 3gr

5

6.30

Total

15
a,b

Test Statistics

Ki67baru
Chi-Square
df
Asymp. Sig.

2.216
2
.330

a. Kruskal Wallis Test
b. Grouping Variable:
Kelompok

72
Universitas Sumatera Utara

NPar Tests
Notes
Output Created

10-Sep-2012 09:50:00

Comments
Input

Data

D:\dwi dkk\spss dwi.sav

Active Dataset

DataSet1

Filter



Weight



Split File



N of Rows in Working Data File
Missing Value Handling

Definition of Missing

25
User-defined missing values are treated as
missing.

Cases Used

Statistics for each test are based on all
cases with valid data for the variable(s)
used in that test.

Syntax

NPAR TESTS
/K-W=Ki67baru BY Kelompok(1 5)
/MISSING ANALYSIS.

Resources

Processor Time

a

Elapsed Time
Number of Cases Allowed

00:00:00.031
00:00:00.015
112347

a. Based on availability of workspace memory.

73
Universitas Sumatera Utara

Kruskal-Wallis Test
Ranks
Kelompok
Ki67baru

N

Mean Rank

3 minggu tanpa intervensi

5

17.20

3 minggu benalu teh 1,5g

5

12.80

6 minggu tanpa intervensi

5

15.00

6mg,3mg benalu teh 1,5

5

11.10

6mg,3mg benalu teh 3gr

5

8.90

Total

25
a,b

Test Statistics

Ki67baru
Chi-Square
df
Asymp. Sig.

4.912
4
.296

a. Kruskal Wallis Test
b. Grouping Variable:
Kelompok

74
Universitas Sumatera Utara

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