Dampak Hemodialisis Terhadap Fungsi Paru Sebelum dan Sesudah Hemodialisis pada Penderita Penyakit Ginjal Kronis Dengan Hemodialisis Reguler

  LAMPIRAN 1 LEMBAR PERSETUJUAN KOMITE ETIK PENELITIAN

  LAMPIRAN 2

LEMBAR PENJELASAN KEPADA CALON SUBJEK PENELITIAN

  Assalamualaikum wr.wb, Salam sejahtera bagi Bapak/Ibu, Terima kasih atas kesediaan Bapak/Ibu meluangkan waktu untuk

membaca dan mengisi surat persetujuan ini, sebelumnya, perkenankan saya

memperkenalkan diri. Nama saya dr. Aini Pertiwi, Peserta Program Pendidikan

Dokter Spesialis Ilmu Penyakit Dalam di Fakultas Kedokteran Universitas

Sumatera Utara (FK-USU). Saya sedang melakukan pengumpulan data penelitian tugas akhir sebagai salah satu syarat menyelesaikan pendidikan di FK-USU.

Adapun judul penelitian saya adalah “Dampak Hemodialisis terhadap Fungsi Paru

Sebelum dan Sesudah Hemodialisis pada Penderita Penyakit Ginjal Kronis dengan Hemodialisis Reguler.” Penelitian ini bertujuan untuk mengetahui ada tidaknya pengaruh

hemodialisis (cuci darah) reguler terhadap fungsi paru pada penderita penyakit

ginjal kronis. Sekitar 60% penderita penyakit ginjal kronis dengan dialisis

mengalami komplikasi paru dimana sebagian besar komplikasi yang terjadi

bersifat asimptomatik (tanpa gejala).

  Penelitian ini dilakukan dengan m e n g u k u r k e k u a t a n , k e c e p a t a n d a n v o l u m e u d a r a di paru-paru selama pernafasan yang dipaksakan dengan

alat spirometri . S ehingga dapat memberikan informasi pengukuran fisiologis

yang dapat mengidentifikasi kelainan obstruksi (sumbatan) atau restriksi

(pengembangan) sistem pernafasan Bapak/Ibu. Sebelum dilakukan pemeriksaan

dengan alat spirometri, dilakukan tanya jawab mengenai usia, jenis kelamin, dan gejala-gejala respirasi (pernafasan), pengukuran tinggi badan dan berat badan.

  

Kemudian dalam posisi berdiri Bapak/Ibu diminta bernafas secara normal 3 kali

(mouthpiece sudah terpasang di mulut dengan posisi bibir rapat pada mouthpiece

dan hidung ditutup dengan penjepit hidung) kemudian menarik nafas dalam-dalam

dan nafas dihembuskan secara maksimal melalui mouthpiece. Manfaat

pengukuran ini adalah untuk mengetahui gambaran fungsi paru dan sebagai

  

deteksi dini komplikasi paru pada penyakit ginjal kronik dengan hemodialisis

regular.

Perlu saya ingatkan, keikutsertaan Bapak/Ibu adalah suka rela dan tidak

dikenakan biaya. Semua data yang terkumpul saya jamin kerahasiaannya. Bila

keterangan yang saya berikan masih belum jelas, Bapak/Ibu dapat langsung

bertanya kepada saya : Nama : dr. Aini Pertiwi Alamat : Jl. Halat No. 62. Medan 20217 Telepon : 085296742984 Peneliti, (dr.Aini Pertiwi)

  LAMPIRAN 3 SURAT PERSETUJUAN SETELAH PENJELASAN (INFORMED CONSENT ) Saya yang bertanda tangan dibawah ini : Nama :...........................................................................................

  Alamat :........................................................................................... Umur :........................ Tahun Jenis Kelamin : Laki-laki/ Perempuan.

  No Telp/HP :

Setelah mendapat penjelasan dari peneliti tentang kebaikan dan keburukan

prosedur penelitian ini , maka dengan penuh kesadaran dan tanpa paksaan saya

menyatakan bersedia ikut serta dalam penelitian tentang ” Dampak Hemodialisis

terhadap Fungsi Paru sebelum dan sesudah Hemodialisis pada Penderita Penyakit

Ginjal Kronis dengan Hemodialisis Reguler”.Apabila sewaktu-waktu saya

mengundurkan diri dari penelitian ini, kepada saya tidak dituntut apapun. Demikianlah surat persetujuan ini dibuat untuk dapat digunakan seperlunya.

  Medan, ...........................2013 Pasien Peneliti ( dr. Aini Pertiwi ) (.................................)

  Saksi (...............................)

  LAMPIRAN 4 LEMBAR KERJA PROFIL PESERTA PENELITIAN Tanggal : MR : No. Peserta :

I. Anamnese Pribadi

  Nama : Umur : tahun

Jenis Kelamin : Laki-laki/Perempuan.

Alamat : No Telp/Hp :

  II. Anamnese Penyakit Etiologi PGK : Durasi HD : Frekuensi HD :

  III. Pemeriksaan a Anamnesis : b BB kering : kg BB sebelum HD: c Laboratorium

• Hemoglobin :
• Ureum :
• Kreatinin : d Foto Toraks : e Spirometri :

  LAMPIRAN 5 DAFTAR RIWAYAT HIDUP

  I. DATA PRIBADI Nama : dr. Aini Pertiwi Tempat/Tgl Lahir : Jakarta / 12 Desember 1974 Jenis Kelamin : Wanita Agama : Islam Pekerjaan : Dokter RSU Sultan Sulaiman NIP : 197412122009032006 Pangkat/ Gol. : Penata Muda/ III C Suami : - Anak : - Alamat Pekerjaan : Fakultas Kedokteran USU

  Jl. dr. Mansyur no. 5 Medan Departemen Ilmu Penyakit Dalam FK-USU RSUP. H. Adam Malik Medan Jl. Bunga Lau no.17 Medan

  Alamat Rumah : Jl. Halat No.62 Medan Telepon selular : 085296742984

  II. PENDIDIKAN

  1. SDN 060810 Medan (1981 – 1987) di Medan

  2. SLTP Negeri 3 Medan (1987 - 1990) di Medan

  3. SMU Negeri 5 Medan (1990 - 1993) di Medan

  

4. Fakultas Kedokteran Universitas Sumatera Utara (1994 -

2000 ) di Medan

  5. PPDS Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Sumatera Utara (2008 - sekarang) di Medan

III. RIWAYAT PEKERJAAN

  1. Dokter RS Imelda Medan

  2. Dokter Puskesmas Gunting Saga, Kab. Labuhan Batu

  3. Dokter RSUD Langsa, Kota Langsa

KEANGGOTAAN PROFESI IV.

  1. Ikatan Dokter Indonesia (IDI)

  2. Perhimpunan Ahli Penyakit Dalam Indonesia (PAPDI)

  V. KURSUS PENATARAN USG Tahap I PUSKI

  VI. KARYA ILMIAH

1. Pertiwi A, Abidin A, Keliat E.N, Zubir Z. Empiema dan Tuberkulosis Milier pada Penderita HIV : Laporan Kasus.

  KONAS PERPARI XI & Temu Ilmiah Penyakit Dalam FK UNSRI, Palembang, 2010.

  2. Pertiwi A, Ginting Y, Rahimi A, Kembaren T. Drug-induced Liver Injury (DILI) in HIV Patients Who Received Antituberculosis Drugs : Laporan Kasus. PETRI XVII & PERKEDWI/ PKWI XIV, Semarang, 2011.

VII. PARTISIPASI DALAM KEGIATAN ILMIAH

  1. Peserta PIT IX 2008 Departemen Penyakit Dalam Fakultas Kedokteran Universitas Sumatera Utara, Danau Toba Convention Hall - Medan 17-19 April 2008.

  2. Peserta Festschrift Prof. Dr. Harun Rasyid Lubis, Sp.PD- KGH Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Sumatera Utara, Tiara Convention Centre Medan,

  10 Nopember 2008

  3. Peserta Simposium “Update from Clinical to Application in Internal Medicine”. Pertemuan Ilmiah Tahunan (PIT) X 2009

  Departemen Penyakit Dalam Fakultas Kedokteran Universitas Sumatera Utara. Medan 23-25 April 2009 th th

  

4. Peserta 5 NTCM Symposium “The 5 New Trend in

Cardiovascular Management: Diagnostic and Therapeutics Challenges in Cardiovascular Diseases Management”, Medan 8-9 Mei 2009. th

  5. Symposium on Critical Care and Emergency Peserta “The 5 Medicine: New Discovery in Emergency and Critical Care Medicine”, Tiara Convention Centre Medan, 15-16 Mei 2009

  6. Peserta Symposium On Hypertension: “Dual Approach for

Singular Success” , Hotel Swissbell Medan, 27 Juni 2009

  7. Peserta Workshop Achieving Ambitious Glycaemic Target in Diabetes: “Stepwise Intensification in Insulin Treatment from Basal to Basal Plus/Bolus”, Medan, 12 Juli 2009

  8. Peserta Simposium “Early Correction Anemia in CKD: A Comprenhensive Management Approach ”, Hotel J.W.

  Marriott Medan, 24 Oktober 2009

  9. Peserta Scientific Weekend “Early Insulin Inisiation, How, When and What Insulin according to Daily Practice Need” , Grand Swiss Belhotel Medan, 21 November 2009

  

10. Peserta Roadshow Ilmiah PD PAPDI “Penggunaan

Testosteron pada Aging Male”, Hotel Grand Aston City Hall Medan, 6 Maret 2010.

  11. Peserta Seminar, Workshop Diabetic Complication and Case Study , Hotel Swissbel Medan, 15 Mei 2010

  12. Peserta Simposium The 1st Medan Respiratory Care Meeting Annualy MERCY 2010, “Respiratory Evidenced and Respiratory Competence Synergy on Clinical Practice”, Hotel J.W. Marriott Medan, 19-21 Maret 2010 th

  13. Peserta Simposium the 11 National Congress of PERPARI, Chest, and Critical Care in Internal Medicine . Palembang, 04-05 Juni 2010.

  14. Pembicara Makalah Bebas Oral/Poster pada Simposium the th

  11 National Congress of PERPARI, Chest, and Critical Care in Internal Medicine . Palembang, 04 Juni 2010

  15. Peserta Simposium Rheumatology Update 2010, Hotel Grand Aston City Hall Medan, 30-31 Juli 2010

  

16. Peserta Bakti Sosial Pemeriksaan Kesehatan Massal dalam

rangka memperingati Dasawarsa Perguruan Buddhis Bodhicitta, Medan, 17 Oktober 2010

  17. Peserta Roadshow “Medical Skill Update (MEDSKUP) Workshop Infection-Immunology”, Hotel J.W. Marriott Medan, 30 Oktober 2010

  18. Peserta Simposium “Hyperglicemia of Patients with Diabetes Mellitus in Clinical Practice ”, Hotel Grand Aston Indonesia,

28 November 2010

  

19. Peserta Pelatihan Program Pengembangan Pendidikan

Keprofesian Berkelanjutan Ultrasonografi Tahap Pertama bagi PPDS Ilmu Penyakit Dalam. Departemen Ilmu Penyakit Dalam FK USU dan PUSKI. Medan, 21-24 Maret 2011

  20. Peserta Seminar Penatalaksanaan Hepatitis B & C“Good Doctor for The Great Liver”, Medan, 19 2011

  

21. Panitia dan peserta PIT XII 2011 Penyakit Dalam Pertemuan

Ilmiah Nasional PERPARI. Medan 28-30 April 2011 th

  

22. Peserta Simposium The 6 New Trend in Cardiovascular

Management , JW. Marriott Hotel Medan, 23-25 Juni 2011

  

23. Peserta Simposium National Congress PETRI XVII &

PERKEDWI/ PKWI XIV “Emerging and Re-emerging Infectious Diseases : A Local and Global Threat” , Patra Semarang Convention Hotel, 8-10 Juli 2011.

  24. Pembicara Makalah Bebas Oral/Poster pada Simposium National Congress PETRI XVII & PERKEDWI/ PKWI XIV “Emerging and Re-emerging Infectious Diseases : A Local

  and Global Threat” , Patra Semarang Convention Hotel, 8-10 Juli 2011.

  25. Peserta Seminar Sehari Lymphoma Update : Deteksi Dini dan Penatalaksanaan, RSUP. H. Adam Malik Medan, 16 Juli 2011

  

26. Peserta Seminar “Plant Stanol Ester: A Novel Dietary

Component in Lowering Cholesterol to Improve Cardio- Vascular Health” , Hotel J.W. Marriott Medan, 19 November 2011

  

27. Peserta Workshop Infection Update IV “Current Challenges

Management on Infection ”. Medan, 25 Nopember 2011.

  

28. Peserta Simposium “The New Option of Insulin Resistance

Treatment in Type 2 Diabetes:Pathogenesis, Prevention and Management Diabetic Vascular Complication ”, Hermes Palace Hotel Medan, 20 November 2011

  29. Peserta Simposium “Rationale Strategy in the Management of Pancreatic B Dysfunction and Role of Oral Incretin Based Therapy in Type 2 Diabetes Mellitus”, Hotel J.W. Marriott Medan, 29 Januari 2012

  

30. Peserta Workshop “Cancer Pain Management”, Hotel Grand

Aston Medan, 10 Maret 2012

  

31. Peserta Simposium “Diabetes Update for Excellent”, Hotel

J.W. Marriott, Medan 17 Maret 2012

  32. Peserta Simposium Medical Skill Upgrade Gastroenterology- Hepatology ( Inflamatory Bowel Disease & Non Alcoholic Steato Hepatitis – Workshop, Hotel Grand Aston City Hall Medan, 24 Maret 2012

  

33. Peserta Simposium The New Direction in The Treatment of

Type 2 Diabetes Melitus “A New Novel DPP-4 Inhibitor For T2DM Treatment” , Hotel J.W. Marriott Medan, 1 April 2012

  

34. Peserta Roadshow Hipertensi PB PAPDI “The Next Big

Target in Hypertension: Controlling All Key BP

Parameters” , Hotel J.W. Marriott Medan, 28 April 2012

  

35. Peserta Workshop Terapi Insulin “Update on Diagnosis and

Management of Comment Clinical Problems ”, Dies Natalis

  60 Tahun Fakultas Kedokteran USU, Hotel Santika Dyandra Convention Hall, 11 September 2012

  

36. Peserta Simposium Kongres Nasional XV Perhimpunan

Dokter Spesialis Penyakit Dalam Indonesia (KOPAPDI XV), Hotel J.W. Marriott dan Hotel Grand Aston Medan, 12-15 Desember 2012 th

  

37. Peserta Simposium “The 5 Endocrinology & Diabetes

Forum of Sumatera Region (FEDS-5), Theme: The Endocrine

• – Metabolic Disease : Present and Future” , Medan 20

  Februari 2013

  38. Peserta Mini Symposium: “Gastro Update” Recent Management in Helicobacter pylori Infection, Irritable Bowel Syndrome and Hepatic Encephalopathy , Hotel Aryaduta, 20 April 2013.

  LAMPIRAN 6

ANALISA STATISTIK

Frequencies jenis kelamin

  Cumulative Frequency Percent Valid Percent Percent Valid Perempuan

  35

  

38.9

  38.9

  38.9 Laki-laki

  55

  

61.1

61.1 100.0 Total 90 100.0 100.0

  Etiologi Cumulative Frequency Percent Valid Percent Percent

  Valid GNC

  25

  27.8

  27.8

  27.8 HN

  25

  27.8

  27.8

  55.6 DN

  27

  30.0

  30.0

  85.6 PNC

  5

  5.6

  5.6

  91.1 PGOI

  8

  8.9 8.9 100.0 Total 90 100.0 100.0 kesan spirometri sebelum HD

  Cumulative Frequency Percent Valid Percent Percent Valid normal

  46

  51.1

  51.1

  51.1 res triks i ringan

  30

  33.3

  33.3

  84.4 res triks i sedang

  3

  3.3

  3.3

  87.8 res triks i berat

  1

  1.1

  1.1

  88.9 res triks i berat,

  2

  2.2

  2.2

  91.1 obstruksi s edang res triks i berat,

  4

  4.4

  4.4

  95.6 obstruksi berat res triks i sedang,

  1

  1.1

  1.1

  96.7 obstruksi s edang res triks i ringan,

  3

  3.3 3.3 100.0 obstruksi ringan Total 90 100.0 100.0

  Pria kesan spirometri setelah HD

  96.4

  1.8 1.8 100.0

55 100.0 100.0

normal res triks i ringan res triks i sedang res triks i berat res triks i berat, obstruk si s edang res triks i sedang, obstruk si s edang res triks i ringan, obstruk si ringan Total Valid

  1

  98.2

  1.8

  1.8

  1

  1.8

  36

  1.8

  1

  94.5

  1.8

  1.8

  1

  Frequency Percent Valid P ercent Cumulative Percent ke san spirome tri sete lah HD

  65.5

  3.6

  94.5

  1.8 1.8 100.0 55 100.0 100.0 normal res triks i ringan res triks i sedang res triks i sedang, obstruk si s edang res triks i ringan, obstruk si ringan Total

  1

  98.2

  3.6

  3.6

  2

  3.6

  65.5

  3.6

  2

  90.9

  25.5

  25.5

  14

  65.5

  92.7

  3.6

  54

  2.2

  91.1

  1.1

  1.1

  1

  90.0

  2.2

  2

  4.4

  87.8

  27.8

  

27.8

  25

  60.0

  60.0

  

60.0

  4

  4.4

  2

  52.7

  89.1

  36.4

  36.4

  20

  52.7

  52.7

  29

  95.6

  Valid

Frequency Percent Valid Percent

Cumulative Percent ke san spirome tri sebe lum HD

  2.2 2.2 100.0 90 100.0 100.0 normal res triks i ringan res triks i sedang res triks i berat, obstruksi s edang res triks i berat, obstruksi berat res triks i sedang, obstruksi s edang res triks i ringan, obstruksi ringan Total

  2

  97.8

  2.2

  2.2

  2

  Valid

Frequency Percent Valid P ercent

Cumulative Percent

  Wanita ke san spirome tri sebe lum HD Cumulative Frequency Percent Valid P ercent Percent

  Valid normal

  17

  48.6

  48.6

  48.6 res triks i ringan

  10

  28.6

  28.6

  77.1 res triks i sedang

  1

  2.9

  2.9

  80.0 res triks i berat,

  1

  2.9

  2.9

  82.9 obstruk si s edang res triks i berat,

  4

  11.4

  11.4

  94.3 obstruk si berat res triks i ringan,

  2

  5.7 5.7 100.0 obstruk si ringan Total 35 100.0 100.0 kesan spirometri setelah HD

  Cumulative Frequency Percent Valid Percent Percent Valid normal

  18

  51.4

  51.4

  51.4 res triks i ringan

  11

  31.4

  31.4

  82.9 res triks i berat,

  1

  2.9

  2.9

  85.7 obstruksi s edang res triks i berat,

  4

  11.4

  11.4

  97.1 obstruksi berat res triks i ringan,

  1

  2.9 2.9 100.0 obstruksi ringan Total 35 100.0 100.0 merokok

  Cumulative Frequency Percent Valid Percent Percent Valid merokok

  21

  

23.3

  23.3

  23.3 tidak merokok

  69

  

76.7

76.7 100.0 Total 90 100.0 100.0

  

Statistics

BB sebelum BB setelah us ia subjek HD HD Durasi HB Ureum Creatinin

  N Valid

  90

  90

  90

  90

  90

  90

  90 Missing Mean

  50.18

  60.20

  58.20 21.27 9.478 110.17 11.504 Std. Deviation 12.507 11.462 11.222 17.875 1.2132 38.402 3.3889 Minimum

  20

  40

  38

  6

  7.2

  48

  4.7 Maximum

  76

  86

  82

  80 12.1 211

  19.0

  4 Mean N St d. Deviat ion St d. E rror Mean

  a.

  .674 .647 2.349 1.510 1.142 1.276 1.259 1.702 .754 .797 .000 .021 .148 .077 .084 .006

  N Mean Std. Deviation

  Normal Parameters

  a,b

  Absolute Positive Negative

  Most Extreme Differences Kolmogorov-Smirnov Z As ymp. Sig. (2-tailed)

  BB sebelum HD

  BB setelah HD FEV1 sebelum HD

  FEV1 setelah HD FVC sebelum HD

  FVC setelah HD

  FEV1/FVC sebelum HD FEV1/FVC setelah HD

  Test distribution is Normal.

  Calculated from data.

  75.91 79.60 1.1282 1.1439 11.462 11.222 12.310 14.616 15.160 16.814 .13821 .12127

  b.

  Pa ired Sa mpl es S tati stics

  60.20 90 11.462 1.208

  58.20 90 11.222 1.183

  84.46 90 12.310 1.298

  89.94 90 14.616 1.541

  75.91 90 15.160 1.598

  79.60 90 16.814 1.772 1.1282 90 .13821 .01457 1.1439 90 .12127 .01278 BB sebelum HD

  BB setelah HD Pair

  1 FE V1 sebelum HD FE V1 setelah HD Pair

  2 FV C s ebelum HD FV C s etelah HD Pair

  3 FE V1/ FVC sebelum HD FE V1/ FVC set elah HD Pair

  .071 .068 .248 .159 .120 .135 .133 .179 .071 .068 .126 .124 .101 .121 .133 .179

  89.94

  NPar Tests (All) T-Test (All) Statistics

  1.63

  90

  

90

  90

  90

  90

  90

  84.46

  

89.94

  75.91 79.60 1.1282 1.1439 12.310 14.616 15.160 16.814 .13821 .12127

  37

  

47

  31 38 .90 .90 118 140 120 142

  1.55 Valid Mis sing N Mean Std. Deviation Minimum Maximum FEV1 sebelum HD FEV1 setelah HD FVC sebelum HD FVC setelah

  84.46

  HD FEV1/FVC sebelum HD FEV1/FVC setelah HD

  

One-Sample Kolmogorov-Smirnov Test

  90

  90

  90

  90

  90

  90

  90

  90

  60.20

  58.20

• .047 -.054 -.248 -.159 -.120 -.135 -.067 -.066

• 5.489 7.420 .782 -7.043 -3.935 -7.017 89 .000
• 3.689 6.968 .734 -5.148 -2.229 -5.022 89
• .01567 .04858 .00512 -.02584 -.00549 -3.060 89 .003
• FEV1/FVC setelah HD Pair
• 7.214
• 4.048

  Normal Parameters

  55

  55

  62.67

  60.71

  86.64

  92.07

  77.87 81.87 1.1278 1.1387 11.563 11.208 8.225 11.592 12.593 14.928 .14385 .12369

  .075 .084 .155 .130 .109 .135 .175 .223 .075 .084 .105 .130 .083 .135 .175 .223

  .555 .624 1.152 .961 .806 .999 1.300 1.655 .918 .830 .141 .314 .534 .271 .068 .008

  N Mean Std. Deviation

  a,b

  55

  Absolute Positive Negative

  Most Extreme Differences Kolmogorov-Smirnov Z Asymp. Sig. (2-tailed)

  BB sebelum HD

  BB setelah HD FEV1 sebelum HD

  FEV1 setelah HD FVC sebelum HD

  FVC setelah HD

  FEV1/FVC sebelum HD FEV1/FVC setelah HD

  Test distribution is Normal.

  a.

  Calculated from data.

  55

  55

  b.

  Paired Differences t df Sig. (2-tailed)

  Wilcoxon Signed Ranks NPar Tests (Pria)

Paired Samples Test

  2.000 1.324 .140 1.723 2.277 14.331 89 .000

  BB sebelum HD - BB setelah HD Pair

  1 FEV1 s ebelum HD - FEV1 s etelah HD

  Pair

  2 FVC sebelum HD - FVC setelah HD Pair

  3 FEV1/FVC s ebelum HD

  4 Mean Std. Deviation Std. Error

  Mean Lower Upper 95% Confidence

  Interval of the Difference

  Test Statistics b

  55

  a

  a

  

.000 .000

Z As ymp. Sig. (2-tailed) FEV1 s etelah

  HD - FEV1 sebelum HD FEV1/FVC setelah HD - FEV1/FVC sebelum HD

  Based on negative ranks .

  a.

  Wilcoxon Signed Ranks Test b.

  

One-Sample Kolmogorov-Smirnov Test

  55

  55

• .060 -.079 -.155 -.108 -.109 -.131 -.078 -.091

• 5.436 7.581 1.022 -7.486 -3.387 -5.318 54 .000
• 4.000 7.589 1.023 -6.052 -1.948 -3.909 54
• .01091 .04923 .00664 -.02422 .00240 -1.644 54 .106
• FEV1/FVC setelah HD Pair
• 2.957

  .084 .090 .279 .207 .158 .157 .130 .153 .084 .083 .152 .115 .117 .106 .130 .153

  35

  35

  35

  35

  35

  35

  35

  56.31

  54.26

  81.03

  86.60

  72.83 76.03 1.1289 1.1520 10.301 10.196 16.415 18.082 18.267 19.095 .13092 .11869

  .497 .532 1.653 1.224 .937 .927 .770 .903 .966 .940 .008 .100 .344 .356 .594 .389

  

One-Sample Kolmogorov-Smirnov Test

  N Mean Std. Deviation

  Normal Parameters

  a,b

  Absolute Positive Negative

  Most Extreme Differences Kolmogorov-Smirnov Z Asymp. Sig. (2-tailed)

  BB sebelum HD

  BB setelah HD FEV1 sebelum HD

  FEV1 setelah HD FVC sebelum HD

  FVC setelah HD

  FEV1/FVC sebelum HD FEV1/FVC setelah HD

  Test distribution is Normal.

  a.

  Calculated from data.

  35

  Wilcoxon Signed Ranks Test b.

  b. b.

  1.964 1.333 .180 1.603 2.324 10.926 54 .000

  T-Test (Pria) Wilcoxon Signed Ranks Test NPar Tests (Wanita) Pa ired Sa mpl es S tati stics

  62.67 55 11.563 1.559

  60.71 55 11.208 1.511

  86.64 55 8.225 1.109

  92.07 55 11.592 1.563

  77.87 55 12.593 1.698

  81.87 55 14.928 2.013 1.1278 55 .14385 .01940 1.1387 55 .12369 .01668 BB sebelum HD

  BB setelah HD Pair

  1 FE V1 sebelum HD FE V1 setelah HD Pair

  2 FV C s ebelum HD FV C s etelah HD Pair

  3 FE V1/ FVC sebelum HD FE V1/ FVC set elah HD Pair

  4 Mean N St d. Deviat ion St d. E rror Mean

  Paired Samples Test

  BB sebelum HD - BB setelah HD Pair

  a.

  1 FEV1 s ebelum HD - FEV1 s etelah HD

  Pair

  2 FVC sebelum HD - FVC setelah HD Pair

  3 FEV1/FVC s ebelum HD

  4 Mean Std. Deviation Std. Error

  Mean Lower Upper 95% Confidence

  Interval of the Difference

  Paired Differences t df Sig. (2-tailed)

  Test Statistics b

  a

  .003 Z As ymp. Sig. (2-tailed)

  FEV1/FVC setelah HD - FEV1/FVC sebelum HD

  Based on negative ranks .

• .069 -.090 -.279 -.207 -.158 -.157 -.086 -.095

  Calculated from data.

  90

  a .000 Z

  As ymp. Sig. (2-tailed) FE V1 s etelah HD - FEV1 sebelum HD

  Based on negat ive ranks .

  a.

  W ilcox on S igned Ranks Tes t b.

  

One-Sample Kolmogorov-Smirnov Test

  90

  90

  90

  90

  90

  90

  Paired Differences t df Sig. (2-tailed)

  90

  1.97 21.27 9.478 110.17 11.504 5.4444 3.6889 .0157 1.336 17.875 1.2132 38.402 3.3889 7.43981 6.96806 .04858

  .180 .211 .089 .114 .066 .228 .203 .151 .132 .211 .076 .114 .066 .228 .203 .151

  .006 .001 .477 .190 .830 .000 .001 .034 N

  Mean Std. Deviation

  Normal Parameters

  a,b

  Absolute Positive Negative

  Most Extreme Differences Kolmogorov-Smirnov Z As ymp. Sig. (2-tailed)

  Perubahan bb Durasi HB Ureum Creatinin Perubahan fev1 Perubahan fvc

  Perubahan fev1fvc Test distribution is Normal.

  a.

  Te st S tatistics b

  Interval of the Difference

  Pair

  Pair

  72.83 35 18.267 3.088

  76.03 35 19.095 3.228 1.1289 35 .13092 .02213 1.1520 35 .11869 .02006

  BB sebelum HD BB setelah HD

  Pair

  1 FE V1 sebelum HD FE V1 setelah HD

  Pair

  2 FV C s ebelum HD FV C s etelah HD

  Mean Lower Upper 95% Confidence

  3 FE V1/ FVC sebelum HD FE V1/ FVC set elah HD

  4 Mean N St d. Deviat ion St d. E rror

  81.03 35 16.415 2.775

  Mean

  

Paired Samples Test

  2.057 1.327 .224 1.601 2.513 9.170 34 .000

  BB sebelum HD - BB setelah HD Pair

  1 FEV1 s ebelum HD - FEV1 s etelah HD

  Pair

  54.26 35 10.196 1.723

  56.31 35 10.301 1.741

  T-Test (Wanita) Wilcoxon Signed Ranks Test NPar Tests (All) Pa ired Sa mpl es S tati stics

  86.60 35 18.082 3.056

• 5.571 7.269 1.229 -8.068 -3.074 -4.534 34 .000
• 3.200 5.935 1.003 -5.239 -1.161 -3.190 34 .003

  2 FVC sebelum HD - FVC setelah HD Pair

  3 FEV1/FVC s ebelum HD

• .02314 .04726 .00799 -.03938 -.00691 -2.897 34 .007
• FEV1/FVC setelah HD Pair
• 4. 736
• .180 -.197 -.089 -.054 -.050 -.175 -.143 -.143 1.711 2.006 .842 1.084 .625 2.166 1.930 1.429
Correlation is significant at the 0.05 level (2-tailed). *.

  4 Mean Std. Deviation Std. Error

  HD Perubahan bb HB Ureum Creatinin FEV1 sebelum HD s Correlation is significant at the 0.01 level (2-tailed).

  90

  90

  90

  90

  90

  90

  90

  90

  90

  90

  90 .094 .111 -.192 .005 -.031 -.016 .716** .378 .300 .070 .962 .773 .880 .000

  90

  90

  90

  90

  90

  90

  90 .045 .075 -.289** -.011 -.068 -.079 .723** .677 .485 .006 .921 .523 .459 .000

  90

  90

  90

  90

  90

  90

  90

  90

  90

  90

  Spearman's rho BB sebelum HD BB setelah

  BB setelah HD Perubahan bb HB Ureum Creatinin FEV1 s ebelum HD FEV1 s etelah HD Perubahan fev1 FVC sebelum HD FVC setelah HD Perubahan fvc FEV1/FVC s ebelum HD FEV1/FVC s etelah HD Perubahan fev1fvc

  90 Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N Correlation Coefficient Sig. (2-tailed) N BB sebelum HD

  90

  90

  90

  90

  90

  90

  90 .243* .258* -.135 -.087 .088 .071 .093 .021 .014 .205 .417 .411 .504 .382

  90

  90

  90

  90

  90

  90

  90 .053 .037 .169 .080 .013 .005 -.210* .622 .727 .112 .451 .903 .965 .047

  90

  90

  90

  90

  90

  90

  90

  90 .154 .140 .128 -.176 .102 .091 .087 .147 .187 .228 .097 .340 .395 .415

  90

  Nonparametric Correlations Correlations 1.000 .994** .178 .115 .148 .015 .039 . .000 .092 .282 .163 .891 .717

  90

  90

  90

  90

  90 .115 .123 -.106 1.000 -.383** -.285** .030 .282 .250 .318 . .000 .006 .778

  90

  90

  90

  90

  90

  90

  90 .178 .088 1.000 -.106 .195 .209* -.224* .092 .410 . .318 .065 .048 .034

  90

  90

  90

  90

  90

  90

  90 .994** 1.000 .088 .123 .131 -.003 .058 .000 . .410 .250 .220 .975 .588

  90

  90

  90

  90

  90

  90

  90

  90

  90

  90

  90

  90

  90

  90 .123 .132 -.144 -.031 -.032 -.032 .832** .248 .216 .176 .771 .767 .766 .000

  90

  90

  90

  90

  90

  90

  90 .039 .058 -.224* .030 -.108 -.113 1.000 .717 .588 .034 .778 .312 .288 .

  90

  90 .148 .131 .195 -.383** 1.000 .442** -.108 .163 .220 .065 .000 . .000 .312

  90

  90

  90

  90

  90 .015 -.003 .209* -.285** .442** 1.000 -.113 .891 .975 .048 .006 .000 . .288

  90

  90

  90

  90

  90

  90

• .022 -.057 .289** -.112 .088 .065 .021 .833 .592 .006 .293 .409 .541 .842
• .009 -.032 .231* .108 -.001 .019 -.247* .933 .762 .028 .312 .993 .859 .019
• .

  Graph

  50.00

  40.00

  30.00 fvc

  20.00 erubahan P

  10.00

  0.00

• 10.00

  1

  

2

  3

  4 Perubahan bb

  Universitas Sumatera Utara

  LAMPIRAN 6 UJI STATISTIK Frequencies jenis kelamin Cumulative Frequency Percent Valid Percent Percent

  Valid Perempuan

  35

  

38.9

  38.9

  38.9 Laki-laki

  55

  

61.1

61.1 100.0 Total 90 100.0 100.0

  Etiologi Cumulative Frequency Percent Valid Percent Percent

  Valid GNC

  25

  27.8

  27.8

  27.8 HN

  25

  27.8

  27.8

  55.6 DN

  27

  30.0

  30.0

  85.6 PNC

  5

  5.6

  5.6

  91.1 PGOI

  8

  8.9 8.9 100.0 Total 90 100.0 100.0 kesan spirometri sebelum HD

  Cumulative Frequency Percent Valid Percent Percent Valid normal

  46

  51.1

  51.1

  51.1 res triks i ringan

  30

  33.3

  33.3

  84.4 res triks i sedang

  3

  3.3

  3.3

  87.8 res triks i berat

  1

  1.1

  1.1

  88.9 res triks i berat,

  2

  2.2

  2.2

  91.1 obstruksi s edang res triks i berat,

  4

  4.4

  4.4

  95.6 obstruksi berat res triks i sedang,

  1

  1.1

  1.1

  96.7 obstruksi s edang res triks i ringan,

  3

  3.3 3.3 100.0 obstruksi ringan Total 90 100.0 100.0

  kesan spirometri setelah HD Cumulative Frequency Percent Valid Percent Percent

  Valid normal

  54

  60.0

  60.0

  60.0 res triks i ringan

  25

  27.8

  27.8

  87.8 res triks i sedang

  2

  2.2

  2.2

  90.0 res triks i berat,

  1

  1.1

  1.1

  91.1 obstruksi s edang res triks i berat,

  4

  4.4

  4.4

  95.6 obstruksi berat res triks i sedang,

  2

  2.2

  2.2

  97.8 obstruksi s edang res triks i ringan,

  2

  2.2 2.2 100.0 obstruksi ringan Total 90 100.0 100.0 merokok

  Cumulative Frequency Percent Valid Percent Percent Valid merokok

  21

  

23.3

  23.3

  23.3 tidak merokok

  69

  

76.7

76.7 100.0 Total 90 100.0 100.0

  

Statistics

  BB sebelum BB setelah FEV1 FEV1 FVC FVC setelah FEV1/FVC FEV1/FVC HD HD Durasi HB Ureum Creatinin sebelum HD setelah HD sebelum HD HD sebelum HD setelah HD

  N Valid

  90

  90

  90

  90

  90

  90

  90

  90

  90

  90

  90

  90 Missing Mean

  60.20

  58.20 21.27 9.478 110.17 11.504

  84.46

  89.94

  75.91 79.60 1.1282 1.1439 Std. Deviation

  11.462 11.222 17.875 1.2132 38.402 3.3889 12.310 14.616 15.160 16.814 .13821 .12127 Minimum

  40

  38

  6

  7.2

  48

  4.7

  37

  47

  31 38 .90 .90 Maximum

  86

  82

  80 12.1 211 19.0 118 140 120 142

  1.63

  1.55 Paired Differences t df Sig. (2-tailed)

  Interval of the Difference

  1 FE V1 sebelum HD FE V1 setelah HD Pair

  Calculated from data.

  b.

  Pa ired Sa mpl es S tati stics

  60.20 90 11.462 1.208

  58.20 90 11.222 1.183

  84.46 90 12.310 1.298

  89.94 90 14.616 1.541

  75.91 90 15.160 1.598

  79.60 90 16.814 1.772 1.1282 90 .13821 .01457 1.1439 90 .12127 .01278 BB sebelum HD

  BB setelah HD Pair

  2 FV C s ebelum HD FV C s etelah HD Pair

  Test distribution is Normal.

  3 FE V1/ FVC sebelum HD FE V1/ FVC set elah HD Pair

  4 Mean N St d. Deviat ion St d. E rror Mean

  Paired Samples Test

  2.000 1.324 .140 1.723 2.277 14.331 89 .000

  BB sebelum HD - BB setelah HD Pair

  1 FEV1 s ebelum HD - FEV1 s etelah HD

  Pair

  2 FVC sebelum HD - FVC setelah HD Pair

  3 FEV1/FVC s ebelum HD

  4 Mean Std. Deviation Std. Error

  Mean Lower Upper 95% Confidence

  a.

  FEV1/FVC sebelum HD FEV1/FVC setelah HD

  89.94

  75.91 79.60 1.1282 1.1439 11.462 11.222 12.310 14.616 15.160 16.814 .13821 .12127

  90

  90

  90

  90

  90

  60.20

  58.20

  84.46

  FVC setelah HD

  .071 .068 .248 .159 .120 .135 .133 .179 .071 .068 .126 .124 .101 .121 .133 .179

  90

  90

  N Mean Std. Deviation

  Normal Parameters

  a,b

  Absolute Positive Negative

  Most Extreme Differences Kolmogorov-Smirnov Z As ymp. Sig. (2-tailed)

  BB sebelum HD

  BB setelah HD FEV1 sebelum HD

  FEV1 setelah HD FVC sebelum HD

  90

• .047 -.054 -.248 -.159 -.120 -.135 -.067 -.066

  .674 .647 2.349 1.510 1.142 1.276 1.259 1.702 .754 .797 .000 .021 .148 .077 .084 .006

  T-Test (ALL)

One-Sample Kolmogorov-Smirnov Test

• 5.489 7.420 .782 -7.043 -3.935 -7.017 89 .000
• 3.689 6.968 .734 -5.148 -2.229 -5.022 89
• .01567 .04858 .00512 -.02584 -.00549 -3.060 89 .003
• FEV1/FVC setelah HD Pair
• 7.214
• 4.048

  b.

  Absolute Positive Negative

  Most Extreme Differences Kolmogorov-Smirnov Z Asymp. Sig. (2-tailed)

  BB sebelum HD

  BB setelah HD FEV1 sebelum HD

  FEV1 setelah HD FVC sebelum HD

  FVC setelah HD

  FEV1/FVC sebelum HD FEV1/FVC setelah HD

  Test distribution is Normal.

  a.

  Calculated from data.

  Pa ired Sa mpl es S tati stics

  Normal Parameters

  62.67 55 11.563 1.559

  60.71 55 11.208 1.511

  86.64 55 8.225 1.109

  92.07 55 11.592 1.563

  77.87 55 12.593 1.698

  81.87 55 14.928 2.013 1.1278 55 .14385 .01940 1.1387 55 .12369 .01668 BB sebelum HD

  BB setelah HD Pair

  1 FE V1 sebelum HD FE V1 setelah HD Pair

  2 FV C s ebelum HD FV C s etelah HD Pair

  3 FE V1/ FVC sebelum HD FE V1/ FVC set elah HD Pair

  a,b

  N Mean Std. Deviation

  4 Mean N St d. Deviat ion St d. E rror Mean

  55

  Wilcoxon Signed Ranks T-Test (Pria) Test Statistics b

  a

  a

  

.000 .000

Z As ymp. Sig. (2-tailed) FEV1 s etelah

  HD - FEV1 sebelum HD FEV1/FVC setelah HD - FEV1/FVC sebelum HD

  Based on negative ranks .

  a.

  Wilcoxon Signed Ranks Test b.

  

One-Sample Kolmogorov-Smirnov Test

  55

  55

  .555 .624 1.152 .961 .806 .999 1.300 1.655 .918 .830 .141 .314 .534 .271 .068 .008

  55

  55

  55

  55

  55

  62.67

  60.71

  86.64

  92.07

  77.87 81.87 1.1278 1.1387 11.563 11.208 8.225 11.592 12.593 14.928 .14385 .12369

  .075 .084 .155 .130 .109 .135 .175 .223 .075 .084 .105 .130 .083 .135 .175 .223

• .060 -.079 -.155 -.108 -.109 -.131 -.078 -.091
• 5.436 7.581 1.022 -7.486 -3.387 -5.318 54 .000
• 4.000 7.589 1.023 -6.052 -1.948 -3.909 54
• .01091 .04923 .00664 -.02422 .00240 -1.644 54 .106
• FEV1/FVC setelah HD Pair
• 2.957

  a,b

  56.31

  54.26

  81.03

  86.60

  72.83 76.03 1.1289 1.1520 10.301 10.196 16.415 18.082 18.267 19.095 .13092 .11869

  .084 .090 .279 .207 .158 .157 .130 .153 .084 .083 .152 .115 .117 .106 .130 .153

  .497 .532 1.653 1.224 .937 .927 .770 .903 .966 .940 .008 .100 .344 .356 .594 .389

  N Mean Std. Deviation

  Normal Parameters

  Absolute Positive Negative

  35

  Most Extreme Differences Kolmogorov-Smirnov Z Asymp. Sig. (2-tailed)

  BB sebelum HD

  BB setelah HD FEV1 sebelum HD