Ekspresi Gen Hoxa 10 Jaringan Endometrium Penderita Endometriosis Yang Infertil

EXPRESSION OF HOXA10 GENE IN ENDOMETRIAL TISSUE OF
INFERTILE WOMEN
Johan Ricardo, Henry Salim, M. Rusda, Letta Lintang, Edi Ardiansyah,
Hanudse Hartono
Obstetric and Gynecology Department
Faculty of Medicine Universitas Sumatera Utara
General Hospital H Adam Malik Medan
ABSTRACT
Objective : To find the difference of HOXA10 gene expression in endometrial
tissue of infertile women with endometriosis and normal endometrium.
Method : This is an analytic study with cross sectional approach. 40 subjects
who fulfilled the inclusion criteria were obtained, 20 subjects with endometriosis
and 20 subjects without endometriosis. Endometrial tissue from infertile women
with endometriosis and from normal women were obtained using endometrial
biopsy.

Immunohistochemistry examination was then performed to evaluate

HOXA10 expression. This study was performed in Obstetric and Gynecology
Department of Adam Malik General Hospital Medan from March to April 2015.
The obtained data was then analyzed statistically.

Result : Majority of subjects from endometriosis group were from the age group
of 31-40 years old with 13 subjects (65%). While the majority of subjects from
non endometriosis group were from the age group 41-50 years old with 15
subjects (75%). Based on parity, majority of the subject from endometriosis were
nulliparous with 19 subjects (95%). From the non endometriosis group, subjects
with parity of 1-3 were 11 subjects (55%). Based on HOXA10 expression
intensity, 14 subjects (70%) showed no expression, expression of +1 with 6
subjects (30%). While from non endometriosis group, expression of +3 were
found in 13 subjects (65%), and expression of +2 were found in 7 subjects (35%),
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