Pengaruh Pemberian Vitamin C Dan E Terhadap Gambaran Histologis Hepar Mencit (Mus musculus L.) Yang Dipajankan Monosodium Glutamat (MSG)
LAMPIRAN A. Data dan Analisis Statistik Berat Hepar Mencit Rataan Berat Hepar Mencit (Mus musculus
L.) dengan Pemberian Vitamin C dan
E setelah Pemajanan Monosodium Glutamat (MSG) (g, X±SD)
Kelompok Perlakuan X±SD K- 1.62 ±0.09 K+ 1.97 ±0.26 P1 1.85 ±0.19
P2 2.12 ±0.30 P3 2.22 ±0.08 P4 2.13 ±0.30
Hasil Uji Statistik Berat Hepar Mencit
Tests of Normality
aKolmogorov-Smirnov Shapiro-Wilk Kel_Per lakuan Statistic Df Sig. Statistic df Sig.
- Berat_Hepar K- .190
5 .200 .949 5 .730 K+ .300 5 .161 .776 5 .051
- P1 .159
5 .200 .979 5 .929
- P2 .240
5 .200 .860 5 .230
- P3 .215
5 .200 .931 5 .603
- P4 .227
5 .200 .905 5 .440
a. Lilliefors Significance Correction *. This is a lower bound of the true significance.
Test of Homogeneity of Variance
Levene Statistic df1 df2 Sig.Berat_Hepar Based on Mean 2.327
5 24 .074 Based on Median .953
5 24 .466 Based on Median and with .953 5 14.450 .477 adjusted df Based on trimmed mean 2.183
5 24 .090
Oneway
K- K+ -.34600 .14007 .315 -.8024 .1104 P1 -.22800 .14007 1.000 -.6844 .2284 P2 -.49800
K+ .15200 .14007 1.000 -.3044 .6084 P1 .27000 .14007 .987 -.1864 .7264 P3 -.10200 .14007 1.000 -.5584 .3544 P4 -.00400 .14007 1.000 -.4604 .4524
P2 K- .49800
P1 K- .22800 .14007 1.000 -.2284 .6844 K+ -.11800 .14007 1.000 -.5744 .3384 P2 -.27000 .14007 .987 -.7264 .1864 P3 -.37200 .14007 .208 -.8284 .0844 P4 -.27400 .14007 .933 -.7304 .1824
K+ K- .34600 .14007 .315 -.1104 .8024 P1 .11800 .14007 1.000 -.3384 .5744 P2 -.15200 .14007 1.000 -.6084 .3044 P3 -.25400 .14007 1.000 -.7104 .2024 P4 -.15600 .14007 1.000 -.6124 .3004
P4 -.50200
P3 -.60000
95% Confidence Interval Lower Bound Upper Bound
ANOVA
Mean Difference (I-J) Std. Error Sig.
(J) Kel_Perlakuan
Berat_Hepar Bonferroni (I) Kel_Perlakuan
Multiple Comparisons
29 Post-Hoc
Berat_Hepar Sum of Squares Df Mean Square F Sig. Between Groups 1.220 5 .244 4.975 .003 Within Groups 1.177 24 .049 Total 2.397
- .14007 .024 -.9544 -.0416
- .14007 .004 -1.0564 -.1436
- .14007 .022 -.9584 -.0456
- .14007 .024 .0416 .9544
- .14007 .004 .1436 1.0564
K+ .25400 .14007 1.000 -.2024 .7104 P1 .37200 .14007 .208 -.0844 .8284 P2 .10200 .14007 1.000 -.3544 .5584 P4 .09800 .14007 1.000 -.3584 .5544
P3 K- .60000
- .14007 .022 .0456 .9584
P4 K- .50200
K+ .15600 .14007 1.000 -.3004 .6124 P1 .27400 .14007 .933 -.1824 .7304 P2 .00400 .14007 1.000 -.4524 .4604 P3 -.09800 .14007 1.000 -.5544 .3584 *. The mean difference is significant at the 0.05 level.
LAMPIRAN B. Data dan Analisis Statistik Kerusakan Histologis Hepar Mencit
Rataan Masing-masing Derajat Kerusakan (Degenerasi Parenkimatosa,
Degenerasi Hidropik, dan Nekrosis) Histologis Hepar Mencit (Mus musculus L.)
dengan Pemberian Vitamin C dan E setelah Pemajanan Monosodium Glutamat
(MSG) (X±SD)Kelompok Perlakuan Degenerasi Parenkimatosa
X±SD Degenerasi Hidropik X±SD
Nekrosis X±SD
K- 61.2±6.10 45±12.55 20±4.90
K+ 54±10.49 33±13.25 18±8.49
P1 58±9.49 127.2±20.74 44±29.26
P2 49.2±9.65 83.4±23.75 52.8±38.72
P3 67.6±7.13 52.2±18.32 18.4±16.15
P4 57.2±8.32 48±22.65 11.2±7.69
Hasil Uji Statistik Histologis Hepar Kruskal-Wallis Test Ranks
5
5
b. Grouping Variable: Kel_Perlakuan
a. Kruskal Wallis Test
5 Asymp. Sig. .030
Derajat_Kerusakan Chi-Square 12.415 df
a,b
30 Test Statistics
11.80 Total
14.40 P4
14.40 K+
5
Kel_Perlakuan N Mean Rank Derajat_Kerusakan K-
5
23.90 P2
5
9.20 P1
5
19.30 P3
Mann-Whitney Test K-K+ Ranks
Kel_Perlakuan N Mean Rank Sum of Ranks Derajat_Kerusakan K-
5
6.50
32.50 K+
5
4.50
22.50 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 7.500 Wilcoxon W 22.500 Z -1.225 Asymp. Sig. (2-tailed) .221
a
Exact Sig. [2*(1-tailed Sig.)] .310 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
K-P1 Ranks
Kel_Perlakuan N Mean Rank Sum of Ranks Derajat_Kerusakan K-
5
3.80
19.00 P1
5
7.20
36.00 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 4.000 Wilcoxon W 19.000 Z -2.032 Asymp. Sig. (2-tailed) .042
a
Exact Sig. [2*(1-tailed Sig.)] .095 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
K-P2 Ranks
Kel_Perlakuan N Mean Rank Sum of Ranks Derajat_Kerusakan K-
5
4.60
23.00 P2
5
6.40
32.00 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 8.000 Wilcoxon W 23.000 Z -1.342 Asymp. Sig. (2-tailed) .180
a
Exact Sig. [2*(1-tailed Sig.)] .421 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
K-P3 Ranks
Kel_Perlakuan N Mean Rank Sum of Ranks Derajat_Kerusakan K-
5
5.50
27.50 P3
5
5.50
27.50 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 12.500 Wilcoxon W 27.500 Z .000 Asymp. Sig. (2-tailed) 1.000
a
Exact Sig. [2*(1-tailed Sig.)] 1.000 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
K-P4 Ranks
Sum of Kel_Perlakuan N Mean Rank Ranks
Derajat_Kerusakan K-
5
6.00
30.00 P4
5
5.00
25.00 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 10.000 Wilcoxon W 25.000 Z -.655 Asymp. Sig. (2-tailed) .513
a
Exact Sig. [2*(1-tailed Sig.)] .690 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
\
K+P1 Ranks
Kel_Perlakuan N Mean Rank Sum of Ranks Derajat_Kerusakan K+
5
3.40
17.00 P1
5
7.60
38.00 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 2.000 Wilcoxon W 17.000 Z -2.324 Asymp. Sig. (2-tailed) .020
a
Exact Sig. [2*(1-tailed Sig.)] .032 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
K+P2 Ranks
Sum of Kel_Perlakuan N Mean Rank Ranks
Derajat_Kerusakan K+
5
3.80
19.00 P2
5
7.20
36.00 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 4.000 Wilcoxon W 19.000 Z -2.032 Asymp. Sig. (2-tailed) .042
a
Exact Sig. [2*(1-tailed Sig.)] .095 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
K+P3 Ranks
Kel_Perlakuan N Mean Rank Sum of Ranks Derajat_Kerusakan K+
5
4.50
22.50 P3
5
6.50
32.50 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 7.500 Wilcoxon W 22.500 Z -1.225 Asymp. Sig. (2-tailed) .221
a
Exact Sig. [2*(1-tailed Sig.)] .310 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
K+P4 Ranks
Kel_Perlakuan N Mean Rank Sum of Ranks Derajat_Kerusakan K+
5
5.00
25.00 P4
5
6.00
30.00 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 10.000 Wilcoxon W 25.000 Z -.600 Asymp. Sig. (2-tailed) .549
a
Exact Sig. [2*(1-tailed Sig.)] .690 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
P1P2 Ranks
Kel_Perlakuan N Mean Rank Sum of Ranks Derajat_Kerusakan P1
5
6.50
32.50 P2
5
4.50
22.50 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 7.500 Wilcoxon W 22.500 Z -1.225 Asymp. Sig. (2-tailed) .221
a
Exact Sig. [2*(1-tailed Sig.)] .310 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
P1P3 Ranks
Kel_Perlakuan N Mean Rank Sum of Ranks Derajat_Kerusakan P1
5
7.20
36.00 P3
5
3.80
19.00 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 4.000 Wilcoxon W 19.000 Z -2.032 Asymp. Sig. (2-tailed) .042
a
Exact Sig. [2*(1-tailed Sig.)] .095 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
P1P4 Ranks
Sum of Kel_Perlakuan N Mean Rank Ranks
Derajat_Kerusakan P1
5
7.40
37.00 P4
5
3.60
18.00 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 3.000 Wilcoxon W 18.000 Z -2.154 Asymp. Sig. (2-tailed) .031
a
Exact Sig. [2*(1-tailed Sig.)] .056 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
P2P3 Ranks
Kel_Perlakuan N Mean Rank Sum of Ranks Derajat_Kerusakan P2
5
6.40
32.00 P3
5
4.60
23.00 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 8.000 Wilcoxon W 23.000 Z -1.342 Asymp. Sig. (2-tailed) .180
a
Exact Sig. [2*(1-tailed Sig.)] .421 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
P2P4 Ranks
Kel_Perlakuan N Mean Rank Sum of Ranks Derajat_Kerusakan P2
5
6.80
34.00 P4
5
4.20
21.00 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 6.000 Wilcoxon W 21.000 Z -1.678 Asymp. Sig. (2-tailed) .093
a
Exact Sig. [2*(1-tailed Sig.)] .222 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan
P3P4 Ranks
Sum of Kel_Perlakuan N Mean Rank Ranks
Derajat_Kerusakan P3
5
6.00
30.00 P4
5
5.00
25.00 Total
10
b Test Statistics
Derajat_Kerusakan Mann-Whitney U 10.000 Wilcoxon W 25.000 Z -.655 Asymp. Sig. (2-tailed) .513
a
Exact Sig. [2*(1-tailed Sig.)] .690 a. Not corrected for ties.
b. Grouping Variable: Kel_Perlakuan