Formulasi Beads Alginat Gastroretentif yang Mengandung Ekstrak Kunyit (Curcuma domestica Val.) dan Uji Efek Penyembuhan Terhadap Lesi Lambung pada Tikus
DAFTAR PUSTAKA
Aggarwal, B.B., Kumar, A., dan Bharti, A.C. (2003). Anticancer Potential of
Curcumin: Preclinical and Clinical Studies. Anticancer. 23: 363-398.
Aihara, T., Nakamura, E., Amagase, K., Tomita, K., Fujishita, T. Furutani, K.
(2003). Pharmacological Control of Gastric Acid Secretion for the
Treatment of Acid-related Peptic Disease: Past, Present, and Future.
Pharmacol Ther. 98: 109-127.
Ali, J., Arora, S., dan Khar, R.K. (2005). Floating Drug Delivery System: A
Review. AAPS Pharm Sci Tech. 6(3). Halaman 372-390.
Allen, A. dan Snary, D. (1972). The Structure and Function of Gastric Mucus. Gut.
13: 666-672.
Anand, P., Kunnumakkara, A. B., Newman, R. A., dan Aggarwal, B. B. (2002).
Bioavailability of Curcumin: Problems and Promises. Mol.
Pharmaceutics. 4 (6): 807- 818.
Apisariyakul, A., Vanittanakomm, N., dan Buddasukh, D. (1995). Antifungal
Activity of Turmeric Oil Extracted from Curcuma longa (Zingiberaceae).
Journal of Ethnopharmacology. 49: 163-169.
Avinash, K. (2011). Peptic Ulcer: A Review with Emphasis on Plants from
Cucurbitaceae Family with Anti Ulcer Potential. International Journal of
Research in Ayurveda & Pharmacy. 2 (6): 1714- 6.
Badoni, A., Ojha, A., Granarajan, G., dan Kothiyal, P. (2012). Review on Gastro
Retentive Drug Delivery System. The Pharma Innovation. 1(8): 32- 6.
Bansar, N. dan Basant, D. (1982). Curcumin as an Effective Chemopreventive
Agent. Indian Journal of Experimental Biology. 11: 115-211.
Bansil, R. dan Turner, B. (2006). Mucin Structure, Aggregation, Physiological
Functions and Biomedical Applications. Curr. Opin. Colloid Interface Sci.
11: 164-170.
Bruschi, M.L. (2015). Strategies to Modify the Drug Release from
Pharmaceutical Systems. UK: Elsevier Ltd. Halaman 158.
Cheng, A.L., Hsu, C. H., dan Lin, J. K. (2001). Phase I Clinical Trial of Curcumin,
a Chemopreventive Agent, in Patients with High-risk or Pre-malignant
Lesions. Anticancer Res. 21: 2895-2900.
Chu, P.K., dan Liu, X. (2008). Biomaterials Fabrication and Processing
Handbook. Boca Raton: CRC Press. Halaman 645.
64
Universitas Sumatera Utara
Cora, L.A., Miranda, J.R. A., Americo, M.F., Oliveira, R.B., dan Baffa, O. (2007).
Biomagnetic Approaches Applied to Drug Delivery Studies. Drug
Delivery Research Advances. New York: Nova Science Publishers, Inc..
Halaman 190, 191.
Davenport, H. W. (1982). Physiology of the Digestive Tract. Yearbook. Chicago:
Medical Publ. Halaman 140-141.
Depkes RI. (1979). Materia Medika Indonesia. Jilid III. Jakarta: Departemen
Kesehatan RI. Halaman 52.
Depkes RI. (1989). Materia Medika Indonesia. Jilid V. Jakarta: Departemen
Kesehatan RI. Halaman 31.
Ditjen POM. (1979). Farmakope Indonesia. Edisi III. Jakarta: Departemen
Kesehatan RI. Halaman 9, 33.
Ditjen POM. (1995). Farmakope Indonesia. Edisi IV. Jakarta: Departemen
Kesehatan RI. Halaman 31.
Farnsworth, N.R., dan Bunyapraphatsara. (1992). Thai Medicinal Plants. First
Edition. Bangkok: MPIC. Halaman 402.
Gathak, N dan Basu, N. (1972). Sodium Curcuminate as an Effective Antiinflammatory Agent. Indian Journal of Experimental Biology. 10:235-236.
Grant, G.T., Morris, E.R., Rees, D.A., Smith, P.J.C., dan Thom, D. (1973).
Biological Interactions between Polysaccharides and Divalent CationsEgg-box Model. Febs. Lett. 32: 195-198.
Hakim, B. dan Arianto, A. (2016). Healing Effect of Alginate Liquid against HClinduced Gastric Mucosal Lesions in Rats. International Journal of
PharmTech Research. 9(3): 287-296.
Halim, E.M., dan Ali, H. (2002). Hypoglycemic, Hypolipidemic, and Antioxidant
Properties of Combination of Curcumin from Curcuma longa Linn. and
Partially Purified Product from Abroma augusta Linn. in Streptozocin
Induced Diabetes. Indian Journal of Clinical Biochemistry. 17(12): 33-43.
Holt, P.R., Katz, S., dan Kirshoff, R. (2005). Curcumin Therapy in Inflammatory
Bowel Disease: A Pilot Study. Dig Dis Sci. 11: 2191- 2193.
Isselbacher. (2000). Harrison’s Principles of Internal Medicine. Penerjemah:
Asdie, A.H. (2000). Prinsip-Prinsip Ilmu Penyakit Dalam. Volume Empat.
Jakarta: Penerbit Buku Kedokteran EGC. Halaman 1532-1549.
Jefferson, W. (2015). The Healing Power of Curcumin. United States of America:
Healthy Living Publications. Halaman 298-299, 302.
65
Universitas Sumatera Utara
Johnson, L.R. dan McCormack, S.A. (1994). Regulation of Gastrointestinal
Mucosal Growth. Physiology of the Gastrointestinal Tract. Third Edition.
Newyork: Johnson LR, Raven Press. Halaman 611- 641.
Jurenka, J.S. (2009). Anti-inflammatory Properties of Curcumin, a Major
Constituent of Curcuma longa: A Review of Preclinical and Clinical
Research. Alternative Medicine Review. 14(2): 141-153.
Koosirirat, C., Linpisam, S., Changsom, D., Chawansuntati, K., dan Wipasa, J.
(2010). Investigation of the Anti-inflammatory Effect of Curcuma longa
in Helicobacter pylori-infected patients. Int. Immunopharmacol. 10: 815818.
Krishnaswamy, K. (2009). Turmeric: The Salt of the Orient is the Spice of Life.
New Delhi: Allied Publishers Pvt. Ltd. Halaman 14 – 24.
Kumavat, S.D., Chaudari, Y.S., Borole, P., Mishra, P., Shenghani, K., dan
Duvvuri, P. (2013). Degradation Studies of Curcumin. Interational
Journal of Pharmacy Review & Research. 3 (2): 50-55.
Li, N., Xie, C., Lu, N.H. (2015). Transforming Growth Factor-β: an Important
Mediator in Helicobacterpylori-associated Pathogenesis. Front. Cell.
Infect. Microbiol. 5:77.
Lipkin, M. (1987). Proliferation and Differentiation of Normal and Diseased
Gastrointestinal Cells. Physiology of Gastrointestinal Cells. Second
Edition. Newyork: Johnson LR, Raven Press. Halaman 255-284.
Mahattanadul, S., Nakamura, T., Panichayupakaranant, P., Phdoongsombut, N.,
Tungsinmunkong, K., dan Bouking, P. (2009). Comparative Antiulcer
Effect of Bisdemethoxycurcumin and Curcumin in a Gastric Ulcer Model
System. Phytomedicine. 16: 342-351.
Mani, H., Sidho, G. S., Kumari, R., Gaddipati, J. P., Seth, P., dan Maheshwari,
R.K. (2002). Curcumin Differentially Regulates TGF-beta1, Its Receptors
and Nitric Oxide Synthase During Impaired Wound Healing. Biofactors.
16 (1 -2): 29- 43.
Mazumdar, A., Raghavan, K., Weinstein, J., Kohn, K.W., dan Pommer, Y. (1995).
Inhibition of Human Immunodeficiency virus type-I Integrase by
Curcumin. Biochemical pharmacology. 49: 165-170.
Mei, X., Xu, D., Wang, S., dan Xu., S. (2009). Pharmacological Researches of
Curcumin Solid Dispersions on Experimental Gastric Ulcer. Zhongguo
Zhong Yao Za Zhi. 34: 2920- 2923.
66
Universitas Sumatera Utara
Milani, S., dan Calabro, S. (2001). Role of Growth Factors and their Receptors in
Gastric Ulcer Healing. Microscopy Research and Technique. 53(5): 360371.
Mishra, M. (2016). Handbook of Encapsulation and Controlled Release. Boca
Raton: CRC Press. Halaman 606.
Morris, E.R., Rees, D.A., Thom, D. (1980). Characterisation of Alginates
Composition and Block Structure by Circular Dichroism. Carbohydrate
Research. 81(2): 305-310.
Munzenmaier, A., Lange. C., Glocker, E., Covacci, A., dan Moran, A.. (1997). A
Secreted Shed Product of Helicobacter pylori Activates Transcription
Factor Nuclear Factor-kappa B. Immunology. 159: 6140- 6147.
Nayak, A. K., Maji, R., dan Das, B. (2010). Gastroretentive Drug Delivery
System: A Review. Asian Journal of Pharmaceutical and Clinical
Research. 3 (1): 2- 4, 7- 9.
Negi, P.S., Jayaprakash, G.K., Jagan, M.R.I., dan Sakariah, K.K. (1999).
Antibacterial Activity of Turmeric Oil; a byproduct from curcumin
manufacture. Journal of Agricultural and Food Chemistry. 47: 297-300.
Porth, C. (2009). Porth Pathophysiology: Concepts of Altered Health States.
Philadelphia: Lippincott Williams & Wilkins. Halaman 884-5.
Ravindran, P.N., Babu, K.N., dan Sivaraman, K. (2007). Turmeric: the Genus
curcuma. Boca Raton: CRC Press. Halaman 298.
Ruby, A.J., Kuttan, G., Dinesh, B.K., Rajasekharan, K.N., dan Kuttan, R. (1995).
Antitumor and antioxidant Activity of Natural Curcuminoids. Cancer
Letters. 94: 79-83.
Sandri, G., Rossi, S., Ferrari, F., Bonferoni, M.C., dan Caramella, C.M. (2015).
Mucoadhesive Polymers as Enabling Excipients for Oral Mucosal Drug
Delivery. Controlled Release Society. Halaman 53-56.
Satoskar, R.R., Shah, S.J., Shenoy, S.G. (1986). Evaluation of Anti-inflammatory
Property of Curcumin (diferuloyl methane) in Patients with Post-operative
in Flammation. Int J Clin Pharmacol Ther Toxicol. 24: 651 -654.
Schreiber, D.S. (2010). Hidup Bebas Kanker: Terobosan Terbaru Mencegah,
Melawan, & Mengobati Kanker. Bandung: PT. Mizan Pustaka. Halaman
158.
Sharma, R.A., Steward,W.P.,dan Gescher, A.J. (2007). Pharmacokinetics and
Pharmacodynamics of Curcumin. Halaman 454.
67
Universitas Sumatera Utara
Sherwood, L. (2011). Human Physiology: From Cells to System. Penerjemah: Pendit,
B.U. (2001). Fisiologi Manusia dari Sel ke Sistem. Jakarta: Penerbit Buku
Kedokteran EGC. Halaman 538-560.
Singh, B.N. dan Kim, K.H. (2000). Floating Drug Delivery Systems: an Approach to Oral
Controlled Drug Delivery via Gastri Retention. J Control Release. 63. Halaman:
235-259.
Sinko, P.J. (2012). Farmasi Fisika dan Ilmu Farmasetika Martin. Jakarta: EGC.
Halaman: 431-432.
Smidsrod, O. dan Skjak-Braek, G. (1990). Alginate as Immobilization Matrix for Cells.
Trend Biotechnol. 8: 71-78.
Sunil. K., Amandeep K., Robin, S., Ramica, S. (2012). Peptic Ulcer: A Review on
Etiology and Pathogenesis. International Research Journal Pharmacy. Volume 3
(6): 34-35.
Szabo, S., Vincze, A., Sandor, Z., Jadus, M., Gombos, Z., dan Pedram, A.. (1998).
Vascular Approach to Gastroduodenal Ulceration: New Studies with endothelins
and VEGF. Dig Dis Sci. 43: 40-45.
Talukder, R. dan Fassihi, R. (2004). Gastroretentive Delivery Systems: A mini review.
Drug Dev. Ind. Pharm. 30(10): 1019-1028.
Tarnawski, A., Hollander, D., Stachura J.Krause W. J., Eltorei, M., Dabros, W., dan
Gergely, H. (1999). Vascular and Microvascular Changes-Key Factors in the
Development of Acetic Acid-induced gastric ulcers in rats. J. Clin. Gastroenterol.
148-157.
Tipton, P.A. (2010). Synthesis of Alginat in Bacteria. Comprehensive Natural Products
II: Chemistry and Biology. UK: Elsevier. Halaman 423-424.
Vetter, A. dan Schnurch, A.B. (2010). Bioadhesive Delivery Systems. Biodrug Delivery
Systems: Fundamentals, Applications and Clinical Development. Boca Raton:
CRC Press. Halaman 220-221.
Wen, H. dan Park, K. (2010). Oral Controlled Release Formulation Design and Drug
Delivery: Theory to Practice. Singapore: John Wiley & Sons, Inc. Halaman 21,
23.
Yu, T., Andrews, G.P., dan Jones, D.S. (2014). Mucoadhesion and Characterization of
Mucoadhesive Properties. Mucosal Delivery of Biopharmaceuticals: Biology,
Challenges dan Strategies. New York: Springers. Halaman 35-43.
Zhang, H., Shahbazi, M.A., Almeida, P.V., dan Santos, H.A. (2014). Mucus as a Barrier
for Biopharmaceuticals and Drug Delivery Systems. Mucosal Delivery of
Biopharmaceuticals: Biology, Challenges dan Strategies. New York: Springers.
Halaman 71.
68
Universitas Sumatera Utara
Aggarwal, B.B., Kumar, A., dan Bharti, A.C. (2003). Anticancer Potential of
Curcumin: Preclinical and Clinical Studies. Anticancer. 23: 363-398.
Aihara, T., Nakamura, E., Amagase, K., Tomita, K., Fujishita, T. Furutani, K.
(2003). Pharmacological Control of Gastric Acid Secretion for the
Treatment of Acid-related Peptic Disease: Past, Present, and Future.
Pharmacol Ther. 98: 109-127.
Ali, J., Arora, S., dan Khar, R.K. (2005). Floating Drug Delivery System: A
Review. AAPS Pharm Sci Tech. 6(3). Halaman 372-390.
Allen, A. dan Snary, D. (1972). The Structure and Function of Gastric Mucus. Gut.
13: 666-672.
Anand, P., Kunnumakkara, A. B., Newman, R. A., dan Aggarwal, B. B. (2002).
Bioavailability of Curcumin: Problems and Promises. Mol.
Pharmaceutics. 4 (6): 807- 818.
Apisariyakul, A., Vanittanakomm, N., dan Buddasukh, D. (1995). Antifungal
Activity of Turmeric Oil Extracted from Curcuma longa (Zingiberaceae).
Journal of Ethnopharmacology. 49: 163-169.
Avinash, K. (2011). Peptic Ulcer: A Review with Emphasis on Plants from
Cucurbitaceae Family with Anti Ulcer Potential. International Journal of
Research in Ayurveda & Pharmacy. 2 (6): 1714- 6.
Badoni, A., Ojha, A., Granarajan, G., dan Kothiyal, P. (2012). Review on Gastro
Retentive Drug Delivery System. The Pharma Innovation. 1(8): 32- 6.
Bansar, N. dan Basant, D. (1982). Curcumin as an Effective Chemopreventive
Agent. Indian Journal of Experimental Biology. 11: 115-211.
Bansil, R. dan Turner, B. (2006). Mucin Structure, Aggregation, Physiological
Functions and Biomedical Applications. Curr. Opin. Colloid Interface Sci.
11: 164-170.
Bruschi, M.L. (2015). Strategies to Modify the Drug Release from
Pharmaceutical Systems. UK: Elsevier Ltd. Halaman 158.
Cheng, A.L., Hsu, C. H., dan Lin, J. K. (2001). Phase I Clinical Trial of Curcumin,
a Chemopreventive Agent, in Patients with High-risk or Pre-malignant
Lesions. Anticancer Res. 21: 2895-2900.
Chu, P.K., dan Liu, X. (2008). Biomaterials Fabrication and Processing
Handbook. Boca Raton: CRC Press. Halaman 645.
64
Universitas Sumatera Utara
Cora, L.A., Miranda, J.R. A., Americo, M.F., Oliveira, R.B., dan Baffa, O. (2007).
Biomagnetic Approaches Applied to Drug Delivery Studies. Drug
Delivery Research Advances. New York: Nova Science Publishers, Inc..
Halaman 190, 191.
Davenport, H. W. (1982). Physiology of the Digestive Tract. Yearbook. Chicago:
Medical Publ. Halaman 140-141.
Depkes RI. (1979). Materia Medika Indonesia. Jilid III. Jakarta: Departemen
Kesehatan RI. Halaman 52.
Depkes RI. (1989). Materia Medika Indonesia. Jilid V. Jakarta: Departemen
Kesehatan RI. Halaman 31.
Ditjen POM. (1979). Farmakope Indonesia. Edisi III. Jakarta: Departemen
Kesehatan RI. Halaman 9, 33.
Ditjen POM. (1995). Farmakope Indonesia. Edisi IV. Jakarta: Departemen
Kesehatan RI. Halaman 31.
Farnsworth, N.R., dan Bunyapraphatsara. (1992). Thai Medicinal Plants. First
Edition. Bangkok: MPIC. Halaman 402.
Gathak, N dan Basu, N. (1972). Sodium Curcuminate as an Effective Antiinflammatory Agent. Indian Journal of Experimental Biology. 10:235-236.
Grant, G.T., Morris, E.R., Rees, D.A., Smith, P.J.C., dan Thom, D. (1973).
Biological Interactions between Polysaccharides and Divalent CationsEgg-box Model. Febs. Lett. 32: 195-198.
Hakim, B. dan Arianto, A. (2016). Healing Effect of Alginate Liquid against HClinduced Gastric Mucosal Lesions in Rats. International Journal of
PharmTech Research. 9(3): 287-296.
Halim, E.M., dan Ali, H. (2002). Hypoglycemic, Hypolipidemic, and Antioxidant
Properties of Combination of Curcumin from Curcuma longa Linn. and
Partially Purified Product from Abroma augusta Linn. in Streptozocin
Induced Diabetes. Indian Journal of Clinical Biochemistry. 17(12): 33-43.
Holt, P.R., Katz, S., dan Kirshoff, R. (2005). Curcumin Therapy in Inflammatory
Bowel Disease: A Pilot Study. Dig Dis Sci. 11: 2191- 2193.
Isselbacher. (2000). Harrison’s Principles of Internal Medicine. Penerjemah:
Asdie, A.H. (2000). Prinsip-Prinsip Ilmu Penyakit Dalam. Volume Empat.
Jakarta: Penerbit Buku Kedokteran EGC. Halaman 1532-1549.
Jefferson, W. (2015). The Healing Power of Curcumin. United States of America:
Healthy Living Publications. Halaman 298-299, 302.
65
Universitas Sumatera Utara
Johnson, L.R. dan McCormack, S.A. (1994). Regulation of Gastrointestinal
Mucosal Growth. Physiology of the Gastrointestinal Tract. Third Edition.
Newyork: Johnson LR, Raven Press. Halaman 611- 641.
Jurenka, J.S. (2009). Anti-inflammatory Properties of Curcumin, a Major
Constituent of Curcuma longa: A Review of Preclinical and Clinical
Research. Alternative Medicine Review. 14(2): 141-153.
Koosirirat, C., Linpisam, S., Changsom, D., Chawansuntati, K., dan Wipasa, J.
(2010). Investigation of the Anti-inflammatory Effect of Curcuma longa
in Helicobacter pylori-infected patients. Int. Immunopharmacol. 10: 815818.
Krishnaswamy, K. (2009). Turmeric: The Salt of the Orient is the Spice of Life.
New Delhi: Allied Publishers Pvt. Ltd. Halaman 14 – 24.
Kumavat, S.D., Chaudari, Y.S., Borole, P., Mishra, P., Shenghani, K., dan
Duvvuri, P. (2013). Degradation Studies of Curcumin. Interational
Journal of Pharmacy Review & Research. 3 (2): 50-55.
Li, N., Xie, C., Lu, N.H. (2015). Transforming Growth Factor-β: an Important
Mediator in Helicobacterpylori-associated Pathogenesis. Front. Cell.
Infect. Microbiol. 5:77.
Lipkin, M. (1987). Proliferation and Differentiation of Normal and Diseased
Gastrointestinal Cells. Physiology of Gastrointestinal Cells. Second
Edition. Newyork: Johnson LR, Raven Press. Halaman 255-284.
Mahattanadul, S., Nakamura, T., Panichayupakaranant, P., Phdoongsombut, N.,
Tungsinmunkong, K., dan Bouking, P. (2009). Comparative Antiulcer
Effect of Bisdemethoxycurcumin and Curcumin in a Gastric Ulcer Model
System. Phytomedicine. 16: 342-351.
Mani, H., Sidho, G. S., Kumari, R., Gaddipati, J. P., Seth, P., dan Maheshwari,
R.K. (2002). Curcumin Differentially Regulates TGF-beta1, Its Receptors
and Nitric Oxide Synthase During Impaired Wound Healing. Biofactors.
16 (1 -2): 29- 43.
Mazumdar, A., Raghavan, K., Weinstein, J., Kohn, K.W., dan Pommer, Y. (1995).
Inhibition of Human Immunodeficiency virus type-I Integrase by
Curcumin. Biochemical pharmacology. 49: 165-170.
Mei, X., Xu, D., Wang, S., dan Xu., S. (2009). Pharmacological Researches of
Curcumin Solid Dispersions on Experimental Gastric Ulcer. Zhongguo
Zhong Yao Za Zhi. 34: 2920- 2923.
66
Universitas Sumatera Utara
Milani, S., dan Calabro, S. (2001). Role of Growth Factors and their Receptors in
Gastric Ulcer Healing. Microscopy Research and Technique. 53(5): 360371.
Mishra, M. (2016). Handbook of Encapsulation and Controlled Release. Boca
Raton: CRC Press. Halaman 606.
Morris, E.R., Rees, D.A., Thom, D. (1980). Characterisation of Alginates
Composition and Block Structure by Circular Dichroism. Carbohydrate
Research. 81(2): 305-310.
Munzenmaier, A., Lange. C., Glocker, E., Covacci, A., dan Moran, A.. (1997). A
Secreted Shed Product of Helicobacter pylori Activates Transcription
Factor Nuclear Factor-kappa B. Immunology. 159: 6140- 6147.
Nayak, A. K., Maji, R., dan Das, B. (2010). Gastroretentive Drug Delivery
System: A Review. Asian Journal of Pharmaceutical and Clinical
Research. 3 (1): 2- 4, 7- 9.
Negi, P.S., Jayaprakash, G.K., Jagan, M.R.I., dan Sakariah, K.K. (1999).
Antibacterial Activity of Turmeric Oil; a byproduct from curcumin
manufacture. Journal of Agricultural and Food Chemistry. 47: 297-300.
Porth, C. (2009). Porth Pathophysiology: Concepts of Altered Health States.
Philadelphia: Lippincott Williams & Wilkins. Halaman 884-5.
Ravindran, P.N., Babu, K.N., dan Sivaraman, K. (2007). Turmeric: the Genus
curcuma. Boca Raton: CRC Press. Halaman 298.
Ruby, A.J., Kuttan, G., Dinesh, B.K., Rajasekharan, K.N., dan Kuttan, R. (1995).
Antitumor and antioxidant Activity of Natural Curcuminoids. Cancer
Letters. 94: 79-83.
Sandri, G., Rossi, S., Ferrari, F., Bonferoni, M.C., dan Caramella, C.M. (2015).
Mucoadhesive Polymers as Enabling Excipients for Oral Mucosal Drug
Delivery. Controlled Release Society. Halaman 53-56.
Satoskar, R.R., Shah, S.J., Shenoy, S.G. (1986). Evaluation of Anti-inflammatory
Property of Curcumin (diferuloyl methane) in Patients with Post-operative
in Flammation. Int J Clin Pharmacol Ther Toxicol. 24: 651 -654.
Schreiber, D.S. (2010). Hidup Bebas Kanker: Terobosan Terbaru Mencegah,
Melawan, & Mengobati Kanker. Bandung: PT. Mizan Pustaka. Halaman
158.
Sharma, R.A., Steward,W.P.,dan Gescher, A.J. (2007). Pharmacokinetics and
Pharmacodynamics of Curcumin. Halaman 454.
67
Universitas Sumatera Utara
Sherwood, L. (2011). Human Physiology: From Cells to System. Penerjemah: Pendit,
B.U. (2001). Fisiologi Manusia dari Sel ke Sistem. Jakarta: Penerbit Buku
Kedokteran EGC. Halaman 538-560.
Singh, B.N. dan Kim, K.H. (2000). Floating Drug Delivery Systems: an Approach to Oral
Controlled Drug Delivery via Gastri Retention. J Control Release. 63. Halaman:
235-259.
Sinko, P.J. (2012). Farmasi Fisika dan Ilmu Farmasetika Martin. Jakarta: EGC.
Halaman: 431-432.
Smidsrod, O. dan Skjak-Braek, G. (1990). Alginate as Immobilization Matrix for Cells.
Trend Biotechnol. 8: 71-78.
Sunil. K., Amandeep K., Robin, S., Ramica, S. (2012). Peptic Ulcer: A Review on
Etiology and Pathogenesis. International Research Journal Pharmacy. Volume 3
(6): 34-35.
Szabo, S., Vincze, A., Sandor, Z., Jadus, M., Gombos, Z., dan Pedram, A.. (1998).
Vascular Approach to Gastroduodenal Ulceration: New Studies with endothelins
and VEGF. Dig Dis Sci. 43: 40-45.
Talukder, R. dan Fassihi, R. (2004). Gastroretentive Delivery Systems: A mini review.
Drug Dev. Ind. Pharm. 30(10): 1019-1028.
Tarnawski, A., Hollander, D., Stachura J.Krause W. J., Eltorei, M., Dabros, W., dan
Gergely, H. (1999). Vascular and Microvascular Changes-Key Factors in the
Development of Acetic Acid-induced gastric ulcers in rats. J. Clin. Gastroenterol.
148-157.
Tipton, P.A. (2010). Synthesis of Alginat in Bacteria. Comprehensive Natural Products
II: Chemistry and Biology. UK: Elsevier. Halaman 423-424.
Vetter, A. dan Schnurch, A.B. (2010). Bioadhesive Delivery Systems. Biodrug Delivery
Systems: Fundamentals, Applications and Clinical Development. Boca Raton:
CRC Press. Halaman 220-221.
Wen, H. dan Park, K. (2010). Oral Controlled Release Formulation Design and Drug
Delivery: Theory to Practice. Singapore: John Wiley & Sons, Inc. Halaman 21,
23.
Yu, T., Andrews, G.P., dan Jones, D.S. (2014). Mucoadhesion and Characterization of
Mucoadhesive Properties. Mucosal Delivery of Biopharmaceuticals: Biology,
Challenges dan Strategies. New York: Springers. Halaman 35-43.
Zhang, H., Shahbazi, M.A., Almeida, P.V., dan Santos, H.A. (2014). Mucus as a Barrier
for Biopharmaceuticals and Drug Delivery Systems. Mucosal Delivery of
Biopharmaceuticals: Biology, Challenges dan Strategies. New York: Springers.
Halaman 71.
68
Universitas Sumatera Utara