I. Introduction
Helminthiasis is still common found on children in Indonesia, especially Soil Transmitted Helminths infection.. Ascaris lumbricoides is the most causes of STH
infection then follow by Trichuris trichiura and hookworm. Besides of growth and development disturbunces, infection of the three species of STH can result another
bad efect.on children.
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Helminthic infection is usually chronic and deaths of host will harm the parasite. Chronic infection of parasite will give persistent antigent stimulation which
will increase immunoglobulin level of the blood and form immune complex. On helmintiasis people, besides of increasing level of immunoglobulin, the eosinophil
level will increase too.
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Immune response of helmintic infection is not effective and difficult to understand. This difficulty may be cause of complex size and structure of the
helmitnhs. Size of the helminths is too large for phagosited but can arranged in layers by Ig E and Ig A. Helminthic infection instructed immune system into Th2 response
and produce Ig E, Ig A and chemotactic Th2 cytokine into eosinophil and mast cell.
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Eosinophil attaches to the helminths through Ig AIg E and release cathionic protein, MBP and neurotoxin. Mast cell and eosinophil will bind surface of parasite
through Fc -R, Fc i-R dan Fcg-R and release their toxic content.
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Bejon, P, Mwamgi, T.W. et all reported that increasing of eosinophil level can be a sensitive sign of parasite infection. Helminthic infection can trigger increasing of
eosinophil level was assured by Pardo et al, 2006, from their study of immigrant African whom suffer from helminthiasis. Pardo stated 27 of that immigrant were
eosinophilia, 16 of them were ancylostomiasis and 17,2 were schistosomiasis.
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On their reports, Quinell, R.J. et all, 2004, stated 14 people with ancylostomiasis have increasing level of eosinophil.
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Based on the states of the researchers above, it is need to make a study to see percentage of increasing level of eosinophilia on helminthic infection people and to
know the serve of eosinophil in immunity into the helminthic infection.
Nurfida Khairina Arrasyid : Eosinophil Profile of Elementary Student, Caused by Soil Transmitted..., 2008 USU e-Repository © 2008
II. References
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