BAB 4 HASIL DAN PEMBAHASAN
4.1. Tabel Data Hasil Ringkasan Komponen Area Betametason Valerat
Batch A60118 T Sample
Name Inj. Channel
Vial Betamethasone valerat
1 A60118 T a
1 W2489 ChA 11
366730 2
A60118 T b 1
W2489 ChA 12 367163
Mean 366947
Std. Dev. 307
RSD 0.1
Batch A60119 T Sample
Name Inj. Channel
Vial Betamethasone valerat
1 A60119 T a
1 W2489 ChA 11
362145 2
A60119 T b 1
W2489 ChA 12 364037
Mean 363091
Std. Dev. 1337
RSD 0.4
Universitas Sumatera Utara
Batch A60120 T Sample
Name Inj. Channel
Vial Betamethasone valerat
1 A60120 T a
1 W2489 ChA 11
357653 2
A60120 T b 1
W2489 ChA 12 358906
Mean 358279
Std. Dev. 886
RSD 0.2
4.2. Tabel Data Hasil Jumlah Komponen Betametason Valerat
Batch A60118 T Sample
Name Inj. Channel
Vial Betamethasone valerat
1 A60118 T a
1 W2489 ChA 11
103.136 2
A60118 T b 1
W2489 ChA 12 103.258
Mean 103.197
Std. Dev. 0.086
RSD 0.1
Universitas Sumatera Utara
Batch A60119 T Sample
Name Inj. Channel
Vial Betamethasone valerat
1 A60119 T a
1 W2489 ChA 11
101.847 2
A60119 T b 1
W2489 ChA 12 102.379
Mean 102.113
Std. Dev. 0.376
RSD 0.4
Batch A60120 T Sample
Name Inj. Channel
Vial Betamethasone valerat
1 A60120 T a
1 W2489 ChA 11
100.583 2
A60120 T b 1
W2489 ChA 12 100.936
Mean 100.760
Std. Dev. 0.249
RSD 0.2
Universitas Sumatera Utara
4.2 Perhitungan 4.2.1 Perhitungan Kadar Betametason Valerat dalam Krim Betason-N
Untuk menghitung kadar Betametason Valerat dalam krim Betason-n krim dengan menggunakan HPLC digunakan rumus sebagai berikut:
���� = �
× Bws
× ×
Kws × � ×
×
Ket : As = Luas area larutan standar
Au = Luas area larutan uji BWS = Bobot betametason valerate yang ditimbang mg
KWS = Kadar betametason valerate Bu = Bobot sampel yang ditimbang mg
1 = Kandungan betametason valerat per gram krim 251x50 = Faktor pengenceran larutan standar
50= Faktor pengenceran larutan uji 100 = Dalam 1 gram massa krim
1.Perhitungan Kadar Betametason valerat dalam krim Betason-N
Batch: A60118 T Diketahui:
Batch A60118 T a Batch A60118 T b Au:366730
Au: 367163 As: 352698
As: 352698 BWS: 25.04
BWS: 25.04
Universitas Sumatera Utara
KWS: 99.190 KWS: 99.190
Bu: 1000.16 Bu: 1000.13
Kadar Batch A60118 T a �
× Bws
× ×
Kws × � ×
×
× .
× ×
. ×
. × ×
=103.285 Kadar Batch A60118 T b
� ×
Bws ×
× Kws
× � × ×
× .
× ×
. ×
. × ×
=103.410 Kadar rata-rata Batch A60118 T yang diperoleh:
Kadar rata-rata=
k d r +k d r
=
. +
.
= 103.347
2. Perhitungan Kadar Betametason valerat dalam krim Betason-N
Batch: A60119 T Diketahui:
Batch A60119 T a Batch A60119 T b Au:362145
Au: 364037 As: 352698
As: 352698
Universitas Sumatera Utara
BWS: 25.04 BWS: 25.04
KWS: 99.190 KWS: 99.190
Bu: 1000.07 Bu: 1000.12
Kadar Batch A60119 T a �
× Bws
× ×
Kws × � ×
×
× .
× ×
. ×
. × ×
= 102.003 Kadar Batch A60119 T b
� ×
Bws ×
× Kws
× � × ×
× .
× ×
. ×
. × ×
= 102.530 Kadar rata-rata Batch A60119 T yang diperoleh:
Kadar rata-rata=
k d r +k d r
=
. +
.
= 102.267
Universitas Sumatera Utara
3. Perhitungan Kadar Betametason valerat dalam krim Betason-N
Batch: A60120 T Diketahui:
Batch A60120 T a Batch A60120 T b Au:357653
Au: 358906 As: 352698
As: 352698 BWS: 25.04
BWS: 25.04 KWS: 99.190
KWS: 99.190 Bu: 1000.27
Bu: 1000.16
Kadar Batch A60120 T a �
× Bws
× ×
Kws × � ×
×
× .
× ×
. ×
. × ×
=100.717 Kadar Batch A60120 T b
� ×
Bws ×
× Kws
× � × ×
× .
× ×
. ×
. × ×
= 101.081 Kadar rata-rata Batch A60120 T yang diperoleh:
Kadar rata-rata=
k d r +k d r
Universitas Sumatera Utara
=
. +
.
=100.899
4.3 Pembahasan