SIMPULAN DAN SARAN
BAB VI SIMPULAN DAN SARAN
A. Simpulan
Ekstrak daun sendok dosis 1 mg/mencit dan 2 mg/mencit menurunkan derajat inflamasi bronkus mencit BALB/c model asma alergi.
B. Saran
Dengan mempertimbangkan hasil penelitian ini, penulis memberi saran sebagai berikut :
1. Dapat dilakukan penelitian lebih lanjut mengenai dosis optimal dan dosis toksik daun sendok sebagai obat antiasma alergi dengan menambah variasi dosis.
2. Dapat dilakukan penelitian lebih lanjut mengenai evaluasi daun sendok sebagai obat antiasma alergi menggunakan mencit model asma alergi kronik.
DAFTAR PUSTAKA
Abbas AK and Lichtman AH. 2003. Cellular and Molecular Immunology. Canada: Elsevier Science, pp: 264: 443-8
Arief M. 2004. Pengantar Metodologi Penelitian untuk Ilmu Kesehatan. Klaten: Community of Self Help Group Forum, hal: 132
Baldy CM. 2006. Gangguan Sel Darah Putih dan Sel Plasma. Dalam: Price SA and Wilson LM. Patofisiologi: Konsep Klinis Proses-Proses Penyakit. Jakarta: EGC. pp: 268-91
Brewer JM, Conacher M, Hunter CA, Mohrs M, Brombacher F, and Alexander J. 1999. Aluminium Hydroxide Adjuvant Initiates Strong Antigen-Specific Th2 Responses in the Absence of IL-4- or IL-13-Mediated Signaling. The Journal of Immunology 163: 6448-54
Caceci T. 2009. Veterinary Histology: Exercise 5: Connective Tissues. http://education.vetmed.vt.edu/Curriculum/VM8054/Labs/Lab5/IMAGES/ MACROPHAGE%20IN%20SITU%20copy.JPG (15 Maret 2010)
Dalimartha S. 1999. Atlas Tumbuhan Obat Indonesia Jilid 1. Jakarta: Trubus Agriwidya, hal: 50-3
David M, Jonathan B, David BR and Ivan R. 2006. Immunology. Seventh Edition. Canada: Elsevier, pp: 423-42
Dorland WAN. 2002. Kamus Kedokteran Dorland. Jakarta: EGC, hal: 60
Duke J. 2009. Chemicals and Their Biological Activities. In: Plantago major L. (Plantaginaceae). In: Dr. Duke's Phytochemical and Ethnobotanical Databases . http://www.ars-grin.gov/cgi-bin/duke/farmacy2.pl. (15 Maret 2010)
Efendi Z. 2003. Daya Fagositosis Makrofag pada Jaringan Longgar Tubuh. http://library.usu.ac.id/download/fk/histologi-zukesti1.pdf (6 April 2010)
Eroschenko, Victor P. 2002. Atlas Histologi di Fiore. Editor Bahasa Indonesia: Dewi A dan Tiara MNS. Jakarta: Penerbit Buku Kedokteran EGC, hal: 63:
Gregory P. 2009. Histology of Selected Organs of the Respiratory System. http://images.google.co.id/imgres?imgurl=http://science.tjc.edu/images/respi ratory_histology/bronchus1.jpg&imgrefurl=http://science.tjc.edu/images/res piratory_histology/Index.htm&usg=__beWQY2HwnrX1JkE9nIDif77rMRc
=&h=401&w=536&sz=30&hl=id&start=1&tbnid=wqCIwToKm6rqwM:&t bnh=99&tbnw=132&prev=/images%3Fq%3Dhistologi%2Bbronkus%26gbv %3D2%26hl%3Did%26sa%3DG (13 Maret 2010)
Harmita dan Maksum R. 2005. Analisa Hayati. Jakarta: Ari Cipta, hal: 73-7
Iris R. 2004. Peranan antihistamin pada inflamasi alergi. Cermin Dunia Kedokteran. 142: 19
Jancquira LC, Carneiro J. 2005. Basic Histology Text and Atlas. New York: McGraw-Hill Companies, pp: 223-36
Janeway CA Jr, Travers P, Walport M, and Mark JS. 2005. Immunobiology the Immune System in Health and Disease 6 th Edition. New York: Garland
Science Publishing, pp: 517-43
Latumahina S. 2008. Peranan Tanaman Obat dalam Pengembangan Hutan dan Strategi Pemanfaatannya Secara Lestari. http:// www. pariwisatamaluku. com/balagu/TANAMAN_OBAT.doc . (13 Maret 2010)
Mangatas SM, Hermawan HM, dan Ketut S. 2006. Imunobiologi Asma Bronkial. Dexa Media 19 (1): 31-9
Myou S, Leff AR, Myo S, Boetticher E, Tong J, Meliton AY et al. 2003. Blockade of inflamation and airway hyperresponsiveness in immune- sensitized mice by dominant-negative phosphoinosite-3-kinase-TAT. J Exp Med . 198: 1573
Ngatidjan. 1991. Petunjuk Laboratorium Metode Laboratorium Dalam
Toksikologi.Yogyakarta: Pusat Antar Universitas Bioteknologi UGM
Nials AT and Uddin S. 2008. Mouse Models of Allergic Asthma: Acute and Chronic Allergen Challenge. Dis Model Mech 1(4-5): 213–20
Nivaldo M. 2009. Atlas of hematology. http:// www. hematologyatlas. com/ principalpage.htm (13 Maret 2010)
Oktaria S. 2008. Obat Herbal vs Obat Modern. http:// www. klikdokter. com/ article/detail/770 (13 Maret 2010)
Persi. 2002. Daun Sendok (Platago mayor L.). http:// www. pdpersi. co.id/ ?show =detailnews&kode=952&tbl=alternatif ( 13 Maret 2010)
Rahmawati I, Yunus F, dan Wiyono WH. 2003. Patogenesis dan Patofisiologi Asma. Cermin Dunia Kedokteran 141: 5-11
Robins CS, Pouladi MA, Fattouh R, Dawe DE, Vujicic N, Richards CD et al. 2005. Mainstream Cigarette Smoke Exposure Attenuates Airway Immune Inflammatory Responses to Surrogate and Common Environmental Allergens in Mice, Despite Evidence of Increased Systemic Sensitization. The Journal of Immunology 175: 2834-42
Rumold R, Jyrala M, and Sanchez DD. 2001. Secondhand Smoke Induces Allergic Sensitization in Mice. The Journal of Immunology 167: 4765-70
Sell S. 2001. Immunology, Immunopathology and Immunity. Washington: ASM Press, pp: 41: 71: 178-9
Shin YS, Takeda K, and Gelfand EW. 2009. Understanding Asthma Using Animal Models. Allergy Asthma Immunol 1(1): 10–8
Soedarto. 2003. Koleksi Tanaman Obat Potensial Seri 2. Lawang-Jawa Timur: BDATPO (Balai Diklat Agribisnis Tanaman Pangan dan Tanaman Obat) Ketindan, hal: 21
Solomon WR. 2006. Asma Bronkial. Dalam: Price S dan Wilson L M. Patofisiologi: Konsep Klinis Proses-Proses Penyakit. Jakarta: EGC, hal: 177-88
Sundaru H dan Sukamto. 2007. Asma Bronkial. Dalam : Sudoyo A W, dkk (eds). Buku Ajar Ilmu Penyakit Dalam . Edisi 4. Jakarta : Pusat Penerbitan Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia, hal : 245-50
Swirski FK, Gajewska BU, Alvarez D, Ritz SA, Cundall M, Cates EC, et al. 2002. Inhalation of A Harmless Antigen (Ovalbumin) Elicits Immune Activation But Divergent Immunoglobulin and Cytokine Activities in Mice. Clinical & Experimental Allergy (32): 411 - 21
Trimble NJ, Botelho FM, Bauer CMT, Fattouh R, and Stampfli MR. 2009. Adjuvant and Anti-Inflammatory Properties of Cigarette Smoke in Murine Allergic Airway Inflammation. American Journal of Respiratory Cell and Molecular Biology (40): 38-46