Hubungan Indeks Massa Tubuh dengan Atopi dan Penyakit Alergi pada Anak
Association of body mass index with atopy and allergic diseases
Afnita Lestary, Lily Irsa, Tiangsa Sembiring, Rita Evalina, Meiviliani Sinaga
Department of Child Health, Medical School, University of Sumatera Utara/
H. Adam Malik Hospital, Medan-Indonesia
ABSTRACT
Background. Nowadays, prevalence of atopy, allergic diseases, obesity and
overweight show increasing. There were researches on association of body
mass index (BMI) with atopy and allergic diseases, but studies were limited
performed in children with conflicting results.
Objective. To assess association of BMI with atopy and allergic diseases in
children
Methods. A cross sectional study was conducted in SD Negeri 1,
Lhokseumawe, Nanggroe Aceh Darussalam in June 2012. Students matched
inclusion and exclusion criteria were assesed for BMI, skin prick test and
ISAAC questionnaire. Data analysis used X2, Fisher exact test and logistic
regression.
Results. Study was consisted of 137 (85.6%) normoweight, 12 (7.5%)
overweight and 11 (6.9%) obesity. Skin prick test results were positive in 44
(27.5%) and negative in 116 (72.5%) subjects. Allergic manifestations were
allergic rhinitis (AR) 17 (10.6%), bronchial asthma 6 (3.8%) and atopic
dermatitis (AD) 3 (1.9%). There was a significant association of atopy in
obesity compared with normoweight (P=0.037, RP= 2.26, 95% CI 1.22- 4.19),
but if atopy family history was analyzed the association became
nonsignificant. There was a significant association of obesity with bronchial
asthma (P=0.004 95%, RP= 8.3, 95% CI 1.54-44.57) and AR (P= 0.015, RP=
4.49, 95% CI 1.71-11.80). The significant association was not found in
overweight.
Conclusion There were association of BMI with atopy, bronchial asthma and
AR in obesity, but not in overweight.
Keywords. body mass index, atopy, bronchial asthma, allergic rhinitis, atopic
dermatitis
Universitas Sumatera Utara
HUBUNGAN INDEKS MASSA TUBUH DENGAN ATOPI DAN
PENYAKIT ALERGI
Afnita Lestary, Lily Irsa, Tiangsa Sembiring, Rita Evalina, Meiviliani Sinaga
Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran, Universitas
Sumatera Utara,
Rumah Sakit Haji Adam Malik, Medan, Indonesia
Abstrak
Latar belakang Saat ini, terjadi peningkatan prevalensi atopi dan penyakit
alergi bersamaan dengan obesitas dan overweight. Banyak penelitian
tentang hubungan indeks massa tubuh (IMT) dengan atopi dan penyakit
alergi, namun masih terbatas pada anak dengan hasil bervariasi.
Tujuan menilai hubungan IMT dengan atopi dan penyakit alergi pada anak.
Metode Penelitian cross sectional dilakukan di SD Negeri 1, Kota
Lhokseumawe, Provinsi Nanggroe Aceh Darussalam pada Juni 2012. Siswa
yang memenuhi kriteria inklusi dan eksklusi dinilai IMT, uji tusuk kulit dan
kuesioner ISAAC. Analisis menggunakan uji X2 , Fisher exact test dan regresi
logistik.
Hasil Pada penelitian, didapatkan 160 subyek dengan 137 (85.6%)
normoweight, 12 (7.5%) overweight dan 11 (6.9%) obesitas. Pada
pemeriksaan uji tusuk kulit, hasil positif 44 (27.5%) dan negatif 116 (72.5%)
subyek. Manifestasi alergi yang muncul adalah rinitis alergik (RA) 17 (10.6%),
asma bronkhial 6 (3.8%) dan dermatitis atopik (DA) 3 (1.9%) subyek.
Terdapat hubungan bermakna obesitas dengan terjadinya atopi (P=0.037,
RP= 2.26, IK 95% 1.22- 4.19), tetapi jika riwayat keluarga atopi ikut dianalisis
hubungan menjadi tidak bermakna. Terdapat hubungan bermakna obesitas
dengan terjadinya asma bronkial (P=0.004 95%, RP= 8.3, IK 95% 1.54-44.57
dan RA (P= 0.015, RP= 4.49, IK 95% 1.71-11.80)). Hubungan bermakna ini
tidak ditemukan pada overweight.
Kesimpulan Terdapat hubungan bermakna IMT dengan atopi dan asma
bronkhial serta RA pada obesitas, tetapi tidak pada overweight.
Kata kunci: indeks massa tubuh. atopi, asma bronkial, rinitis alergik,
dermatitis atopik
Universitas Sumatera Utara
Afnita Lestary, Lily Irsa, Tiangsa Sembiring, Rita Evalina, Meiviliani Sinaga
Department of Child Health, Medical School, University of Sumatera Utara/
H. Adam Malik Hospital, Medan-Indonesia
ABSTRACT
Background. Nowadays, prevalence of atopy, allergic diseases, obesity and
overweight show increasing. There were researches on association of body
mass index (BMI) with atopy and allergic diseases, but studies were limited
performed in children with conflicting results.
Objective. To assess association of BMI with atopy and allergic diseases in
children
Methods. A cross sectional study was conducted in SD Negeri 1,
Lhokseumawe, Nanggroe Aceh Darussalam in June 2012. Students matched
inclusion and exclusion criteria were assesed for BMI, skin prick test and
ISAAC questionnaire. Data analysis used X2, Fisher exact test and logistic
regression.
Results. Study was consisted of 137 (85.6%) normoweight, 12 (7.5%)
overweight and 11 (6.9%) obesity. Skin prick test results were positive in 44
(27.5%) and negative in 116 (72.5%) subjects. Allergic manifestations were
allergic rhinitis (AR) 17 (10.6%), bronchial asthma 6 (3.8%) and atopic
dermatitis (AD) 3 (1.9%). There was a significant association of atopy in
obesity compared with normoweight (P=0.037, RP= 2.26, 95% CI 1.22- 4.19),
but if atopy family history was analyzed the association became
nonsignificant. There was a significant association of obesity with bronchial
asthma (P=0.004 95%, RP= 8.3, 95% CI 1.54-44.57) and AR (P= 0.015, RP=
4.49, 95% CI 1.71-11.80). The significant association was not found in
overweight.
Conclusion There were association of BMI with atopy, bronchial asthma and
AR in obesity, but not in overweight.
Keywords. body mass index, atopy, bronchial asthma, allergic rhinitis, atopic
dermatitis
Universitas Sumatera Utara
HUBUNGAN INDEKS MASSA TUBUH DENGAN ATOPI DAN
PENYAKIT ALERGI
Afnita Lestary, Lily Irsa, Tiangsa Sembiring, Rita Evalina, Meiviliani Sinaga
Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran, Universitas
Sumatera Utara,
Rumah Sakit Haji Adam Malik, Medan, Indonesia
Abstrak
Latar belakang Saat ini, terjadi peningkatan prevalensi atopi dan penyakit
alergi bersamaan dengan obesitas dan overweight. Banyak penelitian
tentang hubungan indeks massa tubuh (IMT) dengan atopi dan penyakit
alergi, namun masih terbatas pada anak dengan hasil bervariasi.
Tujuan menilai hubungan IMT dengan atopi dan penyakit alergi pada anak.
Metode Penelitian cross sectional dilakukan di SD Negeri 1, Kota
Lhokseumawe, Provinsi Nanggroe Aceh Darussalam pada Juni 2012. Siswa
yang memenuhi kriteria inklusi dan eksklusi dinilai IMT, uji tusuk kulit dan
kuesioner ISAAC. Analisis menggunakan uji X2 , Fisher exact test dan regresi
logistik.
Hasil Pada penelitian, didapatkan 160 subyek dengan 137 (85.6%)
normoweight, 12 (7.5%) overweight dan 11 (6.9%) obesitas. Pada
pemeriksaan uji tusuk kulit, hasil positif 44 (27.5%) dan negatif 116 (72.5%)
subyek. Manifestasi alergi yang muncul adalah rinitis alergik (RA) 17 (10.6%),
asma bronkhial 6 (3.8%) dan dermatitis atopik (DA) 3 (1.9%) subyek.
Terdapat hubungan bermakna obesitas dengan terjadinya atopi (P=0.037,
RP= 2.26, IK 95% 1.22- 4.19), tetapi jika riwayat keluarga atopi ikut dianalisis
hubungan menjadi tidak bermakna. Terdapat hubungan bermakna obesitas
dengan terjadinya asma bronkial (P=0.004 95%, RP= 8.3, IK 95% 1.54-44.57
dan RA (P= 0.015, RP= 4.49, IK 95% 1.71-11.80)). Hubungan bermakna ini
tidak ditemukan pada overweight.
Kesimpulan Terdapat hubungan bermakna IMT dengan atopi dan asma
bronkhial serta RA pada obesitas, tetapi tidak pada overweight.
Kata kunci: indeks massa tubuh. atopi, asma bronkial, rinitis alergik,
dermatitis atopik
Universitas Sumatera Utara