Uji Efek Antiinfsi Ekstrak Etanol Rimpang Temu Giring (Curcuma heyneana Val & Zijp) Terhadap Tikus yang Diinduksi λ-Karagenan
Lampiran 1. Surat keterangan sampel
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Lampiran 2. Hasil identifikasi sampel penelitian
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Lampiran 3. Gambar Sampel Penelitian
a
b
c
Keterangan : a.Tumbuhan Temu Giring
b.Bunga Temu Giring
c. Rimpang Temu Giring
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Lampiran 4. Bahan uji efek antiinflamasi
a.
b.
d.
e.
g.
c.
f.
h.
Keterangan : a. Ekstrak etanol rimpang temu giring
b. Suspensi natrium karboksi metil selulosa 0,5 %
c.Suspensi ekstrak etanol rimpang temu giring dosis 5 mg/kg bb
d. Suspensi ekstrak etanol rimpang temu giring dosis 25 mg/kg bb
e. Suspensi ekstrak etanol rimpang temu giring dosis 125 mg/kg bb
f. Suspensi ekstrak etanol rimpang temu giring dosis 625 mg/kg bb
g. Larutan λ-karagenan 1%
h. Suspensi natrium diklofenak dosis 2,25 mg/kg bb
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Lampiran 5. Surat Etik Penelitian
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Lampiran 6. Hewan Percobaan
a
b
Keterangan : a. Tikus di Puasakan
b. Tikus Sebelum Perlakuan
c. Tikus Setelah di Induksi λ-karagenan.
c
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Lampiran 7. Konversi dosis.
Tabel konversi dosis antara jenis hewan dengan manusia (Darmono, 2011).
Mencit
20g
Tikus
200g
Marmut
400 g
Kelinci
1,2 kg
Kera
4 kg
Anjing
12 kg
Manusia
70 kg
Mencit
20 g
Tikus
200 g
Marmut
400 g
Kelinci
1,2 kg
Kera
4 kg
Anjing
12 kg
Manusia
70 kg
1,0
7,0
12,25
27,8
64,1
124,2
387,9
0,14
1,0
1,74
3,9
9,2
17,8
56,0
0,08
0,57
1,0
2,25
5,2
10,2
31,5
0,04
0,25
0,44
1,0
2,4
4,5
14,2
0,016
0,11
0,19
0,42
1,0
1,9
6,1
0,008
0,06
0,10
0,22
0,52
1,0
3,1
0,0026
0,018
0,031
0,07
0,16
0,32
1,0
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Lampiran 8.Contoh perhitungan dosis
Kontrol positif (natrium diklofenak)
Pemakaian untuk manusia 25-50 mg (Tjay dan Rahardja, 2007).
Konversi dari manusia (70 kg) untuk tikus 200 g = 0,018
= 25 mg x 0,018
= 0,45 mg/200 g
= 0,45 mg x
1000
200
kg
= 2,25 mg/kg bb
Diketahui: Berat tikus
Dosis
= 200 g
= 2,25 mg/kg bb x
200 �
1000
= 0,45 mg
Konsentrasi larutan obat
= 25 mg / 10 ml
= 2,5 mg/ml
Volume pemberian
= 0,45 mg / 2,5 mg/ml
=0,18 ml
Bahan uji (ekstrak etanol rimpang temu giring)
Volume pemberian 1% dari berat badan tikus
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Lampiran 9. ContohPerhitungan persen radang
Persen radang dapat dihitung dengan rumus dibawah ini:
Persen radang =
dimana :
��−�0
�0
×100 %
Vt= Volume udem kaki pada waktu t
Vo= Volume awal kaki tikus
Persen radang CMC 0,5 %
Persen radang menit ke-30 =
Tikus 1
=
5,32−3,38
3,38
Vt −V0
V0
Tikus 2
x 100%
=
5,01−3,69
3,69
= 57,40%
= 35,77%
Tikus 4
Tikus 5
=
4,25−2,57
2,57
x 100%
x 100%
= 65,36%
=
4,30−2,37
2,37
Tikus 3
x 100%
=
5,06−3,42
3,42
x 100%
= 47,95%
x 100%
= 81,43%
Persen rata-rata radang
=
57,40+35,77+47,95+65,36+81,43
5
= 57,58%
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Lampiran 10.Contoh Perhitungan persen inhibisi radang dihitung dengan rumus
dibawah ini:
Persen inhibisi radang =
dimana :
�−�
�
×100 %
a= Persen radang rata-rata kelompok kontrol negatif
b= Persen radang rata-rata kelompok bahan uji dan kontrol positif
Persen inhibisi radang EERTG dosis 5 mg/kg bb
Persen inhibisi radang menit ke-30 =
a−b
a
=
x 100%
57,5%−53,64%
57,58%
x 100%
= 6,84%
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Lampiran 11.Hasil perhitungan analisis variansi efek antiinflamasi suspensi
ekstrak etanol rimpang temu giring terhadap kaki tikus
Menit ke-30
Descriptives
persentasi radang
95% Confidence Interval
for Mean
N
Std.
Deviation
Mean
Std.
Error
Lower
Bound
Upper
Bound
Minimum Maximum
Na CMC 0,5%
5
57.5820 17.30460
7.73885
36.0955
79.0685
35.77
81.43
EERTG 5 mg
5
53.6400 10.21055
4.56630
40.9619
66.3181
41.23
67.73
EERTG 25 mg
5
48.7660 16.54888
7.40088
28.2178
69.3142
29.25
67.22
EERTG 125 mg
5
32.6000 26.19491
11.7147
.0747
65.1253
4.00
63.67
EERTG 625 mg
5
32.8320 29.68632
13.2761
-4.0284
69.6924
6.78
79.18
5
26.7500 22.68155
10.1435
-1.4129
54.9129
4.56
52.34
30 42.0283 22.88131
4.17754
33.4843
50.5724
4.00
81.43
Na diklofenak 25mg
Total
ANOVA
persentasi radang
Between Groups
Within Groups
Total
Sum of Squares
Df
Mean Square
F
Sig.
4145.185
11037.892
15183.077
5
24
29
829.037
459.912
1.803
.150
persentasi radang
Duncana
Subset for
alpha = 0.05
dosis perlakuan
N
1
Na diklofenak 25 mg
EERTG 125 mg
EERTG 625 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
5
5
5
5
5
5
26.7500
32.6000
32.8320
48.7660
53.6400
57.5820
.054
Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
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Lampiran 11. Lanjutan
Menit ke-60
Descriptives
persentasi radang
95% Confidence Interval
for Mean
N
Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
Minimum Maximum
Na CMC 0,5%
EERTG 5 mg
5
5
66.8500 22.42937 10.03072
58.0380 13.65579 6.10705
39.0003
41.0821
94.6997
74.9939
41.46
44.74
97.47
77.66
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
5
5
5
5
54.3400
36.1600
31.8080
32.4420
33.5385
8.2864
-1.5991
12.4982
75.1415
64.0336
65.2151
52.3858
36.77
7.43
.88
14.60
73.91
62.17
69.89
51.72
Total
30
46.6063 23.09602
37.9821
55.2305
.88
97.47
16.75294 7.49214
22.44860 10.03932
26.90510 12.03233
16.06214 7.18321
4.21674
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
5645.218
9824.139
5
24
1129.044
409.339
2.758
.042
Total
15469.357
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
EERTG 625 mg
Na diklofenak 25 mg
EERTG 125 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
N
1
5
5
5
5
5
5
31.8080
32.4420
36.1600
54.3400
58.0380
.077
2
54.3400
58.0380
66.8500
.366
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
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Lampiran 11. Lanjutan
Menit ke-90
Descriptives
persentasi radang
95% Confidence
Interval for Mean
N
Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
Minimum Maximum
Na CMC 0,5%
5
75.0940 28.94854 12.94618
39.1496
111.0384
44.44
113.50
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
5
5
5
5
64.1880
59.8380
39.5780
31.8960
44.3821
38.1953
14.7969
3.2938
83.9939
81.4807
64.3591
60.4982
48.25
44.29
10.86
7.99
87.23
80.60
60.30
60.59
20.1650
42.2224
55.7270
60.6243
14.60
7.99
53.29
113.50
Na diklofenak 25 mg
Total
15.95109 7.13355
17.43038 7.79511
19.95797 8.92548
23.03541 10.30175
5 37.9460 14.32029
30 51.4233 24.64068
6.40423
4.49875
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
7486.555
10121.181
5
24
1497.311
421.716
3.551
.015
Total
17607.736
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
EERTG 625 mg
Na diklofenak 25 mg
EERTG 125 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
N
1
5
5
5
5
5
5
2
31.8960
37.9460
39.5780
59.8380
3
37.9460
39.5780
59.8380
64.1880
.059
.075
59.8380
64.1880
75.0940
.278
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
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Lampiran 11. Lanjutan
Menit ke-120
Descriptives
persentasi radang
95% Confidence
Interval for Mean
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
Total
N
Mean
5
5
5
5
5
5
30
82.7360
71.9460
65.6920
45.9920
35.0740
40.8180
57.0430
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
29.21744
20.52662
16.44241
22.15721
26.18911
13.26235
26.72817
46.4578
46.4588
45.2760
18.4802
2.5559
24.3506
47.0625
119.0142
97.4332
86.1080
73.5038
67.5921
57.2854
67.0235
13.06644
9.17978
7.35327
9.90901
11.71213
5.93110
4.87987
Minimum Maximum
52.85
52.05
52.92
16.29
7.69
18.73
7.69
120.68
95.04
86.62
69.29
67.66
52.35
120.68
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
9125.235
11592.222
5
24
1825.047
483.009
3.778
.012
Total
20717.457
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
EERTG 625 mg
Na diklofenak 25 mg
EERTG 125 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
N
1
5
5
5
5
5
5
35.0740
40.8180
45.9920
65.6920
.053
2
45.9920
65.6920
71.9460
.089
3
65.6920
71.9460
82.7360
.258
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
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Lampiran 11. Lanjutan
Menit ke-150
Descriptives
persentasi radang
95% Confidence Interval
for Mean
Lower
Bound
Upper
Bound
5 87.7660 31.87016 14.25277
5 80.8580 25.22385 11.28045
48.1940
49.5385
127.3380
112.1775
60.98
55.56
127.85
111.58
5
5
5
5
52.1264
17.2152
1.7997
26.9509
90.7336
80.7408
74.4323
60.1811
58.19
21.71
7.10
22.87
92.31
77.15
74.35
57.94
50.7630
72.8083
7.10
127.85
N
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
Total
Mean
71.4300
48.9780
38.1160
43.5660
Std.
Deviation
Std.
Error
15.54655 6.95263
25.58085 11.44011
29.24806 13.08013
13.38130 5.98430
30 61.7857 29.51918
5.38944
Minimu Maximu
m
m
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
10939.952
14330.133
5
24
2187.990
597.089
3.664
.013
Total
25270.085
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
38.1160
Na diklofenak 25 mg
5
43.5660
EERTG 125 mg
5
48.9780
48.9780
EERTG 25 mg
EERTG 5 mg
5
5
71.4300
71.4300
80.8580
Na CMC 0,5%
5
Sig.
2
3
71.4300
80.8580
87.7660
.058
.061
.329
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
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Lampiran 11. Lanjutan
Menit ke-180
Descriptives
persentasi radang
95% Confidence Interval
for Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
Na CMC 0,5%
5 91.8720 31.39473 14.04015
52.8903
130.8537
61.25
131.22
EERTG 5 mg
EERTG 25 mg
5 86.0520 22.31580
5 70.4440 16.59285
9.97993
7.42055
58.3433
49.8413
113.7607
91.0467
58.19
54.39
112.36
92.31
EERTG 125 mg
5 46.9760 24.69532 11.04408
16.3127
77.6393
30.72
87.76
EERTG 625 mg
5 35.6100 28.50716 12.74879
.2137
71.0063
6.19
71.38
24.9614
50.3912
56.8826
73.5675
26.45
6.19
59.19
131.22
N
Mean
Na diklofenak 25 mg 5 40.9220 12.85418
Total
30 61.9793 31.03369
5.74856
5.66595
Minimum Maximum
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
14542.842
13386.773
5
24
2908.568
557.782
5.215
.002
Total
27929.616
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
EERTG 625 mg
Na diklofenak 25 mg
EERTG 125 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
N
1
5
5
5
5
5
5
35.6100
40.9220
46.9760
.480
2
40.9220
46.9760
70.4440
.073
3
70.4440
86.0520
91.8720
.187
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
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Lampiran 11. Lanjutan
Menit ke-210
Descriptives
persentasi radang
95% Confidence Interval
for Mean
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
Total
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
33.05899
24.06123
17.77898
23.28184
27.82401
14.26436
14.78443
10.76051
7.95100
10.41196
12.44328
6.37921
52.2418
53.6920
47.3805
16.0918
-1.5441
20.5085
134.3382
113.4440
91.5315
73.9082
67.5521
55.9315
61.25
60.53
50.29
29.45
3.34
22.49
134.60
112.74
92.31
82.65
68.40
60.44
30 60.4230 32.12655
5.86548
48.4267
72.4193
3.34
134.60
N
Mean
5
5
5
5
5
5
93.2900
83.5680
69.4560
45.0000
33.0040
38.2200
Minimu Maximu
m
m
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
15900.848
14030.493
5
24
3180.170
584.604
5.440
.002
Total
29931.341
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
33.0040
Na diklofenak 25 mg
5
38.2200
38.2200
EERTG 125 mg
5
45.0000
45.0000
EERTG 25 mg
5
EERTG 5 mg
5
83.5680
Na CMC 0,5%
5
93.2900
Sig.
2
69.4560
.467
.064
3
69.4560
.153
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
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Lampiran 11. Lanjutan
Menit ke 240
Descriptives
persentasi radang
95% Confidence Interval
for Mean
N
Na CMC 0,5%
5
EERTG 5 mg
5
EERTG 25 mg
5
EERTG 125 mg
5
EERTG 625 mg
5
Na diklofenak 25 mg 5
Total
30
Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
90.7000
80.3140
65.7740
42.8320
28.7220
36.3020
57.4407
35.22213 15.75181
22.96822 10.27170
15.17499 6.78646
22.03031 9.85226
22.81062 10.20122
14.54371 6.50415
31.50345 5.75172
46.9660
51.7952
46.9318
15.4778
.3989
18.2436
45.6771
134.4340
108.8328
84.6162
70.1862
57.0451
54.3604
69.2042
Minimum Maximum
56.64
60.23
46.78
26.24
5.31
22.59
5.31
135.44
105.41
83.61
77.55
59.11
58.57
135.44
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
15919.176
12862.385
5
24
3183.835
535.933
5.941
.001
Total
28781.562
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
28.7220
Na diklofenak 25 mg
5
36.3020
36.3020
EERTG 125 mg
5
42.8320
42.8320
EERTG 25 mg
5
EERTG 5 mg
5
80.3140
Na CMC 0,5%
5
90.7000
Sig.
2
65.7740
.373
.068
3
65.7740
.120
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
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Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke 270
Descriptives
persentasi radang
95% Confidence
Interval for Mean
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
Total
N
Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
Minimum
Maximum
5
5
5
5
5
5
3
0
87.9500
76.9240
56.2860
32.4320
24.3340
36.0400
52.3277
37.20975 16.64071
22.26939 9.95917
12.94797 5.79051
18.02624 8.06158
18.05906 8.07626
15.65995 7.00334
31.32128 5.71846
41.7480
49.2729
40.2090
10.0495
1.9107
16.5956
40.6321
134.1520
104.5751
72.3630
54.8145
46.7573
55.4844
64.0232
51.76
59.63
42.98
17.78
6.80
14.88
6.80
135.86
104.26
74.92
60.54
49.81
56.70
135.86
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
16671.848
11777.801
5
24
3334.370
490.742
6.795
.000
Total
28449.650
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
24.3340
EERTG 125 mg
5
32.4320
32.4320
Na diklofenak 25 mg
5
36.0400
36.0400
EERTG 25 mg
5
EERTG 5 mg
5
Na CMC 0,5%
5
Sig.
2
56.2860
3
4
56.2860
76.9240
76.9240
87.9500
.439
.120
.154
.439
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
57
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-300
Descriptives
persentasi radang
95% Confidence
Interval for Mean
N
Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
Minimum Maximum
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
5 82.1740 33.34713 14.91329 40.7681 123.5799
5 73.3940 20.03837 8.96143 48.5131 98.2749
5 53.3680 14.41487 6.44653 35.4696 71.2664
49.05
54.97
38.89
120.25
96.81
74.92
EERTG 125 mg
EERTG 625 mg
5 21.9180 14.17975 6.34138
5 19.8300 17.79049 7.95615
4.3115
-2.2598
39.5245
41.9198
9.04
4.72
43.54
48.70
Na diklofenak 25 mg 5 27.1560 4.80298 2.14796
Total
30 46.3067 30.91204 5.64374
21.1923
34.7639
33.1197
57.8494
22.12
4.72
34.64
120.25
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
18663.103
9047.967
5
24
3732.621
376.999
9.901
.000
Total
27711.070
29
persentasi radang
Duncan
a
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
19.8300
EERTG 125 mg
5
21.9180
Na diklofenak 25 mg
5
27.1560
EERTG 25 mg
5
53.3680
EERTG 5 mg
5
73.3940
Na CMC 0,5%
5
Sig.
2
3
73.3940
82.1740
.580
.116
.482
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
58
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-330
Descriptives
persentasi radang
95% Confidence
Interval for Mean
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
N
Mean
5
5
5
5
79.3720
76.9240
50.1940
16.7500
Std.
Deviation Std. Error
Lower
Bound
32.79474 14.66626 38.6519
22.26939 9.95917 49.2729
15.93083 7.12448 30.4133
15.22854 6.81041 -2.1587
Upper
Bound
Minimum
Maximum
120.0921
104.5751
69.9747
35.6587
46.34
59.63
34.50
4.08
116.88
104.26
74.58
38.10
EERTG 625 mg
Na diklofenak 25 mg
5 17.2740 18.35227
5 27.1560 4.80298
8.20739
2.14796
-5.5134
21.1923
40.0614
33.1197
2.36
22.12
47.58
34.64
Total
30 44.6117 32.28496
5.89440
32.5563
56.6671
2.36
116.88
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
20559.254
9667.982
5
24
4111.851
402.833
10.207
.000
Total
30227.236
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
N
1
5
5
5
5
5
5
16.7500
17.2740
27.1560
.447
2
3
27.1560
50.1940
.082
76.9240
79.3720
.849
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
59
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-360
Descriptives
persentasi radang
95% Confidence
Interval for Mean
N
Mean
Std.
Deviation
Std. Error
Lower
Bound
Upper
Bound
5
5
5
5
78.3700
68.6460
49.3460
14.5360
32.17865
17.53550
15.74270
13.71216
14.39073
7.84212
7.04035
6.13227
38.4149
46.8728
29.7989
-2.4899
118.3251
90.4192
68.8931
31.5619
46.34
49.12
33.33
1.75
115.19
87.25
72.91
32.31
EERTG 625 mg
Na diklofenak 25 mg
5 14.4480
5 25.4580
15.64804
4.72293
6.99802
2.11216
-4.9816
19.5937
33.8776
31.3223
1.77
21.50
39.97
33.66
Total
30 41.8007
30.82296
5.62748
30.2912
53.3102
1.75
115.19
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
Minimum Maximum
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
19367.666
8183.932
5
24
3873.533
340.997
11.359
.000
Total
27551.598
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
14.4480
EERTG 125 mg
5
14.5360
Na diklofenak 25 mg
5
25.4580
EERTG 25 mg
5
EERTG 5 mg
5
Na CMC 0,5%
5
Sig.
2
3
4
25.4580
49.3460
49.3460
68.6460
68.6460
78.3700
.383
.052
.111
.413
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
60
Universitas Sumatera Utara
Lampiran 12.Alat pletismometerdigital UGO basile cat No.7140
1
2
3
4
5
6
7
Keterangan : 1. Klem
2. Reservoir
3. Statif
4. Layar
5. Sel
6. Saluran air masuk
7. Pedal
61
Universitas Sumatera Utara
39
Universitas Sumatera Utara
Lampiran 2. Hasil identifikasi sampel penelitian
40
Universitas Sumatera Utara
Lampiran 3. Gambar Sampel Penelitian
a
b
c
Keterangan : a.Tumbuhan Temu Giring
b.Bunga Temu Giring
c. Rimpang Temu Giring
41
Universitas Sumatera Utara
Lampiran 4. Bahan uji efek antiinflamasi
a.
b.
d.
e.
g.
c.
f.
h.
Keterangan : a. Ekstrak etanol rimpang temu giring
b. Suspensi natrium karboksi metil selulosa 0,5 %
c.Suspensi ekstrak etanol rimpang temu giring dosis 5 mg/kg bb
d. Suspensi ekstrak etanol rimpang temu giring dosis 25 mg/kg bb
e. Suspensi ekstrak etanol rimpang temu giring dosis 125 mg/kg bb
f. Suspensi ekstrak etanol rimpang temu giring dosis 625 mg/kg bb
g. Larutan λ-karagenan 1%
h. Suspensi natrium diklofenak dosis 2,25 mg/kg bb
42
Universitas Sumatera Utara
Lampiran 5. Surat Etik Penelitian
43
Universitas Sumatera Utara
Lampiran 6. Hewan Percobaan
a
b
Keterangan : a. Tikus di Puasakan
b. Tikus Sebelum Perlakuan
c. Tikus Setelah di Induksi λ-karagenan.
c
44
Universitas Sumatera Utara
Lampiran 7. Konversi dosis.
Tabel konversi dosis antara jenis hewan dengan manusia (Darmono, 2011).
Mencit
20g
Tikus
200g
Marmut
400 g
Kelinci
1,2 kg
Kera
4 kg
Anjing
12 kg
Manusia
70 kg
Mencit
20 g
Tikus
200 g
Marmut
400 g
Kelinci
1,2 kg
Kera
4 kg
Anjing
12 kg
Manusia
70 kg
1,0
7,0
12,25
27,8
64,1
124,2
387,9
0,14
1,0
1,74
3,9
9,2
17,8
56,0
0,08
0,57
1,0
2,25
5,2
10,2
31,5
0,04
0,25
0,44
1,0
2,4
4,5
14,2
0,016
0,11
0,19
0,42
1,0
1,9
6,1
0,008
0,06
0,10
0,22
0,52
1,0
3,1
0,0026
0,018
0,031
0,07
0,16
0,32
1,0
45
Universitas Sumatera Utara
Lampiran 8.Contoh perhitungan dosis
Kontrol positif (natrium diklofenak)
Pemakaian untuk manusia 25-50 mg (Tjay dan Rahardja, 2007).
Konversi dari manusia (70 kg) untuk tikus 200 g = 0,018
= 25 mg x 0,018
= 0,45 mg/200 g
= 0,45 mg x
1000
200
kg
= 2,25 mg/kg bb
Diketahui: Berat tikus
Dosis
= 200 g
= 2,25 mg/kg bb x
200 �
1000
= 0,45 mg
Konsentrasi larutan obat
= 25 mg / 10 ml
= 2,5 mg/ml
Volume pemberian
= 0,45 mg / 2,5 mg/ml
=0,18 ml
Bahan uji (ekstrak etanol rimpang temu giring)
Volume pemberian 1% dari berat badan tikus
46
Universitas Sumatera Utara
Lampiran 9. ContohPerhitungan persen radang
Persen radang dapat dihitung dengan rumus dibawah ini:
Persen radang =
dimana :
��−�0
�0
×100 %
Vt= Volume udem kaki pada waktu t
Vo= Volume awal kaki tikus
Persen radang CMC 0,5 %
Persen radang menit ke-30 =
Tikus 1
=
5,32−3,38
3,38
Vt −V0
V0
Tikus 2
x 100%
=
5,01−3,69
3,69
= 57,40%
= 35,77%
Tikus 4
Tikus 5
=
4,25−2,57
2,57
x 100%
x 100%
= 65,36%
=
4,30−2,37
2,37
Tikus 3
x 100%
=
5,06−3,42
3,42
x 100%
= 47,95%
x 100%
= 81,43%
Persen rata-rata radang
=
57,40+35,77+47,95+65,36+81,43
5
= 57,58%
47
Universitas Sumatera Utara
Lampiran 10.Contoh Perhitungan persen inhibisi radang dihitung dengan rumus
dibawah ini:
Persen inhibisi radang =
dimana :
�−�
�
×100 %
a= Persen radang rata-rata kelompok kontrol negatif
b= Persen radang rata-rata kelompok bahan uji dan kontrol positif
Persen inhibisi radang EERTG dosis 5 mg/kg bb
Persen inhibisi radang menit ke-30 =
a−b
a
=
x 100%
57,5%−53,64%
57,58%
x 100%
= 6,84%
48
Universitas Sumatera Utara
Lampiran 11.Hasil perhitungan analisis variansi efek antiinflamasi suspensi
ekstrak etanol rimpang temu giring terhadap kaki tikus
Menit ke-30
Descriptives
persentasi radang
95% Confidence Interval
for Mean
N
Std.
Deviation
Mean
Std.
Error
Lower
Bound
Upper
Bound
Minimum Maximum
Na CMC 0,5%
5
57.5820 17.30460
7.73885
36.0955
79.0685
35.77
81.43
EERTG 5 mg
5
53.6400 10.21055
4.56630
40.9619
66.3181
41.23
67.73
EERTG 25 mg
5
48.7660 16.54888
7.40088
28.2178
69.3142
29.25
67.22
EERTG 125 mg
5
32.6000 26.19491
11.7147
.0747
65.1253
4.00
63.67
EERTG 625 mg
5
32.8320 29.68632
13.2761
-4.0284
69.6924
6.78
79.18
5
26.7500 22.68155
10.1435
-1.4129
54.9129
4.56
52.34
30 42.0283 22.88131
4.17754
33.4843
50.5724
4.00
81.43
Na diklofenak 25mg
Total
ANOVA
persentasi radang
Between Groups
Within Groups
Total
Sum of Squares
Df
Mean Square
F
Sig.
4145.185
11037.892
15183.077
5
24
29
829.037
459.912
1.803
.150
persentasi radang
Duncana
Subset for
alpha = 0.05
dosis perlakuan
N
1
Na diklofenak 25 mg
EERTG 125 mg
EERTG 625 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
5
5
5
5
5
5
26.7500
32.6000
32.8320
48.7660
53.6400
57.5820
.054
Means for groups in homogeneous subsets are
displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
49
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-60
Descriptives
persentasi radang
95% Confidence Interval
for Mean
N
Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
Minimum Maximum
Na CMC 0,5%
EERTG 5 mg
5
5
66.8500 22.42937 10.03072
58.0380 13.65579 6.10705
39.0003
41.0821
94.6997
74.9939
41.46
44.74
97.47
77.66
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
5
5
5
5
54.3400
36.1600
31.8080
32.4420
33.5385
8.2864
-1.5991
12.4982
75.1415
64.0336
65.2151
52.3858
36.77
7.43
.88
14.60
73.91
62.17
69.89
51.72
Total
30
46.6063 23.09602
37.9821
55.2305
.88
97.47
16.75294 7.49214
22.44860 10.03932
26.90510 12.03233
16.06214 7.18321
4.21674
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
5645.218
9824.139
5
24
1129.044
409.339
2.758
.042
Total
15469.357
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
EERTG 625 mg
Na diklofenak 25 mg
EERTG 125 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
N
1
5
5
5
5
5
5
31.8080
32.4420
36.1600
54.3400
58.0380
.077
2
54.3400
58.0380
66.8500
.366
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
50
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-90
Descriptives
persentasi radang
95% Confidence
Interval for Mean
N
Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
Minimum Maximum
Na CMC 0,5%
5
75.0940 28.94854 12.94618
39.1496
111.0384
44.44
113.50
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
5
5
5
5
64.1880
59.8380
39.5780
31.8960
44.3821
38.1953
14.7969
3.2938
83.9939
81.4807
64.3591
60.4982
48.25
44.29
10.86
7.99
87.23
80.60
60.30
60.59
20.1650
42.2224
55.7270
60.6243
14.60
7.99
53.29
113.50
Na diklofenak 25 mg
Total
15.95109 7.13355
17.43038 7.79511
19.95797 8.92548
23.03541 10.30175
5 37.9460 14.32029
30 51.4233 24.64068
6.40423
4.49875
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
7486.555
10121.181
5
24
1497.311
421.716
3.551
.015
Total
17607.736
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
EERTG 625 mg
Na diklofenak 25 mg
EERTG 125 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
N
1
5
5
5
5
5
5
2
31.8960
37.9460
39.5780
59.8380
3
37.9460
39.5780
59.8380
64.1880
.059
.075
59.8380
64.1880
75.0940
.278
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
51
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-120
Descriptives
persentasi radang
95% Confidence
Interval for Mean
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
Total
N
Mean
5
5
5
5
5
5
30
82.7360
71.9460
65.6920
45.9920
35.0740
40.8180
57.0430
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
29.21744
20.52662
16.44241
22.15721
26.18911
13.26235
26.72817
46.4578
46.4588
45.2760
18.4802
2.5559
24.3506
47.0625
119.0142
97.4332
86.1080
73.5038
67.5921
57.2854
67.0235
13.06644
9.17978
7.35327
9.90901
11.71213
5.93110
4.87987
Minimum Maximum
52.85
52.05
52.92
16.29
7.69
18.73
7.69
120.68
95.04
86.62
69.29
67.66
52.35
120.68
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
9125.235
11592.222
5
24
1825.047
483.009
3.778
.012
Total
20717.457
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
EERTG 625 mg
Na diklofenak 25 mg
EERTG 125 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
N
1
5
5
5
5
5
5
35.0740
40.8180
45.9920
65.6920
.053
2
45.9920
65.6920
71.9460
.089
3
65.6920
71.9460
82.7360
.258
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
52
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-150
Descriptives
persentasi radang
95% Confidence Interval
for Mean
Lower
Bound
Upper
Bound
5 87.7660 31.87016 14.25277
5 80.8580 25.22385 11.28045
48.1940
49.5385
127.3380
112.1775
60.98
55.56
127.85
111.58
5
5
5
5
52.1264
17.2152
1.7997
26.9509
90.7336
80.7408
74.4323
60.1811
58.19
21.71
7.10
22.87
92.31
77.15
74.35
57.94
50.7630
72.8083
7.10
127.85
N
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
Total
Mean
71.4300
48.9780
38.1160
43.5660
Std.
Deviation
Std.
Error
15.54655 6.95263
25.58085 11.44011
29.24806 13.08013
13.38130 5.98430
30 61.7857 29.51918
5.38944
Minimu Maximu
m
m
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
10939.952
14330.133
5
24
2187.990
597.089
3.664
.013
Total
25270.085
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
38.1160
Na diklofenak 25 mg
5
43.5660
EERTG 125 mg
5
48.9780
48.9780
EERTG 25 mg
EERTG 5 mg
5
5
71.4300
71.4300
80.8580
Na CMC 0,5%
5
Sig.
2
3
71.4300
80.8580
87.7660
.058
.061
.329
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
53
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-180
Descriptives
persentasi radang
95% Confidence Interval
for Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
Na CMC 0,5%
5 91.8720 31.39473 14.04015
52.8903
130.8537
61.25
131.22
EERTG 5 mg
EERTG 25 mg
5 86.0520 22.31580
5 70.4440 16.59285
9.97993
7.42055
58.3433
49.8413
113.7607
91.0467
58.19
54.39
112.36
92.31
EERTG 125 mg
5 46.9760 24.69532 11.04408
16.3127
77.6393
30.72
87.76
EERTG 625 mg
5 35.6100 28.50716 12.74879
.2137
71.0063
6.19
71.38
24.9614
50.3912
56.8826
73.5675
26.45
6.19
59.19
131.22
N
Mean
Na diklofenak 25 mg 5 40.9220 12.85418
Total
30 61.9793 31.03369
5.74856
5.66595
Minimum Maximum
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
14542.842
13386.773
5
24
2908.568
557.782
5.215
.002
Total
27929.616
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
EERTG 625 mg
Na diklofenak 25 mg
EERTG 125 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
N
1
5
5
5
5
5
5
35.6100
40.9220
46.9760
.480
2
40.9220
46.9760
70.4440
.073
3
70.4440
86.0520
91.8720
.187
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
54
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-210
Descriptives
persentasi radang
95% Confidence Interval
for Mean
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
Total
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
33.05899
24.06123
17.77898
23.28184
27.82401
14.26436
14.78443
10.76051
7.95100
10.41196
12.44328
6.37921
52.2418
53.6920
47.3805
16.0918
-1.5441
20.5085
134.3382
113.4440
91.5315
73.9082
67.5521
55.9315
61.25
60.53
50.29
29.45
3.34
22.49
134.60
112.74
92.31
82.65
68.40
60.44
30 60.4230 32.12655
5.86548
48.4267
72.4193
3.34
134.60
N
Mean
5
5
5
5
5
5
93.2900
83.5680
69.4560
45.0000
33.0040
38.2200
Minimu Maximu
m
m
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
15900.848
14030.493
5
24
3180.170
584.604
5.440
.002
Total
29931.341
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
33.0040
Na diklofenak 25 mg
5
38.2200
38.2200
EERTG 125 mg
5
45.0000
45.0000
EERTG 25 mg
5
EERTG 5 mg
5
83.5680
Na CMC 0,5%
5
93.2900
Sig.
2
69.4560
.467
.064
3
69.4560
.153
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
55
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke 240
Descriptives
persentasi radang
95% Confidence Interval
for Mean
N
Na CMC 0,5%
5
EERTG 5 mg
5
EERTG 25 mg
5
EERTG 125 mg
5
EERTG 625 mg
5
Na diklofenak 25 mg 5
Total
30
Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
90.7000
80.3140
65.7740
42.8320
28.7220
36.3020
57.4407
35.22213 15.75181
22.96822 10.27170
15.17499 6.78646
22.03031 9.85226
22.81062 10.20122
14.54371 6.50415
31.50345 5.75172
46.9660
51.7952
46.9318
15.4778
.3989
18.2436
45.6771
134.4340
108.8328
84.6162
70.1862
57.0451
54.3604
69.2042
Minimum Maximum
56.64
60.23
46.78
26.24
5.31
22.59
5.31
135.44
105.41
83.61
77.55
59.11
58.57
135.44
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
15919.176
12862.385
5
24
3183.835
535.933
5.941
.001
Total
28781.562
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
28.7220
Na diklofenak 25 mg
5
36.3020
36.3020
EERTG 125 mg
5
42.8320
42.8320
EERTG 25 mg
5
EERTG 5 mg
5
80.3140
Na CMC 0,5%
5
90.7000
Sig.
2
65.7740
.373
.068
3
65.7740
.120
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
56
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke 270
Descriptives
persentasi radang
95% Confidence
Interval for Mean
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
Total
N
Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
Minimum
Maximum
5
5
5
5
5
5
3
0
87.9500
76.9240
56.2860
32.4320
24.3340
36.0400
52.3277
37.20975 16.64071
22.26939 9.95917
12.94797 5.79051
18.02624 8.06158
18.05906 8.07626
15.65995 7.00334
31.32128 5.71846
41.7480
49.2729
40.2090
10.0495
1.9107
16.5956
40.6321
134.1520
104.5751
72.3630
54.8145
46.7573
55.4844
64.0232
51.76
59.63
42.98
17.78
6.80
14.88
6.80
135.86
104.26
74.92
60.54
49.81
56.70
135.86
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
16671.848
11777.801
5
24
3334.370
490.742
6.795
.000
Total
28449.650
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
24.3340
EERTG 125 mg
5
32.4320
32.4320
Na diklofenak 25 mg
5
36.0400
36.0400
EERTG 25 mg
5
EERTG 5 mg
5
Na CMC 0,5%
5
Sig.
2
56.2860
3
4
56.2860
76.9240
76.9240
87.9500
.439
.120
.154
.439
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
57
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-300
Descriptives
persentasi radang
95% Confidence
Interval for Mean
N
Mean
Std.
Deviation Std. Error
Lower
Bound
Upper
Bound
Minimum Maximum
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
5 82.1740 33.34713 14.91329 40.7681 123.5799
5 73.3940 20.03837 8.96143 48.5131 98.2749
5 53.3680 14.41487 6.44653 35.4696 71.2664
49.05
54.97
38.89
120.25
96.81
74.92
EERTG 125 mg
EERTG 625 mg
5 21.9180 14.17975 6.34138
5 19.8300 17.79049 7.95615
4.3115
-2.2598
39.5245
41.9198
9.04
4.72
43.54
48.70
Na diklofenak 25 mg 5 27.1560 4.80298 2.14796
Total
30 46.3067 30.91204 5.64374
21.1923
34.7639
33.1197
57.8494
22.12
4.72
34.64
120.25
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
18663.103
9047.967
5
24
3732.621
376.999
9.901
.000
Total
27711.070
29
persentasi radang
Duncan
a
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
19.8300
EERTG 125 mg
5
21.9180
Na diklofenak 25 mg
5
27.1560
EERTG 25 mg
5
53.3680
EERTG 5 mg
5
73.3940
Na CMC 0,5%
5
Sig.
2
3
73.3940
82.1740
.580
.116
.482
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
58
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-330
Descriptives
persentasi radang
95% Confidence
Interval for Mean
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
N
Mean
5
5
5
5
79.3720
76.9240
50.1940
16.7500
Std.
Deviation Std. Error
Lower
Bound
32.79474 14.66626 38.6519
22.26939 9.95917 49.2729
15.93083 7.12448 30.4133
15.22854 6.81041 -2.1587
Upper
Bound
Minimum
Maximum
120.0921
104.5751
69.9747
35.6587
46.34
59.63
34.50
4.08
116.88
104.26
74.58
38.10
EERTG 625 mg
Na diklofenak 25 mg
5 17.2740 18.35227
5 27.1560 4.80298
8.20739
2.14796
-5.5134
21.1923
40.0614
33.1197
2.36
22.12
47.58
34.64
Total
30 44.6117 32.28496
5.89440
32.5563
56.6671
2.36
116.88
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
20559.254
9667.982
5
24
4111.851
402.833
10.207
.000
Total
30227.236
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
EERTG 125 mg
EERTG 625 mg
Na diklofenak 25 mg
EERTG 25 mg
EERTG 5 mg
Na CMC 0,5%
Sig.
N
1
5
5
5
5
5
5
16.7500
17.2740
27.1560
.447
2
3
27.1560
50.1940
.082
76.9240
79.3720
.849
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
59
Universitas Sumatera Utara
Lampiran 11. Lanjutan
Menit ke-360
Descriptives
persentasi radang
95% Confidence
Interval for Mean
N
Mean
Std.
Deviation
Std. Error
Lower
Bound
Upper
Bound
5
5
5
5
78.3700
68.6460
49.3460
14.5360
32.17865
17.53550
15.74270
13.71216
14.39073
7.84212
7.04035
6.13227
38.4149
46.8728
29.7989
-2.4899
118.3251
90.4192
68.8931
31.5619
46.34
49.12
33.33
1.75
115.19
87.25
72.91
32.31
EERTG 625 mg
Na diklofenak 25 mg
5 14.4480
5 25.4580
15.64804
4.72293
6.99802
2.11216
-4.9816
19.5937
33.8776
31.3223
1.77
21.50
39.97
33.66
Total
30 41.8007
30.82296
5.62748
30.2912
53.3102
1.75
115.19
Na CMC 0,5%
EERTG 5 mg
EERTG 25 mg
EERTG 125 mg
Minimum Maximum
ANOVA
persentasi radang
Sum of Squares
df
Mean Square
F
Sig.
Between Groups
Within Groups
19367.666
8183.932
5
24
3873.533
340.997
11.359
.000
Total
27551.598
29
persentasi radang
Duncana
Subset for alpha = 0.05
dosis perlakuan
N
1
EERTG 625 mg
5
14.4480
EERTG 125 mg
5
14.5360
Na diklofenak 25 mg
5
25.4580
EERTG 25 mg
5
EERTG 5 mg
5
Na CMC 0,5%
5
Sig.
2
3
4
25.4580
49.3460
49.3460
68.6460
68.6460
78.3700
.383
.052
.111
.413
Means for groups in homogeneous subsets are displayed.
a. Uses Harmonic Mean Sample Size = 5.000.
60
Universitas Sumatera Utara
Lampiran 12.Alat pletismometerdigital UGO basile cat No.7140
1
2
3
4
5
6
7
Keterangan : 1. Klem
2. Reservoir
3. Statif
4. Layar
5. Sel
6. Saluran air masuk
7. Pedal
61
Universitas Sumatera Utara