behavior in a Genetic Regulatory System GRS by utilizing KGS. The term ”genes behavior” in this paper is the behavior of genes extracted from genes interaction over a series of time. We will show how
to extract the knowledge from the genes behavior in order to estimate the GRS behavior in the future. The analysis will be viewed in two perspectives. The first one is viewed from all genes interaction
over time and the second one is viewed from the contribution of individual gene over a time interval. In this paper we only present examples of the first perspective’s analysis. For this purpose, we use secondary
data i.e. genes’ interaction values database for yeast25-cdc28 taken from [13] as depicted in Table 2. In this database, there are 25 genes from ACE2 to SIC1 as listed in column A with a time interval from t-1
to t-17 or 17t times as shown in line 1.
Table 2 : Genes’ interaction values for yeast25-cdc28
1. Extracting Knowledge of the Genes Behavior
The knowledge in this case is the GRS behavior viewed from genes interactions over time that will be used as the basis for making an estimation regarding their interactions in the future. The ultimate aim
of this effort is by apprehending the GRS behavior we can suppress the genes that cause poor offspring quality and support the genes that produce good offspring quality. For examples we will deliver
knowledge extracted by KGS for 13 and all the 25 genes in 17t time of interactions. We also present the original data as the comparisons for the results obtained by KGS.
1.1. Interactions Performed by 13 Genes
We take the interaction values of the first 13 genes listed in Table 2 namely ACE2 to CDC21. The knowledge acquired by KGS is depicted in Figure 8.a while its original is depicted in Figure 8.b.
a Knowledge acquired by KGS.
b Original information
Figure 8 : GRS behavior acquired by KGS for 13 genes for 17t time of interactions. 1.2.
Interactions Performed by 25 or All Genes
The knowledge acquired by KGS is depicted in Figure 9.a while its original is depicted in Figure 9.b.
a Knowledge acquired by KGS.
b Original information
Figure 9 : GRS behavior acquired by KGS for 25 or all genes for 17t time of interactions. 2.
Estimation Delivered from the Acquired Knowledge
There are some estimation can be delivered after observing the results presented by KGS in Figure 8 and Figure 9 as follows.
• The highest DoC value of genes interactions is consistently presented by GRS at t = 5 whether for
13 genes or all genes. Therefore, the next highest DoC may be very much likely at t = 22.
