40 3. Resistensi Insulin yang diukur dari nilai HOMA-IR
meningkatkan risiko hiperplasia prostat melalui peningkatan IGF-1 pada obesitas abdominal.
4. IL-6 dan hsCRP tidak terbukti berperan sebagai faktor risiko hiperplasia prostat.
7.2 Saran Dari hasil-hasil penelitian ini dapat diajukan beberapa saran
sebagai berikut: 1. Resistensi insulin yang dinilai dari indeks HOMA-IR dan
kadar IGF-1 dapat dipertimbangkan sebagai faktor yang dapat dipakai untuk memperkirakan risiko terjadinya hiperplasia
prostat pada obesitas abdominal. Perlu dilakukan penelitian lebih lanjut yang meneliti ekspresi IGF-1
2. di jaringan prostat dan reseptor IGF-1 untuk menguji lebih lanjut konsistensi hubungan dan peran sistem IGF dalam
patofisiologihiperplasia prostat pada obesitas abdominal.
41
SUMMARY INSULINE RESISTANCE WAS INCREACED RISK
FACTOR FOR PROSTAT HYPERPLASIA VIA INSULIN LIKE GROWTH FACTOR-1 IN ABDOMINAL OBESITY
Pandemic of obesity, especially abdominal obesity Ab-Ob, recently become serious threat to human being in the world. Ab-
Ob is often acquired with other symptoms and risk factors that considered as cardiovascular disease CVD risk factors which is
known as metabolic syndrome MS Carr
et al.,
2004; IDF, 2013. MS was a risk factors constellation consist of insulin resistance,
Ab-Ob, hypertension, glucose tolerance impairment prediabetes, and dyslipidemia that considered as an initial phase on the natural
history of diabetes mellitus DM and CVD Leahy, 2005; Grundy
et al.,
2008; Gorbanchyski
et al.,
2010. On the natural history of MS as a risk factor of metabolic disorder and CVD, Ab-Ob
occupied the very basic role Carr
et al.,
2004; Grundy
et al.,
2008. Since 1980, obesity pandemic became a fact that have serious
attention from WHO. On 2008, the newest data from WHO showed that more than 1,4 billion world population have an
overweight condition, 200 million male and 300 million female with obesity WHO, 2014. More than 10 world population was
in obesity condition. In United State, 30 adult population was in overweight condition BMI 25-29,9 kgm
2
and 32 with obesity BMI
30 kgm
2
Ogden
et al.,
2006. On the age more than 60 years old, the prevalence even reached 40. In Asia, prevalence of
MS was obtained highest in India due to high prevalence of Ab- Ob, reaching 1.091 population with 8 prevalence on male and
18 on female Johnson, 2013.
Prevalence of DM is also keep increasing from year to year along with increase prevalence of MS and obesity, especially Ab-
Ob. In 2012, International Diabetes Federation IDF was approximating 371 million world people 8,3 suffer from DM
