b Formulasi Sediaan Gel Ekstrak Etanol Daun Teh Hijau (Camellia sinensis (L.) Kuntze) dan Uji Efektivitas Penyembuhan Luka Sayat pada Tikus Putih

74 Lampiran 21. Lanjutan Ranks Perlakuan N Mean Rank H_1 Basis Gel Carbomer 940 5 8.90 F1 GETH 1 5 17.30 F2 GETH 3 5 13.60 F3 GETH 5 5 10.10 Betadine Salep 5 15.10 Total 25 Test Statistics

a,b

H_1 Chi-Square 4.703 df 4 Asymp. Sig. .319 a. Kruskal Wallis Test b. Grouping Variable: perlakuan Mann-Whitney Test Ranks Perlakuan N Mean Rank Sum of Ranks H_1 Basis Gel Carbomer 940 5 3.80 19.00 F1 GETH 1 5 7.20 36.00 Total 10 Test Statistics b H_1 Mann-Whitney U 4.000 Wilcoxon W 19.000 Z -1.820 Asymp. Sig. 2-tailed .069 Exact Sig. [21-tailed Sig.] .095 a a. Not corrected for ties. b. Grouping Variable: perlakuan Ranks Perlakuan N Mean Rank Sum of Ranks H_1 Basis Gel Carbomer 940 5 3.80 19.00 F1 GETH 1 5 7.20 36.00 Total 10 Universitas Sumatera Utara 75 Lampiran 21. Lanjutan Test Statistics b H_1 Mann-Whitney U 4.000 Wilcoxon W 19.000 Z -1.820 Asymp. Sig. 2-tailed .069 Exact Sig. [21-tailed Sig.] .095 a a. Not corrected for ties. b. Grouping Variable: perlakuan Ranks Perlakuan N Mean Rank Sum of Ranks H_1 Basis Gel Carbomer 940 5 4.80 24.00 F2 GETH 3 5 6.20 31.00 Total 10 Test Statistics b H_1 Mann-Whitney U 9.000 Wilcoxon W 24.000 Z -.783 Asymp. Sig. 2-tailed .434 Exact Sig. [21-tailed Sig.] .548 a a. Not corrected for ties. b. Grouping Variable: perlakuan Ranks Perlakuan N Mean Rank Sum of Ranks H_1 Basis Gel Carbomer 940 5 5.10 25.50 F3 GETH 5 5 5.90 29.50 Total 10 Test Statistics b H_1 Mann-Whitney U 10.500 Wilcoxon W 25.500 Z -.447 Asymp. Sig. 2-tailed .655 Exact Sig. [21-tailed Sig.] .690 a a. Not corrected for ties. b. Grouping Variable: perlakuan Universitas Sumatera Utara 76 Lampiran 21. Lanjutan Ranks Perlakuan N Mean Rank Sum of Ranks H_1 Basis Gel Carbomer 940 5 4.20 21.00 Betadine Salep 5 6.80 34.00 Total 10 Test Statistics b H_1 Mann-Whitney U 6.000 Wilcoxon W 21.000 Z -1.410 Asymp. Sig. 2-tailed .159 Exact Sig. [21-tailed Sig.] .222 a a. Not corrected for ties. b. Grouping Variable: perlakuan Ranks Perlakuan N Mean Rank Sum of Ranks H_1 F1 GETH 1 5 6.00 30.00 F2 GETH 3 5 5.00 25.00 Total 10 Test Statistics b H_1 Mann-Whitney U 10.000 Wilcoxon W 25.000 Z -.532 Asymp. Sig. 2-tailed .595 Exact Sig. [21-tailed Sig.] .690 a a. Not corrected for ties. b. Grouping Variable: perlakuan Ranks Perlakuan N Mean Rank Sum of Ranks H_1 F1 GETH 1 5 7.00 35.00 F3 GETH 5 5 4.00 20.00 Total 10 Universitas Sumatera Utara 77 Lampiran 21. Lanjutan Test Statistics b H_1 Mann-Whitney U 5.000 Wilcoxon W 20.000 Z -1.591 Asymp. Sig. 2-tailed .112 Exact Sig. [21-tailed Sig.] .151 a a. Not corrected for ties. b. Grouping Variable: perlakuan Ranks Perlakuan N Mean Rank Sum of Ranks H_1 F1 GETH 1 5 6.10 30.50 Betadine Salep 5 4.90 24.50 Total 10 Test Statistics b H_1 Mann-Whitney U 9.500 Wilcoxon W 24.500 Z -.669 Asymp. Sig. 2-tailed .504 Exact Sig. [21-tailed Sig.] .548 a a. Not corrected for ties. b. Grouping Variable: perlakuan Ranks Perlakuan N Mean Rank Sum of Ranks H_1 F2 GETH 3 5 6.00 30.00 F3 GETH 5 5 5.00 25.00 Total 10 Test Statistics b H_1 Mann-Whitney U 10.000 Wilcoxon W 25.000 Z -.541 Asymp. Sig. 2-tailed .589 Exact Sig. [21-tailed Sig.] .690 a a. Not corrected for ties. b. b. Grouping Variable: perlakuan Universitas Sumatera Utara 78 Lampiran 21. Lanjutan Ranks Perlakuan N Mean Rank Sum of Ranks H_1 F2 GETH 3 5 5.40 27.00 Betadine Salep 5 5.60 28.00 Total 10 Test Statistics b H_1 Mann-Whitney U 12.000 Wilcoxon W 27.000 Z -.112 Asymp. Sig. 2-tailed .911 Exact Sig. [21-tailed Sig.] 1.000 a a. Not corrected for ties. b. Grouping Variable: perlakuan Universitas Sumatera Utara 79 Lampiran 21. Lanjutan Sum of Squares Df Mean Square F Sig. H_2 Between Groups 42.767 4 10.692 1.645 .202 Within Groups 130.013 20 6.501 Total 172.781 24 H_3 Between Groups 58.347 4 14.587 1.121 .374 Within Groups 260.202 20 13.010 Total 318.549 24 H_4 Between Groups 28.272 4 7.068 .291 .881 Within Groups 486.515 20 24.326 Total 514.788 24 H_5 Between Groups 25.138 4 6.285 .104 .980 Within Groups 1211.422 20 60.571 Total 1236.560 24 H_6 Between Groups 146.937 4 36.734 .442 .777 Within Groups 1661.113 20 83.056 Total 1808.049 24 H_7 Between Groups 256.852 4 64.213 .872 .498 Within Groups 1472.941 20 73.647 Total 1729.793 24 H_8 Between Groups 620.697 4 155.174 1.972 .138 Within Groups 1574.017 20 78.701 Total 2194.714 24 H_9 Between Groups 612.579 4 153.145 1.512 .237 Within Groups 2025.602 20 101.280 Total 2638.181 24 H_10 Between Groups 443.115 4 110.779 2.241 .101 Within Groups 988.790 20 49.439 Total 1431.905 24 H_11 Between Groups 297.250 4 74.312 1.890 .152 Within Groups 786.367 20 39.318 Total 1083.617 24 H_12 Between Groups 357.714 4 89.428 3.563 .024 Within Groups 501.991 20 25.100 Total 859.704 24 H_13 Between Groups 353.509 4 88.377 3.527 .025 Within Groups 501.128 20 25.056 Total 854.637 24 H_14 Between Groups 432.926 4 108.232 5.720 .003 Within Groups 378.419 20 18.921 Total 811.345 24 Universitas Sumatera Utara 80 Lampiran 21. Lanjutan H_15 Between Groups 484.556 4 121.139 8.163 .000 Within Groups 296.805 20 14.840 Total 781.361 24 H_16 Between Groups 264.716 4 66.179 5.361 .004 Within Groups 246.882 20 12.344 Total 511.598 24 H_17 Between Groups 355.604 4 88.901 11.409 .000 Within Groups 155.850 20 7.792 Total 511.454 24 H_18 Between Groups 264.652 4 66.163 13.618 .000 Within Groups 97.170 20 4.859 Total 361.822 24 H_19 Between Groups 160.626 4 40.157 12.639 .000 Within Groups 63.543 20 3.177 Total 224.169 24 H_20 Between Groups 112.106 4 28.026 32.329 .000 Within Groups 17.338 20 .867 Total 129.444 24 H_21 Between Groups 29.160 4 7.290 5.245 .005 Within Groups 27.800 20 1.390 Total 56.960 24 H_22 Between Groups 11.560 4 2.890 3.440 .027 Within Groups 16.800 20 .840 Total 28.360 24 H_23 Between Groups .000 4 .000 . . Within Groups .000 20 .000 Total .000 24 Universitas Sumatera Utara 81 Lampiran 21. Lanjutan Multiple Comparisons Depende nt Variable I perlakuan J perlakuan Mean Difference I-J Std. Error Sig. 95 Confidence Interval Lower Bound Upper Bound H_2 Basis Gel Carbomer 940 F1 GETH 1 .40400 1.61253 .999 -4.4213 5.2293 F2 GETH 3 -1.82200 1.61253 .789 -6.6473 3.0033 F3 GETH 5 -2.37400 1.61253 .591 -7.1993 2.4513 Betadine Salep .99800 1.61253 .970 -3.8273 5.8233 F1 GETH 1 Basis Gel Carbomer 940 -.40400 1.61253 .999 -5.2293 4.4213 F2 GETH 3 -2.22600 1.61253 .646 -7.0513 2.5993 F3 GETH 5 -2.77800 1.61253 .443 -7.6033 2.0473 Betadine Salep .59400 1.61253 .996 -4.2313 5.4193 F2 GETH 3 Basis Gel Carbomer 940 1.82200 1.61253 .789 -3.0033 6.6473 F1 GETH 1 2.22600 1.61253 .646 -2.5993 7.0513 F3 GETH 5 -.55200 1.61253 .997 -5.3773 4.2733 Betadine Salep 2.82000 1.61253 .429 -2.0053 7.6453 F3 GETH 5 Basis Gel Carbomer 940 2.37400 1.61253 .591 -2.4513 7.1993 F1 GETH 1 2.77800 1.61253 .443 -2.0473 7.6033 F2 GETH 3 .55200 1.61253 .997 -4.2733 5.3773 Betadine Salep 3.37200 1.61253 .262 -1.4533 8.1973 Universitas Sumatera Utara 82 Lampiran 21. Lanjutan Betadine Salep Basis Gel Carbomer 940 -.99800 1.61253 .970 -5.8233 3.8273 F1 GETH 1 -.59400 1.61253 .996 -5.4193 4.2313 F2 GETH 3 -2.82000 1.61253 .429 -7.6453 2.0053 F3 GETH 5 -3.37200 1.61253 .262 -8.1973 1.4533 H_3 Basis Gel Carbomer 940 F1 GETH 1 2.51400 2.28123 .803 -4.3123 9.3403 F2 GETH 3 -1.58600 2.28123 .955 -8.4123 5.2403 F3 GETH 5 -1.16800 2.28123 .985 -7.9943 5.6583 Betadine Salep 1.30200 2.28123 .978 -5.5243 8.1283 F1 GETH 1 Basis Gel Carbomer 940 -2.51400 2.28123 .803 -9.3403 4.3123 F2 GETH 3 -4.10000 2.28123 .402 - 10.9263 2.7263 F3 GETH 5 -3.68200 2.28123 .506 - 10.5083 3.1443 Betadine Salep -1.21200 2.28123 .983 -8.0383 5.6143 F2 GETH 3 Basis Gel Carbomer 940 1.58600 2.28123 .955 -5.2403 8.4123 F1 GETH 1 4.10000 2.28123 .402 -2.7263 10.9263 F3 GETH 5 .41800 2.28123 1.000 -6.4083 7.2443 Betadine Salep 2.88800 2.28123 .714 -3.9383 9.7143 F3 GETH 5 Basis Gel Carbomer 940 1.16800 2.28123 .985 -5.6583 7.9943 F1 GETH 1 3.68200 2.28123 .506 -3.1443 10.5083 F2 GETH 3 -.41800 2.28123 1.000 -7.2443 6.4083 Betadine Salep 2.47000 2.28123 .813 -4.3563 9.2963 Universitas Sumatera Utara 83 Lampiran 21. Lanjutan Betadine Salep Basis Gel Carbomer 940 -1.30200 2.28123 .978 -8.1283 5.5243 F1 GETH 1 1.21200 2.28123 .983 -5.6143 8.0383 F2 GETH 3 -2.88800 2.28123 .714 -9.7143 3.9383 F3 GETH 5 -2.47000 2.28123 .813 -9.2963 4.3563 H_4 Basis Gel Carbomer 940 F1 GETH 1 2.77600 3.11934 .897 -6.5582 12.1102 F2 GETH 3 1.55600 3.11934 .987 -7.7782 10.8902 F3 GETH 5 -.03200 3.11934 1.000 -9.3662 9.3022 Betadine Salep .64400 3.11934 1.000 -8.6902 9.9782 F1 GETH 1 Basis Gel Carbomer 940 -2.77600 3.11934 .897 - 12.1102 6.5582 F2 GETH 3 -1.22000 3.11934 .995 - 10.5542 8.1142 F3 GETH 5 -2.80800 3.11934 .893 - 12.1422 6.5262 Betadine Salep -2.13200 3.11934 .958 - 11.4662 7.2022 F2 GETH 3 Basis Gel Carbomer 940 -1.55600 3.11934 .987 - 10.8902 7.7782 F1 GETH 1 1.22000 3.11934 .995 -8.1142 10.5542 F3 GETH 5 -1.58800 3.11934 .985 - 10.9222 7.7462 Betadine Salep -.91200 3.11934 .998 - 10.2462 8.4222 F3 GETH 5 Basis Gel Carbomer 940 .03200 3.11934 1.000 -9.3022 9.3662 F1 GETH 1 2.80800 3.11934 .893 -6.5262 12.1422 F2 GETH 3 1.58800 3.11934 .985 -7.7462 10.9222 Betadine Salep .67600 3.11934 .999 -8.6582 10.0102 Universitas Sumatera Utara 84 Lampiran 21. Lanjutan Betadine Salep Basis Gel Carbomer 940 -.64400 3.11934 1.000 -9.9782 8.6902 F1 GETH 1 2.13200 3.11934 .958 -7.2022 11.4662 F2 GETH 3 .91200 3.11934 .998 -8.4222 10.2462 F3 GETH 5 -.67600 3.11934 .999 - 10.0102 8.6582 H_5 Basis Gel Carbomer 940 F1 GETH 1 -2.46200 4.92224 .986 - 17.1912 12.2672 F2 GETH 3 -.87000 4.92224 1.000 - 15.5992 13.8592 F3 GETH 5 -1.95200 4.92224 .994 - 16.6812 12.7772 Betadine Salep -.00800 4.92224 1.000 - 14.7372 14.7212 F1 GETH 1 Basis Gel Carbomer 940 2.46200 4.92224 .986 - 12.2672 17.1912 F2 GETH 3 1.59200 4.92224 .997 - 13.1372 16.3212 F3 GETH 5 .51000 4.92224 1.000 - 14.2192 15.2392 Betadine Salep 2.45400 4.92224 .987 - 12.2752 17.1832 F2 GETH 3 Basis Gel Carbomer 940 .87000 4.92224 1.000 - 13.8592 15.5992 F1 GETH 1 -1.59200 4.92224 .997 - 16.3212 13.1372 F3 GETH 5 -1.08200 4.92224 .999 - 15.8112 13.6472 Betadine Salep .86200 4.92224 1.000 - 13.8672 15.5912 Universitas Sumatera Utara 85 Lampiran 21. Lanjutan F3 GETH 5 Basis Gel Carbomer 940 1.95200 4.92224 .994 - 12.7772 16.6812 F1 GETH 1 -.51000 4.92224 1.000 - 15.2392 14.2192 F2 GETH 3 1.08200 4.92224 .999 - 13.6472 15.8112 Betadine Salep 1.94400 4.92224 .994 - 12.7852 16.6732 Betadine Salep Basis Gel Carbomer 940 .00800 4.92224 1.000 - 14.7212 14.7372 F1 GETH 1 -2.45400 4.92224 .987 - 17.1832 12.2752 F2 GETH 3 -.86200 4.92224 1.000 - 15.5912 13.8672 F3 GETH 5 -1.94400 4.92224 .994 - 16.6732 12.7852 H_6 Basis Gel Carbomer 940 F1 GETH 1 -5.45200 5.76387 .875 - 22.6997 11.7957 F2 GETH 3 -5.33800 5.76387 .883 - 22.5857 11.9097 F3 GETH 5 -6.08600 5.76387 .826 - 23.3337 11.1617 Betadine Salep -1.63800 5.76387 .998 - 18.8857 15.6097 F1 GETH 1 Basis Gel Carbomer 940 5.45200 5.76387 .875 - 11.7957 22.6997 F2 GETH 3 .11400 5.76387 1.000 - 17.1337 17.3617 F3 GETH 5 -.63400 5.76387 1.000 - 17.8817 16.6137 Betadine Salep 3.81400 5.76387 .962 - 13.4337 21.0617 Universitas Sumatera Utara 86 Lampiran 21. Lanjutan F2 GETH 3 Basis Gel Carbomer 940 5.33800 5.76387 .883 - 11.9097 22.5857 F1 GETH 1 -.11400 5.76387 1.000 - 17.3617 17.1337 F3 GETH 5 -.74800 5.76387 1.000 - 17.9957 16.4997 Betadine Salep 3.70000 5.76387 .966 - 13.5477 20.9477 F3 GETH 5 Basis Gel Carbomer 940 6.08600 5.76387 .826 - 11.1617 23.3337 F1 GETH 1 .63400 5.76387 1.000 - 16.6137 17.8817 F2 GETH 3 .74800 5.76387 1.000 - 16.4997 17.9957 Betadine Salep 4.44800 5.76387 .936 - 12.7997 21.6957 Betadine Salep Basis Gel Carbomer 940 1.63800 5.76387 .998 - 15.6097 18.8857 F1 GETH 1 -3.81400 5.76387 .962 - 21.0617 13.4337 F2 GETH 3 -3.70000 5.76387 .966 - 20.9477 13.5477 F3 GETH 5 -4.44800 5.76387 .936 - 21.6957 12.7997 H_7 Basis Gel Carbomer 940 F1 GETH 1 -5.92600 5.42760 .809 - 22.1674 10.3154 F2 GETH 3 -8.61200 5.42760 .522 - 24.8534 7.6294 F3 GETH 5 -7.59600 5.42760 .635 - 23.8374 8.6454 Betadine Salep -2.60400 5.42760 .988 - 18.8454 13.6374 Universitas Sumatera Utara 87 Lampiran 21. Lanjutan F1 GETH 1 Basis Gel Carbomer 940 5.92600 5.42760 .809 - 10.3154 22.1674 F2 GETH 3 -2.68600 5.42760 .987 - 18.9274 13.5554 F3 GETH 5 -1.67000 5.42760 .998 - 17.9114 14.5714 Betadine Salep 3.32200 5.42760 .971 - 12.9194 19.5634 F2 GETH 3 Basis Gel Carbomer 940 8.61200 5.42760 .522 -7.6294 24.8534 F1 GETH 1 2.68600 5.42760 .987 - 13.5554 18.9274 F3 GETH 5 1.01600 5.42760 1.000 - 15.2254 17.2574 Betadine Salep 6.00800 5.42760 .801 - 10.2334 22.2494 F3 GETH 5 Basis Gel Carbomer 940 7.59600 5.42760 .635 -8.6454 23.8374 F1 GETH 1 1.67000 5.42760 .998 - 14.5714 17.9114 F2 GETH 3 -1.01600 5.42760 1.000 - 17.2574 15.2254 Betadine Salep 4.99200 5.42760 .886 - 11.2494 21.2334 Betadine Salep Basis Gel Carbomer 940 2.60400 5.42760 .988 - 13.6374 18.8454 F1 GETH 1 -3.32200 5.42760 .971 - 19.5634 12.9194 F2 GETH 3 -6.00800 5.42760 .801 - 22.2494 10.2334 F3 GETH 5 -4.99200 5.42760 .886 - 21.2334 11.2494 Universitas Sumatera Utara 88 Lampiran 21. Lanjutan H_8 Basis Gel Carbomer 940 F1 GETH 1 .36800 5.61073 1.000 - 16.4214 17.1574 F2 GETH 3 -6.25800 5.61073 .797 - 23.0474 10.5314 F3 GETH 5 -13.27000 5.61073 .166 - 30.0594 3.5194 Betadine Salep -5.60000 5.61073 .853 - 22.3894 11.1894 F1 GETH 1 Basis Gel Carbomer 940 -.36800 5.61073 1.000 - 17.1574 16.4214 F2 GETH 3 -6.62600 5.61073 .762 - 23.4154 10.1634 F3 GETH 5 -13.63800 5.61073 .148 - 30.4274 3.1514 Betadine Salep -5.96800 5.61073 .823 - 22.7574 10.8214 F2 GETH 3 Basis Gel Carbomer 940 6.25800 5.61073 .797 - 10.5314 23.0474 F1 GETH 1 6.62600 5.61073 .762 - 10.1634 23.4154 F3 GETH 5 -7.01200 5.61073 .723 - 23.8014 9.7774 Betadine Salep .65800 5.61073 1.000 - 16.1314 17.4474 F3 GETH 5 Basis Gel Carbomer 940 13.27000 5.61073 .166 -3.5194 30.0594 F1 GETH 1 13.63800 5.61073 .148 -3.1514 30.4274 F2 GETH 3 7.01200 5.61073 .723 -9.7774 23.8014 Betadine Salep 7.67000 5.61073 .654 -9.1194 24.4594 Universitas Sumatera Utara 89 Lampiran 21. Lanjutan Betadine Salep Basis Gel Carbomer 940 5.60000 5.61073 .853 - 11.1894 22.3894 F1 GETH 1 5.96800 5.61073 .823 - 10.8214 22.7574 F2 GETH 3 -.65800 5.61073 1.000 - 17.4474 16.1314 F3 GETH 5 -7.67000 5.61073 .654 - 24.4594 9.1194 H_9 Basis Gel Carbomer 940 F1 GETH 1 -2.77000 6.36491 .992 - 21.8162 16.2762 F2 GETH 3 -8.12600 6.36491 .708 - 27.1722 10.9202 F3 GETH 5 -13.47600 6.36491 .252 - 32.5222 5.5702 Betadine Salep -10.52400 6.36491 .483 - 29.5702 8.5222 F1 GETH 1 Basis Gel Carbomer 940 2.77000 6.36491 .992 - 16.2762 21.8162 F2 GETH 3 -5.35600 6.36491 .914 - 24.4022 13.6902 F3 GETH 5 -10.70600 6.36491 .466 - 29.7522 8.3402 Betadine Salep -7.75400 6.36491 .741 - 26.8002 11.2922 F2 GETH 3 Basis Gel Carbomer 940 8.12600 6.36491 .708 - 10.9202 27.1722 F1 GETH 1 5.35600 6.36491 .914 - 13.6902 24.4022 F3 GETH 5 -5.35000 6.36491 .915 - 24.3962 13.6962 Betadine Salep -2.39800 6.36491 .995 - 21.4442 16.6482 Universitas Sumatera Utara 90 Lampiran 21. Lanjutan F3 GETH 5 Basis Gel Carbomer 940 13.47600 6.36491 .252 -5.5702 32.5222 F1 GETH 1 10.70600 6.36491 .466 -8.3402 29.7522 F2 GETH 3 5.35000 6.36491 .915 - 13.6962 24.3962 Betadine Salep 2.95200 6.36491 .990 - 16.0942 21.9982 Betadine Salep Basis Gel Carbomer 940 10.52400 6.36491 .483 -8.5222 29.5702 F1 GETH 1 7.75400 6.36491 .741 - 11.2922 26.8002 F2 GETH 3 2.39800 6.36491 .995 - 16.6482 21.4442 F3 GETH 5 -2.95200 6.36491 .990 - 21.9982 16.0942 H_10 Basis Gel Carbomer 940 F1 GETH 1 -.36400 4.44700 1.000 - 13.6711 12.9431 F2 GETH 3 -3.69200 4.44700 .918 - 16.9991 9.6151 F3 GETH 5 -11.70200 4.44700 .102 - 25.0091 1.6051 Betadine Salep -3.98200 4.44700 .895 - 17.2891 9.3251 F1 GETH 1 Basis Gel Carbomer 940 .36400 4.44700 1.000 - 12.9431 13.6711 F2 GETH 3 -3.32800 4.44700 .942 - 16.6351 9.9791 F3 GETH 5 -11.33800 4.44700 .119 - 24.6451 1.9691 Betadine Salep -3.61800 4.44700 .923 - 16.9251 9.6891 Universitas Sumatera Utara 91 Lampiran 21. Lanjutan F2 GETH 3 Basis Gel Carbomer 940 3.69200 4.44700 .918 -9.6151 16.9991 F1 GETH 1 3.32800 4.44700 .942 -9.9791 16.6351 F3 GETH 5 -8.01000 4.44700 .400 - 21.3171 5.2971 Betadine Salep -.29000 4.44700 1.000 - 13.5971 13.0171 F3 GETH 5 Basis Gel Carbomer 940 11.70200 4.44700 .102 -1.6051 25.0091 F1 GETH 1 11.33800 4.44700 .119 -1.9691 24.6451 F2 GETH 3 8.01000 4.44700 .400 -5.2971 21.3171 Betadine Salep 7.72000 4.44700 .436 -5.5871 21.0271 Betadine Salep Basis Gel Carbomer 940 3.98200 4.44700 .895 -9.3251 17.2891 F1 GETH 1 3.61800 4.44700 .923 -9.6891 16.9251 F2 GETH 3 .29000 4.44700 1.000 - 13.0171 13.5971 F3 GETH 5 -7.72000 4.44700 .436 - 21.0271 5.5871 H_11 Basis Gel Carbomer 940 F1 GETH 1 -1.96400 3.96577 .987 - 13.8311 9.9031 F2 GETH 3 -6.46000 3.96577 .497 - 18.3271 5.4071 F3 GETH 5 -9.22800 3.96577 .178 - 21.0951 2.6391 Betadine Salep -7.28600 3.96577 .381 - 19.1531 4.5811 F1 GETH 1 Basis Gel Carbomer 940 1.96400 3.96577 .987 -9.9031 13.8311 F2 GETH 3 -4.49600 3.96577 .787 - 16.3631 7.3711 F3 GETH 5 -7.26400 3.96577 .384 - 19.1311 4.6031 Universitas Sumatera Utara 92 Lampiran 21. Lanjutan Betadine Salep -5.32200 3.96577 .669 - 17.1891 6.5451 F2 GETH 3 Basis Gel Carbomer 940 6.46000 3.96577 .497 -5.4071 18.3271 F1 GETH 1 4.49600 3.96577 .787 -7.3711 16.3631 F3 GETH 5 -2.76800 3.96577 .955 - 14.6351 9.0991 Betadine Salep -.82600 3.96577 1.000 - 12.6931 11.0411 F3 GETH 5 Basis Gel Carbomer 940 9.22800 3.96577 .178 -2.6391 21.0951 F1 GETH 1 7.26400 3.96577 .384 -4.6031 19.1311 F2 GETH 3 2.76800 3.96577 .955 -9.0991 14.6351 Betadine Salep 1.94200 3.96577 .987 -9.9251 13.8091 Betadine Salep Basis Gel Carbomer 940 7.28600 3.96577 .381 -4.5811 19.1531 F1 GETH 1 5.32200 3.96577 .669 -6.5451 17.1891 F2 GETH 3 .82600 3.96577 1.000 - 11.0411 12.6931 F3 GETH 5 -1.94200 3.96577 .987 - 13.8091 9.9251 H_12 Basis Gel Carbomer 940 F1 GETH 1 -3.14800 3.16857 .855 - 12.6295 6.3335 F2 GETH 3 -3.95200 3.16857 .725 - 13.4335 5.5295 F3 GETH 5 - 10.81400 3.16857 .021 - 20.2955 -1.3325 Betadine Salep -7.88800 3.16857 .133 - 17.3695 1.5935 F1 GETH 1 Basis Gel Carbomer 940 3.14800 3.16857 .855 -6.3335 12.6295 F2 GETH 3 -.80400 3.16857 .999 - 10.2855 8.6775 Universitas Sumatera Utara 93 Lampiran 21. Lanjutan F3 GETH 5 -7.66600 3.16857 .151 - 17.1475 1.8155 Betadine Salep -4.74000 3.16857 .577 - 14.2215 4.7415 F2 GETH 3 Basis Gel Carbomer 940 3.95200 3.16857 .725 -5.5295 13.4335 F1 GETH 1 .80400 3.16857 .999 -8.6775 10.2855 F3 GETH 5 -6.86200 3.16857 .233 - 16.3435 2.6195 Betadine Salep -3.93600 3.16857 .728 - 13.4175 5.5455 F3 GETH 5 Basis Gel Carbomer 940 10.81400 3.16857 .021 1.3325 20.2955 F1 GETH 1 7.66600 3.16857 .151 -1.8155 17.1475 F2 GETH 3 6.86200 3.16857 .233 -2.6195 16.3435 Betadine Salep 2.92600 3.16857 .884 -6.5555 12.4075 Betadine Salep Basis Gel Carbomer 940 7.88800 3.16857 .133 -1.5935 17.3695 F1 GETH 1 4.74000 3.16857 .577 -4.7415 14.2215 F2 GETH 3 3.93600 3.16857 .728 -5.5455 13.4175 F3 GETH 5 -2.92600 3.16857 .884 - 12.4075 6.5555 H_13 Basis Gel Carbomer 940 F1 GETH 1 -3.73400 3.16584 .763 - 13.2074 5.7394 F2 GETH 3 -3.92600 3.16584 .729 - 13.3994 5.5474 F3 GETH 5 - 10.92000 3.16584 .019 - 20.3934 -1.4466 Betadine Salep -7.88600 3.16584 .133 - 17.3594 1.5874 F1 GETH 1 Basis Gel Carbomer 940 3.73400 3.16584 .763 -5.7394 13.2074 F2 GETH 3 -.19200 3.16584 1.000 -9.6654 9.2814 Universitas Sumatera Utara 94 Lampiran 21. Lanjutan F3 GETH 5 -7.18600 3.16584 .196 - 16.6594 2.2874 Betadine Salep -4.15200 3.16584 .687 - 13.6254 5.3214 F2 GETH 3 Basis Gel Carbomer 940 3.92600 3.16584 .729 -5.5474 13.3994 F1 GETH 1 .19200 3.16584 1.000 -9.2814 9.6654 F3 GETH 5 -6.99400 3.16584 .217 - 16.4674 2.4794 Betadine Salep -3.96000 3.16584 .723 - 13.4334 5.5134 F3 GETH 5 Basis Gel Carbomer 940 10.92000 3.16584 .019 1.4466 20.3934 F1 GETH 1 7.18600 3.16584 .196 -2.2874 16.6594 F2 GETH 3 6.99400 3.16584 .217 -2.4794 16.4674 Betadine Salep 3.03400 3.16584 .870 -6.4394 12.5074 Betadine Salep Basis Gel Carbomer 940 7.88600 3.16584 .133 -1.5874 17.3594 F1 GETH 1 4.15200 3.16584 .687 -5.3214 13.6254 F2 GETH 3 3.96000 3.16584 .723 -5.5134 13.4334 F3 GETH 5 -3.03400 3.16584 .870 - 12.5074 6.4394 H_14 Basis Gel Carbomer 940 F1 GETH 1 -6.22600 2.75107 .198 - 14.4582 2.0062 F2 GETH 3 -8.07000 2.75107 .056 - 16.3022 .1622 F3 GETH 5 - 11.36800 2.75107 .004 - 19.6002 -3.1358 Betadine Salep - 11.17600 2.75107 .005 - 19.4082 -2.9438 F1 GETH 1 Basis Gel Carbomer 940 6.22600 2.75107 .198 -2.0062 14.4582 Universitas Sumatera Utara 95 Lampiran 21. Lanjutan F2 GETH 3 -1.84400 2.75107 .961 - 10.0762 6.3882 F3 GETH 5 -5.14200 2.75107 .365 - 13.3742 3.0902 Betadine Salep -4.95000 2.75107 .401 - 13.1822 3.2822 F2 GETH 3 Basis Gel Carbomer 940 8.07000 2.75107 .056 -.1622 16.3022 F1 GETH 1 1.84400 2.75107 .961 -6.3882 10.0762 F3 GETH 5 -3.29800 2.75107 .752 - 11.5302 4.9342 Betadine Salep -3.10600 2.75107 .790 - 11.3382 5.1262 F3 GETH 5 Basis Gel Carbomer 940 11.36800 2.75107 .004 3.1358 19.6002 F1 GETH 1 5.14200 2.75107 .365 -3.0902 13.3742 F2 GETH 3 3.29800 2.75107 .752 -4.9342 11.5302 Betadine Salep .19200 2.75107 1.000 -8.0402 8.4242 Betadine Salep Basis Gel Carbomer 940 11.17600 2.75107 .005 2.9438 19.4082 F1 GETH 1 4.95000 2.75107 .401 -3.2822 13.1822 F2 GETH 3 3.10600 2.75107 .790 -5.1262 11.3382 F3 GETH 5 -.19200 2.75107 1.000 -8.4242 8.0402 H_15 Basis Gel Carbomer 940 F1 GETH 1 -6.32400 2.43641 .109 - 13.6147 .9667 F2 GETH 3 -6.76600 2.43641 .077 - 14.0567 .5247 F3 GETH 5 - 10.98800 2.43641 .002 - 18.2787 -3.6973 Betadine Salep - 12.66600 2.43641 .000 - 19.9567 -5.3753 F1 GETH 1 Basis Gel Carbomer 940 6.32400 2.43641 .109 -.9667 13.6147 Universitas Sumatera Utara 96 Lampiran 21. Lanjutan F2 GETH 3 -.44200 2.43641 1.000 -7.7327 6.8487 F3 GETH 5 -4.66400 2.43641 .342 - 11.9547 2.6267 Betadine Salep -6.34200 2.43641 .108 - 13.6327 .9487 F2 GETH 3 Basis Gel Carbomer 940 6.76600 2.43641 .077 -.5247 14.0567 F1 GETH 1 .44200 2.43641 1.000 -6.8487 7.7327 F3 GETH 5 -4.22200 2.43641 .438 - 11.5127 3.0687 Betadine Salep -5.90000 2.43641 .150 - 13.1907 1.3907 F3 GETH 5 Basis Gel Carbomer 940 10.98800 2.43641 .002 3.6973 18.2787 F1 GETH 1 4.66400 2.43641 .342 -2.6267 11.9547 F2 GETH 3 4.22200 2.43641 .438 -3.0687 11.5127 Betadine Salep -1.67800 2.43641 .957 -8.9687 5.6127 Betadine Salep Basis Gel Carbomer 940 12.66600 2.43641 .000 5.3753 19.9567 F1 GETH 1 6.34200 2.43641 .108 -.9487 13.6327 F2 GETH 3 5.90000 2.43641 .150 -1.3907 13.1907 F3 GETH 5 1.67800 2.43641 .957 -5.6127 8.9687 H_16 Basis Gel Carbomer 940 F1 GETH 1 -3.41400 2.22208 .552 - 10.0633 3.2353 F2 GETH 3 -5.42600 2.22208 .145 - 12.0753 1.2233 F3 GETH 5 -8.74800 2.22208 .006 - 15.3973 -2.0987 Betadine Salep -8.37400 2.22208 .009 - 15.0233 -1.7247 Universitas Sumatera Utara 97 Lampiran 21. Lanjutan F1 GETH 1 Basis Gel Carbomer 940 3.41400 2.22208 .552 -3.2353 10.0633 F2 GETH 3 -2.01200 2.22208 .891 -8.6613 4.6373 F3 GETH 5 -5.33400 2.22208 .156 - 11.9833 1.3153 Betadine Salep -4.96000 2.22208 .209 - 11.6093 1.6893 F2 GETH 3 Basis Gel Carbomer 940 5.42600 2.22208 .145 -1.2233 12.0753 F1 GETH 1 2.01200 2.22208 .891 -4.6373 8.6613 F3 GETH 5 -3.32200 2.22208 .577 -9.9713 3.3273 Betadine Salep -2.94800 2.22208 .679 -9.5973 3.7013 F3 GETH 5 Basis Gel Carbomer 940 8.74800 2.22208 .006 2.0987 15.3973 F1 GETH 1 5.33400 2.22208 .156 -1.3153 11.9833 F2 GETH 3 3.32200 2.22208 .577 -3.3273 9.9713 Betadine Salep .37400 2.22208 1.000 -6.2753 7.0233 Betadine Salep Basis Gel Carbomer 940 8.37400 2.22208 .009 1.7247 15.0233 F1 GETH 1 4.96000 2.22208 .209 -1.6893 11.6093 F2 GETH 3 2.94800 2.22208 .679 -3.7013 9.5973 F3 GETH 5 -.37400 2.22208 1.000 -7.0233 6.2753 H_17 Basis Gel Carbomer 940 F1 GETH 1 -4.51000 1.76550 .118 -9.7930 .7730 F2 GETH 3 -4.88000 1.76550 .079 - 10.1630 .4030 F3 GETH 5 -8.04600 1.76550 .002 - 13.3290 -2.7630 Betadine Salep - 11.27200 1.76550 .000 - 16.5550 -5.9890 F1 GETH 1 Basis Gel Carbomer 940 4.51000 1.76550 .118 -.7730 9.7930 Universitas Sumatera Utara 98 Lampiran 21. Lanjutan F2 GETH 3 -.37000 1.76550 1.000 -5.6530 4.9130 F3 GETH 5 -3.53600 1.76550 .300 -8.8190 1.7470 Betadine Salep -6.76200 1.76550 .008 - 12.0450 -1.4790 F2 GETH 3 Basis Gel Carbomer 940 4.88000 1.76550 .079 -.4030 10.1630 F1 GETH 1 .37000 1.76550 1.000 -4.9130 5.6530 F3 GETH 5 -3.16600 1.76550 .404 -8.4490 2.1170 Betadine Salep -6.39200 1.76550 .013 - 11.6750 -1.1090 F3 GETH 5 Basis Gel Carbomer 940 8.04600 1.76550 .002 2.7630 13.3290 F1 GETH 1 3.53600 1.76550 .300 -1.7470 8.8190 F2 GETH 3 3.16600 1.76550 .404 -2.1170 8.4490 Betadine Salep -3.22600 1.76550 .386 -8.5090 2.0570 Betadine Salep Basis Gel Carbomer 940 11.27200 1.76550 .000 5.9890 16.5550 F1 GETH 1 6.76200 1.76550 .008 1.4790 12.0450 F2 GETH 3 6.39200 1.76550 .013 1.1090 11.6750 F3 GETH 5 3.22600 1.76550 .386 -2.0570 8.5090 H_18 Basis Gel Carbomer 940 F1 GETH 1 -5.89600 1.39406 .003 - 10.0676 -1.7244 F2 GETH 3 -6.24600 1.39406 .002 - 10.4176 -2.0744 F3 GETH 5 -7.61200 1.39406 .000 - 11.7836 -3.4404 Universitas Sumatera Utara 99 Lampiran 21. Lanjutan Betadine Salep -9.78200 1.39406 .000 - 13.9536 -5.6104 F1 GETH 1 Basis Gel Carbomer 940 5.89600 1.39406 .003 1.7244 10.0676 F2 GETH 3 -.35000 1.39406 .999 -4.5216 3.8216 F3 GETH 5 -1.71600 1.39406 .734 -5.8876 2.4556 Betadine Salep -3.88600 1.39406 .075 -8.0576 .2856 F2 GETH 3 Basis Gel Carbomer 940 6.24600 1.39406 .002 2.0744 10.4176 F1 GETH 1 .35000 1.39406 .999 -3.8216 4.5216 F3 GETH 5 -1.36600 1.39406 .861 -5.5376 2.8056 Betadine Salep -3.53600 1.39406 .122 -7.7076 .6356 F3 GETH 5 Basis Gel Carbomer 940 7.61200 1.39406 .000 3.4404 11.7836 F1 GETH 1 1.71600 1.39406 .734 -2.4556 5.8876 F2 GETH 3 1.36600 1.39406 .861 -2.8056 5.5376 Betadine Salep -2.17000 1.39406 .540 -6.3416 2.0016 Betadine Salep Basis Gel Carbomer 940 9.78200 1.39406 .000 5.6104 13.9536 F1 GETH 1 3.88600 1.39406 .075 -.2856 8.0576 F2 GETH 3 3.53600 1.39406 .122 -.6356 7.7076 F3 GETH 5 2.17000 1.39406 .540 -2.0016 6.3416 H_19 Basis Gel Carbomer 940 F1 GETH 1 -5.29400 1.12732 .001 -8.6674 -1.9206 F2 GETH 3 -5.32800 1.12732 .001 -8.7014 -1.9546 F3 GETH 5 -5.95200 1.12732 .000 -9.3254 -2.5786 Betadine Salep -7.49000 1.12732 .000 - 10.8634 -4.1166 F1 GETH 1 Basis Gel Carbomer 940 5.29400 1.12732 .001 1.9206 8.6674 F2 GETH 3 -.03400 1.12732 1.000 -3.4074 3.3394 Universitas Sumatera Utara 100 Lampiran 21. Lanjutan F3 GETH 5 -.65800 1.12732 .976 -4.0314 2.7154 Betadine Salep -2.19600 1.12732 .326 -5.5694 1.1774 F2 GETH 3 Basis Gel Carbomer 940 5.32800 1.12732 .001 1.9546 8.7014 F1 GETH 1 .03400 1.12732 1.000 -3.3394 3.4074 F3 GETH 5 -.62400 1.12732 .980 -3.9974 2.7494 Betadine Salep -2.16200 1.12732 .340 -5.5354 1.2114 F3 GETH 5 Basis Gel Carbomer 940 5.95200 1.12732 .000 2.5786 9.3254 F1 GETH 1 .65800 1.12732 .976 -2.7154 4.0314 F2 GETH 3 .62400 1.12732 .980 -2.7494 3.9974 Betadine Salep -1.53800 1.12732 .656 -4.9114 1.8354 Betadine Salep Basis Gel Carbomer 940 7.49000 1.12732 .000 4.1166 10.8634 F1 GETH 1 2.19600 1.12732 .326 -1.1774 5.5694 F2 GETH 3 2.16200 1.12732 .340 -1.2114 5.5354 F3 GETH 5 1.53800 1.12732 .656 -1.8354 4.9114 H_20 Basis Gel Carbomer 940 F1 GETH 1 -5.29400 .58887 .000 -7.0561 -3.5319 F2 GETH 3 -5.29400 .58887 .000 -7.0561 -3.5319 F3 GETH 5 -5.29400 .58887 .000 -7.0561 -3.5319 Betadine Salep -5.29400 .58887 .000 -7.0561 -3.5319 F1 GETH 1 Basis Gel Carbomer 940 5.29400 .58887 .000 3.5319 7.0561 F2 GETH 3 .00000 .58887 1.000 -1.7621 1.7621 F3 GETH 5 .00000 .58887 1.000 -1.7621 1.7621 Betadine Salep .00000 .58887 1.000 -1.7621 1.7621 F2 GETH 3 Basis Gel Carbomer 940 5.29400 .58887 .000 3.5319 7.0561 Universitas Sumatera Utara 101 Lampiran 21. Lanjutan F1 GETH 1 .00000 .58887 1.000 -1.7621 1.7621 F3 GETH 5 .00000 .58887 1.000 -1.7621 1.7621 Betadine Salep .00000 .58887 1.000 -1.7621 1.7621 F3 GETH 5 Basis Gel Carbomer 940 5.29400 .58887 .000 3.5319 7.0561 F1 GETH 1 .00000 .58887 1.000 -1.7621 1.7621 F2 GETH 3 .00000 .58887 1.000 -1.7621 1.7621 Betadine Salep .00000 .58887 1.000 -1.7621 1.7621 Betadine Salep Basis Gel Carbomer 940 5.29400 .58887 .000 3.5319 7.0561 F1 GETH 1 .00000 .58887 1.000 -1.7621 1.7621 F2 GETH 3 .00000 .58887 1.000 -1.7621 1.7621 F3 GETH 5 .00000 .58887 1.000 -1.7621 1.7621 H_21 Basis Gel Carbomer 940 F1 GETH 1 -2.70000 .74565 .013 -4.9313 -.4687 F2 GETH 3 -2.70000 .74565 .013 -4.9313 -.4687 F3 GETH 5 -2.70000 .74565 .013 -4.9313 -.4687 Betadine Salep -2.70000 .74565 .013 -4.9313 -.4687 F1 GETH 1 Basis Gel Carbomer 940 2.70000 .74565 .013 .4687 4.9313 F2 GETH 3 .00000 .74565 1.000 -2.2313 2.2313 F3 GETH 5 .00000 .74565 1.000 -2.2313 2.2313 Betadine Salep .00000 .74565 1.000 -2.2313 2.2313 F2 GETH 3 Basis Gel Carbomer 940 2.70000 .74565 .013 .4687 4.9313 F1 GETH 1 .00000 .74565 1.000 -2.2313 2.2313 F3 GETH 5 .00000 .74565 1.000 -2.2313 2.2313 Betadine Salep .00000 .74565 1.000 -2.2313 2.2313 Universitas Sumatera Utara 102 Lampiran 21. Lanjutan F3 GETH 5 Basis Gel Carbomer 940 2.70000 .74565 .013 .4687 4.9313 F1 GETH 1 .00000 .74565 1.000 -2.2313 2.2313 F2 GETH 3 .00000 .74565 1.000 -2.2313 2.2313 Betadine Salep .00000 .74565 1.000 -2.2313 2.2313 Betadine Salep Basis Gel Carbomer 940 2.70000 .74565 .013 .4687 4.9313 F1 GETH 1 .00000 .74565 1.000 -2.2313 2.2313 F2 GETH 3 .00000 .74565 1.000 -2.2313 2.2313 F3 GETH 5 .00000 .74565 1.000 -2.2313 2.2313 H_22 Basis Gel Carbomer 940 F1 GETH 1 -1.70000 .57966 .056 -3.4345 .0345 F2 GETH 3 -1.70000 .57966 .056 -3.4345 .0345 F3 GETH 5 -1.70000 .57966 .056 -3.4345 .0345 Betadine Salep -1.70000 .57966 .056 -3.4345 .0345 F1 GETH 1 Basis Gel Carbomer 940 1.70000 .57966 .056 -.0345 3.4345 F2 GETH 3 .00000 .57966 1.000 -1.7345 1.7345 F3 GETH 5 .00000 .57966 1.000 -1.7345 1.7345 Betadine Salep .00000 .57966 1.000 -1.7345 1.7343 F2 GETH 3 Basis Gel Carbomer 940 1.70000 .57966 .056 -.0345 3.4345 F1 GETH 1 .00000 .57966 1.000 -1.7345 1.7345 F3 GETH 5 .00000 .57966 1.000 -1.7345 1.7345 Betadine Salep .00000 .57966 1.000 -1.7345 1.7345 F3 GETH 5 Basis Gel Carbomer 940 1.70000 .57966 .056 -.0345 3.4345 Universitas Sumatera Utara 103 Lampiran 21. Lanjutan F1 GETH 1 .00000 .57966 1.000 -1.7345 1.7345 F2 GETH 3 .00000 .57966 1.000 -1.7345 1.7345 Betadine Salep .00000 .57966 1.000 -1.7345 1.7345 Betadine Salep Basis Gel Carbomer 940 1.70000 .57966 .056 -.0345 3.4345 F1 GETH 1 .00000 .57966 1.000 -1.7345 1.7345 F2 GETH 3 .00000 .57966 1.000 -1.7345 1.7345 F3 GETH 5 .00000 .57966 1.000 -1.7345 1.7345 . The mean difference is significant at the 0.05 level. Universitas Sumatera Utara 48 DAFTAR PUSTAKA Anonim. 2012. Metode Ekstraksi. Diakses tanggal 29 maret 2015. http:acepqurnadi.wordpress.com20120228rangk-farmakognosi-part2 Ackerman, A.B. 1987. Structure and fungtion of The Skin, Penerjemah: Syarief M. W. Edisi II. Philadelphia: WB Saunder Company. Halaman.1-64. Anief, M. 2000. Farmasetika. Yogyakarta: Gajah Mada University Press. Halaman 118-120. Ansel, H.C. 1989. Pengantar Bentuk Sediaan Farmasi. Edisi Keempat. Jakarta: Penerbit UI Press. Halaman 162, 490, 491, 492. Arisanty, I.P. 2013. Konsep Dasar Manajemen Perawatan Luka. Jakarta: EGC. Halaman 29. Asadi SY, Parsaei P, Karimi M, Ezzati S, Zamiri A, Mohammadizadeh F, Rafieian-Kopaei M. 2013Effect of green tea Camellia sinensis extract on healing process of surgical wounds in rat.Int J Surg;114:332-7. Baroroh, D.B. 2011. Konsep Luka. Malang: Basic Nursing Department PSIK FIKES UMM . Halaman. 2. Boyle, M. 2009. Wound Healing in Midwifery. Abingdon: Radcliffe Publishing Ltd. Halaman 14. Carter, J.S. 1975. Dispensing For Pharmaceutical Student. Edisi dua belas. London: Pitman Medical. Halaman 184. Dewi, I.A.L.P., Damriyasa, I.M., dan Dada, I.K.A. 2013. Bioaktivitas Ekstrak Daun Tapak Dara Catharanthus roseus Terhadap Periode Epitelisasi Dalam Proses Penyembuhan Luka Pada Tikus Wistar. Indonesia Medicus Veterinus. 21: 71-72. Djajadisastra, J., Mun’im., dan Dessy, N.P. 2007. Formulasi Gel Topikal dari Ekstrak Nerii Folium dalam Sediaan Antijerawat . Jurnal Farmasi Indonesia. 44: 210-216. Ditjen POM. 2008. Farmakope Herbal Indonesia, Edisi I. 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BAB III METODE PENELITIAN

Metode yang digunakan dalam penelitian ini adalah metode eksperimental. Penelitian ini meliputi penyiapan sampel, pembuatan ekstrak daun teh hijau, pemeriksaan karakteristik ekstrak, pengelompokan hewan uji, pembuatan sediaan gel ekstrak daun teh hijau, pemeriksaan terhadap sediaan pemeriksaan organoleptis, pengamatan homogenitas, pengukuran pH sediaan, pengukuran viskositas sediaan, pengujian efek penyembuh luka sayat pada tikus putih dan histopatologi epitel kulit tikus putih. 3.1 Alat dan Bahan 3.1.1 Alat