Dengan pemberian ekstrak bunga pepaya jantan dosis 40 mgkgbb Dengan pemberian ekstrak bunga pepaya jantan dosis 80 mgkgbb Tanpa pemberian ekstrak bunga pepaya jantan

64

12.3 Dengan pemberian ekstrak bunga pepaya jantan dosis 40 mgkgbb

Waktu jam Tikus 1 Tikus 2 Tikus 3 Tikus 4 Tikus 5 Absorpsi Kadar mcgml Absorpsi Kadar mcgml Absorpsi Kadar mcgml Absorpsi Kadar mcgml Absorpsi Kadar mcgml 0-6 0,1144 3,0796 0,1326 3.5475 0,1116 3,0077 0,3029 7,9254 0,2721 7,1336 6-12 0,1499 3,9922 0,3077 8,0488 0,0967 2,6246 0,2914 7,6298 0,3905 10,1773 12-18 0,1689 4,4807 0,2744 7,1928 0,1521 4,0488 0,3269 8,5424 0,3109 8,1311 18-24 0,1818 4,8123 0,4153 10,8149 0,1790 4,7403 0,2737 7,1748 0,285 7,4652 24-30 0,1936 5,1156 0,2823 7,3958 0,1667 4,4241 0,1089 2,9383 0,1831 4,8457

12.4 Dengan pemberian ekstrak bunga pepaya jantan dosis 80 mgkgbb

Waktu jam Tikus 1 Tikus 2 Tikus 3 Tikus 4 Tikus 5 Absorpsi Kadar mcgml Absorpsi Kadar mcgml Absorpsi Kadar mcgml Absorpsi Kadar mcgml Absorpsi Kadar mcgml 0-6 0,6310 16,3598 0,5835 15,1388 0,5531 14,3573 0,2799 7,3341 0,2467 6,4807 6-12 0,3431 8,9588 0,3186 8,3290 0,2469 6,4858 0,1726 4,5758 0,1604 4,2622 12-18 0,3733 9,7352 0,2729 7,1542 0,3737 9,7455 0,2561 6,7223 0,4070 10,6015 18-24 0,3002 7,8560 0,4170 10,8586 0,1969 5,2005 0,2262 5,9537 0,2147 5,6580 24-30 0,4103 10,6863 0,3372 8,8020 0,3377 8,8200 0,2911 7,6221 0,1984 5,2339 Universitas Sumatera Utara 65 Lampiran 13. Hasil Perhitungan Parameter Farmakokinetik Urin Kumulatif

13.1 Tanpa pemberian ekstrak bunga pepaya jantan

Tikus 1 t jam Cu mcgml V ml Ae i Ae mcg mcg t jam mid dAedt mcgjam 0-6 8,0616 0,2 1,6123 1,6123 6 0,7076 6-12 7,6555 0,9 6,8899 8,4922 12 0,6281 12-18 5,5269 0,3 1,6580 9,1502 18 0,1620 18-24 6,4318 0,2 1,2863 10,4365 24 0,3984 24-30 6,9897 0,5 3,4948 13,9313 Tikus 2 t jam Cu mcgml V ml Ae i Ae mcg mcg t jam mid dAedt mcgjam 0-6 2,4421 0,8 1,9536 1,9536 6 0,4834 6-12 5,4961 0,7 3,8472 5,8008 12 1,1027 12-18 3,3521 2,8 9,3858 15,1866 18 1,9498 18-24 4,6709 3 14,0127 29,1993 24 1,7858 24-30 5,2982 1,4 7,4174 36,6167 Tikus 3 t jam Cu mcgml V ml Ae i Ae mcg mcg t jam mid dAedt mcgjam 0-6 4,3701 1 4,3701 4,3701 6 0,6376 6-12 4,1028 0,8 3,2822 7,6523 12 0,4457 12-18 2,5835 0,8 2,0668 9,7191 18 0,2332 18-24 2,4395 0,3 0,7318 14,4509 24 0,4341 24-30 4,4781 1 4,4781 14,929 Tikus 4 t jam Cu mcgml V ml Ae i Ae mcg mcg t jam mid dAedt mcgjam 0-6 3,8476 0,6 2,3320 2,3320 6 1,1507 6-12 5,4652 2,1 11,4769 13,8089 12 1,4386 12-18 1,9288 3 5,7864 19,5953 18 0,9020 18-24 1,7994 2,8 5,0383 24,6336 24 0,8123 24-30 2,3547 2 4,7094 29,343 Universitas Sumatera Utara 66 Tikus 5 t jam Cu mcgml V ml Ae i Ae mcg mcg t jam mid dAedt mcgjam 0-6 8,1748 0,6 4,9048 4,9048 6 0,7386 6-12 4,9485 0,8 3,9588 8,8636 12 0,6558 12-18 6,5192 0,6 3,9115 12,7751 18 0,7929 18-24 9,3393 0,6 5,6035 18,3786 24 1,3605 24-30 7,1491 1,5 10,7236 29,1022

13.2 Dengan pemberian ekstrak bunga pepaya jantan dosis 20 mgkgbb