BREAST CARCINOMA TUMOR ICTS2005 The Proceeding

Information and Communication Technology Seminar, Vol. 1 No. 1, August 2005 ISSN 1858-1633 2005 ICTS 136 the decision making systek in diagnosing breast carcinoma tumor in all health service institutions in Indonesia.

2. BREAST CARCINOMA TUMOR

Molecular Biology explains that cancer is caused by genetics mutation of BRCa1 and BRCa2. Around 2 of the cases show that this spontaneous mutation happens because of environmental effect. Based on epidemiology, breast carcinoma tumor caused by some factors called risk factors like age, hormone, diet, virus, radiation, others tumor sufferers and the wrong life pattern. Breast carcinoma develops mostly in dictums then goes through the parenchyma. The spread of this disease goes through the axial lymph local metastasis , then systemic. Further Metastasis can attack to the bone, lungs, and liver. Patient Prognosis is determined based on the spread and potency metastasis. But, without therapy, the ability to survive for the sufferers during 5 years is 16-22 and for 10 years is 1-5 . The survival ability of these sufferers is determined by the stage of the disease, treatment, histopathology description, estrogen and progesterone receptor and other bimolecular signals. Seen from oncology, immunity factor hold an important role towards the occurrence of this disease especially the violation to the immune system which affects the vicious cell formation. Tunor cell is a foreign material in the body with specific antigen arrangement. This material can trigger the immune response so that it is called as tumor associated antigen TAA. TAA is a surface antigen which rise the specific immune e response if injected to the same hospes. The individual response toward the tumor cell development is different because: 1. Body rejection because of incompatibilty 2. Body reception toward the foreign material. 3. the grow of that foreign material in the Genetically T cell is the host in controlling the tumor grows. That cell has the death ability directly the tumor cell through immune system activation. There are 2 kinds of T cell, CD 4 and CD 8; CD 4 will stimulate the emition of any mediator and induct any inflamation respon and CD 8, beside it has the ability to produce limfokin, themani thing is that its ability to kill the tumor cell directly. T cell has the memory to face the tumor cell through the change of T cell surface.one form of the change antigen is CD 44 on the surface of T cell membrane. The recent study expresses that CD 44 gene as the main indicator in diagnosing cancer, mestatasis diagnostic, and control the cure. CD 44 is molecule in leucocyt cell which take part in cell mediated community, limphocyt recirculation, T cell activation, adhetion to the other cells, intercellular matrix, hyaluronida metabolism, signals transduction through membrane cell and secretion. Through the complex mechanism, gens regulate the cell funtion and there is an expression change of the savage of the tumor. Based on this funtion, CD 44 expression is related to the metastasis in cancer Azamris dkk,2003.

3. WATERSHED ALGORITHM